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Pathology SeminarsAssociation of Hyaluronan Metabolic Biomarkers and Inflammation with Aggressiveness in Prostate Cancer Stephen Schmechel, MD, PhD Assistant Professor and Director of Cytopathology Department of Laboratory Medicine University of Minnesota Wednesday, February 15, 2012 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, MD, PhD Why Attend? Steve Schmechel is Assistant Professor and Director of Cytopathology in the Department of Laboratory Medicine at the University of Minnesota (UMN), and founding Director of the UMN Academic Health Center's Biological Materials Procurement Network (BioNet), a central biobank, research histopathology, and digital imaging resource. BioNet supports research by 71 UMN principal investigators and additional studies at other universities and companies in the medical device, biotechnology, and pharmaceutical industries. The Schmechel laboratory utilizes BioNet functions to identify and validate gene products and other metabolic biomarkers of aggressive biologic behavior of prostate cancer. Recent results support a model that a mechanism of aggressive prostate cancer biology is the synthesis of hyaluronan (by HAS2), accumulation of hyaluronan, degradation (presumably) of some hyaluronan (by Hyal1) into hyaluronan fragments*, and upregulation of signaling via the Rhamm pathway that promotes a response including CD45-positive) inflammation. A Systems Approach to Dissecting Immunity Alan Aderem, Ph.D. President and Director, Seattle BioMed Affiliate Professor of Immunology and Medicine, University of Washington Seattle Biomedical Research Institute Wednesday, February 29, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? Alan Aderem, co-founder of the Institute for Systems Biology, is a pioneer in the field of systems biology and is an internationally recognized immunologist and cell biologist. His research focuses on the innate immune system – how it recognizes and formulates responses to infectious agents, and how it instructs the adaptive immune system to provide long-lived immunity to the pathogen. The Aderem laboratory also applies the tools of systems biology to the study of diseases that significantly impact global health with an emphasis on rational vaccine design. He has recently taken over the helm of Seattle BioMed. Presentation Title TBA Joe Beavo, Ph.D. Professor UW Medicine Pharmacology University of Washington Wednesday, March 7, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Bill Mahoney, Ph.D. The Influence of Alternative pre-mRNA Processing in Gene Expression and Disease Klemens Hertel, Ph.D. Professor Department of Microbiology and Molecular Genetics Univeristy of California, Irvine Wednesday, March 21, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Pathology Graduate Students Why Attend? Research in the Hertel laboratory focuses on elucidating the regulation of alternative splicing with the ultimate goal to faithfully predict pre-mRNA processing changes in disease models. With the realization that most diseases are molecularly heterogeneous, novel high throughput technologies have been employed to identify gene expression markers that could be used for early detection and improved prognosis. However, gene expression levels alone cannot fully explain a cellular phenotype or gene functions without considering alternative pre-mRNA processing. Dr. Hertel’s presentation will discuss the prevalence, mechanisms, and potential implications of alternative pre-mRNA processing in maintaining cellular homeostasis. Presentation Title TBA Stan Hamilton, M.D. Division Head, Pathology/Lab Medicine MD Anderson Cancer Center University of Texas Wednesday, April 4, 2012 - 4:30 PM Health Sciences Center, Rm. TBA Faculty Sponsor: Melissa Upton, M.D. Molecular Classification of Breast Cancer: Where Are We and Where Are We Going? Stuart Schnitt, M.D, Professor, Department of Pathology Director, Anatomic Pathology, Beth Israel Deaconess Medical Center Harvard Medical School Wednesday, April 11, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Residents/Mara Rendi, M.D. Why Attend? Stuart Schnitt is the Director of the Division of Anatomic Pathology at Beth Israel Deaconess Medical Center in Boston and a Professor of Pathology at Harvard Medical School. He is also a Past President of the United States and Canadian Academy of Pathology. Dr. Schnitt is an internationally recognized expert in breast pathology, author of a highly acclaimed breast pathology textbook (Biopsy Interpretation of the Breast), and an editor of the 4th Edition of the WHO Classification of Tumours of the Breast. His research interests in the area of breast diseases is broad and in recent years has focused increasingly on the integration of traditional pathology with newer molecular techniques to refine breast tumor classification, assessment of breast cancer risk in women with benign breast disease, and risk of local recurrence in women with invasive breast cancer and DCIS treated with breast conserving therapy. Presentation Title TBA Michael Gale, Ph.D. Professor, UW Medicine Immunology Adjunct Professor, UW Medicine Global Health University of Washington Wednesday, April 18, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Function of Nod-like Receptors in Intestinal Immunity Gabriel Nunez, M.D. Paul de Kruif Endowed Professor Department of Pathology University of Michigan Medical School Wednesday, May 2, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? The Nunez laboratory is interested in mechanisms regulating innate immunity, the pathogenesis of inflammatory disease and the interaction of the microbiota with the host. Specifically, the research focuses on mechanistic studies to understand the role of pattern recognition receptors (PRRs) and in particular Nod-like receptors (NLRs) in the immune response against microbial pathogens and endogenous damage signals. Several NLR proteins including NOD2 and NLRP3 are mutated in patients with inflammatory diseases, Crohn's disease and autoinflammatory syndromes, respectively. However, the function of NLRs in host defense and the mechanisms by which NLR mutant proteins lead to disease remain unclear. Dr. Nuñez's presentation will present and discuss ongoing studies that attempt to understand the role of NLRs in host defense aqainst bacterial pathogens and inflammatory disease in the intestine. Presentation Title TBA Thomas Rando, M.D., Ph.D. Professor, Department of Neurology and Neurological Sciences Director, Glenn Laboratories for the Biology of Aging Stanford University Medical Center Wednesday, May 9, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Matt Kaeberlein, Ph.D. Presentation Title TBA Eddie Fox, Ph.D. Post-Doc, Loeb Lab UW Medicine Pathology University of Washington Wednesday, May 16, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Presentation Title TBA Dan Stetson, Ph.D. Assistant Professor UW Medicine Immunology University of Washington Wednesday, May 23, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. 10th Annual Alvord Lecture: Presentation Title TBA Hannah Kinney, MD Professor Pathology, Division of Neuropathology Children's Hospital Boston, Harvard Medical School Wednesday, June 6, 2012 - 4:30 PM TBC, TBC Faculty Sponsor: Robert Hevner, MD, PhD Presentation Title TBA Nenad Bursac, Ph.D. Associate Professor Biomedical Engineering Duke University Wednesday, June 13, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Mike Laflamme, M.D., Ph.D. Recent Pathology SeminarsPKA Mutations Regulate Energy Homeostasis in Mice Stan McKnight, Ph.D. Professor UW Medicine Pharmacology University of Washington Wednesday, February 8, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Jean Campbell, Ph.D. Why Attend? We count on neurons in the hypothalamus to integrate signals from the rest of our body and balance energy intake with our energy expenditure. For most of us, this means we are not constantly gaining or losing weight. The system works reasonably well in humans and in mice until faced with highly palatable, calorie dense foods and an environment where exercise is discouraged by elevators, cars, and in the case of mice, small cages. The result in the US population is that ~60% of us are overweight and ~30% are classified as obese with all of the adverse health effects associated with obesity. Our lab is studying mice with genetically engineered defects in the cAMP/PKA system that protect animals from diet-induced obesity and also have stimulatory effects on voluntary exercise. Our hypothesis is that these changes in signal transduction pathways in leptin-responsive neuronal circuits have produced mice that are hyper-sensitive to leptin, suppressing the normal tendency to store more fat in adipose tissue. Head and Neck Tumors - Emerging Diseases F. Zahra Aly, MD, BDS, PhD Cytopathology Fellow George Washington University Hospital Thursday, February 2, 2012 - 12:00 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Dolphine Oda, BDS, MSc Speaker is a faculty candidate in Oral Pathology Electrophysiology and Calcium Handling of Human Embryonic Stem Cell-Derived Cardiomyocytes Wei-Zhong Zhu Post-Doc, Laflamme Lab UW Medicine Pathology University of Washington Wednesday, February 1, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Mike Laflamme, M.D., Ph.D. Why Attend? Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have tremendous promise as a cell source for regenerative medicine. To optimize host-graft electromechanical integration and minimize the risk of arrhythmias following transplantation, however, hESC-CMs must have the appropriate electrophysiological properties and mechanisms of excitation-contraction coupling. Toward that end, I will present our recent work on two topics related to the electrical behavior of hESC-CMs in vitro. First, I will describe advances in the derivation of specialized cardiac subtypes (e.g., pacemaker cells) from hESCs, using genetic selection and pharmacological manipulation of neuregulin-ErbB signaling. Second, I will review our current understanding of the mechanisms of excitation-contraction coupling and calcium handling in hESC-CMs, which seem to be surprisingly adult-like given their relatively immature structure and mechanical properties. Molecular Diagnostic Cytopathology in an Era of Targeted Therapeutics Sinchita Roy Chowdhuri, M.D., Ph.D. Molecular Diagnostic Fellow Department of Pathology Memorial Sloan-Kettering Cancer Center Friday, January 27, 2012 - 12:45 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Rochelle Garcia, M.D. Speaker is a faculty candidate in pathology. Humoral Control of Proteostasis and its Impact Upon Aging Andrew Dillin, Ph.D. Professor Molecular and Cell Biology Salk Institute for Biological Studies Tuesday, January 24, 2012 - 4:30 PM UW Genome Sciences Building, Foege Auditorium Faculty Sponsor: Matt Kaeberlein, Ph.D. Novel Approaches to GU Cancers: - Is microvessel density significant in prostate cancer biology? - Renal Tumor Subtyping by Multiplex Ligation-Dependent Probe Amplification (MLPA) Assay Maria Tretiakova, M.D., Ph.D. Anatomic and Clinical Pathology Resident Department of Pathology University of Chicago Friday, January 13, 2012 - 12:30 PM UWMC, NE-110 Conference Room Faculty Sponsor: Larry True, M.D. Speaker is a faculty candidate in Pathology The Challenge of Finding a Clinically Useful Tissue-Based Prostate Cancer Biomarker: A Personal Perspective Larry True, M.D. Professor UW Medicine Pathology University of Washington Wednesday, January 11, 2012 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Why Attend? Based on my multi-year investigation of tissue-based cancer biomarkers, I will discuss some of the challenges that we all face in identifying prognostic and predictive markers, and proposed solutions. Although I'll focus on markers specific to the prostate, the challenges are common to all cancers. Issues to be discussed include sampling, tumor heterogeneity, observer-variability, prognostic and predictive transcriptomes and proteomes, and quantitative tissue assays. Deciphering the Mitochondrial Contribution to Intracellular Signaling Brian Hawkins, Ph.D. Assistant Professor, UW Medicine Anesthesiology and Pain Medicine Researcher, Mitochondria and Metabolism Center University of Washington Wednesday, December 14, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Bill Mahoney, Ph.D. Why Attend? Mitochondria are ubiquitous organelles that are the primary source of energy for most eukaryotic organisms. Aside from ATP generation, mitochondria contribute to intracellular signaling pathways during growth, differentiation, proliferation, and even cell death. Perturbations in mitochondrial function consequently influence a number of conditions including cardiovascular disease, cancer, and neurodegeneration. Due to this almost universal impact on multiple cellular processes and diseases, defining the precise molecular mechanism(s) by which mitochondria decode and transmit cellular metabolic cues into downstream signaling has proven difficult. Our laboratory specializes in delineating how mitochondria direct intracellular signaling by focusing on the delicate relationship between calcium and redox homeostasis. This seminar will highlight our current understanding of mitochondrial-initiated signaling cascades via calcium and reactive oxygen species (ROS) and will introduce a novel means in which mitochondria initiate intracellular signaling through physiologic mitochondrial permeability transition. We anticipate that the identification of unique mitochondrial signaling molecules and pathways will serve as attractive therapeutic targets aimed at combating human disease. An Analysis of the Extracellular Matrix in Hutchinson Gilford Progeria Syndrome Ingrid Harten Doctoral Dissertation Department of Pathology Graduate Student University of Washington School of Medicine Thursday, December 8, 2011 - 4:30 PM UW Medicine South Lake Union, Orin Smith Auditorium Faculty Sponsor: Thomas Wight, Ph.D. Molecular Logic of Neocortical Projection Neuron Development, Degeneration, and Regeneration Jeffrey Macklis, M.D. Professor, Stem Cell and Regenerative Biology Program Head, Neuroscience / Nervous System Diseases Harvard Stem Cell Institute Harvard University Wednesday, December 7, 2011 - 4:30 PM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Chuck Murry, M.D., Ph.D. Why Attend? Jeffrey D. Macklis' laboratory is directed toward both 1) understanding molecular controls over neuron sub-type specification and development in the cerebral cortex, and 2) applying developmental controls toward brain and spinal cord repair - specifically, the cellular repair of complex cerebral cortex and cortical output circuitry (in particular, cortico-spinal motor neuron (CSMN) circuitry that degenerates in ALS and other "upper motor neuron" degenerative diseases, and whose injury is centrally involved in loss of motor function in spinal cord injury). The Macklis lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / "stem cell" biology; induction of adult neurogenesis (the birth of new neurons from within); and directed neuronal differentiation and development of connectivity via molecular manipulation of neural progenitors within murine neocortex. The same biology informs understanding of neuronal subtype specificity of involvement in human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, PLS, HSPs, Huntington's disease, autism spectrum disorders, and Rett Syndrome. Proteolytic Pathways in Innate Immunity William Parks, Ph.D. Professor Director, Center for Lung Biology UW Medicine Wednesday, November 30, 2011 - 4:30 PM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Mike Laflamme, M.D., Ph.D. Why Attend? Innate immunity involves the action of resident cells and leukocytes to maintain and restore healthy tissues challenged by injury and infection. As for most biological processes, the extent, pattern, and duration of inflammation are controlled by a balance between positive and negative factors. Matrix metalloproteinases (MMP) have emerged as important effector enzymes that act on diverse proteins to promote or moderate various immune processes. This presentation will highlight two MMPs-MMP7 and MMP10-that control distinct and somewhat opposing immune processes in response to injury and infection. In acute injury, matrilysin (MMP7) controls the transepithelial advancement and activation of neutrophils by shedding the ectodomain of syndecan-1, a transmembrane heparan sulfate proteoglycan. Similar to MMP7, stromelysin-2 (MMP10) is not expressed in resting tissues; however, in response acute or chronic insults, this proteinase is induced by infiltrated macrophages. In models of acute and chronic inflammation, Mmp10–/– mice have an exaggerated inflammatory response, indicating that the enzyme functions normally to repress inflammation. However, whereas Mmp10–/– mice are susceptible to lethality from acute insults, they are protected against tissue damage associated with prolonged inflammation. Data from both models indicate that MMP10 impact macrophage functions by promoting differentiation into immunosuppressive M2 (alternatively activated) cells. Together, these findings demonstrate both pro- and anti-inflammatory functions of distinct MMPs. Bone Marrow Derived Cells in Cardiac Repair: From Mouse to Man April Stempien-Otero, M.D. Associate Professor, UW Medicine Cardiology Craig and Julie Tall Endowed Professor in Heart Failure Research University of Washington Wednesday, November 16, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Bill Mahoney, Ph.D. Why Attend? Bone marrow-derived cells are critical to myocardial repair contributing directly to cardiac components such as endothelium and fibroblasts and providing paracrine factors that direct neovascularization and collagen production by resident cells. Current data support a model in which bone marrow monocyte-derived macrophages are at the crux of these repair processes in acute injury. Thus, macrophages are an attractive target for cell-based therapies to improve myocardial repair and prevent progression to heart failure. Our interest is in the role of a specific macrophage protease–urokinase plasminogen activator–in directing macrophage phenotype in the heart in mouse models. Moreover, we have initiated human studies of bone marrow cell therapy to the heart to elucidate the role of macrophages and bone marrow derived stem cells in end-stage human heart disease. Cell Signaling in Space and Time John D. Scott, Ph.D. Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology Department of Pharmacology University of Washington School of Medicine Wednesday, November 9, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Jean Campbell, Ph.D. Why Attend? Dr. John Scott is a Howard Hughes Investigator and the Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology with the Department of Pharmacology, University of Washington. Dr. Scott is a fellow of the Royal Society, London, the Royal Society of Edinburgh. He's the author of over 200 scientific articles in peer-reviewed journals and books. He is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates. His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott's lab has identified a family of A-kinase-anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequences of PKA anchoring, and the bigger role of AKAP signaling networks in the coordinate regulation of cellular signaling. Diverse Functions of SKN-1/Nrf Proteins in Stress Defenses and Aging Keith Blackwell, M.D., Ph.D. Co-Head, Islet Cell and Regenerative Biology, Joslin Diabetes Center ofessor of Genetics, Harvard Medical School Harvard Medical School Wednesday, November 2, 2011 - 4:30 PM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Matt Kaeberlein, Ph.D. Why Attend? Most chronic diseases can be considered to be aging-related, in that they manifest themselves primarily in older individuals. In model organisms both lifespan and healthspan can be increased dramatically by dietary restriction or manipulation of certain metabolic or stress defense pathways, holding promise that an understanding of these mechanisms may ultimately be of great benefit for human health. We study aging in the nematode C. elegans, an advantageous organism for pathway discovery. In the seminar I will describe how a protein that protects against oxidative stress (the SKN-1/Nrf transcription factor) also defends against various other metabolic and proteotoxic stresses. I will also describe how SKN-1/Nrf plays a critical role in an opposing relationship between growth and nutrient signals on one hand, and stress defense mechanisms on the other. This relationship may be of critical importance in dietary restriction, and other growth/nutrient-related mechanisms that influence aging. What Leads to Age-Related Changes in the Lenses of Our Eyes? Some Factors Related to Increasing Lens Opacity Leading to Cataract Norm Wolf, D.V.M., Ph.D. Professor UW Medicine Pathology University of Washington Wednesday, October 26, 2011 - 4:30 PM UW Heatlh Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend My laboratory studies age-related changes in the lens in several species. I will present our studies on changes in mouse, rat, dog, monkey, human and bovine lenses. We also study the long known but, we believe, never satisfactorily explained replication condition of two adjacent regions of the lens surface cells- the non-replicating central zone, and the continuously replicating germinative zone next to it. I also will briefly touch on the role of the Sirt1 gene as it directly or indirectly affects age-related lens opacity. Fixing the Furnace: A Mitochondrial Targeted Therapy for Energy-deficient Diseases Hazel Szeto, M.D., Ph.D. Professor Department of Pharmacology Weill Cornell Medical College Wednesday, October 19, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Why Attend? Dr. Szeto is co-discoverer of a class of mitochondrially targeted peptide drugs that have increasingly wide potential application. Originally thought to behave a simple antioxidant, it is now apparent that the tetrapeptide agent SS-31 directly enhances mitochondrial respiration under diverse conditions of mitochondrial energetic stress. It has been found to have benefits, for example, in attenuating ischemia reperfusion injury to the kidney, heart and brain, and to improve heart and muscle function under oxidative challenge. SS-31 is now in phase II clinical trial for prevention of cardiac injury following acute myocardial infarction. Distinctive Features of Liver Immunology Ian N. Crispe, M.D., Ph.D. Member, Seattle BioMed Affiliate Professor, UW Medicine Immunology Seattle BioMed Wednesday, October 12, 2011 - 4:30 PM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Jean Campbell, Ph.D. Why Attend? The liver is the site of common infectious diseases (HAV, HBV, HCV), essential in the development of malaria parasites, and subject to metabolic diseases with an immuno-inflammatory component. There is increasing recognition that immune responses have distinctive local features, and in the liver these are shaped by constitutive exposure to trace levels of bacterial products from the intestinal microbiota. In the presentation, some distinctive features of liver immunology will be discussed. Specifically, we will address: the distinctive lymphocyte populations in the liver; the presentation of hepatocellular antigens to T cells; recruitment of T cells to the liver; and the nature of hepatic immune failure. Experimental models to be discussed include primary human liver leukocytes, AAV gene therapy vectors, and genetically-altered malaria parasites. Role of Sphingosine 1-Phosphate in Muscle Regeneration: Potential Pharmacotherapy for Muscular Dystrophy Morayma Reyes, M.D., Ph.D. Assistant Professor UW Medicine Pathology University of Washington Wednesday, October 5, 2011 - 4:30 PM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Jean Campbell, Ph.D. Why Attend? Presently, there is no effective treatment for the lethal muscle wasting disease Duchenne Muscular Dystrophy. In collaboration with Dr. Hannele Ruohola-Baker, through an unbiased suppression screen of the dystrophic phenotype in Drosophila, we found suppressors that upregulate the levels of sphingosine 1 phosphate (S1P) and thereby ameliorate the dystrophic phenotype in the flies. Previously, S1P has been implicated in satellite cell proliferation and myoblast differentiation in vitro. These essential roles for S1P in skeletal muscle enabled us to hypothesize that S1P mechanisms are conserved in mammals. In extending the S1P studies to the mdx mouse, we found that localized elevation of S1P via direct injection into muscle led to an increase in muscle satellite cell proliferation, newly regenerated fibers as well as fiber size. Additionally, we found that the systemic administration of that 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor that strongly suppressed dystrophic muscle wasting in Drosophila, led to a significant amelioration of known hallmarks of DMD pathology, fibrosis and fat deposition and dramatic increase in muscle fiber size in mdx mice. Similar results were also observed in the dysferlinopathy mouse model, AJ/SCID mice with direct administration of S1P. This increase in muscle fiber size can be attributed to anabolic pathways as indicated by increased levels of phosphorylated ribosomal S6. Thus, THI holds promise as a new pharmacotherapy to treat muscular dystrophy. I will present a general discussion of S1P metabolism and its role in cellular processes with emphasis on the skeletal muscle. I will also discuss the pathology of muscular dystrophy and current challenges in finding therapies to treat this lethal, devastating disease. The one-dimensional and three-dimensional architecture of the genome William Stafford Noble, PhD Professor Dept. of Genome Sciences; Dept. of Computer Science and Engineering UW Tuesday, October 4, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Zhi-jun Duan (Hematology; ISCRM) Proteolytic Pathways in Immunity, MMPs as Effectors of Inflammation William C. Parks, PhD Professor, Division of Pulmonary and Critical Care Medicine, UW Director, Center for Lung Biology, UW Affiliate Investigator, Benaroya Research Institute Tuesday, September 27, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Kelly Smith Mechanisms for Cardioprotection and Regeneration Loren J. Field, PhD Professor Medicine & Pediatrics Indiana University School of Medicine. Monday, September 19, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Charles E. Murry Distingushed Lecture series Platelet Hyperactivity and Inflammation: STAT3 Signaling in Platelets Jing-Fei Dong, MD, PhD Full Member, Puget Sound Blood Center Research Institute Professor of Medicine, Division of Hematology UW Tuesday, September 13, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: William C. Parks Local Controls of L-type Calcium Channels in Muscle Luis Fernando Santana, Ph.D. Professor Physiology and Biophysics UW Tuesday, September 6, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium DNA Damage and its Repair in Young, Adult and Aging Neurons Kalluri Subba Rao, Ph.D. Senior Scientist, Indian National Science Academy Professor Emeritus, Department of Biochemistry University of Hyderabad, India Friday, August 26, 2011 - 10:00 AM UW Health Sciences Center, Rm. K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Why Attend? For many years, Dr. Rao has been one of the few scientists who has addressed important questions about DNA repair in non-dividing eukaryotic cells. His focus has been on the repair of oxygen-mediated DNA damage in neurons by base excision repair and the involvement of DNA polymerase beta in this process. He has considered the importance of deficits in DNA repair in aging and Alzheimer's disease. Mechanisms Underlying Differential Responses to Dietary Restriction Jennifer Schleit Graduate Student UW Medicine Pathology University of Washington School of Medicine Tuesday, August 23, 2011 - 1:00 PM Health Sciences Center, K-069 Faculty Sponsor: Matt Kaeberlein, Ph.D. The Role of TNF-alpha Converting Enzyme in Liver Injury and Regeneration Ryan McMahan Graduate Student UW Medicine Pathology University of Washington School of Medicine Friday, August 12, 2011 - 2:00 PM Health Sciences Center, Room K-069 Faculty Sponsor: Nelson Fausto, M.D. and Jean Campbell, Ph.D. Electrophysiology of Human Embryonic Stem Cell-Derived Cardiomyocytes Michael Laflamme, M.D., Ph.D. Assistant Professor UW Medicine Pathology University of Washington Wednesday, July 20, 2011 - 4:30 PM Health Sciences Center, Rm. T-625 Why Attend? Cardiomyocytes derived from pluripotent human embryonic stem cells (hESCs) have a number of attractive properties for use in cell-based cardiac repair, and their transplantation has been shown to improve mechanical function in rodent models of myocardial infarction. In this presentation, I will address three questions that all relate to the electrophysiological behavior of hESC-derived cardiomyocytes in vivo: 1) Can we derive specialized cardiac subtypes from hESCs, i.e. ventricular versus nodal myocytes? 2) Do hESC-derived cardiac grafts become electromechanically integrated and contract synchronously with host myocardium? 3) Will the transplantation of hESC-derived cardiomyocytes increase or decrease the incidence of arrhythmias? Systems Pathology: Moving Omics to Clinics Michael Roehrl, M.D., Ph.D. Assistant Professor Department of Pathology and Laboratory Medicine Boston University School of Medicine Monday, July 11, 2011 - 12:00 PM UW Health Sciences Center, Room K-069 Faculty Sponsor: Drs. Swanson and True Why Attend? Pathology will be the key player in personalized health care. We will illustrate recent advances in personalized molecular medicine with a particular emphasis on proteomic and metabolomic characterization of cancers. We show that systems-based and quantitative analyses of disease biomarkers will transform pathology into a key discipline for patient-centered tissue-based diagnostics, molecularly targeted therapy selection, and treatment response monitoring. We have also developed novel ultra-rapid biobanking strategies in pathology as a springboard for patient-focused basic cancer research. Ca2+ Mediated Myocyte Hypertrophy, Death, and Regeneration Steven R. Houser, Ph.D., FAHA Laura H. Carnell Professor of Physiology and Medicine; Director, Cardiovascular Research Group Chair, Department of Physiology Temple University School of Medicine, Philadelphia Tuesday, June 21, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Rong Tian Mitochondria beyond ATP production Georgios Karamanlidis, Ph.D. Postdoctoral Fellow Mitochondria and Metabolism Center University of Washington Tuesday, June 14, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Rong Tian Dynamic Recruitment of MicroRNAs to mRNA Targets in the Regenerating Liver Linda Greenbaum, M.D. Associate Professor of Cancer Biology Associate Professor of Medicine, Division of Gastroenterology and Hepatology Thomas Jefferson Medical College Wednesday, June 8, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Jean Campbell, Ph.D. Why Attend? The regenerative capacity of the liver is essential for recovery in response to hepatocyte loss due to acute or chronic viral, metabolic or toxic liver injury. Although microRNAs have been implicated for regulation of proliferation in a variety of tissues including patients with hepatocellular carcinoma and other liver diseases, the mRNAs targeted by specific microRNAs and their function during hepatocyte proliferation is not well understood. Obstacles that have limited identification of important mRNA:miRNA functional relationships have included the identification of a small number of differentially expressed miRNAs in the regenerating liver and limited prediction power of current miRNA prediction programs. We applied the HITS-CLIP assay (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation; Licatolosi, Nature 2008) to the partial hepatectomy model, an established model of liver regeneration. We have identified a large number of mRNAs that are bound by miRNAs in the regenerating liver, thus expanding the functional importance of microRNAs for regulation of liver regeneration. In addition, this assay has allowed us to identified miRNA binding sites in the coding region, 5'UTR in addition to 3'UTR regions of mRNAs. We are currently validating selected miRNA targets target and will use gain and loss-of-function approaches to elucidate the function of these miRNAs during the regenerative response. We anticipate that these studies will advance the current understanding of how miRNAs regulate hepatocyte proliferation in physiologic and pathophysiological states including cirrhosis and hepatocellular carcinoma. Supercharging Stem Cell-mediated Regeneration Mark Sussman, Ph.D. Professor, SDSU Heart Institute Department of Biology California State University, San Diego, California Tuesday, June 7, 2011 - 9:00 AM SLU 815 Mercer Street, Brotman Auditorium Faculty Sponsor: Rong Tian Axon Degeneration: A Neglected Therapeutic Target in Parkinson's Disease Robert Burke, M.D. Professor, Neuroology and Pathology Director, Udall Parkinson's Disease Research Center Columbia Unversity Wednesday, June 1, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Jing Zhang, MD, PhD 9th Annual Alvord Lecture in Neuropathology A special lecture in memory of the life and scientific legacy of Ellsworth C. Alvord, Jr., M.D. (1923-2010), Professor and Chief, UWMC Neuropathology, 1960-2002. Insights into regulation of endothelial and smooth muscle function in vivo William C. Sessa, Ph.D. Professor of Pharmacology; Vice Chairman, Pharmacology; Director, Vascular Biology & Therapeutics Program Yale University Tuesday, May 31, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Stephen M. Schwartz Signaling Pathways and Chromatin Dynamics Regulate Cardiac Differentiation from Human Embryonic Stem Cells Sharon Paige Graduate Student UW Medicine Pathology and MSTP University of Washington Thursday, May 26, 2011 - 10:00 AM UW Medicine South Lake Union, Orin Smith Auditorium Faculty Sponsor: Chuck Murry, M.D., Ph.D. Calcium Currents, Mitochondrial Stress and Parkinson's Disease Dalton Surmeier, Ph.D. Professor and Chair, Ph.D. Department Physiology Feinberg School of Medicine, Northwestern University Wednesday, May 25, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? Dr. D. James Surmeier is the Nathan Smith Davis Professor and Chair of the Department of Physiology at the Feinberg School of Medicine at Northwestern University and Director of the Morris K. Udall Research Center of Research Excellence for Parkinson's Disease at Northwestern University. Dr. Surmeier received his Ph.D. in Physiology and Biophysics from the University of Washington in 1983. He trained with leaders in the field of neurophysiology, including Dr. Arnold Towe, Dr. William Willis, and Dr. Stephen Kitai. In 1998, he moved to the Department of Physiology at Northwestern University and assumed his current position in 2001. Dr. Surmeier's research program focuses on the basal ganglia – neural structures controlling movement and intimately involved in the pathophysiology of Parkinson's disease. He has authored over 150 peer-reviewed publications in journals such as Science, Nature, Neuron, Nature Neuroscience and the Journal of Neuroscience. He has served in several advisory capacities to the National Institutes of Health, including chairing study sections for the National Institute of Neurological Disorders and Stroke (NINDS) and acting as a Councilor for NIAAA. He also serves on the scientific advisory boards of several private foundations and serves on a number of editorial boards, including Molecular and Cellular Neuroscience, Neuron and Current Opinion in Neurobiology. He was elected as a Fellow of the American Association for the Advancement of Science and has received many other scientific awards including the NARSAD Established Investigator award, the Riker Award, the Picower Foundation Award, and the Jacob Javits Neuroscience Investigator Award. The Nitric Oxide/cGMP Pathway and Its Effects on Vascular Inflammation and Atherosclerosis Andrew Cheng, M.D. Fellow Medicine/Cardiology UW Tuesday, May 24, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Francis Kim A Genetic Mechanism of the Evolutionary Theory of Aging: Rong Yuan, Ph.D. Scientific Manager, Jackson Aging Center Research Scientist, Jackson Laboratory Jackson Laboratory, Bar Harbor, Maine Wednesday, May 18, 2011 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Matt Kaeberlein, Ph.D. Why Attend? The objective of my research, guided by the evolutionary theory of aging, is to discover biomarkers of aging and healthspan that can be measured at an early age. Then I use mouse genetics and bioinformatics methods to identify genes that regulate these markers and investigate the effects of these genes on aging and healthspan. My overall goal is to define new ways of delaying aging and extending healthspan. Extracellular Matrix and the Control of Inflammation Thomas N. Wight, Ph.D. Director, Hope Heart Matrix Program, Benaroya research Institute Professor of Pathology (Affiliate) University of Washington Tuesday, May 17, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Stephen M. Schwartz Regulation of Cardiac Tissue Structure and Function by Nano-architectured Matrix Control Deok-Ho Kim, Ph.D. Assistant Professor Bioengineering; Center for Cardiovascular Biology; Institute of Stem Cell and Regenerative Medicine UW Tuesday, May 10, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Chuck Murry Vascular Biology and Health Disparities: Defining Molecular Pathways Gary H. Gibbons, M.D. Director, Cardiovascular Research Institute Chairman, Department of Physiology; Professor of Medicine Morehouse School of Medicine Friday, May 6, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Stephen M. Schwartz This is a Special Breakfast Club webcast from Atlanta The CSF-1 Receptor and its Ligands in Development, Cancer and Inflammatory Disease E. Richard Stanley, Ph.D. Renee and Robert A. Belfer Professor of Developmental Biology Professor, Department of Developmental and Molecular Biology Albert Einstein College of Medicine Wednesday, May 4, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Elaine Raines, M.S. Why Attend Colony stimulating factor-1 (CSF-1), or M-CSF, controls macrophage and osteoclast production and function. These cells, via trophic and scavenger actions, play critical roles in development. CSF-1, via its receptor (CSF-1R), also regulates development of other cell types, including Langerhans cells and Paneth cells, plays autocrine and paracrine roles in neoplasia and is an important regulatory cytokine in many chronic inflammatory diseases. The identification of a second CSF-1R ligand, IL-34, coupled with studies of CSF-1 receptor signal transduction, offer new approaches to our understanding of the regulation by the CSF-1R and its role in these diseases. Regulation of TRPV1 by Phosphoinositides Sharona E. Gordon, Ph.D. Associate Professor Physiology and Biophysics UW Tuesday, May 3, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Eric Senning Molecular and Biochemical Mechanisms of Recessive Osteogenesis Imperfecta Shawna Pyott Graduate Student UW Medicine Pathology University of Washington School of Medicine Thursday, April 28, 2011 - 1:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Byers, M.D. Preventing Vein Graft Stenosis in Peripheral Vascular Surgery Katie Moreno, M.D. General Surgery Resident Surgery, VA Puget Sound health Care System University of Washington Tuesday, April 26, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Michael Sobel Breast Cancer Testing: From Arbitrary to Evidence Based Kim Allison, M.D. Assistant Professor, UW Medicine Pathology Director, UW Medicine Pathology Breast Service University of Washington Wednesday, April 20, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? Tissue-based testing of tumors in pathology has evolved from serving a diagnostic purpose to providing key information about the likelihood a particular neoplasm will respond to a specific therapeutic agent. Because these test results have such a large impact on treatment decisions, there has been a recent focus on standardizing how these tests are performed, interpreted, reported and validated. Dr. Allison will discuss current issues in setting the standards for testing in breast cancer including sentinel lymph node analysis, HER2 testing, hormone receptor testing and RT-PCR based tests, with a focus of where current standards may need to be reevaluated. Multi-Scale Modeling of the Heart: From Crossbridge to Organ Andrew McCulloch, PhD Professor Bioengineering and Medicine University of California, San Diego Tuesday, April 19, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Michael Regnier Distinguished Lecture Series Doctoral Dissertation: Epigenetic Regulation of X Inactivation and Escape from X Inactivation Fan Yang Graduate Student UW Medicine Pathology University of Washington School of Medicine Friday, April 15, 2011 - 2:00 PM Health Sciences Center, Room K-069 Faculty Sponsor: Christine Disteche, Ph.D. Using Human Pluripotent Stem Cells to Study Hepatic Disease and Development Stephen Duncan, Ph.D. Professor, Human and Molecular Genetics Director, Regenerative Medicine and Stem Cell Biology Medical College of Wisconsin Wednesday, April 13, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Graduate Program Students Why Attend? Dr Duncan is the Markus Professor of Human and Molecular Genetics and Director of the Regenerative Medicine Program at the Medical College of Wisconsin. He has authored over 70 articles in scientific journals and books. His research focuses on the use of mice and stem cells to understand the contribution of transcription factors during embryonic development and function of the liver, pancreas, and heart. Traditionally his lab has relied on the use of mouse models including knockout mice and mouse embryonic stem cells. During this time the laboratory has garnered a substantial understanding of the basic molecular pathways controlling hepatic function and development. While the mouse has been a valuable model, the Duncan lab has introduced the use of induced human and mouse pluripotent stem cells as well as human embryonic stem cells because of the belief that they could offer a new and robust experimental model. Members of the Duncan lab have shown that they can control differentiation of human pluripotent stem cells into hepatocytes with high efficiency, to the extent that >95% of cells in the culture dish express characteristic markers of differentiated hepatocytes. In addition they have developed technologies to control differentiation of hepatocytes into both cardiac and pancreatic-like cells. Such approaches have raised the possibility of using stem cell–derived cells for the study of the fundamental molecular mechanisms underlying hepatic, cardiac and pancreatic disease and development. A Journey in Translational Research: From Molecular Mechanisms in Chemical Carcinogenesis to a Phase I Clinical Trial on Adverse Drug Interactions David Eaton, Ph.D. Associate Vice Provost, Office of Research Professor, Env. and Occ. Health Sciences University of Washington Wednesday, April 6, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? Dr. Eaton received his Ph.D. in pharmacology from the University of Kansas Medical Center (KUMC) in 1978, then joined the UW School of Public Health in 1979, and has been here ever since. He is Professor of Environmental and Occupational Health Sciences, with adjunct appointments in Public Health Genetics and Medicinal Chemistry, and serves as founding Director of the Center for Ecogenetics and Environmental Health. He served as Associate Dean for Research in the School of Public Health from 2000-2005, and as Associate Vice Provost for Research from 2005-2010. He is currently Interim Vice Provost for Research, at the UW. He has published over 150 scientific articles and book chapters in the field of toxicology. Dr. Eaton is an Elected Fellow of the American Association for the Advancement of Science and the Academy of Toxicological Sciences, and a Lifetime National Associate of the National Academies of Sciences. This talk will describe an adventure to discover the molecular basis for a remarkable species difference in susceptibility to the potent liver carcinogen, aflatoxin B1, and how unexpected discoveries along the way led to a phase I clinical trial to prevent adverse drug interactions in HIV/AIDS patients being treated for TB. Decoding cell lineage from acquired mutations using deep sequencing Marshall Horwitz, MD, PhD Professor Pathology; Institute for Stem Cell & Regenerative Medicine UW Tuesday, April 5, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Mark Majesky PRDM1 beta in Marginal Zone Lymphoma and Lymphoplasmacytic Lymphoma Cecilia Yeung, M.D. Molecular Genetics Pathology Fellow Washington University Tuesday, April 5, 2011 - 8:00 AM FHCRC, Thomas Building, Sze E/W Conference Room Videoconferencing SCCA, Rm. 3100/3102 UWMC, Rm. 8121 Seattle Children's Hospital, Rm. T-3246 VAPSHCS, Bldg 24, Room 14 Speaker is a candidate for a faculty position in Pathology Innate Immunity Genetics & Susceptibility to Tuberculosis Thomas Hawn, M.D., Ph.D. Associate Professor UW Medicine Allergy and Infectious Diseases University of Washington Wednesday, March 30, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? Why do humans respond differently to infections? How does genetic variation of human innate immunity genes regulate inflammation? To address these questions, Dr. Hawn studies the role of Toll-like Receptors (TLRs) and other genes in coordinating the innate immune response of macrophages to bacterial infection with an emphasis on tuberculosis. He uses a combination of molecular, cellular, and human genetic techniques to pursue an overall research goal of understanding the genetic basis and molecular mechanisms of human susceptibility to infectious diseases. Slicing tissue with photons: non-invasive 3D imaging of microstructure andmicrocirculation in tissue in vivo Ruikang K. Wang, PhD Professor Bioengineering UW Tuesday, March 29, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Michael Regnier, Bioengineering Charting Human Epigenomes and Regulation of the Non-coding Genome Bradley Bernstein, M.D., Ph.D. Associate Professor of Pathology Senior Associate Member, Broad Institute of Harvard and MIT Harvard Medical School Wednesday, March 23, 2011 - 4:30 PM University of Washington Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Stephen Schwartz, M.D., Ph.D. Benditt Lectureship Webcast Please copy and paste the following website address into your browser to view a live webcast of the Benditt Lectureship: http://mediasite.hs.washington.edu/Mediasite/SilverlightPlayer/Default.aspx?peid=246fd75917c94d1298548bef1149fef81d This recording uses the Microsoft Silverlight browser plugin. To view the presentation you will need to install the Silverlight plugin which can be downloaded here: http://www.microsoft.com/getsilverlight/Get-Started/Install/Default.aspx Download and run the installer for your platform (Mac or PC) and refresh your web browser. Thin-Filament Related Cardiomyopathies: An Integrative Approach to a Complex Disorder Jill Tardiff, MD, PhD Associate Professor of Physiology and Biophysics Associate Professor of Internal Medicine (Adult Cardiology) Albert Einstein College of Medicine, Bronx, New York Tuesday, March 22, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Michael Regnier, Bioengineering, DISTINGUISHED LECTURE Series Role of PDGF-C in the Genesis of the Hepatic Tumor Microenvironment Jean Campbell, Ph.D. Assistant Professor UW Medicine Pathology University of Washington Wednesday, March 16, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Matthew Yeh, M.D., Ph.D. Why Attend? Hepatocellular carcinoma (HCC) most commonly arises in the setting of chronic inflammation and cirrhosis, supporting the hypothesis that an abnormal microenvironment contributes to disease progression. Yet understanding the complex cellular interactions in the liver that contribute to the evolution of the tumor microenvironment, and ultimately to tumorigenesis, has been challenging due to a lack of animal models that recapitulate the disease progression observed in humans. During this presentation I will describe a unique mouse model of hepatocellular carcinogenesis that mimics the step-wise progression from fibrosis to cirrhosis, and finally to HCC. We are exploiting this model to understand the role of non-parenchymal cells in regulating fibrogenesis and neoangiogenesis, and to define the contribution of these cells to the tumor microenvironment. My talk will highlight data demonstrating the merits of using this pre-clinical model to evaluate therapeutic strategies that target the hepatic tumor microenvironment by blocking the processes that contribute to its development, including fibrosis and angiogenesis. The Sequelae of Dysfunctional BMPRII Signaling Marlene Rabinovitch, MD Pfizer Visiting Professorship in Pulmonary Vascular Disease Dwight and Vera Dunlevie Professor of Pediatric Cardiology Stanford University School of Medicine Tuesday, March 15, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: William C. Parks Sphingosine-1-phosphate Receptor 2 Induces Expression of Smooth Muscle Alpha-actin: A Role for Rho and Calcium Allison De Wispelaere Graduate Student UW Medicine Pathology University of Washington School of Medicine Friday, March 11, 2011 - 3:30 PM UW Medicine South Lake Union, Orin Smith Auditorium Faculty Sponsor: Alec Clowes, M.D. Using Network Modeling to Predict Wnt Pathway Dysregulation Hamid Bolouri, Ph.D. Research Member Division of Human Biology Fred Hutchinson Cancer Research Center Wednesday, March 9, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? Inter-individual variations, and (nonlinear) gene-gene and gene-environment interactions complicate the analysis of healthy and dysregulated cellular processes. Network models offer integrated views of cellular pathways and can be used to highlight hidden features of large-scale datasets, and to arrive at insights and testable hypotheses. In this talk, I will present a case study in which we used network modeling to re-analyze published data and arrived at new insights and hypotheses. Our methodology is novel in its approach, straight-forward in usage, and general in its applicability to other cellular pathways and processes. For more information please visit Dr. Bolouri's website: http://labs.fhcrc.org/bolouri/ Role of transcription factor CHF1/Hey2 in cardiac differentiation and hypertrophy Farid Moussavi-Harami, M.D. Cardiology Fellow Department of Internal Medicine UW Tuesday, March 8, 2011 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Michael Chin The Role of the Hypoxic Stress Pathway in Worm Aging Scott F. Leiser, Ph.D. Post-Doctoral Fellow Kaeberlein Lab UW Medicine Pathology Wednesday, March 2, 2011 - 4:30 PM Health Sciences Center, Rm. K-069 Faculty Sponsor: Matt Kaeberlein, Ph.D. Why Attend? The aging process is involved in the development of many of the most common human pathologies. By using model organisms to find conserved aging pathways, we are searching for ways to slow human aging and prevent many diseases. Using the nematode, C. elegans, our lab and others have recently implicated a role for the highly-conserved hypoxia pathway in aging. Initial papers suggest that the hypoxia inducible factor, HIF-1, can act as both a positive and negative regulator of aging in worms. This seminar will discuss how HIF-1 can affect lifespan and healthspan in worms and how this work may translate to future human research. Unraveling Genome Architecture Zhi-jun Duan, Ph.D. Research Assistant Professor Department of Hematology UW Institute for Stem Cell and Regenerative Medicine Tuesday, March 1, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Steve Schwartz, Pathology University of North Carolina at Chapel Hill James E. Faber, Ph.D Professor, Department of Cell and Molecular Physiology McAllister Heart Institute University of North Carolina at Chapel Hill Tuesday, February 22, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Steve Schwartz, Pathology This is a podcast from Chapel Hill. Dr. Faber is not physically present at the UW SLU campus but is webcasting from UNC, Chapel Hill. The Impact of Dropping the Requirement for Goblet Cells from the Diagnosis of Barrett's Esophagus Maria Westerhoff, M.D. GI & Liver Pathology Fellow Department of Pathology University of Chicago Medical Center Thursday, February 17, 2011 - 12:00 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Paul Swanson, M.D. Speaker is a candidate for a faculty position with UWMC AP. Molecular Classification of Breast Cancer: What Have We Learned? David Dabbs, M.D. Chief of Pathology Magee Women's Hospital University of Pittsburgh Medical Center Wednesday, February 16, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Mara Rendi Why Attend? The molecular classification of breast cancer has ushered in a new perspective on breast carcinomas. This classification offers a framework that is useful to clinicians and pathologists, and has spawned a host of rival molecular tests that are touted as predictors of patient outcomes to therapy. Select aspects of these molecular tests will be discussed in concert with traditional pathologic analysis of breast carcinomas Insulin Resistance and Cardiovascular Dysfunction – Elucidating Novel Mechanisms E. Dale Abel, M.D., D Phil Professor of Medicine and Biochemistry Chief, Division of Endocrinology, Metabolism and Diabetes University of Utah School of Medicine Tuesday, February 15, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Rong Tian, UW Mitochondria and Metabolism Center DISTINGUISHED LECTURE Series: Dr. Abel is a world expert in the regulation of myocardial biology and metabolism by insulin signaling. His work in the last decade has significantly advanced our knowledge of disease mechanisms for the cardiomyopathy caused by metabolic disorders. Representative publications: 1. Cardiac remodelingin obesity. Physiol Rev. 2008 Apr;88(2):389-419 2. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306 CANCELLED due illness. Rescheduled seminar TBA. Alan Adereem, Ph.D. Co-Founder, Institute for Systems Biology Affiliate Professor, UW Medicine Immunology Institute for Systems Biology Wednesday, February 9, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? Macrophages and dendritic cells represent one of the cornerstones of the innate immune system. They detect infectious organisms and then orchestrate an appropriate host response to them. In order to precisely define the nature of the threat the immune cell needs to read the molecular bar code that is displayed on the specific pathogen. The molecular bar codes have been referred to as PAMPS and they are recognized by pattern recognition receptors (PRR). The Toll-like receptors (TLRs) and the Nod-like receptors (NLRs) are prototypic PRRs that detect extracellular PAMPS and intracellular PAMPS respectively. Since infectious agents carry many different PAMPS the information must be integrated in order to define the specific pathogen and enable the host to formulate an appropriate response. We use the tools of systems biology to identify the molecular networks that lead to this decision-making. Biological results and technological developments will be discussed. Targeting chromatin to accelerate tumor cell senescence Stephen Kron, MD, PhD Ludwig Center for Metastasis Research The University of Chicago Tuesday, February 8, 2011 - 9:00 AM SLU, 815 Mercer Street, Brotman Auditorium Faculty Sponsor: Charles E. Murry, Pathology and Bioengineering Applying Oligonucleotide Aptamers to Diagnostic Pathology and Laboratory Medicine Geoffrey Baird, M.D., Ph.D. Assistant Professor, UW Laboratory Medicine Adjunct Assistant Professor, UW Medicine Pathology UW Medicine Wednesday, February 2, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? Oligonucleotide aptamers are short strands of DNA or RNA that specifically bind other chemical species, much in the same way as monoclonal antibodies. Despite being discovered nearly 20 years ago, none of the hundreds of published applications of aptamers have penetrated into current anatomic or clinical pathology practice, and only very few are utilized in the research setting. This seminar will cover the reasons why this has happened and how the trend is now reversing, focusing on the potential benefits of incorporating aptamers into both clinical and research pathology. Specifically, the seminar will cover work in our laboratory and others describing how one may use aptamers for tissue and fluid proteomics, biomarker discovery, and histochemistry. Gene Regulation Beyond Promoters: Direct, Complete, Integrated, Transcriptional Analysis Daniel Morris, Ph.D. Research Assistant Professor Department of Anesthesiology UW Tuesday, February 1, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Debra Schwinn, Anesthesiology and Pain Medicine Patient-Specific Mathematical Neuro-Oncology: A Paradigm Shift in Glioma Treatment Kristin Swanson, Ph.D. Associate Research Professor UW Medicine Pathology University of Washington Wednesday, January 26, 2011 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Kelly Smith, M.D., Ph.D. Why Attend? Gliomas are complex heterogeneous tumors with a spectrum of behaviors with an overall dismal prognosis. The relative low incidence and the wide variability of this disease across (and within) patients is a challenge to routine clinical studies to determine optimal treatment strategies. This heterogeneity suggests a patient-specific quantification of disease kinetics and treatment response is essential to improving outcomes for these patients. This seminar will discuss the role of the burgeoning field of Mathematical NeuroOncology specifically focusing on the practical application of patient-specific mathematical modeling approaches in providing predictive insight into tumor growth kinetics and response to therapy in individual patients. Novel regulators of ischemic injury and ventricular remodeling Thomas Force, MD James C. Wilson Professor of Medicine Clinical Director, Center for Translational Medicine Thomas Jefferson University Tuesday, January 25, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Rong Tian, Mitochondria and Metabolism Center DISTINGUISHED LECTURE Series: Dr. Force is a recognized leader in stress-induced signaling cascades in cardiac growth and survival. His lab has pioneered research on the cardiotoxicity caused by tyrosine kinase inhibitor cancer therapeutics. His recent work has elucidated the isoform-specific role of GSK-3 in cardiac hypertrophy. Representative publications: 1. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 2. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol. 2009 3. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006 The Cooperation of Epigenetic and Genetic Alterations in Gastrointestinal Cancer William Grady, M.D. Associate Professor UW Medicine University of Washington Wednesday, January 19, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Matthew Yeh, M.D., Ph.D. Dr. Grady will discuss the role of genetic alterations and epigenetic alterations that occur in colon cancer on the behavior of the cancer cells. In particular, an understanding of signal network deregulation and gene cooperation will be gained from attending this lecture. This seminar was originally scheduled for December 15, 2010. The State of Seattle Biotech in 2011 Luke Timmerman National Biotechnology Editor Xconomy Tuesday, January 18, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: David Dichek T Cell Therapy of Cancer Cassian Yee, M.D. Professor, UW Medicine Oncology Member, Clinical Research Division, FHCRC University of Washington Wednesday, January 12, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Kim Allison, M.D. Why Attend? A Renaissance in immunotherapy or another passing fad? My NIH reviewers want to know. Find out what I told them and where the field is headed. Enhanced peer review of NIH grant proposals: how the process is supposed to work but often doesn't: A panel discussion with current members of NIH study sections and review groups Michael E. Rosenfeld, PhD; Karin Bornfeldt, PhD; William Parks, PhD; Jay Heinecke, MD Members of NIH Study Sections Scool of Medicine UW Tuesday, January 11, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Steve Schwartz Michael E. Rosenfeld, PhD Professor, Environmental & Occupational Health Sciences; Professor, Pathology Karin Bornfeldt, PhD Professor, Pathology, Diabetes and Obesity Center of Excellence William Parks, PhD Professor, Center for Lung Biology Jay Heinecke, MD Professor, Division of Metabolism, Endocrinology and Nutrition Mouse Model of Leigh Syndrome: Identifying Critical Brain Regions Involved Richard Palmiter, Ph.D. Professor UW Medicine Biochemistry University of Washington Wednesday, January 5, 2011 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? Leigh syndrome is a necrotizing encephalopathy caused by mitochondrial dysfunction due to mutations in either mitochondrial or nuclear genes involved in electron transport. We have created a mouse with a mutation in Ndufs4, one of the 45 subunits of complex 1, the recapitulates virtually all of the symptoms of Leigh syndrome. We have shown that the disease is caused by mitochondrial dysfunction in the central nervous system and that it results in progressive gliosis, and eventually neuronal loss, in the olfactory bulb, vestibular nucleus and cerebellum. The knockout mice have breathing defects that may be responsible for their demise by about 50 days after birth. Selective inactivation of Ndufs4 in the vestibular nucleus results in premature death, whereas selective restoration of Ndufs4 in the vestibular nucleus prolongs life. HDL, inflammation, and atherosclerosis. A paradigm shift? Tomas Vaisar, PhD Research Assistant Professor of Medicine Division of Metabolism, Endocrinology and Nutrition UW Tuesday, January 4, 2011 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Adult Stem Cells for Cardiac Repair and Regeneration: In it to WNT Ronglih Liao, PhD Associate Professor of Medicine Harvard Medical Schoopl Tuesday, December 14, 2010 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Rong Tian A Systems-Pathology Approach in Transplantation Michael Mengel, M.D. Associate Professor Laboratory Medicine and Pathology University of Alberta Hospital Wednesday, December 8, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Charles Alpers, M.D. Why Attend? After studying medicine at the Semmelweiss University in Budapest, Hungary, Dr. Mengel did his residency in the Department of Pathology at Hannover Medical School, Germany. While there he became specialized in pathology and subsequently transplantation and nephropathology. He was head of the transplant pathology service with responsibility for diagnostics and research based on transplant biopsies at the transplant centre in Hannover. In collaboration with the Department of Nephrology, one of the largest protocol biopsy programs after renal transplantation was established at the transplant centre in Hannover. In December 2006 he came to the University of Alberta in Edmonton, Canada and joined the Alberta Transplant Applied Genomics Centre (Director Philip F. Halloran) where he had the opportunity to apply modern molecular microarray techniques together with sophisticated bioinformatics tools to well-documented clinical material from large biopsy series. Currently he is a Lead Investigator at the Alberta Transplant Applied Genomics Centre and his major research focus is the molecular based refinement of the histopathological assessment of organ transplant biopsies. In November 2008 he joined the faculty as an Associate Professor in the Division of Anatomical Pathology where he assumed the role of the Section Head of Transplantation Pathology. Generation of S1P -based therapy for muscular dystrophy Hannele Ruohola-Baker, PhD Professor Biochemistry UW Tuesday, December 7, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Microchimerism and Cancer V.K. Gadi Assistant Professor UW Medicine University of Washington Wednesday, December 1, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Kim Allison, M.D. Why Attend? A prior history of pregnancy is generally a protective factor against malignancy. How this protection is mediated is presently not completely understood. Dr. Gadi's work involves the study of fetal microchimerism, small numbers of stably persistent cells in a woman originally derived from her fetus. In this seminar, the data supporting a protective role of fetal microchimerism against breast cancer will be discussed. Taming the Beast: Structural biology of alphaB-crystallin, a small heat shock protein implicated in cardiomyopathy Rachel E, Klevit, D. Phil. Professor Biochemistry and Biomolecular Structure Center UW Tuesday, November 30, 2010 - 9:00 AM SLU 815 Mercer Street, Brotman Auditorium Microchimerism: For better or for worse? J. Lee Nelson, M.D. Member, Fred Hutchinson Cancer Research Ctr Professor, Rheumatology, University of Washington UW Tuesday, November 23, 2010 - 9:00 AM SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium Companion Diagnostics; The Pathologist as the Prescribing Physician David Rimm, M.D., Ph.D. Professor Department of Pathology Yale University School of Medicine Wednesday, November 17, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Larry True, M.D. Why Attend? Personalized medicine has put the pathologist in a key position with respect to patient care. Companion diagnostic tests are now required for therapeutic decisions that can save patients lives. So exactly how accurate those tests? This seminar will explore the accuracy of current companion diagnostic tests in breast cancer. You may be surprised to see data that suggests your treatment depends on where you send your tissue. Sources of error, including sampling, pre-analytic variables, and reagents will be shown. Then alternative methods of standardization using quantitative immunofluorescence (AQUA) will be illustrated. Finally some exploratory data for new companion diagnostics will be presented. The role of phosphodiesterases in inflammation Angie Hertz Predoctoral Fellow Pharmacology UW Tuesday, November 16, 2010 - 8:30 AM SLU, 815 Mercer Street, Brotman Auditorium Discovery of 8-Hydroxyguanine (8-oxo-G); Involvement in Mutagenesis and Cancer Susumu Nishimura Visiting Scholar Laboratory Animal Resource Center University of Tsukuba, Japan Wednesday, November 10, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Why Attend? Damage to DNA by oxygen free radicals results from both endogenous metabolic processes and from exposure to environmental agents. In cells, it is estimated that as many as 20,000 nucleotides in DNA are altered per cell per day. Twenty-five years ago, Dr. Susumu Nishimura discovered that 8-hydroxydeoxyguanosine is the principal adduct resulting from oxygen mediated DNA damage. He then established methods to quantify its mutagenic potential and the association of this damage with cancer. He used knockout mice with mutations in DNA repair genes to demonstrate repair of 8- hydroxyguanine lesions in DNA. There is considerable evidence to indicate that 8- hydroxyguanine lesions are involved in human colon and lung cancers. His current studies are directed at reducing the formation of 8- hydroxyguanine lesions in DNA and reducing the frequency by which these lesions mis-code in order to prevent or delay the emergence of human cancers. Transcriptional regulatory circuits controlling mitochondrial function in the developing and diseased heart Daniel P. Kelly, MD Scientific Director Burnham Institute for Medical Research, Orlando, FL Tuesday, November 9, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Nephrotic T Cells: From Immunological Synapses to the Genetics of FSGS Andrey Shaw, M.D. Professor Department of Pathology & Immunology Washington University School of Medicine Wednesday, November 3, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Jing Zhang, M.D., Ph.D. Why Attend? Our work on the immunological synapse led us unexpectedly to become interested in podocytes in the kidney. Our recent work has focused on the genetic causes of FSGS and how the role of NextGen sequencing may transform our understanding of this disease. The Contribution of Mitochondrial Reactive Oxygen Species to Cellular Signaling Brian J. Hawkins, PhD Assistant Professor Anesthesiology and Pain Medicine; Researcher, Mitochondria and Metabolism Center UW Tuesday, November 2, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Quantifying Proteins by LC-MS/MS Andy Hoofnagle, M.D., Ph.D. Assistant Professor UW Laboratory Medicine University of Washington Wednesday, October 27, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine, M.D., Ph.D. Why Attend? There have been significant advances in the quantification of proteins by liquid chromatography-tandem mass spectrometry. Targeted proteomics workflows have major advantages over traditional automated immunoassays in the clinical laboratory. In addition, they are more precise than shotgun proteomics approaches. Using standard isotope dilution methods, we have developed several assays that demonstrate the utility of targeted mass spectrometry for the quantification of proteins in human samples. We will discuss the development of these assays and their application to tumor marker detection in serum and to studying the mechanisms of lipoprotein metabolism. Mitochondria Production of Reactive Oxygen Species and its Role in Ischemia Reperfusion Injury Wang Wang, MD, PhD Assistant Professor Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center UW Tuesday, October 26, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Immunologic Targeting of Oncogenic Proteins in Breast Cancer Nora Disis, M.D. Professor UW Medicine Oncology/Tumor Vaccine Group University of Washington Wednesday, October 20, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Kim Allison, M.D. Why Attend? Human cancers are immunogenic. Immunogenic proteins expressed by tumors have been defined and, in the case of breast cancer, many antigens are proteins that are involved in initiating or maintaining the malignant transformation. The identification of tumor antigens has allowed the development of targeted approaches to immune based breast cancer prevention and treatment strategies. The use of genetically engineered mice provides a model system for investigating the mechanism of action of breast cancer vaccines and clinical trials of vaccines in patients with breast cancer have indicated what type of immune response is needed for tumor eradication. Application of Causal Analysis to the Vessel Wall Stephen M. Schwartz, MD, PhD Professor Pathology UW Tuesday, October 19, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Monocyte/Macrophage Reprogramming - Novel Mechanisms to Control Outcomes in Inflammatory Diseases Jeremy Duffield, M.D., Ph.D. Associate Professor UW Medicine University of Washington Wednesday, October 13, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Charles Alpers, M.D. Why Attend? Jeremy Duffield recently joined University of Washington as Associate Professor of Medicine. He graduated from Oxford University in England, UK (MD) and Edinburgh University, Scotland UK (PhD) and moved to the USA in 2003. He was appointed Assistant Prof of Medicine at Harvard Medical School in 2006, after postdoctoral training there. He is a member of the Nephrology division and directs the Laboratory of Inflammation Research at the South Lake Union Campus in the Stem Cell and Regenerative Medicine Institute focused on the role of innate immune response cells, monocytes, in injury and repair and on the role of pericytes in vascular remodeling and fibrosis. Dr. Duffield is a recipient of the Young Investigator Award from the British Renal Association (2001), the Gottschalk Award from the American Society of Nephrology (2006) and an ARRA Challenge Grant from the NIH (2009) and the NIDDK Early Career Investigator/Scholar Award (2010). He serves on a study section at the NIDDK and the Scientific Advisory Board of Promedior Inc. and Regulus Therapeutics. He practices Nephrology part time at the UW Medical Center with special interests in Systemic Lupus Erythematosis, Systemic Vasculitis and Pregnancy related kidney disorders. In his 'spare' time he races bicycles, climbs mountains, skis, plays tennis, grows organic vegetables, looks after children (his own) and fixes things that are broken. Mouse genetics is a powerful approach to understand vascular remodeling Slava Korshunov, PhD Assistant Professor of Medicine Aab Cardiovascular Research Institute University of Rochester School of Medicine and Dentistry, Rochester, NY Tuesday, October 12, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Saturated Long-chain Acyl-CoA Synthesis: A Novel Link Between TNFα and Saturated Fatty Acid-induced Endothelial Dysfunction Xin Li Department of Pathology Graduate Student UW Medicine Pathology University of Washington School of Medicine Friday, October 8, 2010 - 1:00 PM UW Medicine at South Lake Union, Brotman Auditorium Faculty Sponsor: Karin Bornfeldt, Ph.D. Renal Mitochondrial Dysfunction in a Mouse Model of Diabetic Nephropathy Bardia Askari, Ph.D. UW Medicine Pathology University of Washington School of Medicine Wednesday, October 6, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Charles Alpers, M.D. Why Attend? Diabetic nephropathy is a major complication of diabetes mellitus, affecting approximately 20-40% of all people diagnosed with diabetes and has become the major cause of end stage renal disease. The risk is even higher in Native-American, African-American and Hispanic populations with type 2 diabetes. Current treatment of diabetic nephropathy includes strict dietary, glycemic and blood pressure control with the use of renin-angiotensin-aldosterone system blockers. However, even in the presence of appropriate pharmacotherapy, diabetes can lead to nephropathy and kidney failure. While progressive diabetic nephropathy is most likely the result of a combination of environmental and genetic influences, the exact mechanisms are not clearly delineated. The mouse strain BTBR with the ob/ob leptin deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resistance. We have demonstrated that these mice rapidly develop renal lesions characteristic of both early and advanced human diabetic nephropathy with corresponding renal dysfunction along with changes in the expression in several regulators of mitochondrial biogenesis. We've also demonstrated an amelioration of the development of type 2 diabetes using a novel peroxisome proliferator activated receptor (PPAR) agonist. These observations can give us a clearer view of the pathophysiologic mechanisms underlying the development of diabetic kidney disease. Mitochondrial Dynamics as Studied by Fourier Imaging Correlation Spectroscopy Eric Senning, PhD Sr. Fellow Physiology & Biophysics UW Tuesday, October 5, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Coupled gating of L-type calcium channels Edward P. Cheng Predoctoral Fellow Physiology and Biophysics UW Tuesday, September 28, 2010 - 9:00 AM SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium Motors, Movement, and Malignancy Steven S. Rosenfeld, M.D., Ph.D. John and Elizabeth Harris Professor Director, Division of Neuro-Oncology Department of Neurology, Columbia University Monday, July 19, 2010 - 4:30 PM UWMC, Genome Sciences Building, Foege Auditorium Faculty Sponsor: Thomas Montine, M.D., Ph.D. Metabolic Remodeling and Dysregulation of Lipid Dynamics in Diseased Hearts E. Douglas Lewandowski, PhD Professor, Physiology & Biophysics, and Medicine Director, Program in Integrative Cardiac Metabolism University of Illinois at Chicago Tuesday, July 13, 2010 - 8:30 AM SLU, 815 Mercer Street, Brotman Auditorium Faculty Sponsor: Rong Tian . Regulation of Neointimal Hyperplasia by Sphingosine-1-phosphate in Mice Guenter Daum, Ph.D. Research Associate Professor UW Medicine Surgery University of Washington Wednesday, June 30, 2010 - 4:30 PM Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Chuck Murry, M.D., Ph.D. Why Attend Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation. Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology How to Make a Heart: The Islet Heart Progenitor Story and 'Pregenerative' Medicine Kenneth R. Chien, M.D., Ph.D. Director, MGH Cardiovascular Research Center Department of Cell Biology and Harvard Stem Cell Institute Harvard University Medical School Wednesday, June 23, 2010 - 4:30 PM Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Chuck Murry Extending Lifespan by promoting proliferative homeostasis in Drosophila Heinrich Jasper, Ph.D. Assistant Professor Biology University of Rochester, New York Tuesday, June 22, 2010 - 12:30 PM HSB, K-069 Faculty Sponsor: Peter Rabinovitch Seminar is now RE-SCHEDULED Mapping gene expression subsets in systemic sclerosis to molecular pathways and concordant mouse models Michael L. Whitfield, PhD Assistant Professor Genetics Dartmouth Medical School Tuesday, June 22, 2010 - 8:30 AM SLU, 815 Mercer St, Brotman Auditorium Faculty Sponsor: Stephen M. Schwartz, MD, PhD Mitochondrial signaling in Disease and Aging Gerald Shadel, Ph.D. Professor, Medicine and Molecular Genetics Yale School of Medicine Tuesday, June 15, 2010 - 12:30 PM HSB, K-069 Faculty Sponsor: Peter Rabinovitch Of Old Mice and Men: Lessons in Comparative Pathology from a Mouse Model of Healthy Aging Piper M. Treuting, D.V.M., M.S., DACVP Assistant Professor, UW Comparative Medicine Chief of UW Comparative Pathology Services University of Washington Wednesday, June 9, 2010 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D. Why Attend, Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models. Adenylyl cyclase type 5 (AC5), cardiac stress and longevity Stephen Vatner, M.D. Chair Dept. of Cell Biology & Molecular Medicine UMDNJ, New Jersey Medical School Tuesday, June 8, 2010 - 12:30 PM HSB, K-069 Faculty Sponsor: Peter Rabinovitch The Adventitia: A Novel Hedgehog Signaling Domain and Progenitor Cell Niche in the Vessel Wall Mark Majesky, Ph.D. Professor, UW Medicine Pediatrics Seattle Children's Research Institute University of Washington Wednesday, June 2, 2010 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D. Why Attend An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed. Aortic Dissections, Vascular Diseases and ACTA2 Mutations Dianna M. Milewicz, MD, PhD Professor and Director Medical Genetics University of Texas Medical School at Houston Tuesday, June 1, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium Faculty Sponsor: Stephen M. Schwartz, MD, PhD WEBINAR Window of Opportunity: Artificial Cornea Development for Treatable Blindness Worldwide Tueng Shen Associate Professor University of Washington Eye Institute Wednesday, May 26, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented. Toggling among pluripotent states in embryonic stem cells Carol Ware, PhD Professor Comparative Medicine Institute for Stem Cell and Regenerative Medicine Tuesday, May 25, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Pyroptosis: Coordinated Inflammatory Response Brad Cookson Professor Laboratory Medicine & Microbiology University of Washington Wednesday, May 19, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role. Transcriptional Control of Stroma Dependent Apoptosis in MDS Mario Marcondes Graduate Student Department of Pathology University of Washington School of Medicine Wednesday, May 19, 2010 - 2:00 PM Fred Hutchinson Cancer Research Center, Pelton Auditorium Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D. Weird Animal Genomes and Sex Jenny Graves, Ph.D. Professor, Comparative Genomics Research School of Biological Sciences Australian National University, Canberra Wednesday, May 19, 2010 - 1:30 PM Genome Sciences Building, Foege Auditorium Faculty Sponsor: Christine Disteche, Ph.D. Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes. Quantifying Flow-induced Mechanical Stresses to Understand their Role in Vascular Disease Alberto Aliseda, PhD Assistant Professor Mechanical Engineering UW Tuesday, May 18, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Cellular and Humoral Immune Responses to the Polyomavirus-linked Merkel Cell Carcinoma: Implications for Pathogenesis, Prognosis and Therapy Kelly Paulson Medical Scientist Training Program Department of Pathology Graduate Student University of Washington School of Medicine Thursday, May 13, 2010 - 1:00 PM Fred Hutchinson Cancer Research Center, Pelton Auditorium Faculty Sponsor: Paul Nghiem, M.D., Ph.D. Mechanics and Mechanical Factors in the Structure-Function Relations of Endothelials and Platelets Nathan J. Sniadecki, PhD Assistant Professor Mechanical Engineering UW Tuesday, May 11, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Long-Chain Acyl-CoA Synthesis at the Crossroads Between Glucose and Fatty Acid-Enhanced Inflammation and Atherosclerosis in Diabetes Jenny Kanter Graduate Student Department of Pathology University of Washington School of Medicine Monday, May 10, 2010 - 10:00 AM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Karin Bornfeldt, Ph.D. Annual Alvord Lecture in Neuropathology Alexander R.A. Anderson, PhD H. Lee Moffitt Cancer Center & Research Institute Co-Director of Integrated Mathematical Oncology Lee Moffitt Cancer Center & Research Institute Wednesday, May 5, 2010 - 4:00 PM University of Washinton, Genome Sciences Building, Foege Auditorium Faculty Sponsor: Drs. T. Montine and K. Swanson 8th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. A special remembrance in honor of Dr. Alvord will precede the lecture. Reception to immediately follow the lecture at the Vista Cafe & Patio Genetic Variation in Aging and Longevity Yousin Suh, Ph.D. Associate Professor Medicine and Molecular Genetics Albert Einstein College of Medicine, New York Tuesday, May 4, 2010 - 12:30 PM HSB, K-069 Faculty Sponsor: Peter Rabinovitch Mechanistic studies of myofilament protein phosphorylation modulating striated muscle contraction Vijay S. Rao, PhD Senior Fellow Heart and Muscle Mechanics Laboratory, Bioengineering UW Tuesday, May 4, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Molecular Mechanisms of c-Myc-induced Immortalization of Human Fibroblasts Myra Wang Graduate Student Department of Pathology University of Washington School of Medicine Monday, May 3, 2010 - 3:00 PM Fred Hutchinson Cancer Research Center, Pelton Auditorium Faculty Sponsor: Denise Galloway, Ph.D. We Are What We Eat: Food and Water-borne Infectious Diseases of the Gastrointestinal Tract Laura Lamps, M.D. Professor Department of Pathology University of Arkansas for Medical Sciences Friday, April 30, 2010 - 4:30 PM Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Melissa Upton, M.D. Magnetic resonance imaging - a non-invasive method to study atherosclerosis progression and risk assessment Chun Yuan, PhD Professor of Radiology Vascular Imaging Lab UW Tuesday, April 27, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Apoptosis and Autophagy: Neuropathology in the Balance Kevin Roth, M.D., Ph.D. Professor and Chair Department of Pathology University of Alabama at Birmingham Wednesday, April 21, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dirk Keene Why Attend? Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms. Chemical Modifications of Proteins during Aging John Baynes, Ph.D. Carolina Distinguished Professor Emeritus Dept. of Chemistry & Biochemistry University of South Carolina Tuesday, April 20, 2010 - 12:30 PM HSB, K-069 Faculty Sponsor: Peter Rabinovitch Vascular gene therapy: a vector and a transgene that work! David A. Dichek, MD Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research Medicine/Cardiology UW Tuesday, April 20, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Microbe Hunting in the 21st Century Ian Lipkin, M.D. Professor Departments of Epidemiology, Neurology and Pathology Columbia University Medical Center Wednesday, April 14, 2010 - 3:30 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Michael Linden This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine. Please note time and location change. S100A9 Has Disparate Affects in Neutrophils and Dendritic Cells, but Myeloid S100A9-Deficiency Does Not Affect Atherosclerosis and Insulin Resistance Michelle Averill, PhD Senior Fellow, Karin Bornfeldt Lab Pathology UW Tuesday, April 13, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Severe Gastrointestinal Motility Disorders: Understanding the Underlying Pathology of the Neuromuscular Apparatus of the Gut Michael Schuffler Professor UW Medicine Gastroenterology University of Washington Wednesday, April 7, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Melissa Upton Why Attend Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders. Engineering Vascularized Human Cardiac Tissue for Heart Repair Kareen L. Kreutziger, PhD Postdoctoral Fellow Pathology UW Tuesday, April 6, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Diagnosis and Management of Barrett's Esophagus and its Neoplastic Complications Robert Odze, M.D., F.R.C.P.C Professor, Harvard Medical School Department of Pathology Brigham and Women's Hospital Wednesday, March 31, 2010 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Melissa Upton, M.D. Why Attend Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder. Using simulation methods to address biomedical problems Valerie Daggett, PhD Professor Bioengineering UW Tuesday, March 30, 2010 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Non-Cell Autonomous Neurodegeneration: A Tale of Two Glia Gwenn Garden Associate Professor UW Medicine Neurology University of Washington Wednesday, March 24, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Why Attend The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7. Natural and Artificial Extra-visual Ocular Photoreception Russ Van Gelder, M.D., Ph.D. Professor and Chair UW Medicine Ophthalmology University of Washington Wednesday, March 17, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed. Machine learning approaches for understanding the genetic basis of complex traits Su-In Lee, PhD Assistant Professor Computer Science & Engineering; and Genome Sciences UW Tuesday, March 9, 2010 - 8:30 AM Health Sciences Building, K-069 Microfluidics-assisted Display of Genomic DNA for Analysis of DNA Replication and Repair in Vivo Julia Sidorova, Ph.D. Acting Assistant Professor UW Medicine Pathology University of Washington Wednesday, March 3, 2010 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat Why Attend? DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process. Neuregulin Signaling and Subtype Specialization in Stem Cell Derived Cardiomyocytes Michael Laflamme, MD, PhD Assistant Professor Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine UW Tuesday, March 2, 2010 - 8:30 AM Health Sciences Building , K-069 Similarities and Differences of Diabetic Nephropathy in Type 1 vs. Type 2 Diabetic Patients Behzad Najafian, M.D. Assistant Professor Laboratory Medicine and Pathology University of Minnesota Thursday, February 25, 2010 - 3:30 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Charles Alpers, M.D. Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served Mapping Gene Expression in the CNS: Tools and Data from the Allen Institute for Brain Science Allan Jones, Ph.D. Chief Scientific Officer Allen Institute for Brain Science Wednesday, February 24, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute. Use of the Mouse Conditional and Null Alleles of the Type III Sodium-Dependent Phosphate Cotransporter PiT-1 Maria Festing, PhD Senior Fellow, Ceci Giachelli Lab Bioengineering UW Tuesday, February 23, 2010 - 8:30 AM Health Sciences Building , K-069 Regulation of Neointimal Hyperplasia by Sphingosine-1-Phosphate in Mice Guenter Daum, PhD Research Associate Professor Surgery UW Tuesday, February 16, 2010 - 8:30 AM Health Sciences Building , K-069 Common Disease - Multiple Rare Alleles: Understanding the Genetic Basis of Complex Human Traits Mary-Claire King Professor Medicine & Genome Sciences University of Washington Wednesday, February 10, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients. Biomechanics in carotid atherosclerosis and abdominal aortic aneurysms Gador Canton, PhD Senior Fellow Radiology, Vascular Imaging Laboratory UW Tuesday, February 9, 2010 - 8:30 AM Health Sciences Building , K-069 RNA-based Molecular Circuitry for Conditional Gene Regulation Georg Seelig, Ph.D. Assistant Professor Electrical Engineering, Computer Science & Engineering University of Washington Wednesday, February 3, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway. Using BAC Recombineering for the Analysis of Cardiac Progenitors John L. Mignone, MD, PhD Cardiology Fellow, Murry Lab Pathology UW Tuesday, February 2, 2010 - 8:30 AM Health Sciences Building , K-069 Imaging Circuit Assembly in the Developing Retina Rachel Wong Professor Department of Biological Structure University of Washington Wednesday, January 27, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Suzy Dintzis Why Attend? Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns. When Muscle Runs Out of Gas: nNOS Function in Skeletal and Cardiac Muscle Justin Percival, PhD Research Assistant Professor Physiology and Biophysics UW Tuesday, January 26, 2010 - 8:30 AM Health Sciences Building , K-069 High Throughput Screening at the UW: RNA Interference and Small Molecule Screens Carla Grandori and Tom Martins Research Associate Professors Quellos High Throughput Screening Core, ISCRM UW Medicine Pharmacology Wednesday, January 20, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries. Further Information Website: www.depts.washington.edu/uwhts/ Contact Info General Core Facility Contact: uwhts@uw.edu For RNA Interference Screening Carla Grandori; grandc@uw.edu James Annis; annisj@uw.edu For Chemical Screening Tim Martins; tmartins@uw.edu Role of microRNA-155 in inflammatory/immune responses John M. Harlan, MD Professor of Medicine Division of Hematology UW Tuesday, January 19, 2010 - 8:30 AM Health Sciences Building , K-069 Functional Genetic Approaches in In Vitro Stem Cell Systems Using RNAi Patrick Paddison, Ph.D. Assistant Member Human Biology Division Fred Hutchinson Cancer Research Center Wednesday, January 13, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis. Proteolytic Pathways in Immunity William C. Parks, Ph.D. Professor of Medicine Center for Lung Biology UW Tuesday, January 12, 2010 - 8:30 AM Health Sciences Building , K-069 PET Imaging Tumor Phenotype in Sarcomas Janet Eary, M.D. Associate Professor Department of Nuclear Medicine University of Washington Wednesday, January 6, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies. Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines. The State of Seattle’s Biotech Industry Luke Timmerman National Biotechnology Editor Xconomy Tuesday, January 5, 2010 - 8:30 AM Health Sciences Building, K-069 Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors Bernhard Kuhn, M.D. Associate Professor Department of Cardiology Children's Hospital Boston Wednesday, December 16, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007. Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure. Exome Sequencing & Human Disease Jay Shendure, MD, PhD Assistant Professor Dept. of Genome Sciences UW Tuesday, December 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Fibrillar Collagens and Their Chaperones in Disease: A Tale of Kinky Tails and Brittle Bones Helena Christiansen Graduate Student Molecular and Cellular Biology University of Washington School of Medicine Thursday, December 10, 2009 - 12:00 PM Health Sciences Center, T-739 Faculty Sponsor: Peter Byers, M.D. Nuclear Architecture and Aging Tom Misteli, Ph.D. Senior Investigator Cell Biology of Genomes National Cancer Institute, NIH Wednesday, December 9, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging. Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology. Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making Jordi Bruix, M.D. Associate Professor Director, Liver Cancer Group University of Barcelona Wednesday, December 2, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Jean Campbell Why Attend? Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm. Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice. The what, why, and where of perivascular cells Morayma Reyes, MD, PhD Assistant Professor Pathology and Lab Medicine UW Tuesday, December 1, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease David Marcinek, PhD Research Assistant Professor Dept. of Radiology UW Tuesday, November 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging. Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer Valera Vasioukhin Associate Member Fred Hutchinson Cancer Research Center Wednesday, November 18, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer. Muscle Gene Regulation & Regulatory Cassettes for Gene Therapy Stephen D. Hauschka, PhD Professor Dept. of Biochemistry UIW Tuesday, November 17, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles. Exploring the extraordinary regenerative potential of the mammalian fetal heart Timothy Cox, PhD Research Associate Professor Pediatrics, Division of Craniofacial Medicine UW Tuesday, November 10, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Diet, Death and Demography Linda Partridge, Ph.D. Director, The Institute of Healthy Ageing University College, London Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany Monday, November 9, 2009 - 11:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy Paul Nghiem, M.D., Ph.D. Associate Professor UW Medicine Dermatology and Pathology Wednesday, November 4, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Suzy Dintzis Why Attend? Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases. Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU. Skeletal muscle stem cells: from classic to eclectic Zipora Yablonka-Reuveni, PhD Professor Dept. of Biological Structure UW Tuesday, October 27, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908). The Amazing Liver: New Perspectives on Regeneration and Cancer Nelson Fausto, M.D. Professor and Chair UW Medicine Pathology Wednesday, October 21, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes. Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma Jean Campbell, PhD Research Assistant Professor Dept. of Pathology UW Tuesday, October 20, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mechanisms of enhanced lung injury in febrile hyperthermia Anne Lipke, MD Senior Fellow Division of Pulmonary and Critical Care Medicine UW Tuesday, October 13, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Lynn Schnapp, MD Transcriptional Regulation of Vascular Development Elisabetta Dejana Italian Foundation for Cancer Research Institute of Molecular Oncology Milan, Italy Tuesday, October 6, 2009 - 4:00 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Elaine Raines CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis Jeffrey A. Ledbetter, PhD Research Professor Division of Rheumatology UW Tuesday, October 6, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab). The role of cardiac metabolism in heart diseases Rong Tian, MD, PhD Professor and Director Mitochondria and Metabolism Center UW Tuesday, September 29, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury Tiffany Nguyen Graduate Student Pharmacology and Toxicology Department Medical College of Georgia, Augusta, GA Tuesday, September 22, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Rong Tian, MD, PhD Cell Signaling in Space and Time John D. Scott, PhD Edwin G. Krebs-Hilma Speights Professor Dept. of Pharmacology UW Tuesday, September 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Can We Image a Plaque at Risk? Mat J.A.P. Daemen, MD, PhD Scientific Director of the Cardiovascular Research Institute Maastricht Professor and Head of Pathology University of Maastricht, The Netherlands Tuesday, September 8, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Chun Yuan Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses. The Neurosecretory Vesicle Protein Phogrin Has Phosphatidylinositol Phosphatase Activity That Regulates Insulin Secretion Leslie Ann Caromile Graduate Student Department of Pathology University of Washington School of Medicine Friday, August 14, 2009 - 10:00 AM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Dan Bown-Pope, Ph.D. Long-chain acyl-CoA Synthetase Isoforms 1 and 4 Exhibit Differences in Fatty Acid Preference and Functions in Human Arterial Smooth Muscle Cells Deidre Golej MCB Graduate Student University of Washington School of Medicine Wednesday, August 12, 2009 - 2:00 PM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Karin Bornfeldt, Ph.D. Mitochondria, Age and the Heart Charles L. Hoppel, M.D. Professor Departments of Pharmacology and Medicine Case Western Reserve University Tuesday, July 28, 2009 - 4:00 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry Daniel Martin, M.D. Institute for Systems Biology Tuesday, June 16, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Loss of DNA Polymerase Proofreading Leads to Cancer and Tumor Acceleration in MIce Tina M. Albertson Graduate Student UW Medicine Pathology University of Washington School of Medicine Tuesday, June 9, 2009 - 2:00 PM Health Sciences Center, K-069 Faculty Sponsor: Brad Preston, Ph.D. . talk cancelled UW School of Medicine Tuesday, June 9, 2009 - 8:30 AM HSC, NE110 Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Nitric Oxide and the Development of Insulin Resistance Francis Kim, MD Associate Professor of Medicine Division of Cardiology Harborview Medical Center Tuesday, June 9, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium MicroRNAs as Blood-based Cancer Biomarkers Muneesh Tewari, MD, PhD Assistant Member Human Biology Fred Hutchinson Cancer Research Center Wednesday, June 3, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer. Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions. Genes and Vascular Disease Gail P. Jarvik, MD, PhD Professor of Medicine and Head Division of Medical Genetics UW Tuesday, June 2, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Pancreatic Cancer: Genes to Patients Ralph Hruban, MD Professor Pathology/Oncology John Hopkins University Wednesday, May 27, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families. Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer. Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?) Ian R. Sweet, PhD Research Assitant Professor Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 26, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes Margaret Black, Ph.D. Associate Professor Pharmaceutical Sciences Washington State University Wednesday, May 20, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Why Attend? Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect. Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU. Sterol regulation of the macrophage immune response Jay W. Heinecke, MD Professor of Medicine Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 19, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld Signaling Networks in Vascular Morphogenesis and Homeostasis Luisa Iruela-Arispe, PhD Professor Molecular, Cell and Developmental Biology UCLA Wednesday, May 13, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Charles Murry, M.D., Ph.D. Why Attend? Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology. Anti-Aging Genes, DNA Damage and Cancer Valter Longo, Ph.D. Assistant Professor Department of Gerontology/Alzheimer's Research University of Southern California Tuesday, May 12, 2009 - 12:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence Cell Cycle Regulation in Hematopoietic Disorders Keith Loeb, M.D., Ph.D. Assistant Professor Pathology UW School of Medicine Tuesday, May 12, 2009 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Thomas Montine, MD, PhD Versican: A Matrix Molecule With Some Clout! Thomas N. Wight, Ph.D. Member and Director, Hope Heart Program Benaroya Research Institute at Virginia Mason Affiliate Professor, Pathology, UW Tuesday, May 12, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mitochondrial Signaling and Dynamics in Health and Disease Gyorgy Hajnoczky, PhD Professor Pathology, Anatomy & Cell Biology Jefferson Medical University Wednesday, May 6, 2009 - 4:30 PM Health Sciences Center , K-069 Faculty Sponsor: Charles Murry, M.D., Ph.D. Why Attend? Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases. Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology. Tumor Cell Metabolism: How is it different? David M. Hockenbery, MD Professor of Medicine, UWMC Member, FHCRC Tuesday, May 5, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment Mark Wick, MD Professor Pathology Univeristy of Virginia Friday, May 1, 2009 - 4:30 PM Health Sciences Center, T-639 Faculty Sponsor: Matthew Yeh, M.D., Ph.D. Why Attend? Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues. Mechanisms of Cell Fate Acquisition in the Differentiation of Pluripotent Stem Cells Jonathan Golob Graduate Student UW Medicine Pathology University of Washington School of Medicine Wednesday, April 29, 2009 - 10:00 AM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Chuck Murry, M.D., Ph.D. Mapping Cell Fate through Somatic Mutations Marshall Horwitz, MD, PhD Professor of Pathology Institute for Stem Cell and Regenerative Medicine UW Tuesday, April 28, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Deciphering the Hereditary Prion Protein Amyloidoses Bernardino Ghetti, MD Professor Pathology & Lab Medicine Indiana University Wednesday, April 22, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Montine 7th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. Shaping the vertebrate body: cell migration in development and disease Douglas C. Weiser, PhD Postdoctoral fellow Department of Biochemistry UW Tuesday, April 21, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective Vinay Kumar, MD, PhD Professor and Chairman Pathology University of Chicago Medical School Wednesday, April 15, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: UW Medicine Pathology Residents Why Attend? Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007. Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors. Mitochondrial Oxidative Stress in Cardiac Aging, Pressure-Overload Induced Cardiac Hypertrophy and Failure Dao-Fu Dai Graduate Student UW Medicine Department of Pathology University of Washington Tuesday, April 14, 2009 - 1:00 PM UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Doctoral Dissertation Chordoma Benjamin Hoch, MD Associate Professor, Pathology UW School of Medicine Tuesday, April 14, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Matrix remodeling during lung injury and repair Lynn M. Schnapp, MD Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, April 14, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Genomic Dosage Disorders: Diagnostic Insights and Challenges Nancy Spinner, PhD Professor Genetics in Pediatrics University of Pennsylvania School of Medicine Wednesday, April 8, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Christine Disteche, Ph.D. Why Attend? Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia. Translational control during monocyte/macrophage adherence David Pritchard, PhD Acting Instructor Department of Pathology UW Tuesday, April 7, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Gene Networks as Sensors and Drivers of Disease Eric Schadt, PhD Executive Scientific Director Genetics Rosetta Inpharmatics LLC Wednesday, April 1, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death. Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London. Water, Energy and Life: Fresh Views from the Water’s Edge Gerald H. Pollack, PhD Professor Department of Bioengineering UW Tuesday, March 31, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Laboratory medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Dept. of Laboratory Medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle Stephen Tapscott Member Divisions of Human Biology and Clinical Research Fred Hutchinson Cancer Research Center Wednesday, March 11, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas. Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991. Metabolic Stability and the Evolution of Life Span Lloyd Demetrius, PhD Department of Evolutionary & Organismic Biology Harvard University Tuesday, March 10, 2009 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant Human Pluripotent Stem Cells for Myocardial Repair Michael LaFlamme, MD, PhD Assistant Professor, Pathology UW School of Medicine Tuesday, March 10, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Local Control of Excitation-Transcription Coupling in Smooth Muscle Luis Fernando Santana, Ph.D. Associate Professor Physiology and Biophysics UW Tuesday, March 10, 2009 - 8:30 AM Health Sciences Building, K-069 Chromatin and G-quadruplex Functions at Telomeres and Beyond Brad Johnson, MD, PhD Assistant Professor Pathology/Lab Medicine University of Pennsylvania Wednesday, March 4, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription. Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania. uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms Jie Hong Hu, Ph.D. Senior Fellow Division of Cardiology UW Tuesday, March 3, 2009 - 8:30 AM Health Sciences Building, K-069 Lost in Translation: Ribosomes in Hematopoiesis Akiko Shimamura, MD, PhD Associate Member Division of Pediatric Hematology/Oncology Fred Hutchinson Cancer Research Center Wednesday, February 25, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction. Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital. TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury John C. Keech, M.D. Postdoctoral Fellow Surgery UW Tuesday, February 24, 2009 - 8:30 AM Health Sciences Building, K-069 Translating Pathways to Pancreatic Cancer Sunil Hingorani, MD, PhD Assistant Member Clinical Research and Public Health Sciences Division Fred Hutchinson Cancer Research Center Wednesday, February 18, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results. Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance. Mitochondrial-targeted Peptides: Novel Cardio-, Neuro- and Renal-protective Agents Hazel H. Szeto, M.D., Ph.D. Professor Department of Pharmacology Weill Cornell Medical College Tuesday, February 17, 2009 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant Myofilament Regulation of the Frank-Starling Law of the Heart F. Steven Korte, Ph.D. Senior Fellow Bioengineering UW Tuesday, February 17, 2009 - 8:30 AM Health Sciences Building, K-069 Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility Kristin Swanson, PhD Research Associate Professor, UW Medicine Pathology Adjunct Associate Research Professor, Applied Mathematics University of Washington Wednesday, February 11, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Monnat The FGF Axis: New Therapeutic Opportunities Norman M. Greenberg, Ph.D. Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington FHCRC and UW Tuesday, February 10, 2009 - 8:30 AM Health Sciences Building, K-069 Water Gerald Pollack, PhD Professor, Bioengineering Department of Engineering, Bioengineering Division UW School of Medicine Monday, February 9, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php Archaeoctyes: Monocytes as Universal Probes for Disease Stephen Schwartz, MD, PhD Professor Pathology University of Washington Wednesday, February 4, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Monnat Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays Steven Pelech, Ph.D. President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia Kinexus Bioinformatics Corp. and Univ. of British Columbia Tuesday, February 3, 2009 - 8:30 AM Health Sciences Building, K-069 Roles of Transcription in Genomic Stability or Instability Philip Hanawalt, PhD Professor Biological Sciences Stanford University Wednesday, January 28, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Loeb SMC plasticity and reprogramming in calcifying vasculature Yanfeng (Mei) Speer, Ph.D. Research Assistant Professor Bioengineering UW Tuesday, January 27, 2009 - 8:30 AM Health Sciences Building, K-069 Studying Hematopoietic Disease with Genetics & Genomics Yajuan Liu, PhD Senior Fellow Medical Genetics University of Washington Wednesday, January 21, 2009 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Dr. Monnat Genetic & epigenetic control of aging George Martin, MD Emeritus Professor (active), Pathology UW School of Medicine Tuesday, January 13, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/ Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells Jonathan Golob Graduate Student Pathology UW Tuesday, January 13, 2009 - 8:30 AM Health Sciences Building, K-069 Inights Into Vascular Diseases and Their Treatments from Human Genetics Richard Lifton, M.D., Ph.D. Professor and Chair Department of Genetics Yale University Wednesday, January 7, 2009 - 5:00 PM Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Stephen Schwartz Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222 AAV vectors: biology and utility for gene addition and gene correction David Russell, MD, PhD Professor of Medicine Div. of Hematology UW Tuesday, January 6, 2009 - 8:30 AM Health Sciences Building, K-069 Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you Alan Weiner, PhD Professor and ZymoGenetics Chair Biochemistry UW Tuesday, December 16, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium "Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes" Markus Grompe, MD Professor Molecular & Medical Genetics and Pediatrics Oregon Health & Science University Wednesday, December 10, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat Climb High, Sleep Low Lawrence True, MD Professor, Pathology UW School of Medicine Tuesday, December 9, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. A-type nuclear lamins in aging and disease Brian Kennedy, PhD Associate Professor Biochemistry UW Tuesday, December 9, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers Binghui Shen, PhD Professor Radiation Biology City of Hope Wednesday, December 3, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Loeb Delta 1: A Notch up on cord blood stem cell transplantation Irwin Bernstein, MD Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society UW and FHCRC Tuesday, November 25, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium “Quantum Dots for Cancer Imaging and Therapeutics” Xiaohu Gao, PhD Assistant Professor Bioengineering University of Washington Wednesday, November 19, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat Dissection, disruption, and death--aortic dissection and its causes Peter Byers, MD Professor, Pathology and Medicine UW School of Medicine Tuesday, November 18, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer Jay Rothstein, PhD Director Inflammation Research Amgen, Inc., Seattle, WA Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs Wei-Zhong Zhu, PhD Postdoctoral Fellow Pathology UW Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Michael Laflamme Neuroregeneration in the Cerebral Cortex: Impossible and Crazy? Robert Hevner, M.D., Ph.D. Professor Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology University of Washington Wednesday, November 12, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat "Structural and Functional Characterizations of Alternative Gene Products of an Adaptor Protein (FE65) and an Orphan G-Protein Coupled Receptor (Gprc5b) in Learning- and Memory-Impaired Mice with a Selective Knockout of p97FE65" Bethany Cool Graduate Student Pathology University of Washington Monday, November 10, 2008 - 2:30 PM Health Science Center, K-0690 Faculty Sponsor: Dr. Martin "Pathogenesis of NASH: new insights from mice with metabolic syndrome" Geoffrey Farrell, MD Director/Professor Gastroenterology and Hepatology Australian National University Wednesday, November 5, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Matthew Yeh "The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast" Alan Herr, PhD Senior Fellow Pathology University of Washington Wednesday, October 29, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brad Preston "Control of Cardiovascular Signaling by RGS Proteins" William Mahoney, PhD Senior Fellow Pathology University of Washington Wednesday, October 22, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Monnat Epigenetic programming of mesenchymal stem cells Philippe Collas, PhD Professor Institute of Basic Medical Sciences, Dept. of Biochemistry University of Oslo, Norway Tuesday, October 21, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Karol Bomsztyk Exploring the Interface Between Glial Progenitors and Gliomas Peter Canoll, MD, PhD Assistant Professor Department of Clinical Pathology Columbia University Wednesday, October 15, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Tom Montine Regulation of Nodal Signaling by microRNAs Wen-Yee Choi Graduate Researcher Molecular and Cellular Biology Harvard University Tuesday, October 14, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Charles Murry Contribution of interstitial valve cells to valve calcification Marcello Rattazzi, MD Clinical and Experimental Medicine University of Padua, Italy Wednesday, October 8, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Molecular mechanisms of aging: What can we learn from yeast and worms? Matt Kaeberlein, PhD Assistant Professor Pathology UW Tuesday, October 7, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Pancreatic Cancer: Emerging Ideas About How the Cancer Forms Teri Brentnall, MD Professor Departments of Medicine and Pathology University of Washington Wednesday, October 1, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Rabinovitch PSGL-1 Mediated Signal Transduction and Translational Control Mechanisms During Adherence of Macrophages Richard Fox Graduate Student UW Medicine Pathology University of Washington Thursday, August 14, 2008 - 1:00 PM South Lake Union Auditorium, K-111 Faculty Sponsor: Dr. Schwartz “Magnetic Resonance Imaging of Gene Expression" Anna Naumova, Ph.D. Senior Fellow Radiology UW Tuesday, June 24, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Directly targeting myofibrillar proteins to improve cardiomyocyte contraction" F. Steven Korte, PhD Senior fellow Bioengineering UW Tuesday, June 17, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus” Bardia Askari, Ph.D. Acting Instructor Pathology UW Tuesday, June 10, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Understanding aging through conserved longevity pathways Matt Kaeberlein, PhD Assistant Professor, Pathology UW School of Medicine Tuesday, June 10, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine “Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model” Karin E. Bornfeldt, Ph.D. Professor Pathology Medicine Tuesday, June 3, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer “Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes” Charis L. Himeda, Ph.D. Senior fellow Biochemistry UW Tuesday, May 20, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment” Dalin Tang, Ph.D. Professor Mathematics and Biomedical Engineering Worcester Polytechnic Institute Tuesday, May 13, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chun Yuan, Ph.D. 815 Mercer Street “Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?” Deidre Golej Graduate Student, Molecular and Cellular Biology Pathology UW Tuesday, May 6, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Why Do Biopsies of Ulcerative Colitis Seem to Look More and More Like Crohn’s Disease? And Whatever Happened to the Old Ulcerative Colitis That We Knew and Loved Henry Appelman, M.D. Professor Department of Pathology University of Michigan Health System Thursday, May 1, 2008 - 4:30 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Dr. Melissa Upton A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000. “Diabetic vascular disease: Hitting below the belt” Kanchan Chitaley, Ph.D. Research Assistant Professor Urology UW Tuesday, April 29, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street 6th Annual Alvord Lecture in Neuropathology Arie Perry, MD Associate Professor Pathology, Division of Neuropathology Washington University, St. Louis Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Montine Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed. “FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero” Atis Muehlenbachs MSTP and Incoming Resident Pathology UW Tuesday, April 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Transcriptional regulation of thrombin receptors by vasodilator prostaglandins" Karsten Schror, M.D. Professor and Chair Pharmacology and Clinical Pharmacology Heinrich-Heine-Universitat Dusseldorf Tuesday, April 15, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Alexander W. Clowes, MD 815 Mercer Street A Recurrent Mutation, p.R961W, in the MED12/TRAP/HOPA Gene Causes Opitz-Kaveggia (FG) Syndrome Hiba Risheg, Ph.D. Director Clinical Ctyogenetics Laboratory Genecare Medical Genetics Center Monday, April 14, 2008 - 3:00 PM Health Sciences Center, T-747 Faculty Sponsor: Dr. Christine Disteche Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology Untangling Mitochondrial Mutagenesis and Aging in Mice Marc Vermulst Graduate Student UW Medicine Pathology University of Washington Friday, April 11, 2008 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Larry Loeb “A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice” Richard Frock PhD Candidate Biochemistry UW Tuesday, April 8, 2008 - 8:30 AM Health Sciences Building, K-069 "I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure" Chris Hague, Ph.D. Assistant Professor Pharmacology UW Tuesday, April 1, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Glioma Invasion: Interactions with the Microenvironment Joanna Phillips, MD, PhD UW Medicine, Neuropathology Faculty Candidate Department of Pathology, Division of Neuropathology, Research Fellow University of California, San Francisco Wednesday, March 26, 2008 - 9:30 AM R&T Building, 300 Ninth Ave, auditorium Faculty Sponsor: Montine "Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation" Prabha Sampath, Ph.D. Postdoctoral Fellow Pathology UW Tuesday, March 25, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer” Jeffrey S. Chamberlain, Ph.D. Professor Depts. of Neurology, Medicine and Biochemistry UW Tuesday, March 18, 2008 - 8:30 AM HSB, T-635 “Human RecQ helicases: new roles in biology and disease” Raymond Monnat, MD Professor of Pathology Pathology UW School of Medicine Tuesday, March 11, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level. "The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair" Lynn M. Schnapp, M.D. Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, March 4, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend Dr. Paul Carvey Dean Rush Medical School Wednesday, February 20, 2008 - 4:30 AM Health Sciences Building, T639 Faculty Sponsor: Dr. Zhang "Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites" Elaine W. Raines Research Professor Pathology UW Tuesday, February 12, 2008 - 8:30 AM HSB, K-069 The Genetic Basis of Fanconi Anemia and Other Heritable Chromosome Instability Syndromes Dr. Holger Hoehn Professor Humangenetik Institute University of Wurzburg Thursday, February 7, 2008 - 3:30 PM Health Sciences Center, T-747 Faculty Sponsor: Peter Rabinovitch “The Role of Filamin in Transcriptional Control of Laminin Expression” Christine K. Abrass, MD, FACP Professor of Medicine Division of Gerontology and Geriatric Medicine UW Tuesday, February 5, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Encapsulated vascular smooth muscle cells to treat rat models of diabetes" William Osborne, PhD Research Professor Pediatrics UW Tuesday, January 29, 2008 - 8:30 AM HSB, K-069 “Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system” Esther Lutgens, MD, PhD Associate Professor Pathology CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands Tuesday, January 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Michael Rosenfeld, PhD 815 Mercer Street "Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature" Yanfeng (Mei) Speer, PhD Research Assistant Professor Bioengineering UW Tuesday, January 15, 2008 - 8:30 AM HSB, K-069 TBA Roger E. Bumgarner, PhD Associate Professor Microbiology UW Tuesday, December 18, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Secondary Mutations as a Mechanism of Cisplatin Resistance in BRCA1/2-Mutated Cancers: Lessons Learned from Studies on a Rare Genetic Disease, Fanconi Anemia Toshiyasu Taniguchi, M.D., Ph.D. Assistant Member Divisions of Human Biology and Public Health Sciences Fred Hutchinson Cancer Research Center Monday, December 17, 2007 - 3:00 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology Physiological Functions of Activated Caspases in Macrophages Thomas Nhan Graduate Student UW Medicine Pathology University of Washington Thursday, December 13, 2007 - 10:00 AM South Lake Union, Brotman Building Auditorium Faculty Sponsor: Stephen Schwartz "Innate immune recognition and response to microbial pathogens" Kelly Smith, MD, PhD Assistant Professor Pathology UW Tuesday, December 11, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Studying Connections between Cancer and Aging Peter Rabinovitch, M.D., Ph.D. Professor UW Medicine Pathology University of Washington Tuesday, December 11, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Macrophage Mediators of Cardiac Fibrosis April S. Stempien-Otero, MD Assistant Professor of Medicine Cardiology UW Tuesday, December 4, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Where Do the Cells of the Atherosclerotic Plaque Come from and Where Do They Go? Gwen Randolph, Ph.D. Associate Professor Department of Gene and Cell Medicine Mount Sinai School of Medicine Friday, November 30, 2007 - 4:00 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Stephen Schwartz "Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system" Gustavo Matute-Bello, MD Assistant Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, November 27, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Mitochondria, lifespan and the aging heart" Peter S. Rabinovitch, M.D., Ph.D. Professor Pathology UW Tuesday, November 20, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Loss of the Endocytic Protein Sorting Nexin 1 Promotes Colon Cancer Development Matthew S. Holdren University of Washington School of Medicine Department of Pathology Graduate Student UW Medicine Pathology Monday, November 19, 2007 - 2:00 PM Health Sciences Center, K-069 Faculty Sponsor: Dan Bowen-Pope --- Christine Disteche, PhD Professor of Pathology UW School of Medicine Tuesday, November 13, 2007 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine "Human Embryonic Stem Cell Niches?" C. Anthony Blau, MD Professor of Medicine Hematology UW Tuesday, November 13, 2007 - 8:30 AM Brotman Building, 815 Mercer Street, SLU Auditorium "Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system" Howard M. Shulman, M.D. Professor Pathology/Oncology FHCRC Tuesday, November 6, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street The Role of Epilysin (MMP-28) in Lung Inflammation and Epithelial Cell Survival Anne Manicone, MD Pulmonary and Critical Care Medicine UW - Center for Lung Biology Thursday, November 1, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street - refreshments at 3:45pm "Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine" Glenn D. Prestwich, Ph.D. Presidential Professor of Medicinal Chemistry Department of Medicinal Chemistry and Center for Therapeutic Biomaterials The University of Utah Tuesday, October 30, 2007 - 8:30 AM SLU - Brotman Bulding, Blue Flame Auditorium Faculty Sponsor: Thomas N. Wight, Ph.D. 815 Mercer Street Ribosomes and Spindles in Marrow Failure and Cance Predisposition Akiko Shimamura, MD Associate Professor of Pediatrics Division of Hematology/Oncology UWSOM Tuesday, October 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street When Opportunities Arise, Be Ready Raj Kapur, M.D., Ph.D. Associate Professor UW Medicine Pathology University of Washington Tuesday, October 9, 2007 - 8:30 AM UWMC Anatomic Pathology, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Leptin in Cardiovascular Disease Daniel Eitzman Assistant Professor Internal Medicine/Cardiovascular Disease University of Michigan Wednesday, September 26, 2007 - 8:30 AM Brotman Building, SLU, Blue Flame Faculty Sponsor: Steve Schwartz 815 Mercer Street Reschedule - date tentative Clinical Experience of High Resolution Oligonucleotide Array: Ji Yun Lee, Ph.D. ABMG Training Program Trainee Department of Human Genetics Emory University Monday, September 17, 2007 - 3:00 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Christine Disteche, Ph.D. Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided Epithelial Differentiation in the Prostate: Insights from a Primary Cell Culture System Beatrice Knudsen, M.D., Ph.D. Affiliate Professor UW Medicine Pathology Member, FHCRC Division of Public Health Sciences Tuesday, September 11, 2007 - 8:30 AM UWMC Anatomic Pathology, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Base of Skull Chordoma: The Conundrum of Morphology and Biology Benjamin Hoch, M.D. Assistant Professor Department of Pathology Mount Sinai School of Medicine Monday, August 20, 2007 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson, M.D. Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology Multicolor Karyotyping & Banding in Non-Hodgkin Lymphoma and Bac Array CGH in Chronic Lymphocytic Leukemia Valia S. Lestou, Ph.D. Researcher University of British Columbia Center for Disease Control Tuesday, July 17, 2007 - 2:00 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Christine Disteche Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided Insulin Modulation of Plasma beta-Amyloid levels Pattie S. Green, PhD Research Assistant Professor Medicine UWSOM Tuesday, June 26, 2007 - 8:30 AM TBA, TBA Faculty Sponsor: Renee LeBoeuf It's a Small World After All: The MicroRNA Gene Expression Profile of HCV-Associated Hepatocellular Carcinoma Heike Varnholt, M.D. Staff Pathologist Division of Gastrointestinal and Hepatobiliary Pathology University Hospital of Cologne, Germany Friday, June 22, 2007 - 12:30 PM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Melissa Upton Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided. TBA Larry Adams Senior Research Scientist Pathology UWSOM Tuesday, June 19, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Finding Genes for Uterine Fibroids Jennelle Hodge, Ph.D. Senior Research Fellow Department of OB-GYN and Reproductive Biology Brigham and Women's Hospital, Harvard Medical School Monday, June 11, 2007 - 3:30 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Christine Disteche Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology Roles of cytokines in regulation of bone mass Brendan Boyce Director of Surgical Pathology Department of Pathology and Laboratory Medicine University of Rochester Medical Center in New York Wednesday, June 6, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Larry True RGS5: Regulating the Regulator William M. Mahoney Jr. Postdoctoral Fellow Pathology UWSOM Tuesday, June 5, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Erythropoietin and Cancer – A Window of Opportunity for Pharmacologically Regulated Cell Therapy? C Anthony (Tony) Blau, MD Professor Medicine, Hematology UWSOM Thursday, May 31, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy Dr. Eberhard Neumann Bielefeld, Germany Department of Chemistry University of Bielefeld Wednesday, May 30, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Lawrence Loeb International speaker from Germany How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease? Wendy Thomas Assistant Professor Bioengineering UWSOM Tuesday, May 29, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Chorea vs Parkinsonism: The Search for Primary Centers for Degeneration Jean Paul Vonsattel, M.D. Professor Department of Pathology Columbia University Medical Center Wednesday, May 23, 2007 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tom Montine 5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002. Molecular Mechanisms of Regulation of L-type Calcium Channels Michelle Emrick Senior Fellow Pharmacology UWSOM Tuesday, May 22, 2007 - 8:30 AM Health Sciences, K-069 TGF-beta signaling in kidney cells Anne-Christine Poncelet Acting Instructor Medicine-Gerontology UW School of Medicine Tuesday, May 15, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Chromatin Profiling of the Human Genome: Genomic Distribution and Characterization of Insulator Elements Anton Krumm PhD Research Assistant Professor Radiation Oncology UW School of Medicine Thursday, May 10, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments 3:45 p.m. Mortar and Bricks Melissa Upton, M.D. Associate Professor, Assistant Chief of Anatomic Pathology Department of Pathology University of Washington Tuesday, May 8, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice Guy Odom Senior Fellow Neurology UWSOM Tuesday, May 8, 2007 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek To Call or Not to Call: The Challenge of Intraoperative Frozen Section Gang He, M.D., Ph.D. Bone and Soft Tissue Fellow Department of Pathology University of Chicago Monday, May 7, 2007 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson Dr. He is a clinical faculty candidate for bone and soft tissue pathology. Diabetes, obesity and the brain Michael Schwartz Professor Metabolism, Endocrinology and Nutrition UWSOM, Clincal Nutrition, Harborview Thursday, May 3, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments 3:45 p.m. The role of P2X7 and activated caspases in the regulation of macrophage fusion Thomas Nhan PhD Candidate Pathology UW School of Medicine Tuesday, May 1, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Matrilysin (MMP-7) function in acute and chronic lung injury John K. McGuire, MD Pediatric Critical Care Medicine Children's Hospital & Regional Medical Center UW School of Medicine Thursday, April 26, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Mechanisms Underlying the Influence of Androgens on Prostate Carcinogenesis Peter S. Nelson Associate Professor Medicine, Oncology Fred Hutchinson Cancer Research Center Thursday, April 19, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments 3:45 p.m. Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction Daniel J. Morgan Senior Fellow Pharmacology UWSOM Tuesday, April 17, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Steve Schwartz TBA Ray Monnat, M.D. Professor Department of Pathology University of Washington Tuesday, April 10, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad Joseph McGonigle Research Assistant Bioengineering UWSOM Tuesday, April 10, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Cecilia Giachelli 815 Mercer Street Saving the World from the Next Pandemic: Can Functional Genomics and Computational Biology Save Us? Michael G. Katze, PhD Professor of Microbiology Core Staff Scientist and Associate Director Washington NPRC Thursday, April 5, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street Refreshments 4:45 p.m. Understanding macrophage foam cell formation using a proteomics-based approach Lev Becker Senior Fellow Medicine, Division of Metabolism, Endocrinology and Nutrition UWSOM Tuesday, April 3, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Jay Heinecke 815 Mercer Street DNA Processing in Autoimmune Disease Fred Perrino, Ph.D. Professor Department of Biochemistry Wake Forest University Health Sciences Monday, April 2, 2007 - 11:30 AM Health Sciences Center, K-069 Faculty Sponsor: Larry Loeb and Brad Preston Immunomodulation of breast cancer? Nora Disis, MD Professor Medicine UWSOM, Member Fred Hutchinson Cancer Research Center Thursday, March 29, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Probing chromatin dynamics Karol Bomsztyk Professor Medicine UWSOM Tuesday, March 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Repair of oxidative DNA damage and human disease Dr. Will Bohr NIA Wednesday, March 21, 2007 - 4:30 PM Health Sciences Building, K-069 Faculty Sponsor: Dr. Monnat This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP). Angiotensin II-induced vascular pathologies - a multitude of mechanisms Alan Daugherty Professor Cardiovascular Medicine University of Kentucky Tuesday, March 20, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Mike Rosenfeld 815 Mercer Street Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: Systemic Sclerosis Richard A Nash, MD Associate Professor Medicine, Division of Oncology Fred Hutchinson Cancer Research Center Thursday, March 15, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies Steven A. Moore, M.D., Ph.D. Co-Director Wellstone Muscular Dystrophy Research Center University of Iowa Wednesday, March 14, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Hevner Sponsored by PathPresents. My Adventures in Biomed Research: How You Can Help Us Move Beyond Gleason Grade Larry True, M.D. Professor Department of Pathology University of Washington Tuesday, March 13, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine A ROCK and Role for Syndecans in Cytoskeletal Regulation John R. Couchman Professor National Heart & Lung Institute Imperial College, London Tuesday, March 13, 2007 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Bill Parks 815 Mercer Street Chemical Genetics and Translational Research in Skin Cancer Paul Nghiem, MD PhD Asst. Professor, UW Dermatology/Medicine Affiliate Investigator Fred Hutchinson Cancer Research Center Thursday, March 8, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz * Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer. Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries? Jo Fleming Scleroderma Research Fellow Pathology UWSOM Tuesday, March 6, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street RESCHEDULED! Understanding HSV-2 Reactivations: New Observations, New Surprises Lawrence Corey, MD Professor, Laboratory Medicine Adjunct Professor, Pediatrics Fred Hutchinson Cancer Research Center Thursday, March 1, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation Jonathan Golob Graduate Student Pathology UWSOM Tuesday, February 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street The Regulation of Long-term Repopulating Hematopoietic Stem Cells (LTR-HSC) by Endogenous Transforming Growth Factor Beta (TGF-beta) Stephen Bartelmez PhD BetaStem Therapeutics Inc, San Francisco Thursday, February 22, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Pathological Protein in Neurodegenerative Diseases Tom Montine, M.D., Ph.D. Professor, Director of Neuropathology Department of Pathology University of Washington Tuesday, February 13, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Adult Stem Cells: Epigenetics, pluripotency and plasticity Morayma Reyes Assistant Professor Pathology and Laboratory Medicine UWSOM Tuesday, February 13, 2007 - 8:30 AM SLU, Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Immunoexpression of Hypoxia-related Genes in Retroperitoneal Sarcomas Paul Zhang, M.D. Associate Professor Pathology and Lab Medicine University of Pennsylvania School of Medicine Monday, February 12, 2007 - 1:00 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Larry True Speaker is a candidate for a clinical faculty position with the Department of Pathology A Trojan Horse Nips at an Achilles Heel: Gallium as an Anti-infective Therapy Pradeep Singh MD Associate Professor Medicine and Microbiology, Pulmonary and Critical Care Medicine UW School of Medicine Thursday, February 8, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments: 3:45 p.m. Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies. Jason D. Morrow F. Tremaine Billings Professor of Medicine and Pharmacology Chief, Division of Clinical Pharmacology Vanderbilt University School of Medicine Wednesday, February 7, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Thomas Montine Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis Ranjini M. Krishnan Fellow Cardiology UWSOM Tuesday, February 6, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: David Dichek Subtelomere Dynamics: Why So Many Breaks? Katie Rudd, Ph.D. Postdoctoral Fellow Fred Hutchinson Cancer Research Center Wednesday, January 31, 2007 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Christine Disteche Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology Monocytes, Dendritic Cells, and Atherosclerosis Gwen Randollph Associate Professor Gene & Cell Medicine Mt. Sinai School of Medicine Tuesday, January 30, 2007 - 10:00 AM Health Sciences, K-069 Faculty Sponsor: Elaine Raines/Stephen Schwartz Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project Genome of Weird Australian Mammals Jenny Graves, Ph.D. Professor Comparative Genomics Australian National University Monday, January 29, 2007 - 4:30 PM Genome Sciences Building, Foege Auditorium Faculty Sponsor: Christine Disteche Gene Action in the Pathobiology of Aging George M. Martin Director Emeritus, Alzheimer’s Disease Research Center (ADRC) Professor Emeritus (Active), Department of Pathology UW School of Medicine Thursday, January 25, 2007 - 4:00 PM Brotman Building (SLU), Blue Flame Auditorium 815 Mercer Street Magnetic Resonance Imaging of Atherosclerosis Hunter R. Underhill Fellow Vascular Imaging Lab UWSOM Tuesday, January 23, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Caspase regulation of macrophage functions Thomas Q. Nhan PhD Candidate Pathology UWSOM Tuesday, January 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street How Autopsies Have Expedited Research on Human Progeroid Syndromes, With Comments on the Viability and Cryopreservation of Postmortem Tissues George Martin, M.D. Professor Department of Pathology University of Washington Tuesday, January 9, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Tissue voxelation with a high-speed transverse microtome John Welsh, PhD Associate Professor Molecular and Cancer Biology Program Sidney Kimmel Cancer Center, San Diego, California Tuesday, January 9, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Marshall Horwitz 815 Mercer Street Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease Hangjun Duan Senior Fellow Pathology UWSOM Tuesday, December 19, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Neurogenesis and Malformations of Cortical Development Robert Hevner, M.D., Ph.D. Associate Professor Department of Pathology University of Washington Tuesday, December 12, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine BTNL2, a novel B7 family member and regulator of T cell activation Heather Arnett Scientist Amgen, Inc. Tuesday, December 5, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street The Ins and Outs of Bcl-2 in Cell Death John M. Harlan, MD Chief Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology University of Washington Tuesday, November 21, 2006 - 8:30 AM Health Sciences Building, K-069 Update of Cervical Cancer Control Nancy Kiviat MD Professor, Chief of HMC Pathology Pathology UWSOM, Harborview Thursday, November 16, 2006 - 4:00 PM Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Updates on Cervical Cytology Nancy Kiviat, M.D. Professor, Chief of HMC Pathology Department of Pathology University of Washington Tuesday, November 14, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine TSLP and Th2-mediated inflammation Steven F. Ziegler, PhD Director Immunology Program Benaroya Research Institute Tuesday, November 14, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Towards Targeted Therapy in Sarcoma: Somatostatin Type-2 Receptor Expression in Bone and Soft Tissue Tumors William Ahrens Senior Fellow Surgical Pathology - Bone and Soft Tissue Mayo Clinic Tuesday, November 7, 2006 - 11:00 AM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology Differentiation of Endothelium from Human Embryonic Stem Cells Marilyn Nourse PhD Candidate Pathology UWSOM Tuesday, November 7, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice Fredrik Johansson Postdoctoral Fellow Pathology UWSOM Tuesday, October 31, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Karin Bornfeldt Calcium Sparklets in Vascular Smooth Muscle Manuel F. Navedo Senior Fellow Physiology and Biophysics UWSOM Tuesday, October 24, 2006 - 8:30 AM Health Sciences Building, K-069 Mutation avoidance, disease, and error catastrophy: The great escape Bradley D. Preston Professor Pathology UWSOM Thursday, October 19, 2006 - 3:45 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Cancelled will reschedule for spring David Lovett - postponed Professor in Residence Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital University of California, San Francisco Tuesday, October 17, 2006 - 8:30 AM TBA, TBA Hepatitis C Associated Cryoglobulinemia and Glomerulonephritis: A Tale of Mice and Men Charles Alpers, M.D. Professor Department of Pathology University of Washington Tuesday, October 10, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine PSGL-1 Adherence and mTOR Modulate Translation in Macrophages Richard Fox PhD Candidate Pathology UW School of Medicine Tuesday, October 10, 2006 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street cFLIP Regulates Fas-induced Apoptosis and Pro-inflammatory Gene Expression in Human Vascular Smooth Muscle Cells Monja Dishmon Pathology UW School of Medicine Thursday, October 5, 2006 - 1:00 PM 815 Mercer Bldg, Room 111 Faculty Sponsor: Bowen-Pope An unexpected role for the tissue factor pathway in atherosclerosis Robert D. Simari Professor Cardiovascular Diseases Mayo Clinic Tuesday, October 3, 2006 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Of mice and mice; why some do and some don't develop arterial lesions Michael A Reidy PhD Professor Pathology UWSOM Tuesday, September 26, 2006 - 8:30 AM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Interventional imaging of vascular gene delivery and expression Xiaoming Yang, MD, PhD Professor, Director, Image-Guided Bio-Molecular Interventions Research Radiology University of Washington School of Medicine Thursday, September 21, 2006 - 4:00 PM Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz Thyroid Dysfunction in Heart Failure A. Martin Gerdes Professor, Medicine and Director South Dakota Cardiovascular Research Institute, Sioux Falls University of South Dakota Thursday, September 14, 2006 - 8:30 AM Brotman Building, 815 Mercer Street, Room 111, Auditorium Faculty Sponsor: Chuck Murry Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able. Arterial Rupture--Pathology and Genetics Peter Byers, M.D. Professor Department of Pathology University of Washington Tuesday, September 12, 2006 - 8:00 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Electrophysiological Cortical Imaging of Brain Electrical Activity Yuan Lai, PhD Fellow Candidate Electrical Engineering University of Illinois, Chicago Thursday, August 31, 2006 - 1:30 PM Brotman Building (SLU), 110 Faculty Sponsor: Chun Yuan 815 Mercer Street Vascular Imaging Labororatory Seminar Mechanism of Endocytosis of CD33/Siglec-3:Role of ITIMs, Tyrosine Phosphorylation, and Monoubiquitylation Roland Walter Pathology UWSOM Wednesday, August 9, 2006 - 4:30 PM Fred Hutchinson Cancer Research Center, Pelton Auditorium Faculty Sponsor: Dr. Steve Collins Toxicogenomics of Endemic Nephropathy: A Multinational Disease Arthur Grollman, M.D. Distinguished Professor of Pharmacological Sciences and Medicine State University of New York at Stony Brook Wednesday, August 2, 2006 - 3:30 PM Health Sciencs Center, K-069 Faculty Sponsor: Dr. Larry Loeb “Functional genomics and liver regeneration” Jiangning Li Doctoral Dissertation Pathology Medicine Tuesday, August 1, 2006 - 8:30 AM HSB, T-473 Faculty Sponsor: Dr. Bumgarner Role of CHF1/Hey2 in Cardiovascular Development Michael T. Chin, MD/Phd Assistant Professor Medicine Harvard Medical School Thursday, July 27, 2006 - 4:15 AM SLU 815 Mercer Street, 111, Auditorium SLUGs Present Tapas The rupture-prone human plaque: how to define and detect it Erling Falk Professor Department of Cardiology Skejby University Hospital, Aarhus, Denmark Tuesday, June 27, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Steve Schwartz Protection of cardiovascular stem cells by cholesterol-lowering therapy Yong-Jian Geng, MD PhD Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research Dept. of Internal Medicine, Cardiology Division University of Texas School of Medicine, Houston, TX Tuesday, June 20, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Chuck Murry Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma Laura Beretta Associate Member, FHCRC, Affiliate Associate Professor, UW Pathology UW - Pathology Wednesday, June 7, 2006 - 4:00 AM HSB, K-069 "X Chromosome Upregulation and its Biological Significance in Mammals" Di Kim Nguyen Doctoral Dissertation Pathology UWSOM Wednesday, May 31, 2006 - 10:30 AM HSB, T-435 Faculty Sponsor: Christine Disteche Distinct Wnt signaling pathways play opposing roles during organ regeneration Cristi Stoick-Cooper CVP Graduate Student Neurobiology & Behavior UWSOM Tuesday, May 30, 2006 - 8:30 AM HSB, K-069 Therapeutic use of the endogenous metalloprotease inhibitor TIMP-3 Roy A. Black, Ph.D. Associate Director of Research Department of Inflammation Amgen Inc. Thursday, May 25, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease Daniel J Morgan Senior Fellow Pharmacology UWSOM Tuesday, May 23, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Stephen M Schwartz Matrix Revisited Thomas N. Wight, Ph.D. Benaroya Research Institute Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology School of Medicine Thursday, May 18, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks “Global analysis of X chromosome dosage compensation" Brian Oliver Section Chief of Developmental Genomics National Institutes of Health, Bethesda, MD Wednesday, May 10, 2006 - 4:30 PM HSB, K-069 Faculty Sponsor: Christine Disteche Cardiac applications for human embryonic stem cells Michael Laflamme Acting Instructor Pathology Center for Cardiovascular Biology & Regenerative Medicine, UWSOM Tuesday, May 2, 2006 - 8:30 AM SLU 815 Mercer St, 111 Faculty Sponsor: Chuck Murry Wnt Signaling in Regeneration and Regenerative Medicine Randall T. Moon, Ph.D. Professor and Director, Institute for Stem Cell and Regenerative Medicine Department of Pharmacology School of Medicine Thursday, April 27, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: BIll Parks Neurovascular Dementia: How Abnormalities of Cerebral Blood Vessels and Brain Parenchyma Compete Harry Vinters, M.D. Professor and Chief, Neuropathology Departments of Pathology and Laboratory Medicine University of California, Los Angeles Wednesday, April 26, 2006 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tom Montine **NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology" Keith Cheng Jake Gittlen Cancer Research Foundation Penn State College of Medicine Wednesday, April 26, 2006 - 1:30 PM HSB, K-069 Faculty Sponsor: Dr. Loeb Inflammation loci and carotid artery disease Gail Jarvik MD Professor Medicine, Medical Genetics UWSOM Tuesday, April 25, 2006 - 8:30 AM SLU 815 Mercer, 111 Auditorium Faculty Sponsor: Stephen M Schwartz Proteomic Analysis of the Cardiac Calcium Channel Michelle Emrick PhD Senior Fellow Pharmacology UWSOM Tuesday, April 18, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz The role of estrogens in maintaining brain function after injury: Views of a basic scientist and provost Phyllis M. Wise, Ph.D. Provost and Vice President for Academic Affairs University of Washington Friday, April 14, 2006 - 12:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Chuck Murry Diabetic Macrovascular Disease in Mice: What the &#@*'s going on? Renee C. LeBoeuf, Ph.D. Research Professor of Medicine Division of Metabolism, Endocrinology and Nutrition School of Medicine Thursday, April 13, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks The Role of Pattern Recognition Receptors in Macrophage Death Ira Tabas, MD/PhD Professor, Medicine and Anatomy & Cell Biology Deputy Editor - Journal of Clinical Investigation Columbia University Tuesday, April 11, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Michael Rosenfeld Defining a Functional Role for Discoidin Domain Receptors in Vascular Biology Michelle Bendeck, Ph.D. Associate Professor Department of Laboratory Medicine and Pathobiology University of Toronto Friday, April 7, 2006 - 10:00 AM 815 Mercer, Blue Flame Auditorium Faculty Sponsor: Michael Reidy Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology? Adam S. Wilkins Editor, BioEssays Company of Biologists, Ltd. Cambridge, UK Tuesday, April 4, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Karol Bomsztyk A Systems Approach to Dissecting Immunity Alan Aderem, Ph.D. Institute for Systems Biology, and Affiliate Professor UW Department of Immunology Institute for Systems Biology Thursday, March 30, 2006 - 4:00 AM 815 Mercer St., SLU, Blue Flame Auditorium Faculty Sponsor: Bill Parks "Effects of Regulated Expression of Hepatitis C Virus Proteins on HH4 Human Hepatocytes" Weiliang Tang Pathology University of Washington Tuesday, March 28, 2006 - 1:30 PM HSB, K-069 Faculty Sponsor: Dr. Fausto Regulatory T cells, TGF-beta and atherosclerosis Goran K. Hansson Professor Cardiovascular Research, Molecular Medicine Karolinska Institutet, Stockhom, Sweden Tuesday, March 28, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Structure Biology of Ubiquitin Ligase Machinery Ning Zheng Assistant Professor Pharmacology UWSOM Tuesday, March 21, 2006 - 8:30 AM Health Sciences Building, K-069 Atheroprotective Effects of Transforming Growth Factor Beta-1 Andrew D. Frutkin, MD Acting Instructor/Senior Fellow Cardiology Division UWSOM Tuesday, March 14, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: David Dichek Please note change of venue Mechanism of the Cerebral Cortex Malformation Caused by FGFR3 Mutations Tomoko Iwata, Ph.D. Beatson Laboratories for Cancer Research University of Glasgow Scotland, UK Friday, March 10, 2006 - 9:30 AM Harborview Medical Center, R&T Building, Room 109 Faculty Sponsor: Robert Hevner Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning. The lecture is free and open to the public. Cell Therapy for Cardiac Arrhythmias and Myocardial Regeneration Lior Gepstein, M.D., Ph.D. Associate Professor, Faculty of Medicine Department of Physiology and Biophysics Technion-Israel Institute of Technology Thursday, March 9, 2006 - 4:00 AM 815 Mercer Street, SLU, Blue Flame Auditorium Faculty Sponsor: Chuck Murry The CD4+ autoreactive T cell: chance or necessity? Gerald T. Nepom, MD/PhD Director Benaroya Research Institute at Virginia Mason Tuesday, March 7, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Distinguished Faculty Lecture "Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice" Michael Rosenfeld, Ph.D. Professor Department of Pathobiology University of Washington Thursday, March 2, 2006 - 3:30 PM Health Sciences Center, Room T-625 Faculty Sponsor: Terrance Kavanagh For more information, please contact Billie Grace at 206.543.1144 C-reactive protein and cardiovascular risk: a population genomics approach Alex Reiner, MD MSc Research Associate Professor Epidemioloy & Laboratory Medicine UWSOM Tuesday, February 28, 2006 - 8:30 AM SLU 815 Mercer, 111 Faculty Sponsor: Stephen M. Schwartz VEGF: From Bench to Bedside Napoleone Ferrara Genentech Fellow Molecular Oncology Genentech, Inc Wednesday, February 22, 2006 - 4:00 PM Health Sciences Center, Room T-739 Faculty Sponsor: Stephen Schwartz Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer. The lecture is free and open to the public. Clinical Genetics and Genomics of Type I Collagen Peter Byers, MD Professor Pathology & Medicine UWSOM Tuesday, February 21, 2006 - 8:30 AM Health Sciences, K-069 Wnt pathways can control cardiogenesis in mouse embryonic stem cells Shuichi Ueno, MD/PhD Senior Fellow Pathology UWSOM Tuesday, February 14, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Chuck Murry ABC cholesterol transporters as rescuers from cardiovascular disease John F. Oram Research Professor Medicine UWSOM Thursday, February 9, 2006 - 4:00 PM SLU 815 Mercer Street, 111 South Lake Union Seminar Series The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions Alain Mauviel, PhD Director INSERM U697 Hospital Saint-Louis, Paris, France Tuesday, February 7, 2006 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Bill Parks HnRNP K: Gene expression, hubs and scale-free networks Karol Bomsztyk Professor Medicine UWSOM Tuesday, January 31, 2006 - 8:30 AM Health Sciences Building, K-069 Molecular Basis of Information Daniel Storm Professor Pharmacology UWSOM Tuesday, January 24, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz Metalloproteinases: Effectors of Repair or Conspirators of Disease? William Parks Director Center for Lung Biology UWSOM Thursday, January 19, 2006 - 4:00 AM SLU South Lake Union, 111 (Auditorium) Faculty Sponsor: Stephen M. Schwartz Special Tapas. Refreshments 3:45 p.m. Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons Jennifer O'Brien Senior Fellow Pharmacology UWSOM Tuesday, January 17, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M. Schwartz Regulation of Nitric Oxide Synthase by Shear Stress David G. Harrison MD Professor, Medicine Director, Division of Cardiology Emory University School of Medicine Tuesday, January 10, 2006 - 8:30 AM South Lake Union (SLU), 111 Faculty Sponsor: Stephen M. Schwartz Current Diagnosis of Ovarian Mucinous Tumors Hongxiu Ji, M.D., Ph.D. Assistant Professor Departments of Pathology and Obstetrics/Gynecology The Johns Hopkins University School of Medicine Tuesday, January 10, 2006 - 8:00 AM UWMC, NE-110 Conference Room The special seminar will be presented as part of a didactic session with the residents. Apoptosis and Macrophage Inflammation Keith Elkon, MD Prof. of Medicine & Adjunct Prof. Immunology Head, Division of Rheumatology UWSOM Tuesday, December 20, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Vaccines Targeting Breast and Ovarian Cancers Nora Disis MD Associate Professor Department of Medicine, Division of Oncology UWSOM Thursday, December 15, 2005 - 4:00 PM SLU 815 Mercer Street, 111 Special Tapas Seminar Assaying Methylation Markers using Coded Silica Particles Simon Corrie Visiting Fellow Pathology University of Queensland, Australia Thursday, December 15, 2005 - 9:30 AM SLU, 815 Mercer Street, 111 Faculty Sponsor: Nancy Kiviat SLUG Seminar: A Progress Report Mechanisms of Arterial Constriction due to Urokinase Overexpression Philip Massey, MD Acting Instructor Medicine/Cardiology UWSOM Tuesday, December 13, 2005 - 8:30 AM Health Sciences Building, K-069 "Keeping the Balence: Dosage Compensation of the Active X Chromosome in Mammals" Christine Disteche Professor Department of Pathology University of Washington Friday, December 9, 2005 - 12:30 PM Health Sciences Center, Room K-069 Division of Medical Genetics presents the Markey Molecular Medicine Seminar Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin Samantha Harris, PhD Research Assistant Professor Bioengineering UWSOM Tuesday, December 6, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Epigenetic Change in the Differentiating Embryonic Stem Cell Jonathan Golob PhD Fellow Department of Pathology UWSOM Thursday, December 1, 2005 - 4:15 PM South Lake Union, 111 Tapas Seminar Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS) Conrad Liles Associate Professor Medicine, Infectious Diseases UWSOM Tuesday, November 29, 2005 - 8:30 AM SLU 815 Mercer Street, 111 What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice? Karin Bornfeldt PhD Associate Professor Pathology UWSOM Tuesday, November 22, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Developmental Genome Anatomy Project (DGAP): Identification of Genes Critical to Human Development Azra H. Ligon, Ph.D. Assistant Professor Department of Pathology Harvard Medical School Thursday, November 17, 2005 - 12:00 PM Health Sciences Center, Room T-639 Faculty Sponsor: Christine Disteche Transcription Factor Regulation of Glial Progenitor Development and Gliomas Keith L. Ligon, M.D., Ph.D. Staff Pathologist and Associate Neuropathologist Department of Pathology Brigham and Women's Hospital Wednesday, November 16, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Vascular Calcification: role of smooth muscle cells and phosphate Cecilia Giachelli PhD Professor Bioengineering UWSOM Tuesday, November 15, 2005 - 8:30 AM Health Sciences Building, K-069 N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems Yong Tae Kwon Assistant Professor Pharmaceutical Sciences University of Pittsburgh Thursday, November 10, 2005 - 8:30 AM Health Sciences Building, T-635 Faculty Sponsor: Stephen M. Schwartz Special Breakfast Club Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control Richard Fox PhD Candidate Pathology, Cardiovascular Biology UWSOM Tuesday, November 8, 2005 - 8:30 AM Health Sciences Bldg., K-069 Faculty Sponsor: Stephen M Schwartz A Genome-wide Hunt for Public Mechanisms of Aging Matt Kaeberlein, Ph.D. Senior Fellow Department of Genome Sciences University of Washington Wednesday, November 2, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs Charles Frevert, DVM, ScD Research Associate Professor Medicine/Pulmonary & Critical Care Medicine VA Medical Center/UWSOM Tuesday, November 1, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Bill Parks FISHing for Answers in Pediatric Gliomas Christine Fuller, M.D. Assistant Member Department of Pathology St. Jude Children's Research Hospital Wednesday, October 26, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Role of PAI-1 in Progressive Renal Disease Allison Eddy, MD Professor & Head Division of Pediatric Nephrology Children's Hospital & Med Center, UWSOM Tuesday, October 25, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz "Stromal" Tumors of the Prostate Donna Hansel, M.D., Ph.D. Resident Department of Pathology Johns Hopkins Hospital Friday, October 21, 2005 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Larry True Dr. Hansel is being considered for a faculty position in the Department of Pathology Roundtable Discussion: Pathologic implications of vascular developmental biology Brant Weinstein Senior Investigator and Head of Section of Vertebrate Organogenesis Laboratory of Molecular Genetics NIH National Institute of Child Health & Human Development (NICHD) Tuesday, October 18, 2005 - 9:30 AM Health Sciences Building, E-212 Faculty Sponsor: Elaine Raines/Steve Schwartz Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments. Assembly of the Developing Vasculature Brant M. Weinstein, Ph.D. Senior Investigator and Head of Section of Vertebrate Organogenesis Laboratory of Molecular Genetics, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD Monday, October 17, 2005 - 3:00 PM Health Sciences Center, Room D-209 Faculty Sponsor: Elaine Raines Regulation of GPCR Function by RGS Chris Hague Assistant Professor Pharmacology UWSOM Tuesday, October 11, 2005 - 8:30 AM SLU 815 Mercer Street, Auditorium, Rm. 111 Faculty Sponsor: Stephen M. Schwartz Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits Eric Schadt, PhD Senior Scientific Director Research Genetics Rosetta Inpharmatics, Inc., Seattle, WA Tuesday, October 4, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Lifestyle modifications improve vascular dysfunction in a mouse model of Type II Diabetes Dr. Ismail "Issy" Laher Associate Professor Pharmacology & Therapeutics University of British Columbia Friday, September 23, 2005 - 1:00 PM HSB, T-359 Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information. Translation control in activated endothelial cells Larry W. Kraiss MD Assistant Professor & Chief Division of Vascular Surgery University of Utah Tuesday, September 13, 2005 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Richard Kenagy "Anchoring Molecular Lifelines: Integrin Mediated Survival Signals" Julie Rice Graduate Student Pathology University of Washington Thursday, August 18, 2005 - 11:00 AM Chem, 102 Faculty Sponsor: Giachelli Doctoral Dissertation Oncolytic adenoviruses: Progress and Challenges Andre Lieber, MD PhD Research Associate Professor Medical Genetics UWSOM Thursday, August 4, 2005 - 4:00 PM South Lake Union, 815 Mercer St., 111 Auditorium Faculty Sponsor: Stephen M. Schwartz Special Tapas Presentation Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD) Xia (Clare) Shen PhD Postdoc Candidate Pharmacology & Toxicology University of Louisville Tuesday, July 26, 2005 - 8:30 AM HSB, K-069 Faculty Sponsor: Karin Bornfeldt Special Breakfast Club Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium? Chris Sullivan Postdoctoral Fellow Urology UWSOM Tuesday, July 19, 2005 - 9:00 AM South Lake Union, 111 Faculty Sponsor: Hunter Wessells Arrhythmogenic Right Ventricular Cardiomyopathy: From Anatomical Theatre to Double Helix Gaetano Thiene, M.D., FRCP Professor, Cardiovascular Patholology Director, Institute of Pathological Anatomy University of Padua Medical School Thursday, June 16, 2005 - 3:30 PM Health Sciences Center, Room T-435 Faculty Sponsor: Chuck Murry The role of wnt signaling in zebrafish heart development and regeneration Cristi Stoick Graduate Student Neurobiology & Behavior UWSOM Tuesday, June 14, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Potassium Channel Regulation in Cerebral Arterial Smooth Muscle Gregory Amberg Senior Fellow Physiology & Biophysics UWSOM Tuesday, June 7, 2005 - 8:30 AM Health Sciences Building, K-069 Physiological and Genomic Consequences of Mitochondrial Oxidative Stress Simon Melov Buck Institute Tuesday, May 31, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Aldosterone and cardiovascular disease: past, present and future Bardia Askari Acting Instructor Pathology UWSOM Tuesday, May 31, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Searching for Conserved Mechanisms of Eukaryotic Aging Brian Kennedy University of Washington Tuesday, May 24, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle Kenneth Marro Research Assistant Professor Radiology UWSOM Tuesday, May 24, 2005 - 9:00 AM South Lake Union, 100 Faculty Sponsor: Chun Yuan Please note change of venue to 815 Mercer Street. Role of Renal Biopsy in Renal Transplantion Robert Colvin, M.D. Castleman Professor & Chair Department of Pathology Massachusetts General Hospital Monday, May 23, 2005 - 2:00 PM UWMC, Anatomic Pathology Conference Room, NE-110K Faculty Sponsor: Charles Alpers Intraepithelial Neoplasia in the Pancrea David Klimstra Director, Oncologic Pathology Fellowship Programs Department of Pathology Memorial Sloan-Kettering Cancer Center Thursday, May 19, 2005 - 4:00 PM Health Sciences Center, Room T-747 Faculty Sponsor: Brian Rubin New Insights on Mechanisms of Calorie Restriction Rafael DeCabo Laboratory of Experimental Gerontology NIA Tuesday, May 10, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor Marilyn Nourse Graduate Student Bioengineering UWSOM Tuesday, May 10, 2005 - 8:30 AM Health Sciences Building, K-069 Tough mice and aging: How to survive with a damaged proteome" Steve Clarke Professor Department of Chemistry and Biochemistry UCLA Wednesday, May 4, 2005 - 4:30 PM health science bldg, K-069 Faculty Sponsor: George Martin New Roles for Uncoupling Proteins in Protection Against Mitochondrial Radical Production and Aging Martin Brand MRC Dunn Human Nutrition Unit, Cambridge, UK Tuesday, May 3, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies Robert Welikson Senior Research Fellow Biochemistry UWSOM Tuesday, May 3, 2005 - 8:30 AM SLU 815 Mercer Street, 100 Faculty Sponsor: Stephen Schwartz Please note change of venue. "Grial Cell Regulated, Apolipoprotein E Isoform-Specific Mechanism of Neuroprotection and Neurodegeneration" Izumi Maezawa Doctoral Dissertation Medicine Pathology Monday, May 2, 2005 - 1:00 PM Health Sciences Center, T-639 Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde? Catherine Clarke Professor Dept Chemistry and Biochemistry UCLA Wednesday, April 27, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Tony Parks Age-Related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age Ahmad Heydari Wayne State University Tuesday, April 26, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Uncovering the role of receptor trafficking in disease Matthew Holdren Graduate Student Pathology UWSOM Tuesday, April 26, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tony Parks The Role of Protein Tyrosine Phosphatase Receptor Q in Development of Disease Carmen Jane Booth, D.V.M. Doctoral Dissertation Pathology University of Washington Friday, April 22, 2005 - 10:00 AM 815 Mercer Building, Room 111 Faculty Sponsor: Dan Bowen-Pope Does Oxidative Stress Play an Important Role in Determining Lifespan Holly Van Remmen University of Texas, San Antonio Tuesday, April 19, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Can bacteria cause blood vessels to calcify? Michael Rosenfeld Professor Pathobiology and Pathology UWSOM Tuesday, April 19, 2005 - 8:30 AM Health Sciences Building, K-069 The Role of GH and IGF-1 in Extension of Lifespan and Resistance to Toxic Challenges in Mice Andrzej Bartke Southern Illinois University Tuesday, April 12, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Exploring the immunomodulatory action of mechanical ventilation William A. Altemeier Assistant Professor Pulmonary & Critical Care Medicine UWSOM Tuesday, April 12, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Conrad Liles Please note change of venue. Modeling Neurodegeneration in Yeast Susan Lindquist, Ph.D. Member, Whtitehead Institute for Biomedical Research Professor, Department of Biology Massachusetts Institutute of Technology Wednesday, April 6, 2005 - 4:00 PM Health Sciences Center, Hogness Auditorium Faculty Sponsor: Nelson Fausto Why do Big Mice Die Young? Size, Stress, and the Cell Biology of Aging Rich Miller University of Michigan Tuesday, April 5, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center FDR, April 12, 1945 Karol Bomsztyk Professor Medicine, Allergy and Infectious Disease UWSOM, South Lake Union Tuesday, April 5, 2005 - 8:30 AM Health Sciences Building, K-069 PKA Mutations in Mice Affect Metabolism and Adiposity Stanley McKnight University of Washington Tuesday, March 29, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Integrin Signaling: Grasping the survival mechanisms Donald Courter PhD Candidate Bioengineering University of Washington Tuesday, March 29, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Hedgehog signaling in angiogenesis Ronald Heimark PhD Associate Professor Surgery, Cell Biology & Anatomy, and Pathology Arizona Health Sciences Center Tuesday, March 22, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Stephen M. Schwartz Please note change of venue. Vascular malformations and guidance Dean Li Faculty Candidate Medicine, Division of Cardiology University of Utah Tuesday, March 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Research Training Seminar Narci Teoh Department of Pathology Thursday, March 10, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Fausto Pathology 511 Seminar "The liver as a model system for cell growth, proliferation, and carcinogenesis" Jeffrey Albrecht Associate Professor Medicine University of Minnesota Wednesday, March 9, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Tony Parks Recombomice" Shed Light on Homologous Recombination in Mammals Bevin Engelward, Sc.D. Associate Professor of Molecular Toxicology Biological Engineering Division MIT Wednesday, March 2, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Ray Monnat Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix Robert Mecham Alumni Endowed Professor Cell Biology and Physiology Medicine, Pediatrics and Bioengineering Washington University, St. Louis MO Tuesday, March 1, 2005 - 9:00 AM South Lake Union, 815 Mercer Street, 110 Faculty Sponsor: Bill Parks Please note change of location. Research Training Seminar Izumi Maezawa Department of Pathology Thursday, February 24, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Montine Pathology 511 Seminar Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble Anne M. Stevens Acting Assistant Professor Pediatrics, Division of Immunology/Rheumatology Children's Hospital and Regional Medical Center Tuesday, February 22, 2005 - 8:30 AM Health Sciences Building, K-069 "DNA Repair: Winning the Race with Replication" Dr. John Heddle Professor Emeritus & Senior Scholar Department of Biology York University, Toronto, Canada Wednesday, February 16, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Dr. Loeb ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage Richard Fox Graduate Student Pathology University of Washington Tuesday, February 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Research Training Seminar Rich Fox Department of Pathology Thursday, February 10, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Schwartz Pathology 511 Seminar Hepsins: Lethal giant larvae Valeri Vasioukhin Assistant Member Human Biology Fred Hutchinson Cancer Research Center Tuesday, February 8, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Bill Parks Placental malaria and maternal blood pressure Atis Muehlenbachs Graduate Student, Concurrent Degree Molecular & Cellular Biology UWSOM Tuesday, February 1, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Dan Bowen-Pope Research Training Seminar Galynn Zitnik Department of Pathology Thursday, January 27, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Martin Pathology 511 Seminar The Role of PI-3 Kinase in Cardioprotection Charles Steenbergen, MD PhD Faculty Candidate Pathology Duke University, Durham, NC Tuesday, January 25, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Chuck Murry "Females Have Reduced Cardiac Ischemia-Reperfusion Injury and Hypertrophy: A Role for Estrogen Receptor Beta and Nitric Oxide" Elizabeth Murphy, Ph.D. Faculty Candidate Cell Biology Group, Lab of Signal Transduction Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC Monday, January 24, 2005 - 4:00 PM HSB Turner Autitorium, Room D-209 Inhibitors of Adipogenesis, Stress and Lipotoxicity: Enough to Drive Aging Preadipocytes Mad? James Kirkland, M.D., Ph.D. Associate Professor Department of Medicine Boston University School of Medicine Tuesday, January 18, 2005 - 9:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant Metalloproteinases: Effectors of Innate Immunity William C. Parks Professor Pulmonary & Critical Care Medicine UWSOM, Harborview Tuesday, January 18, 2005 - 8:30 AM Health Sciences Building, K-069 Research Training Seminar Ashwini Kamath-Loeb Department of Pathology Thursday, January 13, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Loeb Pathology 511 Seminar Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination Dr Yannick Saintigny Wednesday, January 12, 2005 - 4:30 PM Health Sciences Center, T-747 Faculty Sponsor: Dr. Ray Monnat Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy Tom Doetschman Professor of Molecular Genetics Biochemistry & Micorbiology University of Cincinnati College of Medicine Tuesday, January 11, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek/Stephen M. Schwartz "Genome Maintenance, Telomeres and RecQ Helicases" Dr. Judith Campisi Professor Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging University of California, Berkeley Wednesday, January 5, 2005 - 3:00 PM HSB, K-069 Faculty Sponsor: Dr. Rabinovitch Angiogenesis in Prostate Cancer Norman M. Greenberg Professor Clinical Research Fred Hutchinson Cancer Research Center Tuesday, December 14, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Chaos out of Order: Splicing and Mosaicism in Genetic Collagen Disorders Peter H. Byers, M.D. Professor, Adjunct Professor of Genome Sciences & Oral Biology Pathology University of Washington Thursday, December 9, 2004 - 12:00 PM HSB, T-625 http://depts.washington.edu/mednews/sim04_05.html Defective DNA Damage Responses and Neurodegeneration and Brain Tumors." Peter McKinnon, Ph.D. Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN Pathology University of Washington Wednesday, December 8, 2004 - 4:30 PM HSB, K-069 Faculty Sponsor: Ray Monnat Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics Tomas Vaisar Research Scientist Metabolism, Endocrinology & Nutrition University of Washington School of Medicine Tuesday, December 7, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Elaine Raines Angiogenesis and Lymphangiogenesis in Inflammation and Tumor Progression Sam Dadras, M.D., Ph.D. candidate for a Pathology Faculty Position Pathology University of Washington Monday, December 6, 2004 - 1:15 PM UWMC, NE-110K Patterning of Cortical Regions and Connections John Rubenstein Nina Ireland Distinguished Professor in Child Psychiatry University of California, San Francisco Wednesday, December 1, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Endothelial Cell Activation and Apoptosis John M. Harlan Professor of Medicine Division of Hematology University of Washington School of Medicine Tuesday, November 30, 2004 - 8:30 AM Health Sciences Building, K-069 Probing the determinants of inter-individual variability in innate immune inflammatory responses Mark Wurfel Acting Instructor Division of Pulmonary and Critical Care Medicine University of Washington Tuesday, November 23, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tom Martin Characterization of Adenovirus Serotype 35 as a Gene Therapy Vector Anuj Gaggar Doctoral Dissertation Pathology Dept of Pathology Thursday, November 18, 2004 - 2:45 PM UWMC, RR-134 The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis Shireen Lamande Departmenet of Pediatrics University of Melbourne, Australia Wednesday, November 17, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Byers Magnetic Resonance Imaging: The Coronary Frontier Won Yong Kim, MD PhD MR-Center & Department of Cardiology Skejby University Hospital, Aarhus Denmark Tuesday, November 16, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Hypoxia and Angiogenesis: Why Do Endothelial Cells Move into Growing Tumors? Randall Johnson Professor Molecular Biology Section, Division of Biological Sciences University of California, San Diego Monday, November 15, 2004 - 8:30 AM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Chuck Murry Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine Pharmacological modulation of medial elastocalcinosis Pierre Moreau, PhD Associate Professor Pharmacology Universit de Montral Tuesday, November 9, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecelia Giachelli Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo Jan E. Schnitzer, MD Professor Cellular & Molecular Biology Scientific Director Sidney Kimmel Cancer Center, San Diego, CA Tuesday, November 2, 2004 - 8:30 AM Health Sciences Building, K-069 Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages Andrew Bender Senior Fellow Pharmacology University of Washington School of Medicine Tuesday, October 26, 2004 - 8:30 AM Health Sciences Building, K-069 The Molecular Architecture of Signal Transduction Complexes John D. Scott Scientist Oregon Health Sciences University Wednesday, October 20, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz LMNA mutations in progeroid syndromes Junko Oshima Research Associate Professor Pathology University of Washington Tuesday, October 19, 2004 - 8:30 AM Health Sciences Building, K-069 Intersections between apoptosis and inflammation Gustave Matute-Bello Assistant Professor Department of Medicine, Division of Pulmonary & Critical Care University of Washington Pulmonary Research Laboratories, VA Puget Sound Health Care System Tuesday, October 12, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Martin Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease Donald McDonald Professor of Anatomy University of California, San Francisco Wednesday, October 6, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis Giulio Gabbiani Professor Departments of Pathology and Immunology University of Geneva-CMU Tuesday, October 5, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz Longevity and Stress-resistance: Mapping the Genes Responsible for Natural Variation in C. Elegans Robert J. Reis Professor Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology University of Arkansas Friday, October 1, 2004 - 11:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch What Are the Roles of Mammalian DNA Damage Binding Protein (DDB) Heterodimer and Its Two Individual Subunits Stuart Linn Professor Department of Biochemistry and Molecular Biology University of California, Berkeley Monday, September 27, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Genetics of Coronary Heart Disease Jan L. Breslow, M.D. Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism Rockefeller University Monday, September 27, 2004 - 10:30 AM Health Sciences Center, T-439 Faculty Sponsor: Elaine Raines Evolving Concepts in Soft Tissue Neoplasia Christopher Fletcher Professor and Director of Surgical Pathology Brigham & Women's Hospital Boston, MA Wednesday, September 22, 2004 - 4:30 PM Health Sciences Center, Room T-733 Faculty Sponsor: Dr. Brian Rubin Seminar Title: TBA Paul DiCorleto Director Lerner Institute Cleveland Clinic Wednesday, July 14, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Dan Bowen-Pope Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics Joseph Metzger Professor Departments of Physiology and Internal Medicine University of Michigan Tuesday, July 13, 2004 - 4:30 PM Health Sciences Center, Room K-069 Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway Kun-Liang Guan Professor Department of Biological Chemistry University of Michigan Monday, July 12, 2004 - 4:30 PM Health Sciences Center, K-069 Hepatocellular Carcinoma: A Translational Research Challenge Jordi Bruix Director Liver Cancer Unit Hospital Clinic, Barcelona, Spain Friday, July 2, 2004 - 9:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Division of Gastroenterology and the Department of Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy Agnos Fogo Professor Department of Pathology Vanderbilt University Thursday, June 17, 2004 - 10:30 AM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Charles Alpers NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction Rick Rossow Senior Fellow Physiology and Biophysics University of Washington Tuesday, June 15, 2004 - 8:30 AM Health Sciences Building, K-069 Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease Mary Wiser-Evans Assistant Professor Departments of Pediatrics and Cell and Developmental Biology University of Colorado Tuesday, June 8, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Michael Reidy Embryonic Stem Cells for Myocardial Infarct Repair Jeannette Nussbaum Graduate Student Department of Pathology University of Washington Tuesday, June 8, 2004 - 9:30 AM Health Sciences Center, Room T-733 The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells Bardia Askari Associate Howard Hughes Medical Institute University of Washington Tuesday, June 8, 2004 - 8:30 AM Health Sciences Building, K-069 Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart Bodo Levkau Professor Institute of Pathophysiology University of Essen Monday, June 7, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Elaine Raines Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics Andras Nagy Professor Department of Molecular and Medical Genetics University of Toronto Wednesday, May 26, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Stephen Schwartz Harnessing Adult Stem Cells for Myocardial Repair Ronglih Liao Associate Professor Department of Medicine Boston University School of Medicine Wednesday, May 26, 2004 - 10:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Mislocalization of Neutrophil Elastase is the Major Cause of Inherited Neutropenia Richard E. Person Doctoral Dissertation Department of Pathology University of Washington School of Medicine Tuesday, May 25, 2004 - 11:30 AM Health Sciences Center, K-069 Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury David Granville University of British Columbia Tuesday, May 25, 2004 - 8:30 AM HSB, K-069 Understanding protein tolerance to random amino acid change through directed evolution Haiwei H. Guo Doctoral Dissertation Department of Pathology University of Washington School of Medicine Friday, May 21, 2004 - 12:15 PM University of Washington Medical Center, RR-134 Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate Timothy Hla Professor of Cell Biology and of Genetics and Developmental Biology Director, Center for Vascular Biology University of Connecticut School of Medicine Thursday, May 20, 2004 - 4:30 PM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Michael Reidy Histone Methyltransferases in Tumor Suppression Shi Huang Associate Professor The Burnham Institute La Jolla, California Wednesday, May 19, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Marshall Horwitz Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development Ujwal Pyati Graduate Student Biochemistry University of Washington Tuesday, May 18, 2004 - 8:30 AM HSB, K-069 Pathway Profiling of Glioblastoma Paul Mischel Assistant Professor Department of Pathology and Laboratory Medicine UCLA School of Medicine Thursday, May 13, 2004 - 4:30 PM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Tom Montine New Entities in Pediatric Renal Neoplasia Pedram Argani Assistant Professor Department of Pathology Johns Hopkins University School of Medicine Wednesday, May 12, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brian Rubin Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart Jeanette Nussbaum Graduate Student Department of Pathology University of Washington Tuesday, May 11, 2004 - 8:30 AM Health Sciences Building, K-069 Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story Stuart Schnitt Professor Department of Pathology Harvard Medical School Wednesday, May 5, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brian Rubin Greater Potency of Adult Stem Cells: Possible Mechanisms and Uses Catherine Verfaillie  Director Stem Cell Institute University of Minnesota Tuesday, May 4, 2004 - 10:00 AM Health Sciences Center, Hogness Auditorium Faculty Sponsor: Charles Murry Genetic Basis of Aortic Aneurysms and Dissections Dianna Milewicz Professor Department of Medical Genetics University of Texas Medical School Wednesday, April 28, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Eileen Mulvihill Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension Gregory C. Amber Senior Fellow Physiology and Biophysics University of Washington Tuesday, April 27, 2004 - 8:30 AM HSB, K069 Biological Roles of ADAMTS Metalloproteases Suneel Apte Associate Professor Department of Molecular Medicine CANCELED Wednesday, April 21, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Ulrike Schwarze The role of endothelial cells in erectile function and dysfunction Hunter Wessells Associate Professor Urology University of Washington Tuesday, April 20, 2004 - 8:30 AM HSB, K-069 Smooth Muscle Cells and Disease - Insights from Microarray Studies Eileen Mulvihill Research Assistant Professor Pathology University of Washington Tuesday, April 13, 2004 - 8:30 AM Health Sciences Building, K-069 Studies in the Pathology and Pathogenesis of Multiple Sclerosis Samuel Ludwin Professor Department of Neuropathology Queens University: Kingston, Ontario, Canada Wednesday, April 7, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Thomas Montine Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis Marta Scatena Research Assistant Professor Department of Bioengineering University of Washington Tuesday, April 6, 2004 - 8:30 AM Health Sciences Building, K-069 Cytologic Diagnosis of Lymphomas Xiaohua Qian Clinical Fellow Department of Pathology Brigham and Women's Hospital Friday, April 2, 2004 - 12:30 PM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Brian Rubin C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis Joachim Fruebis Associate Director, ZymoGenetics, Inc. Tuesday, March 30, 2004 - 8:30 AM Health Sciences Building, K-069 Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment Mei Speer Senior Fellow Bioengineering University of Washington Tuesday, March 23, 2004 - 8:30 AM HSB, K069 The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes Paul Hagerman Professor Department of Biological Chemistry University of California, Davis Monday, March 15, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Brad Preston and Charles Laird Pathology Reporting of Colorectal Cancer in the Molecular Era - When does research become best clinical practice? Kieran Sheahan Consultant Pathologist Center for Colorectal Disease St. Vincent's University Hospital: Dublin, Ireland Friday, March 12, 2004 - 9:00 AM Health Sciences Center, K-069 Development Gone Awry: Genetics and Pathology of Medulloblastoma Charles Eberhart Assistant Professor Department of Pathology Johns Hopkins University School of Medicine Wednesday, March 10, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Tom Montine Inflammation and atherosclerosis: Role of serum amyloid A Alan Chait Edwin L. Bierman Professor of Medicine Head, Division of Metabolism, University of Washington Tuesday, March 9, 2004 - 8:30 AM HSB, K069 Vascular Calcification in Chronic Kidney Disease William G. Goodman Professor Department of Medicine U.C.L.A. School of Medicine Wednesday, March 3, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Cecilia Giachelli New Developments in an Integrated Model of Cardiac Function N.P Smith and P.J. Hunter Bioengineering Institute University of Auckland Tuesday, March 2, 2004 - 8:30 AM Health Science Building, K069 Faculty Sponsor: James B Bassingthwaighte Genes, Lymphocytes and Autoimmunity Abul K. Abbas, M.D. Professor & Chair Department of Pathology University of California, San Francisco Friday, February 27, 2004 - 12:00 PM Health Sciences Center, Room T-733 Utilizing Human Genetics to Understand Vascular Development Dean Li Associate Professor Department of Medicine University of Utah Wednesday, February 25, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Stephen Schwartz TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models Andrew Frutkin Senior Fellow Cardiology University of Washington Tuesday, February 24, 2004 - 8:30 AM HSB, K069 Characterization of Cancer-Associated Mutants of DNA Polymerase Beta Joann Sweasy Associate Professor Departments of Therapeutic Radiology and Genetics Yale University School of Medicine Wednesday, February 11, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Larry Loeb Functional analysis of RGS5 in vascular smooth muscle Xi Wang Senior Fellow Pathology University of Washington Tuesday, February 3, 2004 - 8:30 AM HSB, K069 Reduced BRCA1 Expression and Ovarian Tumorigenesis Rachel M. Gonzalez Graduate Student Department of Pathology University of Washington Friday, January 30, 2004 - 11:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Mary Claire King Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer Dusty Miller Member, FHCRC Affiliate Professor, Department of Pathology University of Washington Wednesday, January 28, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tony Parks Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity Todd Gillis Senior Fellow Bioengineering University of Washington Tuesday, January 27, 2004 - 8:30 AM HSB, K069 Gene transfer to striated muscles using AAV Jeff Chamberlain Professor Neurology University of Washington Tuesday, January 20, 2004 - 8:30 AM HSB, K069 Fundamental Issues in Engineered Vessel Development Laura Niklason Assistant Professor Departments of Biomedical Engineering, Anesthesia and Surgery Duke University Friday, January 16, 2004 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Chuck Murry and Thomas Wight Linking Mathmatical Modeling with Clinical Research to Better Understand Brain Cancer (Gliomas) Kristin R. Swanson Research Assistant Professor Departments of Pathology and Applied Mathematics University of Washington Tuesday, January 13, 2004 - 2:30 PM Guggenheim Hall, 317 Myocardial Reperfusion Injury Tim Pohlman Professor Surgery University of Washington Tuesday, January 13, 2004 - 8:30 AM HSB, K069 Prelamin A Processing and Progeria Stephen Young, M.D. Senior Investigator Gladstone Institute of Cardiovascular Disease University of California, San Francisco Wednesday, December 17, 2003 - 4:30 PM Health Sciences Center, K-069 The role of Factor XIII in Hemostasis and Wound Healing Paul Bishop Distinguished Fellow ZymoGenetics Tuesday, December 16, 2003 - 8:30 AM Health Sciences, K069 The Role of Runt-Related Transcription Factor @ (Runx2) in Arterial Smooth Muscle Cell Mineralization Gabrielle Mercedes Curinga Graduate Student Department of Pathology University of Washington Friday, December 12, 2003 - 10:30 AM Health Sciences Center, Room RR-134 Leukocyte Bcl-2 and ischemia-reperfusion injury Robert K. Winn Research Professor Surgery and Physiology-Biophysics Harborview Medical Center Tuesday, December 9, 2003 - 8:30 AM Health Sciences, K069 Translational Control in Macrophage Inflammation Paul L. Fox Professor of Molecular Medicine Department of Cell Biology The Lerner Research Institute, Cleveland Clinic Foundation Wednesday, December 3, 2003 - 4:30 PM Health Sciences Center, K-069 Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science David Siscovick Professor of Medicine & Epidemiology Cardiovascular Health Research Unit University of Washington Tuesday, December 2, 2003 - 8:30 AM HSB, K069 Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector Shan Wen Acting Instructor Medicine/Division of Cardiology University of Washington Tuesday, November 25, 2003 - 8:30 AM HSB, K069 Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis Michelle Chaisson Post-Doctoral Fellow Amgen, Inc. Wednesday, November 19, 2003 - 4:30 PM Health Sciences Center, Room K-069 Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock John Hogenesch Program Manager, Genomics Genomics Institute Novartis Research Foundation Tuesday, November 18, 2003 - 8:30 AM HSB, K069 Parkinson's Disease Caused by Alpha-synuclein Locus Triplication Lee-Way Jin, M.D., Ph.D. Assistant Professor Department of Pathology University of Washington Friday, November 7, 2003 - 9:30 AM Harboview Medical Center, R & T Building, Room 113 A Murine Model of Intestinal Pseudo-Obstruction Raj Kapur, M.D., Ph.D. Associate Professor Department of Pathology and Department of Laboratories University of Washington and Children's Hospital and Regional Medical Center Wednesday, November 5, 2003 - 4:30 PM Health Sciences Center, Room K-069 Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes Dale Abel Assistant Professor of Medicine and Biochemistry Division of Endocrinology Diabetes and Metabolism Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine Tuesday, November 4, 2003 - 8:30 AM HSB, K069 Mechanisms of transforming growth factor-beta1-induced neointimal formation Goro Otsuka Senior Fellow Medicine/Cardiology University of Washington Tuesday, October 28, 2003 - 8:30 AM HSB, K069 Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding Emilie Clemmens Graduate Student (Defense date Oct. 7th) Bioengineering University of Washington Tuesday, October 21, 2003 - 8:30 AM HSB, K069 Natural antibodies protect against atherogenesis Gregg Silverman Professor in Medicine Dept. of Medicine UCSD Tuesday, October 14, 2003 - 8:30 AM HSB, K069 Many Genes and Many Tumors: Genetics of Uterine Leiomyomata Cynthia Morton Professor Department of Pathology Brigham and Women's Hospital, Boston, MA Wednesday, October 8, 2003 - 4:30 PM Health Sciences Center, Room K-069 Thyroid Hormone and Cardiac Metabolism Michael Portman Professor of Pediatrics Children's Hospital and Regional Medical Center University of Washington, Division of Cardiology Tuesday, October 7, 2003 - 8:30 AM Health Science Buidling, K069 The Cell Cycle Phase Specificity of DNA Damage and Repair Induced by Radiation, Oxidation and Anti-Topoisomerase II Chemotherapy Drugs Alan Potter Graduate Student Department of Pathology University of Washington Thursday, October 2, 2003 - 10:30 AM Health Sciences Center, Room D-310 "Pituitary Tumor Pathogeneis M. Beatriz S. Lopes, M.D. Associate Professor Department of Pathology University of Virginia Health Sciences Center Wednesday, September 17, 2003 - 8:00 AM Harborview Medical Center, Research and Training Auditori The Role of Hypoxia and Genetics in the Progression of Glioblastoma Daniel J. Brat Associate Professor Department of Pathology and Laboratory Medicine Emory University School of Medicine Thursday, September 11, 2003 - 4:30 PM Health Sciences Center, Room T-739 The Functions of FE65 Proteins and Their Roles in Dementias of Alzheimer's Disease Baiping Wang Graduate Student Department of Pathology University of Washington Tuesday, August 19, 2003 - 10:00 AM Health Sciences Center, Room K-069 "Neurospheres and Neurosphere Forming Cells: Morphological and Ultrastructural Characterization Alessandra Bez National Neurologic Institute "C.Besta" Milan, Italy Monday, July 28, 2003 - 1:00 PM VA Medical Center, Building 1, Room 812 Telomere Length and Chromosomal Instability in the Neoplastic Progression of Barrett's Esophagus Jennifer C. Finley Graduate Student Department of Pathology University of Washington Wednesday, July 23, 2003 - 3:00 PM Health Sciences Center, Room K-069 Cardiovascular Genomics: Clinical Implications Gary H. Gibbons, M.D Cardiovascular Research Institute Morehouse School of Medicine Monday, June 23, 2003 - 8:30 AM Health Sciences Building, K069 "Links between contractile and electrical dysfunction in heart" Jeffrey E. Saffitz, M.D., Ph.D. Lacy Professor of Pathology Department of Pathology and Immunology Washington University School of Medicine Thursday, June 19, 2003 - 10:00 AM Health Sciences Building, K069 Microscale Systems and Applications for Life-on-a-Chip Deirdre Meldrum Professor Department of Electrical Engineering University of Washington Wednesday, June 11, 2003 - 4:30 PM Health Sciences Center, Room K-069 Sheep Retroviral Envelope Glycoprotiens: Mechanisms of Oncogenesis and Incorporation into HIV-1 Lentiviral Vectors Shan-Lu Liu Graduate Student Department of Patholgy University of Washington Tuesday, June 10, 2003 - 2:00 PM Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud Integrative signaling in angiogenesis Michael Simons A. G. Huber Professor of Medicine & Chief of Cardiology Medical School Dartmouth Tuesday, June 10, 2003 - 8:30 AM Health Sciences Building, T747 Biotechnology Drug Discovery in the Post-Human Genome Era Thomas Bumol, Ph.D. Vice President Biotechnology Discovery Research Lilly Research Laboratories Thursday, June 5, 2003 - 4:30 PM Health Sciences Center, T-747 An Informal Career/Research Workshop Thomas Bumol, Ph.D. Vice President Biotechnology Discovery Research Lilly Research Laboratories Thursday, June 5, 2003 - 9:30 AM South Campus Center, Room 303 Evolutionary Theories of Aging and How We Test Them Daniel Promislow Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Georgia Tuesday, June 3, 2003 - 12:30 PM HSB, T-639 Population Mortality Analyses: A Tool for the Study of Aging Scott Pletcher Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 Baylor College of Medicine Tuesday, May 27, 2003 - 12:30 PM HSB, T-639 Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases Hans-Peter Kiem Associate Member Fred Hutchinson Cancer Research Center Wednesday, May 21, 2003 - 4:30 PM Health Sciences Center, K-069 Design of Human Aging Studies Norm Wolf Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, May 20, 2003 - 12:30 PM HSB, T-639 Regional Cardiac Sympathetic Dysfunction in CHF James Caldwell, MD Professor Medicine VA Medical Center Tuesday, May 20, 2003 - 8:30 AM Health Sciences Building, K069 Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum David Ron, M.D. Professor Departments of Medicine and Cell Biology NYU School of Medicine Wednesday, May 14, 2003 - 4:30 PM Health Sciences Center, Room K-069 Oligodendrogliomas and Mixed Gliomas: An Epidemic Peter Burger, M.D. Professor Department of Pathology Johns Hopkins University Wednesday, May 14, 2003 - 8:00 AM Harborview Medical Center, R&T Building Auditorium Faculty Sponsor: Dr. Tom Montine Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors. Design of Human Aging Studies William Hazzard Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, May 13, 2003 - 12:30 PM HSB, T-639 Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome Brad Johnson, M.D., Ph.D. Assistant Professor Department of Pathology and Laboratory Medicine University of Pennsylvania Wednesday, May 7, 2003 - 4:30 PM Health Sciences Center, Room K-069 Use of Nonhuman Primates for Studies of Caloric Restriction and Aging George Roth Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 National Institute on Aging Tuesday, May 6, 2003 - 12:30 PM HSB, T-639 Quantitative proteomics: new technology and applications Reudi Abersold Professor and Co-founder of the Institutes for Systems Biology The Institute for Systems Biology Tuesday, May 6, 2003 - 8:30 AM HSB, K069 Bacteriophages: Natures Self-replicating, Self-limiting Antibiotics Betty Kutter, Ph.D. Faculty Member Department of Biophysics Evergreen State College Wednesday, April 30, 2003 - 4:30 PM HSC, Room K-069 Gene Expression Profile Assays: Strengths and Pitfalls Richard Miller Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Michigan Tuesday, April 29, 2003 - 12:30 PM HSB, T-639 Marrow Derived Stem Cells- What do we really know? Beverly J Torok-Storb Member & Associate Program Head Transplantation Biology Program Fred Hutchinson Cancer Research Center Tuesday, April 29, 2003 - 8:30 AM HSB, K069 Why Is the Gastric Cardia Such a Big Deal When It Is So Small? Henry Appelman, M.D. Professor Pathology University of Michigan Wednesday, April 23, 2003 - 4:30 PM HSC, Room K-069 Transgenic Models: Strengths and Pitfalls Warren Ladiges Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, April 22, 2003 - 12:30 PM HSB, T-639 Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System Michelle Bendeck, Ph.D. Associate Professor Laboratory Medicine and Pathobiology University of Toronto Wednesday, April 16, 2003 - 4:30 PM HSC, Room K-069 Caloric Restriction: A Tool for the Study of Aging Edward Masoro Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Texas at San Antonio Tuesday, April 15, 2003 - 12:30 PM HSB, T-639 Use of Rodent Models in Aging Research Edward Masoro Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Texas at San Antonio Monday, April 14, 2003 - 12:30 PM HSB, T-639 Pros and Cons of Non-Mammalian Models in Aging Research Steven Austad Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Idaho Tuesday, April 8, 2003 - 12:30 PM HSB, T-639 Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y Jenny Graves Professor Comparative Genomics Australian National University Wednesday, April 2, 2003 - 4:30 PM HSC, Room K-069 Concepts and Theories of Aging George Martin Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, April 1, 2003 - 12:30 PM HSB, T-639 The Genetics and Biology of Tumor Suppression by p27/Kipl Chris Kemp, Ph.D. Affiliate Associate Professor Department of Pathology Fred Hutchinson Cancer Research Center Wednesday, March 26, 2003 - 4:30 PM HSC, K-069 X Inactivation: The Role of the XIST RNA in Silencing a Chromosome Carolyn Brown Associate Professor Department of Medical Genetics University of British Columbia Friday, March 21, 2003 - 12:30 PM Health Sciences Center, Room K-069 TBA Marsha Whitney Graduate Student Bioengineering University of Washington Tuesday, March 18, 2003 - 8:30 AM HSB, K069 TBA Lisa Tannock Acting Instructor/Senior Fellow Division of Metabolism, Endocrinology and Nutrition University of Washington Tuesday, March 4, 2003 - 8:30 AM HSB, K069 Biology and Evolution of Cervical Squamous Intraepithelial Lesions: A Hypothesis with Diagnostic/Prognostic Implications Kumarasen Cooper, MBChB, DPhil, FRC Path Director of Anatomic Pathology University of Vermont College of Medicine Thursday, February 27, 2003 - 4:30 PM University of Washington Medical Center, BB-204 Array CGH for High Resolution Analysis of Genomic Aberrations Dan Pinkel, Ph.D. Professor Department of Laboratory Medicine UCSF Tuesday, February 25, 2003 - 4:30 PM Health Sciences Center, Room K-069 Innate Immune Recognition and Response to Microbial Pathogens Kelly Smith, Ph.D., M.D. Department of Pathology University of Washington Wednesday, February 19, 2003 - 4:30 PM Health Sciences Center, Room K-069 TBA Joe Beavo/ Sergei Rybalkin Professor/ Acting Instructor Pharmacology University of Washington Tuesday, February 18, 2003 - 8:30 AM HSB, K069 The Role of Proteolysis in the Pathogenesis of Atherosclerosis Peter Gough Research Assistant Professor Department of Pathology University of Washington Wednesday, February 12, 2003 - 4:30 PM Health Sciences Center, Room K-069 TBA Joanne Hulme Senior Fellow Pharmacology University of Washington Tuesday, February 11, 2003 - 8:30 AM HSB, K069 Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis Karin Bornfeldt, Ph.D. Associate Professor Department of Pathology University of Washington Wednesday, February 5, 2003 - 4:30 PM Health Sciences Center, Room K-069 Signaling Pathways Regulating Endothelial Cell Survival and Activation Xianwu (James) Li Graduate Student Department of Pathology University of Washington Friday, January 31, 2003 - 3:15 PM Health Sciences Center, Room K-069 Protein Interactions Stan Fields, Ph.D. Professor Departments of Genome Sciences and Medicine University of Washington Tuesday, January 21, 2003 - 4:30 PM Health Sciences Center, T-747 TBA Jin-Yong Hwang, M.D. (Visiting Scientist) Assitant Professor Department of Medicine Gyeongsang National University, Republic of South Korea Tuesday, January 21, 2003 - 8:30 AM HSB, K069 Molecular Medicine in the Post Genome Era Dr. Richard Klausner  Executive Director, Global Health Program Gates Foundation Wednesday, January 15, 2003 - 12:00 PM Hogness Auditorium, TBA Themis Kyriakides Research Assistant Professor Biochemistry University of Washington Tuesday, January 14, 2003 - 8:30 AM HSB, K069 From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment Douglas Ross, M.D., Ph.D. Chief Scientific Officer Applied Genomics Inc. Wednesday, December 18, 2002 - 4:30 PM HSC, K-069 Delta1: A Notch Up on Hematopoietic Stem Cell Expansion Irwin Bernstein Professor FHCRC Tuesday, December 17, 2002 - 8:30 AM HSC, K-069 Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma Daniel E. Sabath Associate Professor Laboratory Medicine University of Washington Wednesday, December 4, 2002 - 4:30 PM HSC, K-069 "A Genetic Approach to Understanding Basement Membrane Assembly" Mats Paulsson Professor of Biochemistry School of Medicine University of Cologne Tuesday, December 3, 2002 - 8:30 AM HSC, K-069 "Microarray Analysis in Cancer Research: Progress and Promise" Paul Meltzer, M.D., Ph.D. Senior Investigator Cancer Genetics Branch NIH, National Human Genome Research Institute Wednesday, November 20, 2002 - 4:30 PM Health Sciences Center, K-069 Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome Ulrike Schwarze, M.D. Assistant Professor Department of Pathology University of Washington Wednesday, November 13, 2002 - 4:30 PM Health Sciences Center, K-069 Single Cell Proteomics Norm Dovichi Professor Department of Chemistry University of Washington Wednesday, November 6, 2002 - 4:30 PM HSC, K-069 DNA Repair Genes Select Stem Cells in Vivo Stan Gerson, M.D. Professor and Chief Hematology/Oncology Case Western Reserve University Wednesday, October 30, 2002 - 4:30 PM HSC, K-069 Science in Medicine Lecture: Genetic Instability and Human Disease Raymond J. Monnat, Jr., M.D. Professor Department of Pathology University of Washington Thursday, October 24, 2002 - 12:00 PM HSC, Turner Auditorium, D-209 Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease James Scott Professor Genetics and Genomics Research Institute Imperial College of Science Wednesday, October 16, 2002 - 4:30 PM Health Sciences Center, K-069 Mouse Models Unravel the p53 Pathway Gigi Lozano, Ph.D. Professor and Geneticist Department of Molecular Genetics MD Anderson Cancer Center University of Texas Wednesday, October 2, 2002 - 4:30 PM Health Sciences Center, K-069 Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer Robert F. Hevner, M.D, Ph.D. Assistant Professor Department of Pathology University of Washington Thursday, September 26, 2002 - 12:00 PM Health Sciences Center, D-209 Neurochemical Dynamics of Traumatic Brain Injury J. Clay Goodman, M.D. Professor and Neuropathology Program Director Departments of Pathology, Neurology, and Neurosurgery Baylor College of Medicine Thursday, September 19, 2002 - 4:30 PM HSC, T-747 Fas/FADD-Mediated Activation of a Specific Program of Inflammatory Gene Expression in Vascular Smooth Muscle Cells Friedemann J. Schaub Graduate Student Department of Pathology University of Washington Thursday, September 19, 2002 - 11:00 AM HSC, K-069 Diagnosis of Minimal Prostate Cancer in Needle Biopsies - When Should You Jump off the Fence? John Srigley Professor Department of Pathology and Molecular Medicine McMaster University Monday, August 26, 2002 - 8:00 AM UWMC, BB-204 Cohesion proteins SMC1 and SMC3: roles in aneuploidy and in meiotic chromosome dynamics Rosalina James Graduate Stdent of Pathology School of Medicine University of Washington Friday, August 23, 2002 - 11:00 AM HSC, D-209 Characterization of Genomic Instability in Neoplastic Progression of Ulcerative Colitis Ru Chen Graduate Student of Pathology School of Medicine University of Washington Tuesday, August 20, 2002 - 1:00 PM HSC, K-069 Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer Santo Nicosia, M.D. Professor Interdisciplinary Oncology Program Moffitt Cancer Center and Research Institute University of South Florida Wednesday, July 31, 2002 - 4:30 PM Health Sciences Center, Room T-747 In Vitro Modeling of Breast Cancer Krishna Rao Graduate Student of Pathology School of Medicine University of Washington Wednesday, July 10, 2002 - 1:00 PM Doctoral Dissertation, Pelton Auditorium Day Campu "Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing" Peter J. Dempsey, Ph.D. Principal Scientist Pacific Northwest Research Institute Seattle, Washington Wednesday, June 26, 2002 - 4:30 PM Health Sciences Center, K-069 "Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex" Robert Hevner, M.D., Ph.D. Assistant Professor Department of Pathology University of Washington Wednesday, June 5, 2002 - 4:30 PM Health Sciences Building, K-069 "Immunohistochemistry in Urologic Tumor Pathology" Mark Wick, M.D. Associate Director Surgical Pathology University of Virgina Health System Wednesday, May 29, 2002 - 4:30 PM Health Sciences Building, K-069 Cell Adhesion in the Vasculature Richard O. Hynes, Ph.D., F.R.S. Daniel K. Ludwig Professor for Cancer Research Department of Biology Massachusetts Institute of Technology Friday, May 24, 2002 - 11:00 AM Health Sciences Center, D-209 Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men Charles Alpers, M.D. Professor Department of Pathology University of Washington Wednesday, May 15, 2002 - 4:30 PM Health Sciences Center, Genetics in Everyday Life
David R. Cox, M.D., Ph.D. Professor and Associate Chair Department of Genetics Stanford University Thursday, January 10, 2002 - 4:30 PM Health Sciences Center, T-739 |
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