Holoprosencephaly
•Defect of dorsovental
patterning in the embryonic forebrain.
•Frequently associated with
facial anomalies (cyclopia, proboscis)
•Associated with mutations of
Shh, Zic2, other genes
• Lobar
• Semilobar
• Alobar
• Lobar
• Semilobar
• Alobar