Clinical and Research Background
Dr. Zhang, Professor and Shaw Endowed Chair, is board-certified in anatomic pathology and neuropathology. Dr. Zhang participates in surgical neuropathology and autopsy as well as ocular pathology services.
Dr. Zhang obtained his M.D. from the Second Military Medical University in Shanghai, China, and Ph.D. in cell biology at Duke University, Durham, North Carolina. He completed his residency in anatomic pathology and fellowship in neuropathology training at Vanderbilt University, Nashville, Tennessee.
Dr. Zhang is exceedingly interested in molecular mechanisms, particularly mitochondrial dysfunction, oxidative stress and neuroinflammation, related to neurodegenerative disease development and progression. His lab has particularly focused on the relationship between important Parkinson and Alzheimer related proteins and alterations in the function of brain cells leading to neurodegeneration. He has also been deeply involved in proteomics-based discovery work as well as targeted validation of candidate proteins with mass spectrometry and immunoassays of proteins related to neurodegenerative disorders, typically via collaborations involving multiple medical centers, including across different countries. Recently, he has extended his efforts to understanding how key proteins transfer between the brain and the periphery, and how understanding of these processes, including glial responses, can be leveraged to develop novel and accessible biomarkers or identify novel targets for existing and future neuroprotective therapies.
In his spare time, Dr. Zhang enjoys boating, hiking and reading.
Board Certified in Anatomic Pathology, 2001
Board Certified in Neuropathology, 2001
Brain Tumors and Neurodegenerative Disorders
Academic and Medical Appointments
Shaw Endowed Professor of Pathology, University of Washington, Seattle, WA, 2010-Present
Associate Professor of Pathology, University of Washington, Seattle, WA, 2006-2010
Assistant Professor of Pathology, University of Washington, Seattle, WA, 2002-2006
Education and Training
Armed Forces Institute of Pathology, Fellowship, Ophthalmic Pathology
Pathology Residency and Neuropathology Fellowship, Vanderbilt University, Nashville, TN, 2001
Duke University, Durham, NC, Cell Biology, Ph.D., 1995
Second Military Medical University, Shanghai, P.R. China, Medicine, B.A./M.D., 1987
Latest publications from PubMed