Christine M. Disteche, PhD

Professor

Christine M. Disteche, PhD

E-mail:

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Office Location:

HSB- Room C-526

Mailing Address:

Box 357470
1959 NE Pacific St.
Seattle, WA 98195

Research Lab

Disteche Lab


Clinical and Research Background

The focus of research in my lab, the X chromosome, provides a model for a naturally occurring “aneuploidy” caused by the evolution of a specific set of sex-determining chromosomes that differ in their copy number between males (XY) and females (XX). A fundamental issue in biology and medicine is to understand the effects of aneuploidy on gene expression and the mechanisms that alleviate imbalances of the genome. Such imbalances cause specific disorders including mental retardation and cancer. The X chromosome has evolved specific genetic and epigenetic mechanisms of dosage compensation, which we investigate using global approaches in terms of chromatin modifications during stem cell differentiation and embryo development. We are also interested in the impact of X-linked genes in producing sex-specific differences. My research is funded by grants from the NIGMS and NIMH.

Academic and Medical Appointments

Academic Appointments

Adjunct Professor of Medicine (Medical Genetics), University of Washington, Seattle, WA, 1996-Present

Professor of Pathology, University of Washington, Seattle, WA, 1992-Present

Associate Professor of Pathology, University of Washington, Seattle, WA, 1986-1992

Assistant Professor of Pathology, University of Washington, Seattle, WA, 1983-1986

Instructor of Pathology, University of Washington, Seattle, WA, 1980-1983

Medical Appointments

Director of the University of Washington Regional Cytogenetics Laboratory, Seattle, WA, 2011-Present

Co-director of the University of Washington Regional Cytogenetics Laboratory, Seattle, WA, 1980-2011

Education and Training

Postdoctoral Research Fellow, Harvard Medical School, Boston, MA, 1977-1980

Université de Liège, Belgium: Docteur en Sciences biomédicales expérimentales, 1970-1976

Université de Liège, Belgium: Licence en Sciences Zoologique, 1966-1970

Publications

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