Upcoming Doctoral Dissertations 

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Recent Doctoral Dissertations

Human Embryonic Stem Cell-Derived Cardiomyocytes Migrate in Response to Gradients of Fibronectin and Wnt5a: Implications for Cardiac Repair

Kara White Moyes
Graduate Student, Laflamme Lab
UW Medicine Patholology Molecular Basis of Disease PhD Program
University of Washington

Monday, May 13, 2013 - 1:00 PM
UW Medicine South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Mike Laflamme, MD, PhD


Merkel Cell Polyomavirus-specific T Cell Responses, Immune Evasion Mechanisms & Immune Therapy in Merkel Cell Carcinoma

Olga Afanasiev
Department of Pathology Graduate Student
Medical Scientist Training Program
University of Washington School of Medicine

Friday, April 5, 2013 - 1:00 PM
UW Medicine South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Paul Nghiem, MD, PhD


Macrophage ADAM17 limits CD36-mediated apoptotic cell uptake

Will Driscoll
Graduate Student, Raines Lab
Department of Pathology
University of Washington School of Medicine

Wednesday, December 12, 2012 - 10:00 AM
UW Medicine at South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Elaine Raines


The roles of IL-12 and IL-23 in the Innate Immune Responses against Salmonella Infection

Olumuyiwa Awoniyi
Graduate Student, Kelly Smith Lab
Molecular & Cellular Biology Program
University of Washington

Monday, December 3, 2012 - 9:00 AM
Health Sciences Center, Room RR-134

Faculty Sponsor: Kelly Smith, MD, PhD


Isolation of Antimutator Yeast Strains: An Exploration of DNA Replication Fidelity

Lindsey N. Williams
Graduate Student, Preston Lab
Molecular & Cellular Biology Program
University of Washington

Wednesday, November 28, 2012 - 10:00 AM
Health Sciences Center, Room T-747

Faculty Sponsor: Brad Preston, PhD


Elucidation of the Molecular Pathways of Lifespan Extension by Dietary Restriction in Yeast

Joseph Delaney
Graduate Student
Kaeberlein Lab
UW Medicine Pathology

Tuesday, July 31, 2012 - 3:00 PM
Health Sciences Center, Room: RR-134

Faculty Sponsor: Matt Kaeberlein, PhD


An Analysis of the Extracellular Matrix in Hutchinson Gilford Progeria Syndrome

Ingrid Harten
Doctoral Dissertation
Department of Pathology Graduate Student
University of Washington School of Medicine

Thursday, December 8, 2011 - 4:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Thomas Wight, Ph.D.


Mechanisms Underlying Differential Responses to Dietary Restriction

Jennifer Schleit
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Tuesday, August 23, 2011 - 1:00 PM
Health Sciences Center, K-069

Faculty Sponsor: Matt Kaeberlein, Ph.D.


The Role of TNF-alpha Converting Enzyme in Liver Injury and Regeneration

Ryan McMahan
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Friday, August 12, 2011 - 2:00 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Nelson Fausto, M.D. and Jean Campbell, Ph.D.


Signaling Pathways and Chromatin Dynamics Regulate Cardiac Differentiation from Human Embryonic Stem Cells

Sharon Paige
Graduate Student
UW Medicine Pathology and MSTP
University of Washington

Thursday, May 26, 2011 - 10:00 AM
UW Medicine South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Chuck Murry, M.D., Ph.D.


Molecular and Biochemical Mechanisms of Recessive Osteogenesis Imperfecta

Shawna Pyott
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Thursday, April 28, 2011 - 1:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Peter Byers, M.D.


Doctoral Dissertation: Epigenetic Regulation of X Inactivation and Escape from X Inactivation

Fan Yang
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Friday, April 15, 2011 - 2:00 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Christine Disteche, Ph.D.


Sphingosine-1-phosphate Receptor 2 Induces Expression of Smooth Muscle Alpha-actin: A Role for Rho and Calcium

Allison De Wispelaere
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Friday, March 11, 2011 - 3:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Alec Clowes, M.D.


Saturated Long-chain Acyl-CoA Synthesis: A Novel Link Between TNFα and Saturated Fatty Acid-induced Endothelial Dysfunction

Xin Li
Department of Pathology Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Friday, October 8, 2010 - 1:00 PM
UW Medicine at South Lake Union, Brotman Auditorium

Faculty Sponsor: Karin Bornfeldt, Ph.D.


Transcriptional Control of Stroma Dependent Apoptosis in MDS

Mario Marcondes
Graduate Student
Department of Pathology
University of Washington School of Medicine

Wednesday, May 19, 2010 - 2:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium

Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D.


Cellular and Humoral Immune Responses to the Polyomavirus-linked Merkel Cell Carcinoma: Implications for Pathogenesis, Prognosis and Therapy

Kelly Paulson
Medical Scientist Training Program
Department of Pathology Graduate Student
University of Washington School of Medicine

Thursday, May 13, 2010 - 1:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium

Faculty Sponsor: Paul Nghiem, M.D., Ph.D.


Long-Chain Acyl-CoA Synthesis at the Crossroads Between Glucose and Fatty Acid-Enhanced Inflammation and Atherosclerosis in Diabetes

Jenny Kanter
Graduate Student
Department of Pathology
University of Washington School of Medicine

Monday, May 10, 2010 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium

Faculty Sponsor: Karin Bornfeldt, Ph.D.


Molecular Mechanisms of c-Myc-induced Immortalization of Human Fibroblasts

Myra Wang
Graduate Student
Department of Pathology
University of Washington School of Medicine

Monday, May 3, 2010 - 3:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium

Faculty Sponsor: Denise Galloway, Ph.D.


Fibrillar Collagens and Their Chaperones in Disease: A Tale of Kinky Tails and Brittle Bones

Helena Christiansen
Graduate Student
Molecular and Cellular Biology
University of Washington School of Medicine

Thursday, December 10, 2009 - 12:00 PM
Health Sciences Center, T-739

Faculty Sponsor: Peter Byers, M.D.


The Neurosecretory Vesicle Protein Phogrin Has Phosphatidylinositol Phosphatase Activity That Regulates Insulin Secretion

Leslie Ann Caromile
Graduate Student
Department of Pathology
University of Washington School of Medicine

Friday, August 14, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium

Faculty Sponsor: Dan Bown-Pope, Ph.D.


Long-chain acyl-CoA Synthetase Isoforms 1 and 4 Exhibit Differences in Fatty Acid Preference and Functions in Human Arterial Smooth Muscle Cells

Deidre Golej
MCB Graduate Student
University of Washington School of Medicine

Wednesday, August 12, 2009 - 2:00 PM
UW Medicine at 815 Mercer, Orin Smith Auditorium

Faculty Sponsor: Karin Bornfeldt, Ph.D.


Loss of DNA Polymerase Proofreading Leads to Cancer and Tumor Acceleration in MIce

Tina M. Albertson
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Tuesday, June 9, 2009 - 2:00 PM
Health Sciences Center, K-069

Faculty Sponsor: Brad Preston, Ph.D.


Mechanisms of Cell Fate Acquisition in the Differentiation of Pluripotent Stem Cells

Jonathan Golob
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine

Wednesday, April 29, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium

Faculty Sponsor: Chuck Murry, M.D., Ph.D.


Mitochondrial Oxidative Stress in Cardiac Aging, Pressure-Overload Induced Cardiac Hypertrophy and Failure

Dao-Fu Dai
Graduate Student
UW Medicine Department of Pathology
University of Washington

Tuesday, April 14, 2009 - 1:00 PM
UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium

Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Doctoral Dissertation


"Structural and Functional Characterizations of Alternative Gene Products of an Adaptor Protein (FE65) and an Orphan G-Protein Coupled Receptor (Gprc5b) in Learning- and Memory-Impaired Mice with a Selective Knockout of p97FE65"

Bethany Cool
Graduate Student
Pathology
University of Washington

Monday, November 10, 2008 - 2:30 PM
Health Science Center, K-0690

Faculty Sponsor: Dr. Martin


PSGL-1 Mediated Signal Transduction and Translational Control Mechanisms During Adherence of Macrophages

Richard Fox
Graduate Student
UW Medicine Pathology
University of Washington

Thursday, August 14, 2008 - 1:00 PM
South Lake Union Auditorium, K-111

Faculty Sponsor: Dr. Schwartz


Untangling Mitochondrial Mutagenesis and Aging in Mice

Marc Vermulst
Graduate Student
UW Medicine Pathology
University of Washington

Friday, April 11, 2008 - 3:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Larry Loeb


Physiological Functions of Activated Caspases in Macrophages

Thomas Nhan
Graduate Student
UW Medicine Pathology
University of Washington

Thursday, December 13, 2007 - 10:00 AM
South Lake Union, Brotman Building Auditorium

Faculty Sponsor: Stephen Schwartz


Loss of the Endocytic Protein Sorting Nexin 1 Promotes Colon Cancer Development

Matthew S. Holdren
University of Washington School of Medicine
Department of Pathology Graduate Student
UW Medicine Pathology

Monday, November 19, 2007 - 2:00 PM
Health Sciences Center, K-069

Faculty Sponsor: Dan Bowen-Pope


cFLIP Regulates Fas-induced Apoptosis and Pro-inflammatory Gene Expression in Human Vascular Smooth Muscle Cells

Monja Dishmon
Pathology
UW School of Medicine

Thursday, October 5, 2006 - 1:00 PM
815 Mercer Bldg, Room 111

Faculty Sponsor: Bowen-Pope


Mechanism of Endocytosis of CD33/Siglec-3:Role of ITIMs, Tyrosine Phosphorylation, and Monoubiquitylation

Roland Walter
Pathology
UWSOM

Wednesday, August 9, 2006 - 4:30 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium

Faculty Sponsor: Dr. Steve Collins


“Functional genomics and liver regeneration”

Jiangning Li
Doctoral Dissertation
Pathology
Medicine

Tuesday, August 1, 2006 - 8:30 AM
HSB, T-473

Faculty Sponsor: Dr. Bumgarner


"X Chromosome Upregulation and its Biological Significance in Mammals"

Di Kim Nguyen
Doctoral Dissertation
Pathology
UWSOM

Wednesday, May 31, 2006 - 10:30 AM
HSB, T-435

Faculty Sponsor: Christine Disteche


"Effects of Regulated Expression of Hepatitis C Virus Proteins on HH4 Human Hepatocytes"

Weiliang Tang
Pathology
University of Washington

Tuesday, March 28, 2006 - 1:30 PM
HSB, K-069

Faculty Sponsor: Dr. Fausto


"Anchoring Molecular Lifelines: Integrin Mediated Survival Signals"

Julie Rice
Graduate Student
Pathology
University of Washington

Thursday, August 18, 2005 - 11:00 AM
Chem, 102

Faculty Sponsor: Giachelli
Doctoral Dissertation


"Grial Cell Regulated, Apolipoprotein E Isoform-Specific Mechanism of Neuroprotection and Neurodegeneration"

Izumi Maezawa
Doctoral Dissertation
Medicine
Pathology

Monday, May 2, 2005 - 1:00 PM
Health Sciences Center, T-639


The Role of Protein Tyrosine Phosphatase Receptor Q in Development of Disease

Carmen Jane Booth, D.V.M.
Doctoral Dissertation
Pathology
University of Washington

Friday, April 22, 2005 - 10:00 AM
815 Mercer Building, Room 111

Faculty Sponsor: Dan Bowen-Pope


Characterization of Adenovirus Serotype 35 as a Gene Therapy Vector

Anuj Gaggar
Doctoral Dissertation
Pathology
Dept of Pathology

Thursday, November 18, 2004 - 2:45 PM
UWMC, RR-134


Embryonic Stem Cells for Myocardial Infarct Repair

Jeannette Nussbaum
Graduate Student
Department of Pathology
University of Washington

Tuesday, June 8, 2004 - 9:30 AM
Health Sciences Center, Room T-733


Mislocalization of Neutrophil Elastase is the Major Cause of Inherited Neutropenia

Richard E. Person
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine

Tuesday, May 25, 2004 - 11:30 AM
Health Sciences Center, K-069


Understanding protein tolerance to random amino acid change through directed evolution

Haiwei H. Guo
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine

Friday, May 21, 2004 - 12:15 PM
University of Washington Medical Center, RR-134


Reduced BRCA1 Expression and Ovarian Tumorigenesis

Rachel M. Gonzalez
Graduate Student
Department of Pathology
University of Washington

Friday, January 30, 2004 - 11:00 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Mary Claire King


The Role of Runt-Related Transcription Factor @ (Runx2) in Arterial Smooth Muscle Cell Mineralization

Gabrielle Mercedes Curinga
Graduate Student
Department of Pathology
University of Washington

Friday, December 12, 2003 - 10:30 AM
Health Sciences Center, Room RR-134


The Cell Cycle Phase Specificity of DNA Damage and Repair Induced by Radiation, Oxidation and Anti-Topoisomerase II Chemotherapy Drugs

Alan Potter
Graduate Student
Department of Pathology
University of Washington

Thursday, October 2, 2003 - 10:30 AM
Health Sciences Center, Room D-310


The Functions of FE65 Proteins and Their Roles in Dementias of Alzheimer's Disease

Baiping Wang
Graduate Student
Department of Pathology
University of Washington

Tuesday, August 19, 2003 - 10:00 AM
Health Sciences Center, Room K-069


Telomere Length and Chromosomal Instability in the Neoplastic Progression of Barrett's Esophagus

Jennifer C. Finley
Graduate Student
Department of Pathology
University of Washington

Wednesday, July 23, 2003 - 3:00 PM
Health Sciences Center, Room K-069


Sheep Retroviral Envelope Glycoprotiens: Mechanisms of Oncogenesis and Incorporation into HIV-1 Lentiviral Vectors

Shan-Lu Liu
Graduate Student
Department of Patholgy
University of Washington

Tuesday, June 10, 2003 - 2:00 PM
Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud


Signaling Pathways Regulating Endothelial Cell Survival and Activation

Xianwu (James) Li
Graduate Student
Department of Pathology
University of Washington

Friday, January 31, 2003 - 3:15 PM
Health Sciences Center, Room K-069


Fas/FADD-Mediated Activation of a Specific Program of Inflammatory Gene Expression in Vascular Smooth Muscle Cells

Friedemann J. Schaub
Graduate Student
Department of Pathology
University of Washington

Thursday, September 19, 2002 - 11:00 AM
HSC, K-069


Cohesion proteins SMC1 and SMC3: roles in aneuploidy and in meiotic chromosome dynamics

Rosalina James
Graduate Stdent of Pathology
School of Medicine
University of Washington

Friday, August 23, 2002 - 11:00 AM
HSC, D-209


Characterization of Genomic Instability in Neoplastic Progression of Ulcerative Colitis

Ru Chen
Graduate Student of Pathology
School of Medicine
University of Washington

Tuesday, August 20, 2002 - 1:00 PM
HSC, K-069


In Vitro Modeling of Breast Cancer

Krishna Rao
Graduate Student of Pathology
School of Medicine
University of Washington

Wednesday, July 10, 2002 - 1:00 PM
Doctoral Dissertation, Pelton Auditorium
Day Campu