Pathology Presents: Epigenetic regulation of differentiation block in rhabdomyosarcoma

This event has ended.

Speaker

Eleanor Chen, MD, PhD
Assistant Professor
Pathology
University of Washington

Faculty Sponsor

William Mahoney, PhD


Date & Time

April 26, 2017 at 4:30pm - 5:30pm

Location

Health Sciences Building, T-739

Calendar

Pathology Presents

Export
Add to Calendar 04/26/2017 04:30 PM 04/26/2017 05:30 PM America/Los_Angeles Pathology Presents: Epigenetic regulation of differentiation block in rhabdomyosarcoma Pathology Presents: Epigenetic regulation of differentiation block in rhabdomyosarcoma

Eleanor Chen, MD, PhD
Assistant Professor
Pathology
University of Washington
Dysregulated gene expression resulting from abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstrated to play an important role in driving tumor growth and progression. Using pediatric rhabdomyosarcoma (RMS) as a paradigm to elucidate the mechanism underlying differentiation arrest in solid tumors, we have used an integrated approach of genome editing, functional genomics and animal models to characterize the function of Histone Deacetylases (HDACs) and have identified HDAC3 as a major suppressor of myogenic differentiation in RMS. This seminar will offer insights into epigenetic regulation by the HDACs in modulating the differentiation status of tumor cells and potential new options in targeting the HDACs as differentiation therapy in cancer.
Health Sciences Building, T-739 false MM/DD/YYYY

Description

Dysregulated gene expression resulting from abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstrated to play an important role in driving tumor growth and progression. Using pediatric rhabdomyosarcoma (RMS) as a paradigm to elucidate the mechanism underlying differentiation arrest in solid tumors, we have used an integrated approach of genome editing, functional genomics and animal models to characterize the function of Histone Deacetylases (HDACs) and have identified HDAC3 as a major suppressor of myogenic differentiation in RMS. This seminar will offer insights into epigenetic regulation by the HDACs in modulating the differentiation status of tumor cells and potential new options in targeting the HDACs as differentiation therapy in cancer.