Nancy Linford

I joined the Rabinovitch lab in 2001 after completing a Ph.D. in Pharmacology in the lab of Dr. Dan Dorsa at the University of Washington. My interests include studying the basic biology of aging and in particular the biochemical and gene expression phenotype associated with life extension. In the Rabinovitch lab, I have been studying a transgenic mouse model of extended lifespan in which catalase is expressed in mitochondria under a ubiquitous promoter. This mouse model was developed in collaboration with the laboratories of Dr. George Martin, also in the Department of Pathology, and Dr. Warren Ladiges and the Transgenic Resources Program at the University of Washington. My initial work has included characterization of the mouse model, which has been done in collaboration with the laboratories of Dr. Doug Wallace at UC Irvine and Dr. Holly Van Remmen at UTSAHSC. Currently I am involved in two projects which include studying the gene expression patterns across the aging process in normal and long lived mice using microarray analysis and defining the stress response characteristics of cells derived from these long lived animals using a flow cytometric assay to measure the entry into early apoptosis in response to cytotoxic stress.