Pathology Academic Programs Courses

Graduate Program

UW Time Schedule

Required

PATH500 - Molecular Basis of Disease Course Director: Laflamme Prerequisite: Permission of instructor Quarters Offered: W Credits: 3	Designed for first and second-year graduate students to introduce the concepts of general pathology at the cellular and molecular levels.
PATH501 - Pathology Proseminar Course Director: Varies Prerequisite: Permission of instructor Quarters Offered: AWSpSu (must complete 3 quarters) Credits: 1	Small group discussions and presentations by students based on critical reading of original papers, or on concurrent seminars, in many areas of experimental pathology and medicine. Topic varies by quarter. Spring 2008 - Dr. Paul Nghiem - “Discovery and Disruption of Critical Cancer Pathways” This would cover illustrative classical and recent discoveries of processes essential for a given tumor type. For example: the history of CML/BCR-ABL/gleevec. Would also cover the power/limitations of certain approaches to discover cancer-driving mutations such as direct DNA sequencing. Comparative genomic hybridization, micro-array analysis, etc. May do a session on chemical genetics for discovery of inhibitors.
PATH507 - Introduction to Pathology Research Course Director: Bornfeldt, Smith Prerequisite: Permission of instructor Quarters Offered: A Credits: 2	Current developments and approaches to investigation of the molecular and cellular basis of disease. Members of the Pathology faculty present and discuss their own research projects. Credit/no credit only.
PATH512 - Molecular Basis of Disease: Death and Repair Course Director: Bowen-Pope Prerequisite: Permission of instructor Quarters Offered: A Credits: 1.5	First in a series designed to introduce students to medically important diseases and physiologic processes and experimental approaches to elucidating the cellular processes underlying these diseases. Covers basic cell/tissue processes that underlie normal homeostasis and most diseases and including apoptosis, necrosis, stem cells, inflammation, granulation tissue, tissue regeneration, repair and fibrosis.
PATH513 - Molecular Basis of Disease: Mechanisms of Neurodegeneration Course Director: Zhang Prerequisite: Permission of instructor Quarters Offered: A Credits: 1.5	Introduction to the cellular and molecular mechanisms that underlie neurodegenerative diseases, including introduction ot the normal development and anatomy of the central nervous system, a review of epidemioloogic, genetic, and clinical research tools used in the investigation of these diseases, and a systematic review of the major neurodegenerative diseases.
PATH515 - Molecular Basis of Disease: Atherosclerosis and Myocardial Infarction Course Director: Murry Prerequisite: Permission of instructor Quarters Offered: Sp Credits: 1.5	Introduces medically important diseases and experimental approaches to understanding the basis of diseases and their treatments. Covers artherosclerosis, including lipids, extracellular matrix, cell signaling, inflammation, and downstream complications such as myocardial infarction and arrhythmias. Spring 2008 - Course Syllabus
PATH516 - Molecular Basis of Disease: Human Genetic Disease Course Director: Byers Prerequisite: Permission of the instructor Quarters Offered: Sp Credits: 3	Introduces the underlying mechanisms in human genetic disorders, ranging from the single nucleotide through genomic instability, and chromosomal rearragements. Includes tissue and organ specific examples of the manner in which these disorders provide insights into human biology.
PATH551 - Experimental and Molecular Pathology Course Director: Varies Prerequisite: Permission of instructor Quarters Offered: AWSpSu Credits: 2-5, max 20	Introduction to experimental pathology. A tutorial course with lab rotations designed to introduce a graduate student (medical, dental) or senior undergraduate to selected methods and problems through literature surveys and/or laboratory experience. Exploration of causes at the cellular and molecular levels in the study of disease is emphasized.
PATH600 - Independent Study or Research Course Director: Varies Prerequisite: Permission of instructor Quarters Offered: AWSpSu Credits: Credit/no credit only.
PATH800 - Doctoral Dissertation Course Director: Varies Prerequisite: Permission of instructor Quarters Offered: AWSpSu Credits: Credit/no credit only.
BIOST511 - Medical Biometry I Course Director: N/A Prerequisite: Quarters Offered: ASu Credits: 4	Presentation of the principles and methods of data description and elementary parametric and nonparametric statistical analysis. Examples are drawn from the biomedical literature, and real data sets are analyzed by the students after a brief introduction to the use of standard statistical computer packages. Statistical techniques covered include description of samples, comparison of two sample means and proportions, simple linear regression and correlation.
CONJ538 - Genetic Instability and Cancer Course Director: Maizels, Monnat Prerequisite: Permission of instructor Quarters Offered: Credits: 1-1.5	Seminar focusing on molecular pathways that maintain genomic stability in all cells and that carry out programmed changes in genomic structure in the immune system. Special attention devoted to understanding how failure in these pathways leads to genomic instability and malignancy.
CONJ539 - Biological Basis of Neoplasia Course Director: Kemp, Zarbl Prerequisite: Introductory biochemistry and cell biology Quarters Offered: Sp Credits: 1.5	Lecture/discussion on cellular and molecular mechanisms underlying phenotypes associated with cancer, including genetic pre-disposition, injury, and instability; alteration in control of cell division and cell death; failure of differentiation; tumor angiogenesis and metatasis. Molecular biology of tractable model systems is emphasized.

Recommended

CONJ531 - Signaling Mechanisms in Excitable Cells Course Director: Hille Prerequisite: Comprehensive undergraduate course in general biochemistry and molecular biology or permission of instructor Quarters Offered: A Credits: 1.5	Membrane electricity. Structure and roles of voltage-gated and ligand-gated ion channels in electrical signaling. Calcium as a second messenger. Exocytosis and its regulation. Phototransduction in photoreceptors.
CONJ532 - Signal Transduction from the Cell Membrane to the Nucleus Course Director: Beavo, Moon, Storm Prerequisite: Basic knowledge of biochemistry Quarters Offered: A Credits: 1.5	Intracellular signaling pathways leading from cell membrane receptors to nucleus. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, nitric oxide and WNTs and mechanisms of signal termination. Cytokine/Jak/Stat signaling and role of subcellular localization in signal transduction.

Other Graduate Courses

PATH502 - Inflammation and Repair Course Director: Varies Prerequisite: Permission of instructor Quarters Offered: Currently not offered. Credits: 2	Lecture-seminar; a seminar course dealing with an in-depth examination of the processes involved inflammation and repair of tissue. Credit/no credit only.
PATH510 - Introduction to Pathology Methods Course Director: Bowen-Pope Prerequisite: Permission of instructor Quarters Offered: Sp Credits: 3	Laboratory course designed to introduce graduate students to the fundamentals of image analysis, histology, histopathology, post mortem evaluation, surgical pathology, and other methods used to investigate disease etiology, progression, and manifestation in humans and in animal models.
PATH511 - Topics in Experimental Pathology Course Director: Bornfeldt Prerequisite: Permission of instructor Quarters Offered: AWSpSu Credits: 1-2, max 10	Focus on areas of research relevant to experimental pathology.
PATH514/CONJ514 - Molecular Medicine Course Director: Rosen Prerequisite: N/A Quarters Offered: W Credits: 3	Graduate-level introduction to the interplay of basic science and clinical medicine. Covers inflammation, vascular disease, metabolic disorders, cancer biology, and molecular-, gene-, and cell-based therapies. Each topic introduced with a patient history.
PATH517 - Biology and Pathology of Aging Course Director: Wolf Prerequisite: Coursework in biology, biochemistry, molecular biology, and genetics Quarters Offered: Sp Credits: 3-4	Surveys the biology and pathologies of the aging phenomena in multiple species and at multiple organismal levels from whole animals to molecules.
PATH520 - Experimental Pathology Seminar Course Director: Byers Prerequisite: None Quarters Offered: Currently not offered Credits: 1	Review of current research in various areas of experimental pathology by members of the department and visiting scientists. Credit/no credit only.
PATH522/LABM522 - Hematopathology Seminar Course Director: Fromm Prerequisite: Permission of instructor Quarters Offered: W - Even Years Credits: 2	Identification of normal lymphocyte and bone marrow subpopulations, diagnosis of leukemias, lymphomas, and benign conditions that resemble them. Emphasis on histopathology, cytochemical, immunological, and molecular markers. Clinicopathologic correlation.
PATH530 - Human Cytogenetics Course Director: Disteche Prerequisite: Permission of instructor Quarters Offered: Sp, even Years Credits: *, max 4	Sources and methods of preparation and identification of human chromosomes. Molecular structure and mapping of chromosomes. Human cytogenetic pathology: karyotype-phenotype interactions, chromosome breakage, and cancer cytogenetics. Spring 2008 - Course Schedule
PATH544 - General and Systemic Pathology Course Director: Narayanan Prerequisite: 1st year dental students and graduate students; non-dental students need permission of instructor, requires reasonable grounding in biological and chemical sciences Quarters Offered: Credits: 2-3, max 5	Basic pathologic processes that underlie disease, including cell alterations, genetic and developmental pathology, environmental pathology, neoplasia, inflammation, infection, and systemic diseases. Correlates gross, functional, and biochemical alterations.
PATH552 - Heart and Vessels: Molecular Frontiers Course Director: Schwartz Prerequisite: Permission of instuctor Quarters Offered: AWSpS Credits: 1	Ongoing course in cardiovascular biology. Integrates mini courses in cutting edge areas of cardiovascular biology, basic introductory cardiovascular biology, and seminars covering heart research. Active discussion is stressed and students are invited to meet with guest lecturers.
PATH555 - Environmental Pathology Course Director: Montine Prerequisite: PATH410 or PATH444 or HUBIO520; recommended ENVH514 and ENVH515. Quarters Offered: Even years as requested Credits: 3	Modern morphologic, cell biological and molecular approaches to environmental disease associated with exposure/predisposition. Lectures, seminar discussion, and student presentations.
PATH560 - Molecular Analysis of Human Disease Course Director: Varies Prerequisite: Medical, graduate, or professional standing and permission of instructor Quarters Offered: Currently not offered. Credits: *, max 10	Review and discussion of contemporary research on molecular basis of human disease. Focus on mutational mechanisms, genetic instability, AIDS, and cancer. Students participate in weekly group discussion and work with faculty to select, develop, and present discussion topic.