Pathology Residency Program
Renal Pathology Fellowship
Charles E. Alpers, MD
Director, Renal Pathology Fellowship Program
Professor, Pathology; Adjunct Professor, Medicine
Roberto Nicosia, MD - Professor & Director, VA Pathology
Jolanta Kowalewska, MD - Clinical Asst. Professor, Pathology
Kelly Smith, MD PhD - Assistant Professor, Pathology
Laura S. Finn, MD - Associate Professor, CHRMC Pathology (Pediatric Pathology)
Joe Rutledge, MD - Professor, CHRMC Laboratories (Pediatric Renal Pathology)
Description: The Renal Pathology Fellowship at the University of Washington is a fellowship jointly supported by the University of Washington Medical Center and the Department of Pathology. The purpose of this fellowship is to provide an intensive experience in diagnostic renal pathology, with broad experience in the techniques of evaluation of histology specimens, immunofluorescence microscopy, electron microscopy, immunohistochemistry, and other adjunctive techniques relevant to the clinical diagnosis of renal biopsy material. The fellow will join with the pathology faculty in all aspects of the routine diagnostic work-up of all renal biopsies accessioned by this hospital, including immunofluorescence microscopy studies and full work-up and analysis by electron microscopy. In the course of such studies, the fellow will also gain experience in the management and supervision of hospital laboratories that perform each of these functions. It is expected that at the end of one year, the fellow would have sufficient diagnostic experience to be able to function independently as a diagnostic renal pathologist in an academic medical center.
The long-range goal of this fellowship is to train academic renal pathologists, and therefore an important component of the fellowship is engagement in clinical and/or basic research. Clinical research studies are incorporated into the daily diagnostic work of the fellow, and are based on the material accessioned by the renal pathology service. More basic research will utilize projects ongoing in the investigators’ research laboratories, as well as other nephrology based research laboratories, principally those previously linked by their participation in an NIH funded O’Brien Kidney Research Center at the University of Washington. It is anticipated that involvement in these latter studies would involve one or more additional years of research training beyond that provided in the diagnostic portion of the renal pathology fellowship. The laboratories of Dr. Alpers and Nicosia are currently engaged in NIH funded investigations of membranoproliferative glomerulonephritis, knockout and transgenic murine models of diabetes, HIV induced renal injury, roles of chemokines and growth factors in renal development and injury, and angiogenesis. Dr. Smith has an NIH funded research program focused on Toll-like receptors in regulation of immune response. With others at the University of Washington, we have also recently created a Center for Comparative Genomics,currently funded by the NIH, with Dr. Alpers as Principal Investigator, to use microarray gene profiling technology for studies of murine disease models, seeking to eventually adapt this technology to studies of our library of human renal biopsy tissues. Fellows will be encouraged to participate in these studies or in relevant studies conducted by other members of the University of Washington community, such as those in areas of vascular biology or diabetes.
There are five graduates of this fellowship to date. The first and third are currently assistant professors at another medical school with primary responsibility in diagnostic renal pathology. And the fifth will have a similar positon as of August 2004. The second (Dr. Smith) has joined the faculty of the University of Washington with primary academic interests in renal pathology and immunobiology. One of our fellowship trainees is pursuing additional fellowship training in basic kidney research in Dr. Alpers' laboratory under a two-year fellowship competitively funded by the National Kidney Foundation and anticipates assuming a faculty position in Nephropathology in July 2005.
Requirements: Applicants are expected to have completed the training required for certification in Clinical and/or Anatomic Pathology by the American Board of Pathology. This requirement may be waived by the Program Director in exceptional cases.
Stipends: Appointment is for 1-3 years. Stipend and benefits are based on the schedule for residents at an equivalent level. Fellows are encouraged to apply for extramural funding if additional years of research training is desired.
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