Upcoming Special Seminars 

Genetic Studies of Autopsy-confirmed Parkinson Disease and Autopsy-confirmed Controls

Jeffery Vance, MD, PhD
Professor, Department of Human Genetics
Professor, Department of Neurology
University of Miami School of Medicine

Thursday, June 6, 2013 - 3:00 PM
Health Sciences Center, Room T-739

Faculty Sponsor: Tom Montine, MD, PhD

Why Attend?
Parkinson disease (PD) is a neurodegenerative disorder with a strong genetic component and complex etiology. However, 10-25% of clinically-diagnosed PD patients have differing diagnoses upon autopsy. To reduce potential heterogeneity in patient ascertainment, Dr. Vance led the Autopsy-confirmed Parkinson Disease Genetics Consortium (APDGC) to conduct a genome-wide association study (GWAS) of PD. The results differed substantially from clinically ascertained GWAS in PD. The study strongly supports the heterogeneity of the PD phenotype, identifies the PARK 10 PD locus as an important locus in neuropathologic- confirmed PD and suggests that the use of autopsy-proven controls may be critical to late-onset disorders. This approach may benefit other genetic studies in genetically heterogeneous disease.


Mind the "I" GAP: The Power of Collaboration in Alzheimer's Disease Genetics

Margaret Pericak-Vance, PhD
Professor, Department of Human Genomics
Director, Hussman Institute for Human Genomics
University of Miami School of Medicine

Thursday, June 6, 2013 - 4:00 PM
Health Sciences Center, Room T-739

Faculty Sponsor: Tom Montine, MD, PhD

Why Attend? TBA


Recent Special Seminars

Engineering Stem Cell Fate to Enable Human Cell- and Tissue-based Drug Screening and Development

Peter Zandstra, PhD
Canada Research Chair in Stem Cell Bioengineering; Professor, Institute of Biomaterials and Biomedical Engineering
Department of Chemical Engineering and Applied Chemistry and the Donnelly Centre for Cellular and Biomolecular Research
University of Toronto

Wednesday, January 16, 2013 - 9:00 AM
UW Medicine South Lake Union, Brotman Auditorium

Faculty Sponsor: Chuck Murry, MD, PhD

Why Attend?
Peter Zandstra is a leading figure in the world of stem cell engineering, studying key barriers to commercialization of stem cell therapies for heart, blood and endocrine diseases. We are hoping that Peter will lend some expertise to the Seattle area’s efforts at stem cell based tissue regeneration. After completing his PhD in chemical engineering, Peter did postdoctoral training with Doug Lauffenburger at MIT, bringing an engineer’s quantitative rigor to systems biology. Peter now works on problems like control of the stem cell’s microenvironment, scaling cell production, control of differentiation, pattern formation, bioreactors and the creative use of biomaterials. Dr. Zandstra is the recipient of numerous awards, including a Guggenheim Fellowship and the McLean Award. He also is funny, quick on his feet and gives a good lecture.


Well-Differentiated & Dedifferentiated Liposarcoma: Current Perspectives and Future Directions

Ashley Gullett, MD
Fellow in Bone and Soft Tissue Pathology
University of Washington

Tuesday, December 18, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Suzy Dintzis, MD, PhD

Speaker is a faculty candidate in Pathology.


Barrett's Esophagus: Variations on a Theme of Prediction

Xuefeng Zhang, MD, PhD
GI and Hepatic Fellow
University of Chicago

Tuesday, November 27, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Suzy Dintzis, MD, PhD

Speaker is a faculty candidate in Pathology


Druggable Pathways in Embryonal Rhabdomyosarcoma: Insights from a Zebrafish Disease Model

Eleanor Chen, MD, PhD
Instructor
Department of Pathology
Harvard Medical School

Tuesday, November 20, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Suzy Dintzis, MD, PhD

Speaker is a faculty candidate in Pathology


Head & Neck Squamous Cell Carcinoma: Histologic Variants, Potential Problems, and New Directions

Nicole Cipriani, MD
Surgical Pathology Fellow
Massachusetts General Hospital

Tuesday, October 23, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Tom Montine, MD, PhD

Speaker is a faculty candidate in pathology


Non-invasive Whole Genome Sequencing of a Human Fetus

Jay Shendure, MD, PhD
Associate Professor
Genome Sciences
University of Washington School of Medicine

Wednesday, June 27, 2012 - 4:30 PM
Genome Sciences Building, Foege Auditorium

Faculty Sponsor: Christine Disteche, PhD

Why Attend?
Dr. Jay Shendure will present exciting new work that demonstrates the feasibility of obtaining whole genome sequence information on a human fetus by sequencing DNA from maternal blood that contains circulating fetal DNA as well as maternal DNA. A new approach to sequence analysis allowed fetal DNA to be distinguished from maternal and paternal genomes, as well as the identification of new mutations in the fetus. This pioneering study opens new avenues for prenatal detection of mutations using a noninvasive procedure.


A Novel TAK1 Signaling Network in Myocardial Survival and Remodeling

Qinghang (Chris) Liu, PhD
Assistant Professor
Department of Physiology & Biophysics
University of Washington School of Medicine

Wednesday, June 20, 2012 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Bill Mahoney, PhD

Why Attend?
Cardiac hypertrophy and heart failure are the major causes of morbidity and mortality in humans. In a number of pathological conditions (e.g., hypertension, vascular disease, myocardial infarction, and cardiomyopathy) that impose overwork on the heart, postnatal cardiac myocytes undergo hypertrophic growth and cell death. Despite years of investigation, the molecular mechanisms that mediate the development of hypertrophy and its culmination in heart failure have not been clearly defined. Our previous work demonstrated that TGFβ-activated kinase 1 (TAK1) functions as a critical control point for the hypertrophic signaling network that also involves calcineurin-NFAT, NFκB, and MAPKs in the heart. Moreover, our recent studies reveal a previously unidentified, novel role for the TAK1 signaling in promoting cardiac cell survival and homeostasis by using genetically modified mouse models. Mechanistically, TAK1 functions as a molecular switch in TNFR1-mediated cell survival/death signaling via FADD-RIP1-caspase 8 and NFκB-Bnip3 pathways. These findings define an important cardio-protective signaling network, which may suggest new therapeutic strategies in the treatment of heart disease.


Therapeutic Targets for Cognitive Impairment

Thomas Montine, M.D., Ph.D.
Alvord Professor and Interim Chair
Department of Pathology
University of Washington

Wednesday, April 11, 2012 - 3:30 PM
Health Sciences Center, Room T-733

Speaker is a candidate for the Chair of the Department of Pathology

For more information contact the Dean of Medicine Office at 206 543-7718.


Studies of Dynamic Remodeling: Mucosal Barriers and the Practice of Pathology

Jerrold Turner, MD, PhD
Professor and Vice Chair
Department of Pathology
University of Chicago

Wednesday, April 4, 2012 - 3:00 PM
Health Sciences Center, Room T-733

Speaker is a candidate for the Chair of the Department of Pathology

For more information contact the Dean of Medicine Office at 206 543-7718.


Apoptosis and Autophagy: Key Partners in Neuronal Cell Death Regulation

Kevin A. Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham

Friday, March 30, 2012 - 1:30 PM
Health Sciences Center, Room T-733

Speaker is a candidate for the Chair of the Department of Pathology

For more information contact the Dean of Medicine Office at 206 543-7718.


Evolution of Sex Chromosomes and Dosage Compensation in Mammals

Jennifer A. Marshall Graves, PhD
Distinguished Professor
Institute of Molecular Sciences
La Trobe University, Melbourne, Australia

Wednesday, March 14, 2012 - 3:30 PM
Genome Sciences Builiding, Foege Auditorium

Faculty Sponsor: Christine Disteche, PhD

A special seminar hosted by the Departments of Pathology and Genome Sciences


Head and Neck Tumors - Emerging Diseases

F. Zahra Aly, MD, BDS, PhD
Cytopathology Fellow
George Washington University Hospital

Thursday, February 2, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Dolphine Oda, BDS, MSc

Speaker is a faculty candidate in Oral Pathology


Molecular Diagnostic Cytopathology in an Era of Targeted Therapeutics

Sinchita Roy Chowdhuri, M.D., Ph.D.
Molecular Diagnostic Fellow
Department of Pathology
Memorial Sloan-Kettering Cancer Center

Friday, January 27, 2012 - 12:45 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Rochelle Garcia, M.D.
Speaker is a faculty candidate in pathology.


Novel Approaches to GU Cancers: - Is microvessel density significant in prostate cancer biology? - Renal Tumor Subtyping by Multiplex Ligation-Dependent Probe Amplification (MLPA) Assay

Maria Tretiakova, M.D., Ph.D.
Anatomic and Clinical Pathology Resident
Department of Pathology
University of Chicago

Friday, January 13, 2012 - 12:30 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Larry True, M.D.

Speaker is a faculty candidate in Pathology


DNA Damage and its Repair in Young, Adult and Aging Neurons

Kalluri Subba Rao, Ph.D.
Senior Scientist, Indian National Science Academy
Professor Emeritus, Department of Biochemistry
University of Hyderabad, India

Friday, August 26, 2011 - 10:00 AM
UW Health Sciences Center, Rm. K-069

Faculty Sponsor: Larry Loeb, M.D., Ph.D.

Why Attend?
For many years, Dr. Rao has been one of the few scientists who has addressed important questions about DNA repair in non-dividing eukaryotic cells. His focus has been on the repair of oxygen-mediated DNA damage in neurons by base excision repair and the involvement of DNA polymerase beta in this process. He has considered the importance of deficits in DNA repair in aging and Alzheimer's disease.


Electrophysiology of Human Embryonic Stem Cell-Derived Cardiomyocytes

Michael Laflamme, M.D., Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington

Wednesday, July 20, 2011 - 4:30 PM
Health Sciences Center, Rm. T-625

Why Attend?
Cardiomyocytes derived from pluripotent human embryonic stem cells (hESCs) have a number of attractive properties for use in cell-based cardiac repair, and their transplantation has been shown to improve mechanical function in rodent models of myocardial infarction. In this presentation, I will address three questions that all relate to the electrophysiological behavior of hESC-derived cardiomyocytes in vivo: 1) Can we derive specialized cardiac subtypes from hESCs, i.e. ventricular versus nodal myocytes? 2) Do hESC-derived cardiac grafts become electromechanically integrated and contract synchronously with host myocardium? 3) Will the transplantation of hESC-derived cardiomyocytes increase or decrease the incidence of arrhythmias?


Systems Pathology: Moving Omics to Clinics

Michael Roehrl, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
Boston University School of Medicine

Monday, July 11, 2011 - 12:00 PM
UW Health Sciences Center, Room K-069

Faculty Sponsor: Drs. Swanson and True

Why Attend? Pathology will be the key player in personalized health care. We will illustrate recent advances in personalized molecular medicine with a particular emphasis on proteomic and metabolomic characterization of cancers. We show that systems-based and quantitative analyses of disease biomarkers will transform pathology into a key discipline for patient-centered tissue-based diagnostics, molecularly targeted therapy selection, and treatment response monitoring. We have also developed novel ultra-rapid biobanking strategies in pathology as a springboard for patient-focused basic cancer research.


PRDM1 beta in Marginal Zone Lymphoma and Lymphoplasmacytic Lymphoma

Cecilia Yeung, M.D.
Molecular Genetics Pathology Fellow
Washington University

Tuesday, April 5, 2011 - 8:00 AM
FHCRC, Thomas Building, Sze E/W Conference Room

Videoconferencing
SCCA, Rm. 3100/3102
UWMC, Rm. 8121
Seattle Children's Hospital, Rm. T-3246
VAPSHCS, Bldg 24, Room 14

Speaker is a candidate for a faculty position in Pathology


The Impact of Dropping the Requirement for Goblet Cells from the Diagnosis of Barrett's Esophagus

Maria Westerhoff, M.D.
GI & Liver Pathology Fellow
Department of Pathology
University of Chicago Medical Center

Thursday, February 17, 2011 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Paul Swanson, M.D.
Speaker is a candidate for a faculty position with UWMC AP.


Motors, Movement, and Malignancy

Steven S. Rosenfeld, M.D., Ph.D.
John and Elizabeth Harris Professor
Director, Division of Neuro-Oncology
Department of Neurology, Columbia University

Monday, July 19, 2010 - 4:30 PM
UWMC, Genome Sciences Building, Foege Auditorium

Faculty Sponsor: Thomas Montine, M.D., Ph.D.


Weird Animal Genomes and Sex

Jenny Graves, Ph.D.
Professor, Comparative Genomics
Research School of Biological Sciences
Australian National University, Canberra

Wednesday, May 19, 2010 - 1:30 PM
Genome Sciences Building, Foege Auditorium

Faculty Sponsor: Christine Disteche, Ph.D.

Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes.



Similarities and Differences of Diabetic Nephropathy in Type 1 vs. Type 2 Diabetic Patients

Behzad Najafian, M.D.
Assistant Professor
Laboratory Medicine and Pathology
University of Minnesota

Thursday, February 25, 2010 - 3:30 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Charles Alpers, M.D.
Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served


Anti-Aging Genes, DNA Damage and Cancer

Valter Longo, Ph.D.
Assistant Professor
Department of Gerontology/Alzheimer's Research
University of Southern California

Tuesday, May 12, 2009 - 12:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence


Metabolic Stability and the Evolution of Life Span

Lloyd Demetrius, PhD
Department of Evolutionary & Organismic Biology
Harvard University

Tuesday, March 10, 2009 - 3:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.

Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant


Mitochondrial-targeted Peptides: Novel Cardio-, Neuro- and Renal-protective Agents

Hazel H. Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College

Tuesday, February 17, 2009 - 3:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant


A Recurrent Mutation, p.R961W, in the MED12/TRAP/HOPA Gene Causes Opitz-Kaveggia (FG) Syndrome

Hiba Risheg, Ph.D.
Director
Clinical Ctyogenetics Laboratory
Genecare Medical Genetics Center

Monday, April 14, 2008 - 3:00 PM
Health Sciences Center, T-747

Faculty Sponsor: Dr. Christine Disteche
Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology


Glioma Invasion: Interactions with the Microenvironment

Joanna Phillips, MD, PhD
UW Medicine, Neuropathology Faculty Candidate
Department of Pathology, Division of Neuropathology, Research Fellow
University of California, San Francisco

Wednesday, March 26, 2008 - 9:30 AM
R&T Building, 300 Ninth Ave, auditorium

Faculty Sponsor: Montine


The Genetic Basis of Fanconi Anemia and Other Heritable Chromosome Instability Syndromes

Dr. Holger Hoehn
Professor
Humangenetik Institute
University of Wurzburg

Thursday, February 7, 2008 - 3:30 PM
Health Sciences Center, T-747

Faculty Sponsor: Peter Rabinovitch


Secondary Mutations as a Mechanism of Cisplatin Resistance in BRCA1/2-Mutated Cancers: Lessons Learned from Studies on a Rare Genetic Disease, Fanconi Anemia

Toshiyasu Taniguchi, M.D., Ph.D.
Assistant Member
Divisions of Human Biology and Public Health Sciences
Fred Hutchinson Cancer Research Center

Monday, December 17, 2007 - 3:00 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat
Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology


Clinical Experience of High Resolution Oligonucleotide Array:

Ji Yun Lee, Ph.D.
ABMG Training Program Trainee
Department of Human Genetics
Emory University

Monday, September 17, 2007 - 3:00 PM
Health Sciences Center, Turner Auditorium, D-209

Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided


Base of Skull Chordoma: The Conundrum of Morphology and Biology

Benjamin Hoch, M.D.
Assistant Professor
Department of Pathology
Mount Sinai School of Medicine

Monday, August 20, 2007 - 1:00 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Paul Swanson, M.D.
Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology


Multicolor Karyotyping & Banding in Non-Hodgkin Lymphoma and Bac Array CGH in Chronic Lymphocytic Leukemia

Valia S. Lestou, Ph.D.
Researcher
University of British Columbia Center for Disease Control

Tuesday, July 17, 2007 - 2:00 PM
Health Sciences Center, Turner Auditorium, Room D-209

Faculty Sponsor: Christine Disteche

Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology

Refreshments provided


It's a Small World After All: The MicroRNA Gene Expression Profile of HCV-Associated Hepatocellular Carcinoma

Heike Varnholt, M.D.
Staff Pathologist
Division of Gastrointestinal and Hepatobiliary Pathology
University Hospital of Cologne, Germany

Friday, June 22, 2007 - 12:30 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Dr. Melissa Upton
Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided.


Finding Genes for Uterine Fibroids

Jennelle Hodge, Ph.D.
Senior Research Fellow
Department of OB-GYN and Reproductive Biology
Brigham and Women's Hospital, Harvard Medical School

Monday, June 11, 2007 - 3:30 PM
Health Sciences Center, Turner Auditorium, D-209

Faculty Sponsor: Christine Disteche
Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology


To Call or Not to Call: The Challenge of Intraoperative Frozen Section

Gang He, M.D., Ph.D.
Bone and Soft Tissue Fellow
Department of Pathology
University of Chicago

Monday, May 7, 2007 - 1:00 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Paul Swanson
Dr. He is a clinical faculty candidate for bone and soft tissue pathology.


DNA Processing in Autoimmune Disease

Fred Perrino, Ph.D.
Professor
Department of Biochemistry
Wake Forest University Health Sciences

Monday, April 2, 2007 - 11:30 AM
Health Sciences Center, K-069

Faculty Sponsor: Larry Loeb and Brad Preston


Repair of oxidative DNA damage and human disease

Dr. Will Bohr
NIA

Wednesday, March 21, 2007 - 4:30 PM
Health Sciences Building, K-069

Faculty Sponsor: Dr. Monnat
This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP).


Immunoexpression of Hypoxia-related Genes in Retroperitoneal Sarcomas

Paul Zhang, M.D.
Associate Professor
Pathology and Lab Medicine
University of Pennsylvania School of Medicine

Monday, February 12, 2007 - 1:00 PM
University of Washington Medical Center, NE-110 Conference Room

Faculty Sponsor: Larry True
Speaker is a candidate for a clinical faculty position with the Department of Pathology


Subtelomere Dynamics: Why So Many Breaks?

Katie Rudd, Ph.D.
Postdoctoral Fellow
Fred Hutchinson Cancer Research Center

Wednesday, January 31, 2007 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Christine Disteche
Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology


Genome of Weird Australian Mammals

Jenny Graves, Ph.D.
Professor
Comparative Genomics
Australian National University

Monday, January 29, 2007 - 4:30 PM
Genome Sciences Building, Foege Auditorium

Faculty Sponsor: Christine Disteche


Towards Targeted Therapy in Sarcoma: Somatostatin Type-2 Receptor Expression in Bone and Soft Tissue Tumors

William Ahrens
Senior Fellow
Surgical Pathology - Bone and Soft Tissue
Mayo Clinic

Tuesday, November 7, 2006 - 11:00 AM
UWMC, NE-110 Conference Room

Faculty Sponsor: Paul Swanson
Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology


Thyroid Dysfunction in Heart Failure

A. Martin Gerdes
Professor, Medicine and Director
South Dakota Cardiovascular Research Institute, Sioux Falls
University of South Dakota

Thursday, September 14, 2006 - 8:30 AM
Brotman Building, 815 Mercer Street, Room 111, Auditorium

Faculty Sponsor: Chuck Murry
Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able.


Electrophysiological Cortical Imaging of Brain Electrical Activity

Yuan Lai, PhD
Fellow Candidate
Electrical Engineering
University of Illinois, Chicago

Thursday, August 31, 2006 - 1:30 PM
Brotman Building (SLU), 110

Faculty Sponsor: Chun Yuan
815 Mercer Street Vascular Imaging Labororatory Seminar


Toxicogenomics of Endemic Nephropathy: A Multinational Disease

Arthur Grollman, M.D.
Distinguished Professor of Pharmacological Sciences and Medicine
State University of New York at Stony Brook

Wednesday, August 2, 2006 - 3:30 PM
Health Sciencs Center, K-069

Faculty Sponsor: Dr. Larry Loeb


Mechanism of the Cerebral Cortex Malformation Caused by FGFR3 Mutations

Tomoko Iwata, Ph.D.
Beatson Laboratories for Cancer Research
University of Glasgow
Scotland, UK

Friday, March 10, 2006 - 9:30 AM
Harborview Medical Center, R&T Building, Room 109

Faculty Sponsor: Robert Hevner

Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning.

The lecture is free and open to the public.


Distinguished Faculty Lecture
"Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice"


Michael Rosenfeld, Ph.D.
Professor
Department of Pathobiology
University of Washington

Thursday, March 2, 2006 - 3:30 PM
Health Sciences Center, Room T-625

Faculty Sponsor: Terrance Kavanagh
For more information, please contact Billie Grace at 206.543.1144


ABC cholesterol transporters as rescuers from cardiovascular disease

John F. Oram
Research Professor
Medicine
UWSOM

Thursday, February 9, 2006 - 4:00 PM
SLU 815 Mercer Street, 111
South Lake Union Seminar Series


Metalloproteinases: Effectors of Repair or Conspirators of Disease?

William Parks
Director
Center for Lung Biology
UWSOM

Thursday, January 19, 2006 - 4:00 AM
SLU South Lake Union, 111 (Auditorium)

Faculty Sponsor: Stephen M. Schwartz
Special Tapas. Refreshments 3:45 p.m.


Current Diagnosis of Ovarian Mucinous Tumors

Hongxiu Ji, M.D., Ph.D.
Assistant Professor
Departments of Pathology and Obstetrics/Gynecology
The Johns Hopkins University School of Medicine

Tuesday, January 10, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
The special seminar will be presented as part of a didactic session with the residents.


Vaccines Targeting Breast and Ovarian Cancers

Nora Disis MD
Associate Professor
Department of Medicine, Division of Oncology
UWSOM

Thursday, December 15, 2005 - 4:00 PM
SLU 815 Mercer Street, 111
Special Tapas Seminar


Assaying Methylation Markers using Coded Silica Particles

Simon Corrie
Visiting Fellow
Pathology
University of Queensland, Australia

Thursday, December 15, 2005 - 9:30 AM
SLU, 815 Mercer Street, 111

Faculty Sponsor: Nancy Kiviat
SLUG Seminar: A Progress Report


"Keeping the Balence: Dosage Compensation of the Active X Chromosome in Mammals"

Christine Disteche
Professor
Department of Pathology
University of Washington

Friday, December 9, 2005 - 12:30 PM
Health Sciences Center, Room K-069
Division of Medical Genetics presents the Markey Molecular Medicine Seminar


Epigenetic Change in the Differentiating Embryonic Stem Cell

Jonathan Golob PhD
Fellow
Department of Pathology
UWSOM

Thursday, December 1, 2005 - 4:15 PM
South Lake Union, 111
Tapas Seminar


Developmental Genome Anatomy Project (DGAP): Identification of Genes Critical to Human Development

Azra H. Ligon, Ph.D.
Assistant Professor
Department of Pathology
Harvard Medical School

Thursday, November 17, 2005 - 12:00 PM
Health Sciences Center, Room T-639

Faculty Sponsor: Christine Disteche


Transcription Factor Regulation of Glial Progenitor Development and Gliomas

Keith L. Ligon, M.D., Ph.D.
Staff Pathologist and Associate Neuropathologist
Department of Pathology
Brigham and Women's Hospital

Wednesday, November 16, 2005 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Tom Montine


A Genome-wide Hunt for Public Mechanisms of Aging

Matt Kaeberlein, Ph.D.
Senior Fellow
Department of Genome Sciences
University of Washington

Wednesday, November 2, 2005 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Peter Rabinovitch
Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology


FISHing for Answers in Pediatric Gliomas

Christine Fuller, M.D.
Assistant Member
Department of Pathology
St. Jude Children's Research Hospital

Wednesday, October 26, 2005 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Tom Montine


"Stromal" Tumors of the Prostate

Donna Hansel, M.D., Ph.D.
Resident
Department of Pathology
Johns Hopkins Hospital

Friday, October 21, 2005 - 1:00 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Larry True
Dr. Hansel is being considered for a faculty position in the Department of Pathology


Lifestyle modifications improve vascular dysfunction in a mouse model of Type II Diabetes

Dr. Ismail "Issy" Laher
Associate Professor
Pharmacology & Therapeutics
University of British Columbia

Friday, September 23, 2005 - 1:00 PM
HSB, T-359

Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information.


Oncolytic adenoviruses: Progress and Challenges

Andre Lieber, MD PhD
Research Associate Professor
Medical Genetics
UWSOM

Thursday, August 4, 2005 - 4:00 PM
South Lake Union, 815 Mercer St., 111 Auditorium

Faculty Sponsor: Stephen M. Schwartz
Special Tapas Presentation


Arrhythmogenic Right Ventricular Cardiomyopathy: From Anatomical Theatre to Double Helix

Gaetano Thiene, M.D., FRCP
Professor, Cardiovascular Patholology
Director, Institute of Pathological Anatomy
University of Padua Medical School

Thursday, June 16, 2005 - 3:30 PM
Health Sciences Center, Room T-435

Faculty Sponsor: Chuck Murry


Physiological and Genomic Consequences of Mitochondrial Oxidative Stress

Simon Melov
Buck Institute

Tuesday, May 31, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Searching for Conserved Mechanisms of Eukaryotic Aging

Brian Kennedy
University of Washington

Tuesday, May 24, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Role of Renal Biopsy in Renal Transplantion

Robert Colvin, M.D.
Castleman Professor & Chair
Department of Pathology
Massachusetts General Hospital

Monday, May 23, 2005 - 2:00 PM
UWMC, Anatomic Pathology Conference Room, NE-110K

Faculty Sponsor: Charles Alpers


Intraepithelial Neoplasia in the Pancrea

David Klimstra
Director, Oncologic Pathology Fellowship Programs
Department of Pathology
Memorial Sloan-Kettering Cancer Center

Thursday, May 19, 2005 - 4:00 PM
Health Sciences Center, Room T-747

Faculty Sponsor: Brian Rubin


New Insights on Mechanisms of Calorie Restriction

Rafael DeCabo
Laboratory of Experimental Gerontology
NIA

Tuesday, May 10, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


New Roles for Uncoupling Proteins in Protection Against Mitochondrial Radical Production and Aging

Martin Brand
MRC Dunn Human Nutrition Unit, Cambridge, UK

Tuesday, May 3, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Age-Related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age

Ahmad Heydari
Wayne State University

Tuesday, April 26, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Does Oxidative Stress Play an Important Role in Determining Lifespan

Holly Van Remmen
University of Texas, San Antonio

Tuesday, April 19, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


The Role of GH and IGF-1 in Extension of Lifespan and Resistance to Toxic Challenges in Mice

Andrzej Bartke
Southern Illinois University

Tuesday, April 12, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Why do Big Mice Die Young? Size, Stress, and the Cell Biology of Aging

Rich Miller
University of Michigan

Tuesday, April 5, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


PKA Mutations in Mice Affect Metabolism and Adiposity

Stanley McKnight
University of Washington

Tuesday, March 29, 2005 - 1:30 PM
HSB, T-747

Faculty Sponsor: The Nathan Shock Center


Research Training Seminar

Narci Teoh
Department of Pathology

Thursday, March 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473

Faculty Sponsor: Fausto
Pathology 511 Seminar


Research Training Seminar

Izumi Maezawa
Department of Pathology

Thursday, February 24, 2005 - 4:00 PM
Health Sciences Center, Room T-473

Faculty Sponsor: Montine
Pathology 511 Seminar


Research Training Seminar

Rich Fox
Department of Pathology

Thursday, February 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473

Faculty Sponsor: Schwartz
Pathology 511 Seminar


Research Training Seminar

Galynn Zitnik
Department of Pathology

Thursday, January 27, 2005 - 4:00 PM
Health Sciences Center, Room T-473

Faculty Sponsor: Martin
Pathology 511 Seminar


"Females Have Reduced Cardiac Ischemia-Reperfusion Injury and Hypertrophy: A Role for Estrogen Receptor Beta and Nitric Oxide"

Elizabeth Murphy, Ph.D.
Faculty Candidate
Cell Biology Group, Lab of Signal Transduction
Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC

Monday, January 24, 2005 - 4:00 PM
HSB Turner Autitorium, Room D-209


Inhibitors of Adipogenesis, Stress and Lipotoxicity: Enough to Drive Aging Preadipocytes Mad?

James Kirkland, M.D., Ph.D.
Associate Professor
Department of Medicine
Boston University School of Medicine

Tuesday, January 18, 2005 - 9:30 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Peter Rabinovitch
The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant


Research Training Seminar

Ashwini Kamath-Loeb
Department of Pathology

Thursday, January 13, 2005 - 4:00 PM
Health Sciences Center, Room T-473

Faculty Sponsor: Loeb
Pathology 511 Seminar


Chaos out of Order: Splicing and Mosaicism in Genetic Collagen Disorders

Peter H. Byers, M.D.
Professor, Adjunct Professor of Genome Sciences & Oral Biology
Pathology
University of Washington

Thursday, December 9, 2004 - 12:00 PM
HSB, T-625
http://depts.washington.edu/mednews/sim04_05.html


Angiogenesis and Lymphangiogenesis in Inflammation and Tumor Progression

Sam Dadras, M.D., Ph.D.
candidate for a Pathology Faculty Position
Pathology
University of Washington

Monday, December 6, 2004 - 1:15 PM
UWMC, NE-110K


Hypoxia and Angiogenesis: Why Do Endothelial Cells Move into Growing Tumors?

Randall Johnson
Professor
Molecular Biology Section, Division of Biological Sciences
University of California, San Diego

Monday, November 15, 2004 - 8:30 AM
Health Sciences Center, Turner Auditorium, Room D-209

Faculty Sponsor: Chuck Murry
Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine


Longevity and Stress-resistance: Mapping the Genes Responsible for Natural Variation in C. Elegans

Robert J. Reis
Professor
Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology
University of Arkansas

Friday, October 1, 2004 - 11:30 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Peter Rabinovitch


What Are the Roles of Mammalian DNA Damage Binding Protein (DDB) Heterodimer and Its Two Individual Subunits

Stuart Linn
Professor
Department of Biochemistry and Molecular Biology
University of California, Berkeley

Monday, September 27, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat


Hepatocellular Carcinoma: A Translational Research Challenge

Jordi Bruix
Director
Liver Cancer Unit
Hospital Clinic, Barcelona, Spain

Friday, July 2, 2004 - 9:00 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Division of Gastroenterology and the Department of


Harnessing Adult Stem Cells for Myocardial Repair

Ronglih Liao
Associate Professor
Department of Medicine
Boston University School of Medicine

Wednesday, May 26, 2004 - 10:00 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry


Pathway Profiling of Glioblastoma

Paul Mischel
Assistant Professor
Department of Pathology and Laboratory Medicine
UCLA School of Medicine

Thursday, May 13, 2004 - 4:30 PM
Health Sciences Center, Room T-747

Faculty Sponsor: Dr. Tom Montine


Cytologic Diagnosis of Lymphomas

Xiaohua Qian
Clinical Fellow
Department of Pathology
Brigham and Women's Hospital

Friday, April 2, 2004 - 12:30 PM
UWMC, NE-110 Conference Room

Faculty Sponsor: Dr. Brian Rubin


Pathology Reporting of Colorectal Cancer in the Molecular Era - When does research become best clinical practice?

Kieran Sheahan
Consultant Pathologist
Center for Colorectal Disease
St. Vincent's University Hospital: Dublin, Ireland

Friday, March 12, 2004 - 9:00 AM
Health Sciences Center, K-069


Linking Mathmatical Modeling with Clinical Research to Better Understand Brain Cancer (Gliomas)

Kristin R. Swanson
Research Assistant Professor
Departments of Pathology and Applied Mathematics
University of Washington

Tuesday, January 13, 2004 - 2:30 PM
Guggenheim Hall, 317


Parkinson's Disease Caused by Alpha-synuclein Locus Triplication

Lee-Way Jin, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington

Friday, November 7, 2003 - 9:30 AM
Harboview Medical Center, R & T Building, Room 113


"Pituitary Tumor Pathogeneis

M. Beatriz S. Lopes, M.D.
Associate Professor
Department of Pathology
University of Virginia Health Sciences Center

Wednesday, September 17, 2003 - 8:00 AM
Harborview Medical Center, Research and Training Auditori


The Role of Hypoxia and Genetics in the Progression of Glioblastoma

Daniel J. Brat
Associate Professor
Department of Pathology and Laboratory Medicine
Emory University School of Medicine

Thursday, September 11, 2003 - 4:30 PM
Health Sciences Center, Room T-739


"Neurospheres and Neurosphere Forming Cells: Morphological and Ultrastructural Characterization

Alessandra Bez
National Neurologic Institute "C.Besta"
Milan, Italy

Monday, July 28, 2003 - 1:00 PM
VA Medical Center, Building 1, Room 812


An Informal Career/Research Workshop

Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories

Thursday, June 5, 2003 - 9:30 AM
South Campus Center, Room 303


Evolutionary Theories of Aging and How We Test Them

Daniel Promislow
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Georgia

Tuesday, June 3, 2003 - 12:30 PM
HSB, T-639


“Population Mortality Analyses: A Tool for the Study of Aging”

Scott Pletcher
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
Baylor College of Medicine

Tuesday, May 27, 2003 - 12:30 PM
HSB, T-639


Design of Human Aging Studies

Norm Wolf
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington

Tuesday, May 20, 2003 - 12:30 PM
HSB, T-639


Design of Human Aging Studies

William Hazzard
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington

Tuesday, May 13, 2003 - 12:30 PM
HSB, T-639


Use of Nonhuman Primates for Studies of Caloric Restriction and Aging

George Roth
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
National Institute on Aging

Tuesday, May 6, 2003 - 12:30 PM
HSB, T-639


“Gene Expression Profile Assays: Strengths and Pitfalls”

Richard Miller
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Michigan

Tuesday, April 29, 2003 - 12:30 PM
HSB, T-639


“Transgenic Models: Strengths and Pitfalls”

Warren Ladiges
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington

Tuesday, April 22, 2003 - 12:30 PM
HSB, T-639


Caloric Restriction: A Tool for the Study of Aging

Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio

Tuesday, April 15, 2003 - 12:30 PM
HSB, T-639


Use of Rodent Models in Aging Research

Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio

Monday, April 14, 2003 - 12:30 PM
HSB, T-639


Pros and Cons of Non-Mammalian Models in Aging Research

Steven Austad
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Idaho

Tuesday, April 8, 2003 - 12:30 PM
HSB, T-639


Concepts and Theories of Aging

George Martin
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington

Tuesday, April 1, 2003 - 12:30 PM
HSB, T-639


X Inactivation: The Role of the XIST RNA in Silencing a Chromosome

Carolyn Brown
Associate Professor
Department of Medical Genetics
University of British Columbia

Friday, March 21, 2003 - 12:30 PM
Health Sciences Center, Room K-069


Biology and Evolution of Cervical Squamous Intraepithelial Lesions: A Hypothesis with Diagnostic/Prognostic Implications

Kumarasen Cooper, MBChB, DPhil, FRC Path
Director of Anatomic Pathology
University of Vermont College of Medicine

Thursday, February 27, 2003 - 4:30 PM
University of Washington Medical Center, BB-204


Science in Medicine Lecture: Genetic Instability and Human Disease

Raymond J. Monnat, Jr., M.D.
Professor
Department of Pathology
University of Washington

Thursday, October 24, 2002 - 12:00 PM
HSC, Turner Auditorium, D-209


Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer

Robert F. Hevner, M.D, Ph.D.
Assistant Professor
Department of Pathology
University of Washington

Thursday, September 26, 2002 - 12:00 PM
Health Sciences Center, D-209


Neurochemical Dynamics of Traumatic Brain Injury

J. Clay Goodman, M.D.
Professor and Neuropathology Program Director
Departments of Pathology, Neurology, and Neurosurgery
Baylor College of Medicine

Thursday, September 19, 2002 - 4:30 PM
HSC, T-747


Diagnosis of Minimal Prostate Cancer in Needle Biopsies - When Should You Jump off the Fence?

John Srigley
Professor
Department of Pathology and Molecular Medicine
McMaster University

Monday, August 26, 2002 - 8:00 AM
UWMC, BB-204