Clinical and Research Background
People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke, and peripheral cardiovascular disease that can lead to the necessity to amputate limbs) caused by atherosclerosis. These complications also develop earlier in life than in people without diabetes. Risk factors for cardiovascular disease associated with diabetes include sub-optimal metabolic control and lipid abnormalities, such as increased levels of triglycerides and decreased levels of HDL. Our work focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that these complications can be treated or prevented.
We have shown, using a mouse model of diabetes-accelerated atherosclerosis (Renard et al. 2004; Johansson et al. 2008) that type 1 diabetes stimulates both initiation of lesions of atherosclerosis and progression to advanced lesions. Our working hypothesis is that diabetes stimulates lesion initiation and progression by increasing macrophage recruitment and arterial inflammation.
Our work is, or has been, funded by the National Heart, Lung, and Blood Institute, the American Heart Association, the American Diabetes Association, Seattle Foundation, the Royalty Research Fund at the University of Washington, and the Juvenile Diabetes Research Foundation.
Academic and Medical Appointments
Professor (Primary), Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, 2011-Present
Professor, Department of Pathology, University of Washington, Seattle, WA, 2007-Present
Associate Professor, Department of Pathology, University of Washington, Seattle, WA, 2001-2007
Assistant Professor, Department of Pathology, University of Washington, Seattle, WA, 1998-2001
Research Assistant Professor, Department of Pathology, University of Washington, Seattle, WA, 1995-1998
Lecturer, Department of Biology, Linköping University, Linköping, Sweden, 1987-1990
Education and Training
Senior Fellow in the laboratory of Dr. Russell Ross, Dept. of Pathology, University of Washington, Seattle, WA, 1991-1995
Linköping University, Faculty of Health Sciences Graduate School, Department of Pharmacology, Linköping, Sweden, Ph.D., 1991
Linköping University, Linköping, Sweden (Physiology & Pharmacology), B.S., 1985
Latest publications from PubMed