Rosana Risques, PhD

Assistant Professor

Rosana Risques, PhD

E-mail:

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Office Location:

HSB - Room - E506

Mailing Address:

Box 357470
1959 NE Pacific St.
Seattle, WA 98195

Research Lab

Risques Lab


Clinical and Research Background

My main research interest is the study of the molecular alterations that underlie the transformation of an apparently normal human epithelial cell into a tumor and in the translation of these alterations into potential tests to detect and predict cancer. My lab is especially interested in two alterations that link cancer and aging: telomere shortening and mitochondrial dysfunction. We have studied these alterations in the context of ulcerative colitis, an inflammatory bowel disease that predisposes to colorectal cancer. Ulcerative colitis is an excellent model disease to study early tumor progression and also a clinically challenging condition that could greatly benefit from better biomarkers for early cancer detection. We are currently using two novel technologies, NanoString (Project 1) and Duplex Sequencing (Project 2) to study mitochondrial alterations in ulcerative colitis. We are also developing PolyG-MIP (Project 3), a new sequencing technology that can detect early cancer in non-dysplastic ulcerative colitis colon biopsies. In addition, both PolyG-MIP and Duplex Sequencing have multiple applications in cancer research and we are currently validating these technologies for analysis of colorectal cancer evolution (PolyG-MIP, Project 3) and for early detection of ovarian cancer (Duplex Sequencing, Project 4). The Risques lab is also in charge of the Telomere Length Q-PCR Analysis cost-center and we have several ongoing collaborative projects aimed to study the role of leukocyte telomere length in cancer, stress, and aging.

Academic and Medical Appointments

Assistant Professor of Pathology, University of Washington, Seattle, WA, 2013-Present

Acting Assistant Professor of Pathology, University of Washington, Seattle, WA, 2011-2013

Acting Instructor of Pathology, University of Washington, Seattle, WA, 2007-2011

Education and Training

Post-doctoral Fellow in Pathology, University of Washington, Seattle, WA, 2003-2007

Post-doctoral Associate, Department of Molecular Biology, Sidney Kimmel Cancer Center, San Diego, CA, 2001-2003

Cancer Research Institut and Autonomous University of Barcelona, Spain, Molecular and Cell Biology, Ph.D., 1996-2001

Autonomous University of Barcelona, Spain, Biology, B.S., 1992-1996

Publications

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