Pathology Presents: X Chromosome 3D Structure and Role in Sex Differences in Disease

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Speaker

Christine M. Disteche, Ph.D.
Professor
Department of Pathology
University of Washington


Date & Time

February 14, 2018 at 4:30pm - 5:30pm

Location

T-739

Calendar

Pathology Presents

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Add to Calendar 02/14/2018 04:30 PM 02/14/2018 05:30 PM America/Los_Angeles Pathology Presents: X Chromosome 3D Structure and Role in Sex Differences in Disease Pathology Presents: X Chromosome 3D Structure and Role in Sex Differences in Disease

Christine M. Disteche, Ph.D.
Professor
Department of Pathology
University of Washington
Sex differences in health and disease are mediated by hormones, but also by a fundamental genetic difference between the sexes, that is, males are XY and females are XX. This difference led to the evolution of regulatory mechanisms of the X chromosome, including X inactivation. The Disteche lab works on understanding the role of long non-coding RNAs in the 3D chromatin structure of the inactive X chromosome inside the nucleus. The lab is also investigating genes that have higher expression in females versus males due to escape from X inactivation, which plays a role in sex-specific susceptibility to disease and in sex chromosome aneuploidy.
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Description

Sex differences in health and disease are mediated by hormones, but also by a fundamental genetic difference between the sexes, that is, males are XY and females are XX. This difference led to the evolution of regulatory mechanisms of the X chromosome, including X inactivation. The Disteche lab works on understanding the role of long non-coding RNAs in the 3D chromatin structure of the inactive X chromosome inside the nucleus. The lab is also investigating genes that have higher expression in females versus males due to escape from X inactivation, which plays a role in sex-specific susceptibility to disease and in sex chromosome aneuploidy.