Peter S. Rabinovitch, MD, PhD

Professor and Vice Chair of Research | Director, Flow Cytometry Laboratory

Peter S. Rabinovitch, MD, PhD

E-mail:

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Office Location:

HSB - Room K-081

Mailing Address:

Box 357705
1959 NE Pacific St.
Seattle, WA 98195

Research Lab

Rabinovitch Lab


Clinical and Research Background

The focus of Dr. Rabinovitch’s laboratory research is on the use of genetically altered mouse models to examine the effects of cell signaling and reactive oxygen species (ROS) on lifespan and healthspan. Transgenic mice that overexpress catalase have been found to be protected against multiple health challenges, including cardiac aging, sarcopenia and some cancers. Similar benefits are conferred by treating mice with the SS-31 tetrapeptide. The interrelationships of mitochondrial ROS and mitochondrial damage with cell signaling pathways that mediate improved healthspan, including resistance to cardiac hypertrophy and failure, are thus of central interest to the laboratory. As the mTOR pathway is a strong candidate in this linkage, we are using transgenic mice with altered mTOR signaling to explore this relationship. In addition to physiological and biochemical assays, proteomic and genomic technologies are being actively utilized in laboratory studies.

Dr. Rabinovitch is the founding director (1985) of the University of Washington Nathan Shock Center for Excellence in the Basic Biology of Aging, one of 5 such NIA funded Centers in the country. He has been the Director of a T32 Biology of Aging Training Grant at the University of Washington since 1997. He is current Chairman of the NIA-B Study Section (NIH Biological Aging Review Committee). He has been funded continuously by the NIA since 1981, including as the PI of a Program Project in aging since 2004. He is a current recipient of an Ellison Medical Foundation Senior Scholar in Aging grant award, and a Breakthroughs in Gerontology grant award from the American Federation for Aging Research.

Board Certifications

Board Certified in Pathology

Academic and Medical Appointments

Academic Appointments

Joint Member, Fred Hutchinson Cancer Research Center, Seattle, WA, 1998-Present

Professor, Department of Pathology, University of Washington, Seattle, WA, 1992-Present

Associate Professor, Department of Pathology, University of Washington, Seattle, WA, 1987-1992

Assistant Professor, Department of Pathology, University of Washington, Seattle, WA, 1983-1987

Instructor, Department of Pathology, University of Washington, Seattle, WA, 1981-1983

Medical Appointments

Director, Flow Cytometry Laboratory, Hospital Pathology, University Hospital, Seattle, WA, 1986-Present

Administrative Responsibilities

Co-director, Seattle Cancer and Aging Program, Seattle, WA, 2003-2008

Faculty Advisor, Cytometry Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, WA, 1998-2009

Director, Genetic Approaches to Aging Training Grant, University of Washington, Seattle, WA, 1997-Present

Associate Director, Genetic Approaches to Aging Training Grant, University of Washington, Seattle, WA, 1995-1997

Director, Nathan Shock Center for Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA, 1995-Present

Associate Director, Medical Scientist Training Program, University of Washington, Seattle, WA, 1984-1997

Director, Flow Cytometry and Cell Sorting Cost Recovery Center, Department of Pathology, University of Washington, Seattle, WA, 1981-Present

Education and Training

Resident, Pathology Department, University of Washington, Seattle, WA, 1980-1981

Medical Doctorate, University of Washington, Seattle, WA, 1979-1980

Doctorate of Philosophy, University of Washington, Seattle, WA, 1972-1979

Bachelor of Science, University of Washington, Seattle, WA, 1968-1972

Publications

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