Basic Biology of Aging: Hyperploidy and cell cycle re-entry in the aging Drosophila brain

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Speaker

Laura Buttitta, PhD
Assistant Professor
Molecular, Cellular and Developmental Biology
University of Michigan

Faculty Sponsor

Dana Miller, PhD


Date & Time

January 6, 2016 at 3:30pm - 5:00pm

Location

Foege Building, N-130A

Calendar

Basic Biology of Aging

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Add to Calendar 01/06/2016 03:30 PM 01/06/2016 05:00 PM America/Los_Angeles Basic Biology of Aging: Hyperploidy and cell cycle re-entry in the aging Drosophila brain Basic Biology of Aging: Hyperploidy and cell cycle re-entry in the aging Drosophila brain

Laura Buttitta, PhD
Assistant Professor
Molecular, Cellular and Developmental Biology
University of Michigan
Why Attend? Hyperploidy and cell cycle re-entry in the aging Drosophila brain Cell cycle re-entry of postmitotic cells in the brain has been suggested to underlie age-related cognitive decline and neurodegeneration. Patients with neurodegen­eration exhibit hyperploid neurons and gene expression analysis of aged brains has shown aberrant cell cycle gene reactivation in organisms ranging from flies to humans. Despite a long history of literature describing this correlation, the mechanism(s) of how aging impacts cell cycle re-entry in the brain and its conse­quences on aging-associated neurodegeneration remains unknown. We recently discovered that under normal physiological conditions the aging adult fly brain exhibits age-associated hyperploidy, making it an excellent model system to study this process. Our work thus far indicates that cell cycle re-entry occurs in multiple cell types, peaks at middle age, and can precede neurodegenerative phenotypes. Based upon these observations, we are developing new assays to monitor and genetically manipulate cell cycle re-entry in the adult fly brain. Importantly our approach is distinct from other Drosophila-based models of neurodegeneration, as we assay and manipulate cell cycle re-entry in the absence of ectopic expression of disease-associated mutant proteins.
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Description

Why Attend?

Hyperploidy and cell cycle re-entry in the aging Drosophila brain

Cell cycle re-entry of postmitotic cells in the brain has been suggested to underlie age-related cognitive decline and neurodegeneration. Patients with neurodegen­eration exhibit hyperploid neurons and gene expression analysis of aged brains has shown aberrant cell cycle gene reactivation in organisms ranging from flies to humans. Despite a long history of literature describing this correlation, the mechanism(s) of how aging impacts cell cycle re-entry in the brain and its conse­quences on aging-associated neurodegeneration remains unknown. We recently discovered that under normal physiological conditions the aging adult fly brain exhibits age-associated hyperploidy, making it an excellent model system to study this process. Our work thus far indicates that cell cycle re-entry occurs in multiple cell types, peaks at middle age, and can precede neurodegenerative phenotypes. Based upon these observations, we are developing new assays to monitor and genetically manipulate cell cycle re-entry in the adult fly brain. Importantly our approach is distinct from other Drosophila-based models of neurodegeneration, as we assay and manipulate cell cycle re-entry in the absence of ectopic expression of disease-associated mutant proteins.