Xinxian Deng, PhD

Research Assistant Professor

Xinxian Deng, PhD

E-mail:

.(JavaScript must be enabled to view this email address)

Office Location:

HSB - Room - C-526

Mailing Address:

Box 357470
1959 NE Pacific St.
Seattle, WA 98195


Clinical and Research Background

My research focus is the epigenetic mechanisms of X chromosome regulation. Mammalian females have two X chromosomes and males have only one X and a gene-poor Y. The phenotypic effects of chromosomal imbalance in mammals are deleterious and haplo-insufficiency for a whole chromosome is not tolerated. Thus dosage compensation has evolved to restore equal expression between the X and autosomes by doubling X-linked gene expression (X upregulation) and between the sexes by silencing one X in females (X inactivation). We are investigating how mammalian X-linked genes are upregulated at transcriptional and posttranscriptional levels. This research is directly relevant to the study of gene dosage effects on diseases such as birth defects and cancer.

Academic and Medical Appointments

Research Assistant Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2016-Present

Acting Assistant Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2014-2016

Acting Instructor, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2010-2014

Education and Training

Postdoctoral Fellow, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2006-2010

Ph.D., Department of Biology, Tufts University, Medford, MA, 2006

B.S., Fudan University, Shanghai, China, 1999

Publications

View on PubMed

Latest publications from PubMed

    Loading list of publications from PubMed.