Research Centers: HPV Research Group

The HPV Research Group is comprised of a variety of researchers from several institutions in Western Washington and Senegal, Africa that include the University of Washington, the Fred Hutchinson Cancer Research Center, and the University of Dakar.

Over the last 15 years, the HPV research group has conducted a variety of studies focused on HPV and HPV related cancers. These have included studies describing the epidemiology and natural history of HPV and its role in the development of cervical cancer in a variety of different populations, including subjects with and without human immunodeficiency virus infection or other sexually transmitted infections. Our studies have examined novel approaches to detection and treatment of women with cervical cancer and cervical cancer precursor lesions in both developed countries and in resource poor settings. Our studies are currently focusing on strategies to detect women at risk for cervical cancer, including the use of assays to detect HPV and specific HPV variants, as well as assays to detect specific genes associated with lesions or lesion severity (based on the presence of over-expressed proteins or hypermethylated genes). We are also currently assessing the relationship between infections with non-genital (cutaneous) HPVs and squamous cell cancer.

Other studies being conducted by investigators of the HPV Research Group concern the development and translation of research findings into procedures appropriate for use in resource-poor settings. These studies include comparison of the immune response of HIV-1 as compared to HIV-2 which will help identify epitopes that may be important for HIV vaccine development, and the evaluation of potential biomarkers that may serve as the basis for assays of use in the early detection and treatment of women with breast cancer.

HPV and Epithelial Malignancy

Human papillomaviruses are small, double-stranded DNA viruses, which infect stratified squamous or endocervical glandular epithelium, where they stimulate epithelial proliferation. At present, over 100 different human papillomavirus (HPV) types have thus far been identified, but many more likely exist. These viruses are classified biologically (and phylogenetically) into cutaneous or mucosal types depending on whether they generally infect keratinizing or non-keratinizing epithelium. (Formal classification of individual genotypes is based on the sequence homology in the L1 region of the genome.) There is a great deal of interest in HPVs because of their central role in the development of many squamous epithelial cancers. Over the last several years, detection of specific types of HPV has been integrated into cervical cancer control efforts.

 

HPV Research Group Contact Information

HPV Research Group
University of Washington
Box 359933
1914 North 34th Street, Suite 300
Seattle, WA 98103
Phone: (206) 616-9740
Fax: (206) 616-9788

HPV Laboratory
Harborview Medical Center
Box 359939
300 Ninth Ave, Rm 710
Seattle, Wa 98104
Phone: (206) 341-5903
Fax: (206) 341-5906

Faculty

Name Position Phone Location
Baseman, Janet
jbaseman@uw.edu
Associate Professor of Epidemiology Work: 206-616-9746
Fax: 206-616-9788
 
HPV Research Group
Box 359933
Chien, Andy
andchien@uw.edu
Senior Fellow Work: 206-543-5290
Fax: 206-543-2489
UWMC Dermatology
Box 356524
Hawes, Steve
hawes@uw.edu
Associate Professor of Epidemiology Work: 206-616-9744
Fax: 206-616-9788
HPV Research Group
Box 359933
Kiviat, Nancy
nbk@uw.edu
Professor of Pathology, Director HPV Research Group Work: 206-731-3145
Fax: 206-731-8240
HMC Rm 2EH-87
Box 359791
Koutsky, Laura
kouts@uw.edu
Professor Emeritus of Epidemiology Work: 206-616-9784
Fax: 206-616-9788
HPV Research Group
Box 359933
Mao, Connie
cmao@uw.edu
Acting Assistant Professor of Obstetrics and Gynecology Work: 206-616-6097
Fax: 206-616-9788
HPV Research Group
Box 359933
Winer, Rachel
rlw@uw.edu
Associate Professor of Epidemiology Work: 206-616-5081
Fax: 206-616-9788
HPV Research Group
Box 359933

Collaborators

Name Position Phone Location
McElrath, Julie
jmcelrat@fhcrc.org
Professor of Allergy and Infectious Diseases Work: 206-667-6704
Fax: 206-667-4411
FHCRC
Box 358080
McIntosh, Marty
mmcintosh@fhcrc.org
Research Associate Professor of Biostatisticy Work: 206-667-4612
Fax: 206-667-7850
FHCRC
Box 358080
Urban, Nicole
nurban@fhcrc.org
Research Professor Emeritus of Health Services Work: 206-667-4677
Fax: 206-667-7850
FHCRC
Box 358080
Lieber, Andre
lieber00@uw.edu
Professor of Medical Genetics Work: 206-221-3973
Fax: 206-685-8675
UW
Box 357720

Staff

Name Position Phone Location
Aganan, Jiezel
agananj@uw.edu
Fiscal Specialist Work: 206-744-2564
Fax: 206-744-8240
HMC Rm 2EC08
Box 359791
Arnold, Carol
carnold@uw.edu
Grants and Contracts Manager Work: 206-731-3083
Fax: 206-73-8240
HMC Rm 2EC08
Box 359791
Balasubramanian, Akhila
akhila@uw.edu
Data Analyst Work: 206-616-9745
Fax: 206-616-9788
HPV Research Group
Box 359933
Cherne, Stephen
cherne@uw.edu
Research Scientist Work: 206-341-5901
Fax: 206-341-5906
HMC R&T
Box 359933
Deng, Linda Lab Technician I Work: 206-341-5902
Fax: 206-341-5906
HMC R&T
Box 359939
Hertel, Debi
dphertel@uw.edu
Data Entry Operator Work: 206-685-3210
Fax: 206-616-9788
HPV Research Group
Box 359933
Kenney, Donna
dkenney@uw.edu
Research Scientist Work: 206-341-5905
Fax: 206-341-5906
HMC R&T
Box 359939
Lee, Shu-Kuang
sklee@uw.edu
Biostatistician Work: 206-616-9738
Fax: 206-616-9788
HPV Resarch Group
Box 359933
Lin, John
indigo@uw.edu
Research Study Coordinator Work: 206-616-8526
Fax: 206-616-9788
HPV Research Group
Box 359933
Lu, Hiep Research Scientist Work: 206-341-5901
Fax: 206-341-5906
HMC R&T
Box 359939
Morihara, Janice
jmorih@uw.edu
Clinical Tech I Work: 206-341-5900
Fax: 206-341-5906
HMC R&T
Box 359939
Partridge, Jeff
jmp9@uw.edu
Research Assistant Work: 206-616-5081
Fax: 206-616-9788
HPV Research Group
Box 359933
Seal, Nicholas
roadkitty@hotmail.com
Courier Work: 206-685-0308
Fax: 206-616-9788
HPV Research Group
Box 359933
Starling, Alison
aks@uw.edu
Data Manager Work: 206-616-9748
Fax: 206-616-9788
HPV Research Group
Box 359933
Stern, Joshua
jstern77@uw.edu
Biostatistician Work: 206-616-6150
Fax: 206-616-9788
HPV Research Group
Box 359933
Weese, Martha
mweese@uw.edu
Manager of Program Operations Work: 206-616-9740
Fax: 206-616-9788
HPV Research Group
Box 359933
Xi, Long-Fu
longfu@uw.edu
Research Scientist Work: 206-616-9787
Fax: 206-616-9788
HPV Research Group
Box 359933