Pathology Presents: Two New Tales from the Long-Running Mystery Series “What Does Werner Syndrome RECQ Helicase Do?”

This event has ended.

Speaker

Julia Sidorova, PhD
Research Assistant Professor
Department of Pathology
University of Washington

Faculty Sponsor

Ray Monnat, MD


Date & Time

September 30, 2015 at 4:30pm - 5:30pm

Location

Health Sciences Building, Room T-739

Calendar

Pathology Presents

Export
Add to Calendar 09/30/2015 04:30 PM 09/30/2015 05:30 PM America/Los_Angeles Pathology Presents: Two New Tales from the Long-Running Mystery Series “What Does Werner Syndrome RECQ Helicase Do?” Pathology Presents: Two New Tales from the Long-Running Mystery Series “What Does Werner Syndrome RECQ Helicase Do?”

Julia Sidorova, PhD
Research Assistant Professor
Department of Pathology
University of Washington
Why Attend? Two New Tales from the Long-Running Mystery Series “What Does Werner Syndrome RECQ Helicase Do?” Understanding the biology of WRN, a RECQ helicase/exonuclease mutated in the Werner syndrome of premature aging and cancer susceptibility, has long been one of the areas of research focus in the Department of Pathology.  Since the demonstration of its helicase activity by the Loeb lab in 1997, WRN continues to be a subject of discoveries, its guises ranging from that of a homologous recombination factor, to a tumor suppressor, and to a tumor enabler. Using our technology of visualizing individual DNA fibers from human cells (maRTA), we have provided one of the direct demonstrations that WRN is involved in supporting replication fork progression during a normal S phase and under conditions of nucleotide depletion, which may be relatively common in replicating cancer cells. We followed up these findings with an siRNA screen, and uncovered novel functional interactions of WRN with the histone deacetylase 1 (HDAC1) and BRCA1 genes. This seminar will discuss these interactions and their biological and translational significance.  Please Note:  If you are unable to attend any of the seminars, you can view the coursecast (webcast) of the lecture with your UWNetID approximately one hour after the seminar is over. The coursecast website address will be provided as soon as it becomes available.
Health Sciences Building, Room T-739 false MM/DD/YYYY

Description

Why Attend?

Two New Tales from the Long-Running Mystery Series “What Does Werner Syndrome RECQ Helicase Do?”

Understanding the biology of WRN, a RECQ helicase/exonuclease mutated in the Werner syndrome of premature aging and cancer susceptibility, has long been one of the areas of research focus in the Department of Pathology.  Since the demonstration of its helicase activity by the Loeb lab in 1997, WRN continues to be a subject of discoveries, its guises ranging from that of a homologous recombination factor, to a tumor suppressor, and to a tumor enabler. Using our technology of visualizing individual DNA fibers from human cells (maRTA), we have provided one of the direct demonstrations that WRN is involved in supporting replication fork progression during a normal S phase and under conditions of nucleotide depletion, which may be relatively common in replicating cancer cells. We followed up these findings with an siRNA screen, and uncovered novel functional interactions of WRN with the histone deacetylase 1 (HDAC1) and BRCA1 genes. This seminar will discuss these interactions and their biological and translational significance.