Daniel F. Bowen-Pope, PhD

Professor Emeritus

Daniel F. Bowen-Pope, PhD


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Office Location:

SLU- Room 443

Mailing Address:

Box 358050
815 Mercer St.
Seattle, WA 98109

Clinical and Research Background

My general interests are in vascular biology and molecular regulation of vascular (and other tissue) response to injury. My lab is currently working in three project areas. For more detailed information about these projects, Read the Specific Aims of the NIH grants that fund my research. To see a list of publications, go to my COS site.

We are developing a system of conditional reporters and cell-type-specific markers in transgenic mice to determine the origin of cells involved in formation of new blood vessels in injured tissue. We are most interested in cell derivation from undifferentiated “stem cells” and via “transdifferentiation” from other cell types.

We have developed a system for regulating apoptosis of vascular smooth muscle cells (SMCs) in vivo, and have used this system to determine that SMC apoptosis initiated by FADD overexpression includes a specific program of expression of pro-inflammatory genes that results in recruitment of macrophages. We are attempting to further define this program of gene expression, determine the signaling mechanisms through which it is regulated, and further investigate the consequences of SMC apoptosis in vivo.

We have identified a protein tyrosine phosphatase (PTPase)-like protein that resembles the tumor suppressor PTEN in that its biological activity is due to its activity as a phosphatidylinositol phosphatase (PIPase) rather as a PTPase. The receptor-like form of PTPRQ protein appears to be largely localized to specialized regions of non-proliferating cell types (including podocytes, inner ear hair cells and Sertoli cells) that are involved in cell-cell or cell-matrix interactions. Targeted disruption of PTPRQ in mice results in deafness and altered response to renal injury. We are testing hypothesis that subcellular localization of PTPRQ in specialized membrane regions plays a role in regulation of local membrane PIP composition, and that this plays a role in regulating specialized cell architecture and function by altering the local binding and/or activity of PIP-binding proteins.

Academic and Medical Appointments

Professor Emeritus, Dept of Pathology, Univ. of Washington, Seattle, 2013 - present

Professor, Dept of Pathology, Univ. of Washington, Seattle, 7/1/92 – 6/30/13

Associate Professor, Dept. of Pathology, Univ. of Washington, Seattle, 7/1/87

Assistant Professor, Dept. of Pathology, Univ. of Washington, Seattle, 7/1/86

Graduate Faculty, School of Medicine, University of Washington, Seattle, 5/1/84 – present

Research Assist. Professor, Dept. of Pathology, Univ. of Washington, Seattle, 7/1/82

Departmental Responsibilities

Director of Pathology Graduate Program, 1993-present

Pathology Graduate Admissions Committee, 1983 to present; Chairman, 1993-present

Pathology Administrative Committee, 1994-present

Co-Chairman, Committee to organize Symposium to honor Ross, Summer, 1994

Pathology Dept Retreat Chairman, 1989, 1990, 1994, 2005

Search Committee, Assistant Professor, pulmonary, 1998

Appointments and Promotions Committee, 1987 to 1993

Pathology Postdoctoral Fellows Committee, 1983 to 1994


Search Committee, Comp Med, 1999

Focus Group on Industry/University Relations, 7/98

ZymoGenetics Initiative steering committee, 4/98

University of Washington Faculty Senate: Senator, 9/95-9/97

School of Medicine Council on University Relations, 1995-1996

Interdepartmental Molecular and Cellular Biology Program, Steering Committee, 1995

Member, Interdisciplinary Group in Nutrition, 1994-2000

Molecular and Cellular Biology Training Grant Evaluation Committee, Chairman, 1994 – 1995

School of Medicine Council on Scientific Affairs, 1993-1996

Chairman of Selection Committee of Interdisciplinary Molecular and Cellular Biology Program, 1991-1993

Molecular and Cellular Biology Program Development Committee, 1991

Search Committee for physician/scientist position in Cardiology, 1991

UW Academic Senate, representative, 1989-91; 1995-97; and 2004-06

Search Committee for Director Division of Hematology, member, 1989/90

Steering Committee, Cardiovascular Pathology Training Grant, member, 1989-current

Scientific Review Committee for Research Center in Oral Biology, 1988-current

Education and Training

University of California at Berkeley, Berkeley, CA, Ph.D. in Molecular Biology, 1980

University of California at San Diego, San Diego, CA, B.A In Biology, 1973

Postgraduate Training

Postdoctoral Fellow, Department of Pathology, University of Washington, Seattle, WA, 1979-1982


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