Path Grand Rounds: Androgenetic-Biparental Mosaicism and the Pathogenesis of Hepatic Mesenchymal Hamartoma
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Speaker
Raj Kapur, MD, PhD
Professor
Pathology
Seattle Children’s Hospital
- Date & Time
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March 4, 2015 at 12:00pm - 1:00pm
- Location
UWMC, NE110 conference room
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Description
Why Attend?
Many conditions presented to the pediatric pathology are rare and have a genetic basis. The chance encounter of two such lesions, placental mesenchymal dysplasia and hepatic mesenchymal hamartoma, in a single patient suggested a common pathogenetic basis, and opportunities to learn more about potential molecular “underpinnings” for these seemingly disparate entities. Learn how a series of investigations, conducted primarily with resources in the clinical laboratory, have helped explain this association and implicated expression of a cluster of evolutionarily new miRNAs in hepatic hamartoma formation.
Reference: PMID: 24555441