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Home Lab Members Director's Message Research Interests Publications Protocols Related Info Photos Contact Us		PUBLICATIONS Caudle WM, Kitsou E, Li J, Bradner J, Zhang J (2009). A role for a novel protein, nucleolin, in Parkinson’s disease, Neurosci Lett. 2009 Jul 31;459(1):11-5. Epub 2009 May 4. Shi M, Bradner J, Bammler TK, Eaton DL, Zhang JP, Ye ZC, Wilson AM, Montine TJ, Pan C and Zhang J (2009). Identification of synaptosomal glutathione S-transferase Pi as a key protein in Parkinson disease progression, Am J Pathol. 2009 Jun 4. Jung HO, Pan S, Zhang J, Gao J (2008). MSQ: a tool for quantification of proteomics data generated by LC-MALDI TOF/TOF based targeted quantitative proteomics platform, Rapid Communication Mass Spec, in revision Hwang H, Zhang JP, Chung KA, Leverenz JB, Zabetian CP, Peskind ER, Jankovic J, Su Z, Hancock AM, Pan C, Montine TJ, Pan S, Nutt J, Albin R, Gearing M, Beyer RP, Shi M, and Zhang J (2009). Glycoproteomics in Neurodegenerative Diseases. Mass Spectrom Rev. 2009 Apr 8. Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J (2009). Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci. 4;29(5):1480-5. Pan S, Aebersold R, Chen R, Rush J, Goodlett DR, McIntosh MW, Zhang J, Brentnall TA (2009), Mass spectrometry based targeted protein quantification: methods and applications, J. Proteome Res. 6;8(2):787-797 Shi M, Caudle WM and Zhang J (2008). Biomarker Discovery in Neurodegenerative Diseases: A Proteomic Approach, Neurobiol Dis. 2008 Sep 26 online Hu X, Zhang D, Pang H, Caudle WM, Li Y, Gao H, Liu Y, Qian L, Wilson B, Di Monte DA, Ali SF, Zhang J, Block ML, Hong JS (2008). Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease, J Immunol. 181(10):7194-204. Kitsou E, Pan S, Zhang JP, Dickson DW, Albin R, Gearing M, Kashima DT, Wang Y, Beyer DP, Zhou Y, Pan C, Caudle WM, Zhang J (2008), Identification of proteins in human substantia nigra, Proteomics, Clin Application, 2 (5):776-782. Liu J, Hong Z, Ding JQ, Liu JR, Zhang J, Chen SD (2008), Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies. J Proteome Res. 7(5):2033-49 Caudle WM, Pan S, Shi M, Quinn T, Hoekstra J, Beyer RP, Montine TJ, Zhang J (2008), Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease. Proteomics - Clin Application 2(10-11): 1484-1497 Zhang J, Keene CD, Pan C, Montine KS, Montine TJ. Proteomics of human neurodegenerative diseases (2008). J Neuropathol Exp Neurol. 67(10):923-32 Klegeris A, Li J, Bammler TK, Jin J, Zhu D, Kashima DT, Pan S, Hashioka S, Maguire J, McGeer PL, Zhang J (2008), Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity. Glia. 56(6):675-85 Shi M, Jin J, Wang Y, Beyer RP, Kitsou E, Albin RL, Gearing M, Pan C, Zhang J (2008) Mortalin: A Protein Associated With Progression of Parkinson Disease? 1: J Neuropathol Exp Neurol. 67(2):117-124 Zhang J , Sokal I, Peskind E, Quinn J, Jankovic J, Kenney C, Chung K, Millard S, Nutt J, Montine TJ (2008), CSF multianalyte profile distinguishes Alzheimer's and Parkinson's diseases, Am J Clin Path, 129(4):526-9. Pan S, Rush J, Peskind ER, Galasko D, Chung K, Quinn J, Jankovic J, Leverenz JB, Zabetian C, Pan C, Wang Y, Oh JH, Gao J, Zhang J, Montine T, Zhang J (2008). Application of Targeted Quantitative Proteomics Analysis in Human Cerebrospinal Fluid Using a Liquid Chromatography Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Tandem Mass Spectrometer (LC MALDI TOF/TOF) Platform. J Proteome Res. 7(2):720-30. Pan S, Shi M, Jin J, Albin RL, Lieberman A, Gearing M, Lin B, Pan C, Yan X, Kashima DT, Zhang J (2008), Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer. Mol Cell Proteomics. 6(10):1818-23. Zhang J (2007), Proteimics of Human cerebrospinal fluid – the good, the bad, and the ugly. Proteomics Clinical Applications. Rev. 2007,1, 805-919 Liu, J, Zhou Y, Liu J, Fong H, Murray TM, and, Zhang J (2007), Proteins involved in phagocytosis of aggregated ?-synuclein. J Proteome Res. 6(9):3614-27. Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J , Perl DP, Galasko DR, Montine TJ (2007). Quantitative Proteomics Identifies Surfactant-Resistant alpha-Synuclein in Cerebral Cortex of Parkinsonism-Dementia Complex of Guam but Not Alzheimer's Disease or Progressive Supranuclear Palsy. Am J Pathol. 171(3):993-1002. Jin J, Davis J, Zhu D, Kashima DT, Leroureil M, Pan, C, Montine KS, and Zhang J (2007) Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells, BMC Neurology, 8(1):6 Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J , Peskind ER, and Montine TJ (2007). CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology. 2007 69(7):631-9 Sonnen JA, Keene CD, Montine KS, Li G, Peskind ER, Zhang J , Montine TJ (2007). Biomarkers for Alzheimer's disease, Expert Rev Neurother. 7(8):1021-8. Chen L, Davis J, Jin J, Zhou Y, Wang Y, Liu J, Lockhart P, and Zhang J (2007), Oligomeric a-synuclein inhibits tubulin polymerization, Biochem. Biophy. Res. Comm, 356(3):548-53. Zhang W, Dallas S, Guo JP, Pang H, Wilson B, Miller DS, Jia J, Chen B, Zhang W, McGeer PL, Hong JS, and Zhang J (2007), Microglial Mac-1 and PHOX are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant ?-synuclein, Glia, 55:1178-88 Jin J, Li GJ, Davis J, Zhu D, Wang C, Pan C, and Zhang J (2007), Identification of novel proteins interacting with both a-synuclein and DJ-1, Mol Cell Proteomics. 6:845-59, 2007. Jin J, Shie FS, Liu J, Wang Y, Davis J, Schantz AM, Montine KS, Montine TJ, Zhang J (2007), Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein, J Neuroinflammation. 4;4:2 Pan S, Zhu D, Quinn JF, Peskind ER, Montine TJ, Lin B, Goodlett DR, Taylor G, Eng J, Zhang J . (2007), A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectroscopy, Proteomics, 7(3):469-73. Leverenz, JB, Umar I, Wang Q, Montine TJ, Jin J, Pan C, Shin J, Zhu D, and Zhang J (2007), Proteomic identification of heat shock cognate 71 kDa protein as a novel component of Lewy bodies, submitted to Brain Pathology, 17(2):139-145. Zhang J and Montine TJ. Proteomic discovery of CSF biomarkers for Alzheimer's disease. Ann Neurol. 61(5):497, 2007. Pan S, Wang W, Quinn JF, Peskind ER, Waichunas D, Wimberger JT, Jin J, Li DJ, Zhu D, Pan C, and Zhang J (2006), Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach, Journal of Proteomic Research, 5:2769-2779 Zhang H, Loriaux P, Eng J, Campbell D, Keller A, Moss P, Bonneau R, Zhang N, Zhou Y, Wollscheid B, Cooke K, Yi EC, Lee H, Peskind ER, Zhang J , Smith RD, Aebersold R (2006), UniPep, a database for human N-linked glycosites: A Resource for Biomarker Discovery, Genome Biology, August online Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li J, Liu Y, Waichunas D, Montine TJ, Zhang J (2006), Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders, Journal of Alzheimer’s Disease 9:293-348. Jin J, Hulette C, Wang Y, Zhang T, Pan C, Wadhwa R, and and, Zhang J (2006), Quantitative proteomics identified mortalin as a key player in the pathogenesis of Parkinson’s disease, Mol Cell Proteomics, 5(7):1193-204. Epub 2006 Mar 24.Mar 24 McLaughlin P, Zhou Y, Ma T, Liu J, Kovacs M, and, Zhang J (2006), Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity, Glia 53:567-82 Xu J, Chen J, Peskind, ER, Jin J, Eng J, Pan P, Montine TJ, Goodlett DR, Zhang J (2006), Characterization of proteome of human cerebral spinal fluid. Int. Rev Neurob, 73:29-98 Thakker MM, Zhang J , Sires BS (2005). Chronic Inflammation from polycarbonate motility peg inhibits osteogenesis in a human hydroxyapatite orbital implant. Ophthal Plast Reconstr Surg. 21(5):399-401 Xiong X, Shie FS, Zhang J , Lee CP, and Ho YS (2005). Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. J. Neurochem. 95(3):732-44. Woltjer RL, Cimino PJ, Pan C, Zhang J , Montine KS, Montine TJ (2005). Proteomic analysis of insoluble proteins in Alzheimer’s disease. FASEB J. 19(13):1923-5. Zhou Y, Wang Y, Kovacs M, Jin J, and Zhang J (2005), Microglial activation induced by neurodegeneration – A proteomic analysis, Molecular Cellular Proteomics, Oct;4(10):1471-9. Zhang J , Goodlett DR, Peskind ER, Quinn, JF, Zhou, Y, Pan, P, Yi, E, Eng, J, Aebersold, R. and Montine, TJ (2005), Quantitative proteomics of cerebrospinal fluid from Alzheimer disease and controls using isotope-coded affinity tags. Journal of Alzheimer’s Disease, 7:125-33. Yenerel, NM, Boada, R, Clifton, B, Zhang J , and Saperstein, DA (2005), Ganciclovir Implant with Cyst-like Abnormality Arch Ophthal, 123(2):282-3 Wang Q, Woltjer RL, Cimino PJ, Pan C, Montine KS, Zhang J , Montine TJ (2005). Proteomic analysis of neurofibrillary tangles in Alzheimer Disease identifies GAPDH as a detergent-insoluble paired helical filament tau-binding protein. FASEB J. 19:869-71. Jin J, Meredith G, Chen L, Zhou Y, Xu J, Xie FX, Lockhart P, and Zhang J (2005), Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson’s disease. Molecular Brain Res, 24;134(1):119-38. Zhang W, Wang T, Pei Z, Meng Y, Wu XF, Belinda W, Zhang W, Hong JS and Zhang J (2005), Aggregated ?-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. FASEB J 19:532-541. Zaja-Milatovic S, Schantz, A, Zhang J , Montine KS, Samii A, Deutch A, and Montine, TJ (2005), Dendritic Degeneration in Neostriatal Medium Spiny Neurons in Parkinson Disease. Neurol 64:545-7. Zhang J , Goodlett, DR, Peskind, ER, Quinn, JF, Zhou, Y, Pan, P, Yi, E, Eng, J, Aebersold, R. and Montine, TJ (2005), Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiol Aging, 26: 207-227. Ye X., Shie F,S., Zhang J , and Ho, YS (2004) The protective role of cellular glutathione peroxidase against mitochondrial dysfunction in head trauma, J Stroke and Cereb Dis, 13:129-137. Zhou Y, Gu G, Goodlett, DR, Yi, EC, Eng J, Pan P, Montine, KS, Montine, TJ, Aebersold, RH, and Zhang J (2004), Analysis of ?-Synuclein Associated Proteins by Quantitative Proteomics. J. Biol. Chem, 279:39155-39164. Zhou Y, Shie FS, Piccardo P, Montine TJ and Zhang J (2004), Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson’s disease. Neuroscience, 128:281–291? Zhang J , and Goodlett, DR (2004). Proteomic approach to studying Parkinson’s disease. Mol Neurol, 29:271-88. Fessel JP, Hulette C, Powell S, Roberts LJ, Zhang J (2003). Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson’s disease and with dementia with Lewy body disease. J Neurochem. 85:645-50. Zhang J , Fitsanakis V, Gu G, Jing DJ, Ao M, Amarnath V, and Montine TJ (2003) Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: A link through mitochondrial dysfunction. J. Neurochem. 84:1-11 Fitsanakis VA, Amarnath V, Moore JT, Zhang J , and Montine TJ (2002). Catalysis of catechol oxidation by metal- dithiocarbamate complexes in pesticides. Free Rad Biol Med 33(12):1714-23. Sidell KR, Zhang J , and Montine TJ (2002). Dopamine thioethers: formation in brain and neurotoxicity Neurotoxicity Res. 4: 663-669 Zhang J (2002) Diagnosis of parkinsonism at autopsy Ann. Contem. Diag. Path. 5:45-50 Gu G, Patricio FR, Golden GT, Woltjer R, Hulette C, Montine TJ, and Zhang J (2002) Mitochondrial DNA Deletions/Rearrangements in Parkinson's Disease and Related Neurodegenerative Disorders J. Neuropathol. Exp. Neurol 61:634-9 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J , Montine T, Sayre LM, Smith MA (2002) Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci Lett. 8;319(1):25-8. Zhang J , Montine TJ, Smith MA, Siedlak SL, Robertson D, and Perry G(2002) The mitochondrial common deletion in Parkinson's disease and related movement disorders. Parkinsonism and Related Dis 8:165-170. Boyd A. and Zhang J (2001) Hemangioblastoma arising from the skin. Am J Dermatopathol 23: 482-4. Tsai JS, Sivak-Callcott JA, Haik BG, Zhang J , McLean IW (2001) Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report. J Glaucoma 10:411-3. Shappell SB, Keeney DS, Zhang J , Page R, Olson SJ, and Brash AR(2001) 15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. J Invest Dermatol 2001 Jul;117(1):36-43. Amarnath V, Amarnath K, Graham DG, Qi Q, Valentine H, Zhang J , and Valentine WM (2001) Identification of a new urinary metabolite of carbon disulfide using an improved method for determination of 2- thioxothiazolidine-4-carboxyulic acid. Chem. Res. Toxical 14:1277-1283. Montine TJ, Amarnath V, Picklo MJ, Sidell KR, Zhang J , Graham DG (2000). Dopamine mercapturate can augment dopaminergic neurodegeneration. Drug Metab Rev 32(3-4):363-76. Zhang J , Kravtsov V, Amarnath V, Picklo MJ, Graham DG, and Montine TJ (2000). Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: Relevance to Parkinson's disease. J. Neurochem. 74:970-978. Zhang J , Graham DG, Montine TJ, and Ho YS (2000). Enhanced N-methyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in Cu-Zn superoxide dismutase or glutathione peroxidase J. Neuropathol. Exp. Neurol 59:58-66. Zhang J , Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, and Montine TJ (1999). Parkinson's disease is associated with oxidative damage to cytoplamic DNA and RNA. Am. J. Pathol. 154: 1423- 1430. Nunomura A, Perry G, Zhang J , Montine TJ, Takeda A, Chiba S, and Smith MA (1999). RNA oxidation in Alzheimer and Parkinson disease. J. Anti-Aging Med. 2:227-230. Picklo MJ, Zhang J , Nguyen VQ, Graham DG, and Montine TJ (1999). High-pressure liquid chromatography quantification of cytochrome C using 393 nm detection. Analytic Biochem. 276:166- 170. Zhang J , Price J, Graham DG, and Montine TJ (1998). Secondary excitotoxicity contributes to dopamine induced apoptosis in dopaminergic neuronal cultures. Biochem. Biophy. Res. Comm. 248:812-816. Piantadosi CA, Zhang J , Folz R, Levin ED, and Schmechel D (1997) Apoptosis and delayed neuronal death after carbon monoxide poisoning in the rat. Exp. Neurol.. 147:103-114. Piantadosi CA, Zhang J and Demchenko IT. (1997) Production of hydroxyl radicals in the hipocampus after CO hypoxia or hypoxic hypoxia in the rat. J. Free Radic. Biol. Med. 22:725-732. Piantadosi CA and Zhang J . (1996) Mitochondrial origin of reactive oxygen species after brain ischemia in vivo. Stroke 27:327-332. Kil HY, Zhang J and Piantadosi CA (1996) Ischemic brain temperature alters hydroxyl radical production in rats during cerebral ischemia/reperfusion. J. Cereb. Blood Flow Metab. 16:100-106. Zhang J , Sam AD, Klitzman B and Piantadosi CA. (1995) Inhibition of nitric oxide synthase does not decrease oxygenation in brain cortex of rats exposed to hyperbaric oxygen. Undersea Hyper. Med. 22:377-382. Zhang J , Benveniste H, Klitzman BM and Piantadosi CA. (1995) Nitric oxide synthase inhibition alters extracellular glutamate concentration after global cerebral ischemia. Stroke 26:298-304. Piantadosi CA, Tatro L and Zhang J (1995) Hydroxyl radical production in the brain after CO hypoxia in rats. J. Free Radic. Biol. Med. 18:603-609. Zhang J , and Piantadosi CA. (1994) Production of hydroxyl radicals in rat hippocampus during global brain ischemia/reperfusion. Neurosci. Lett. 177:127-130. Zhang J , Benveniste H and Piantadosi CA. (1993) Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neurosci. Lett. 157:179-182. Zhang J , Su YF, Oury TD and Piantadosi CA. (1993) Cerebral amino acids, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. Brain Res. 606:56-62. Simonson SG, Zhang J , Canada AT, Su YF, Benveniste H and Piantadosi CA. (1993) Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. J. Cereb. Blood Flow Metab. 13:125-134. Zhang J and Piantadosi CA. (1992) Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. J. Clin. Invest. 90:1193-1199. Ghio AJ, Zhang J and Piantadosi CA. (1992) Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]. Arch. Biochem. Biophys. 298:646-650. Zhang J and Piantadosi CA. (1991) Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity. J. Appl. Physiol. 71:1057-1061. Zhang J , Fife CE, Currie MS, Moon RE, Piantadosi CA and Vann RD. (1991) Venous gas emboli and complement activation after deep repetitive air diving. Undersea Biomed. Res. 18:293-302. Zhang J and Ni GT (1989), Prevention of decompression sickness with drugs. J. Env. Med. of China 26:354-359 Zhang J (1988) Metabolites of arachidonic acid and decompression sickness. Med. Foreign Countries 5:270-274. Zhang J and Ni GT. (1986) Changes in thromboxane A2 and prostacyclin in rabbits suffering from decompression sickness. Acad. 2nd Milit. Med. Univ. 7:762-764. Book Chapters Zhang J and Montine TJ. Oxidative Processes. Primer on the Autonomic Neurvous System, 2nd Edition, ed. D. Robertson. In press Graham DG, Picklo MJ, Amarnath V, Zhang J , and Montine TJ. (2001) Role of quinones in catechol neurotoxicity. In press. Montine TJ, Amarnath V, Zhang J , and. Graham GG (2001) Role of catechol thioethers in neurotoxicity. Ed C.R. Creveling. In press. Zhang J , Oury TD, Tatro LG and Piantadosi CA. (1994) Cerebral amino acids and hyperbaric oxygen toxicity. In: Bennett P.B. and R.E. Marquis ed. Basic and Applied High Pressure Biology, University of Rochester Press, New York, pp 431-436.