Basic Biology of Aging: Sensory perception and central control of aging in Drosophila

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Speaker

Scott Pletcher, PhD
Associate Professor
Molecular & Integrative Physiology
University of Michigan


Date & Time

May 5, 2016 at 2:30pm - 3:30pm

Location

Foege N-130

Calendar

Basic Biology of Aging

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Add to Calendar 05/05/2016 02:30 PM 05/05/2016 03:30 PM America/Los_Angeles Basic Biology of Aging: Sensory perception and central control of aging in Drosophila Basic Biology of Aging: Sensory perception and central control of aging in Drosophila

Scott Pletcher, PhD
Associate Professor
Molecular & Integrative Physiology
University of Michigan
Why Attend? Sensory perception & central control of aging in Drosophila In Drosophila, the effects of dietary restriction, which robustly increases lifespan and reduces aging-related disease across taxa, are fast-acting, reversible, and large­ly independent of the energetic content of the food. Indeed, certain characteristic of the diet are apparently “sensed” by the flies independent of their tendency to eat it, and this perception may trigger rapid physiological changes that promoted lon­gevity. More broadly, our laboratory has shown that sensory inputs relate informa­tion about nutrition, conspecifics, and danger to rapidly initiate changes in physi­ology and mortality rate, often within a few days. In this presentation I will present evidence showing that specific set of neurons that are involved in the valuation of individual nutrients in the diet influence aging by either promoting or limiting lifespan, fat deposition, or general vigor in old age. I will also discuss our progress identifying specific neural circuits and deeper brain regions that are important for integrating sensory input and orchestrating organism-wide effects on health and lifespan.
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Why Attend?

Sensory perception & central control of aging in Drosophila

In Drosophila, the effects of dietary restriction, which robustly increases lifespan and reduces aging-related disease across taxa, are fast-acting, reversible, and large­ly independent of the energetic content of the food. Indeed, certain characteristic of the diet are apparently “sensed” by the flies independent of their tendency to eat it, and this perception may trigger rapid physiological changes that promoted lon­gevity. More broadly, our laboratory has shown that sensory inputs relate informa­tion about nutrition, conspecifics, and danger to rapidly initiate changes in physi­ology and mortality rate, often within a few days. In this presentation I will present evidence showing that specific set of neurons that are involved in the valuation of individual nutrients in the diet influence aging by either promoting or limiting lifespan, fat deposition, or general vigor in old age. I will also discuss our progress identifying specific neural circuits and deeper brain regions that are important for integrating sensory input and orchestrating organism-wide effects on health and lifespan.