Path Grand Rounds: Androgenetic-Biparental Mosaicism and the Pathogenesis of Hepatic Mesenchymal Hamartoma

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Speaker

Raj Kapur, MD, PhD
Professor
Pathology
Seattle Children’s Hospital


Date & Time

March 4, 2015 at 12:00pm - 1:00pm

Location

UWMC, NE110 conference room

Calendar

Path Grand Rounds

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Add to Calendar 03/04/2015 12:00 PM 03/04/2015 01:00 PM America/Los_Angeles Path Grand Rounds: Androgenetic-Biparental Mosaicism and the Pathogenesis of Hepatic Mesenchymal Hamartoma Path Grand Rounds: Androgenetic-Biparental Mosaicism and the Pathogenesis of Hepatic Mesenchymal Hamartoma

Raj Kapur, MD, PhD
Professor
Pathology
Seattle Children’s Hospital
Why Attend? Many conditions presented to the pediatric pathology are rare and have a genetic basis. The chance encounter of two such lesions, placental mesenchymal dysplasia and hepatic mesenchymal hamartoma, in a single patient suggested a common pathogenetic basis, and opportunities to learn more about potential molecular “underpinnings” for these seemingly disparate entities. Learn how a series of investigations, conducted primarily with resources in the clinical laboratory, have helped explain this association and implicated expression of a cluster of evolutionarily new miRNAs in hepatic hamartoma formation. Reference: PMID: 24555441 Please Note: This lecture can also be viewed via teleconference: HMC room: 2NJ251 & VA room: BD152
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Description

Why Attend?

Many conditions presented to the pediatric pathology are rare and have a genetic basis. The chance encounter of two such lesions, placental mesenchymal dysplasia and hepatic mesenchymal hamartoma, in a single patient suggested a common pathogenetic basis, and opportunities to learn more about potential molecular “underpinnings” for these seemingly disparate entities. Learn how a series of investigations, conducted primarily with resources in the clinical laboratory, have helped explain this association and implicated expression of a cluster of evolutionarily new miRNAs in hepatic hamartoma formation.

Reference: PMID: 24555441