Marshall S. Horwitz, MD, PhD

Professor

Marshall S. Horwitz, MD, PhD

E-mail:

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Office Location:

SLU - Room N-435

Mailing Address:

Box 358056
815 Mercer St.
Seattle, WA 98109


Clinical and Research Background

Dr. Marshall Horwitz is an internist and clinical medical geneticist whose research interests relate to genetic factors predisposing to hematopoietic malignancy and the clonal evolution of cancer. The major focus of his research centers on defining the genetic origins of cancers of the blood and using that as a paradigm for further understanding development. His laboratory employs genetic mapping and sequencing strategies to identify genes responsible for familial predisposition to leukemia, lymphoma, and bone marrow failure syndromes. His lab has successfully identified genes responsible for human cyclic neutropenia, canine cyclic neutropenia, severe congenital neutropenia (Kostmann syndrome), Hodgkin’s lymphoma, myelodysplasia and acute myeloid leukemia, and, recently, acute lymphocytic leukemia. In related work, Dr. Horwitz’s laboratory has developed a new approach for mapping cell fate during development by phylogenetically inferring the order in which mutations accumulate in somatic tissues. Dr. Horwitz directs the University of Washington School of Medicine Medical Scientist Training Program (MSTP) for concurrent M.D./Ph.D. students. He is Cancer Genetics Section Editor of the Public Library of Science journal PLOS Genetics and former chair of the NIH Genetics of Health and Disease study section. Among his honors, Dr. Horwitz is a recipient of the Presidential Early Career Award for Scientists and Engineers, received from the President at the White House in 2002, as well as the 2007 NIH Director’s Pioneer Award.

Board Certifications

Board Certified in Medical Genetics and Internal Medicine

Academic and Medical Appointments

Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2008-Present

Professor, Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, 2005-2008

Associate Professor, Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, 2000-2005

Attending Physician, General Internal Medicine Service, University of Washington, Seattle, WA, 1996-2001

Attending Physician, Medical Genetics Clinic, University of Washington, Seattle, WA, 1995-Present

Assistant Professor, Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, 1995-2000

Education and Training

Postdoctoral Fellowship, Harold Weintraub Laboratory, HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA, 1992-1995

Medical Genetics Fellowship, University of Washington, Seattle, WA, 1992-1995

Resident, University of Washington School of Medicine, Seattle, WA, 1990-1992

University of Washington School of Medicine, Seattle, WA, Medical Doctorate, 1990

University of Washington, Department of Pathology (mentor, Dr. Lawrence Loeb), Seattle, WA, Doctorate of Philosophy, 1988

Revelle College University of California, San Diego, Chemistry, B.A., 1983

Publications

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