 |
 |
 |
Pathology SeminarsDiet, Death and Demography Linda Partridge, Ph.D. Director, The Institute of Healthy Ageing University College, London Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany Monday, November 9, 2009 - 11:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch Exploring the extraordinary regenerative potential of the mammalian fetal heart Timothy Cox, PhD Research Associate Professor Pediatrics, Division of Craniofacial Medicine UW Tuesday, November 10, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Muscle Gene Regulation & Regulatory Cassettes for Gene Therapy Stephen D. Hauschka, PhD Professor Dept. of Biochemistry UIW Tuesday, November 17, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer Valera Vasioukhin Associate Member Fred Hutchinson Cancer Research Center Wednesday, November 18, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Why Attend? Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer. Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease David Marcinek, PhD Research Assistant Professor Dept. of Radiology UW Tuesday, November 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging. TBA Morayma Reyes, MD, PhD Assistant Professor Pathology and Lab Medicine UW Tuesday, December 1, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making Jordi Bruix, M.D. Associate Professor Director, Liver Cancer Group University of Barcelona Wednesday, December 2, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Jean Campbell Why Attend? Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm. Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice. TBA Mark Majesky, PhD Professor Dept. of Pathology University of North Carolina at Chapel Hill Tuesday, December 8, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Nuclear Architecture and Aging Tom Misteli, Ph.D. Senior Investigator Cell Biology of Genomes National Cancer Institute, NIH Wednesday, December 9, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging. Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology. Exome Sequencing & Human Disease Jay Shendure, MD, PhD Assistant Professor Dept. of Genome Sciences UW Tuesday, December 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors Bernhard Kuhn, M.D. Associate Professor Department of Cardiology Children's Hospital Boston Wednesday, December 16, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007. Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure. Presentation Title TBA Janet Eary, M.D. Associate Professor Department of Nuclear Medicine University of Washington Wednesday, January 6, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Presentation Title TBA Patrick Paddison, Ph.D. Assistant Member Human Biology Division Fred Hutchinson Cancer Research Center Wednesday, January 13, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Presentation Title TBA Carla Grandori and Tom Martins Research Associate Professors UW Medicine Pharmacology Wednesday, January 20, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Presentation Title TBA Rachel Wong Professor Department of Biological Structure University of Washington Wednesday, January 27, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Suzy Dintzis Presentation Title TBA Georg Seelig Quantitative Biology and DNA Nanotechnology UW Electrical Engineering Wednesday, February 3, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Presentation Title TBA Mary-Claire King Professor Medical Genetics & Genome Sciences University of Washington Wednesday, February 10, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Presentation Title TBA Brad Cookson Professor Laboratory Medicine & Microbiology University of Washington Wednesday, February 24, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Presentation Title TBA Russ Van Gelder, M.D., Ph.D. Professor and Chair UW Medicine Ophthalmology Wednesday, March 17, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Presentation Title TBA Gwenn Garden Associate Professor UW Medicine Neurology Wednesday, March 24, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Presentation Title TBA Michael Schuffler Professor UW Medicine Gastroenterology Wednesday, April 7, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Melissa Upton Presentation Title TBA Ian Lipkin, M.D. Professor Departments of Epidemiology, Neurology and Pathology Columbia University Medical Center Wednesday, April 14, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Michael Linden Presentation Title TBA Kevin Roth, M.D., Ph.D. Professor Department of Pathology University of Alabama at Birmingham Wednesday, April 21, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Presentation Title TBA Tueng Shen Associate Professor UW Medicine Ophthalmology/Bioengineering Wednesday, May 12, 2010 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Recent Pathology SeminarsMerkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy Paul Nghiem, M.D., Ph.D. Associate Professor UW Medicine Dermatology and Pathology Wednesday, November 4, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Suzy Dintzis Why Attend? Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases. Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU. Skeletal muscle stem cells: from classic to eclectic Zipora Yablonka-Reuveni, PhD Professor Dept. of Biological Structure UW Tuesday, October 27, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908). The Amazing Liver: New Perspectives on Regeneration and Cancer Nelson Fausto, M.D. Professor and Chair UW Medicine Pathology Wednesday, October 21, 2009 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Why Attend? Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes. Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma Jean Campbell, PhD Research Assistant Professor Dept. of Pathology UW Tuesday, October 20, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mechanisms of enhanced lung injury in febrile hyperthermia Anne Lipke, MD Senior Fellow Division of Pulmonary and Critical Care Medicine UW Tuesday, October 13, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Lynn Schnapp, MD Transcriptional Regulation of Vascular Development Elisabetta Dejana Italian Foundation for Cancer Research Institute of Molecular Oncology Milan, Italy Tuesday, October 6, 2009 - 4:00 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Elaine Raines CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis Jeffrey A. Ledbetter, PhD Research Professor Division of Rheumatology UW Tuesday, October 6, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab). The role of cardiac metabolism in heart diseases Rong Tian, MD, PhD Professor and Director Mitochondria and Metabolism Center UW Tuesday, September 29, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury Tiffany Nguyen Graduate Student Pharmacology and Toxicology Department Medical College of Georgia, Augusta, GA Tuesday, September 22, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Rong Tian, MD, PhD Cell Signaling in Space and Time John D. Scott, PhD Edwin G. Krebs-Hilma Speights Professor Dept. of Pharmacology UW Tuesday, September 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Can We Image a Plaque at Risk? Mat J.A.P. Daemen, MD, PhD Scientific Director of the Cardiovascular Research Institute Maastricht Professor and Head of Pathology University of Maastricht, The Netherlands Tuesday, September 8, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Chun Yuan Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses. The Neurosecretory Vesicle Protein Phogrin Has Phosphatidylinositol Phosphatase Activity That Regulates Insulin Secretion Leslie Ann Caromile Graduate Student Department of Pathology University of Washington School of Medicine Friday, August 14, 2009 - 10:00 AM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Dan Bown-Pope, Ph.D. Long-chain acyl-CoA Synthetase Isoforms 1 and 4 Exhibit Differences in Fatty Acid Preference and Functions in Human Arterial Smooth Muscle Cells Deidre Golej MCB Graduate Student University of Washington School of Medicine Wednesday, August 12, 2009 - 2:00 PM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Karin Bornfeldt, Ph.D. Mitochondria, Age and the Heart Charles L. Hoppel, M.D. Professor Departments of Pharmacology and Medicine Case Western Reserve University Tuesday, July 28, 2009 - 4:00 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry Daniel Martin, M.D. Institute for Systems Biology Tuesday, June 16, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Loss of DNA Polymerase Proofreading Leads to Cancer and Tumor Acceleration in MIce Tina M. Albertson Graduate Student UW Medicine Pathology University of Washington School of Medicine Tuesday, June 9, 2009 - 2:00 PM Health Sciences Center, K-069 Faculty Sponsor: Brad Preston, Ph.D. . talk cancelled UW School of Medicine Tuesday, June 9, 2009 - 8:30 AM HSC, NE110 Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Nitric Oxide and the Development of Insulin Resistance Francis Kim, MD Associate Professor of Medicine Division of Cardiology Harborview Medical Center Tuesday, June 9, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium MicroRNAs as Blood-based Cancer Biomarkers Muneesh Tewari, MD, PhD Assistant Member Human Biology Fred Hutchinson Cancer Research Center Wednesday, June 3, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer. Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions. Genes and Vascular Disease Gail P. Jarvik, MD, PhD Professor of Medicine and Head Division of Medical Genetics UW Tuesday, June 2, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Pancreatic Cancer: Genes to Patients Ralph Hruban, MD Professor Pathology/Oncology John Hopkins University Wednesday, May 27, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families. Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer. Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?) Ian R. Sweet, PhD Research Assitant Professor Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 26, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes Margaret Black, Ph.D. Associate Professor Pharmaceutical Sciences Washington State University Wednesday, May 20, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Larry Loeb, M.D., Ph.D. Why Attend? Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect. Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU. Sterol regulation of the macrophage immune response Jay W. Heinecke, MD Professor of Medicine Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 19, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld Signaling Networks in Vascular Morphogenesis and Homeostasis Luisa Iruela-Arispe, PhD Professor Molecular, Cell and Developmental Biology UCLA Wednesday, May 13, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Charles Murry, M.D., Ph.D. Why Attend? Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology. Anti-Aging Genes, DNA Damage and Cancer Valter Longo, Ph.D. Assistant Professor Department of Gerontology/Alzheimer's Research University of Southern California Tuesday, May 12, 2009 - 12:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence Cell Cycle Regulation in Hematopoietic Disorders Keith Loeb, M.D., Ph.D. Assistant Professor Pathology UW School of Medicine Tuesday, May 12, 2009 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Thomas Montine, MD, PhD Versican: A Matrix Molecule With Some Clout! Thomas N. Wight, Ph.D. Member and Director, Hope Heart Program Benaroya Research Institute at Virginia Mason Affiliate Professor, Pathology, UW Tuesday, May 12, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mitochondrial Signaling and Dynamics in Health and Disease Gyorgy Hajnoczky, PhD Professor Pathology, Anatomy & Cell Biology Jefferson Medical University Wednesday, May 6, 2009 - 4:30 PM Health Sciences Center , K-069 Faculty Sponsor: Charles Murry, M.D., Ph.D. Why Attend? Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases. Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology. Tumor Cell Metabolism: How is it different? David M. Hockenbery, MD Professor of Medicine, UWMC Member, FHCRC Tuesday, May 5, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment Mark Wick, MD Professor Pathology Univeristy of Virginia Friday, May 1, 2009 - 4:30 PM Health Sciences Center, T-639 Faculty Sponsor: Matthew Yeh, M.D., Ph.D. Why Attend? Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues. Mechanisms of Cell Fate Acquisition in the Differentiation of Pluripotent Stem Cells Jonathan Golob Graduate Student UW Medicine Pathology University of Washington School of Medicine Wednesday, April 29, 2009 - 10:00 AM UW Medicine at 815 Mercer, Orin Smith Auditorium Faculty Sponsor: Chuck Murry, M.D., Ph.D. Mapping Cell Fate through Somatic Mutations Marshall Horwitz, MD, PhD Professor of Pathology Institute for Stem Cell and Regenerative Medicine UW Tuesday, April 28, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Deciphering the Hereditary Prion Protein Amyloidoses Bernardino Ghetti, MD Professor Pathology & Lab Medicine Indiana University Wednesday, April 22, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Montine 7th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. Shaping the vertebrate body: cell migration in development and disease Douglas C. Weiser, PhD Postdoctoral fellow Department of Biochemistry UW Tuesday, April 21, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective Vinay Kumar, MD, PhD Professor and Chairman Pathology University of Chicago Medical School Wednesday, April 15, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: UW Medicine Pathology Residents Why Attend? Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007. Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors. Mitochondrial Oxidative Stress in Cardiac Aging, Pressure-Overload Induced Cardiac Hypertrophy and Failure Dao-Fu Dai Graduate Student UW Medicine Department of Pathology University of Washington Tuesday, April 14, 2009 - 1:00 PM UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Doctoral Dissertation Chordoma Benjamin Hoch, MD Associate Professor, Pathology UW School of Medicine Tuesday, April 14, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Matrix remodeling during lung injury and repair Lynn M. Schnapp, MD Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, April 14, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Genomic Dosage Disorders: Diagnostic Insights and Challenges Nancy Spinner, PhD Professor Genetics in Pediatrics University of Pennsylvania School of Medicine Wednesday, April 8, 2009 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Christine Disteche, Ph.D. Why Attend? Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia. Translational control during monocyte/macrophage adherence David Pritchard, PhD Acting Instructor Department of Pathology UW Tuesday, April 7, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Gene Networks as Sensors and Drivers of Disease Eric Schadt, PhD Executive Scientific Director Genetics Rosetta Inpharmatics LLC Wednesday, April 1, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death. Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London. Water, Energy and Life: Fresh Views from the Water’s Edge Gerald H. Pollack, PhD Professor Department of Bioengineering UW Tuesday, March 31, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Laboratory medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Dept. of Laboratory Medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle Stephen Tapscott Member Divisions of Human Biology and Clinical Research Fred Hutchinson Cancer Research Center Wednesday, March 11, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas. Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991. Metabolic Stability and the Evolution of Life Span Lloyd Demetrius, PhD Department of Evolutionary & Organismic Biology Harvard University Tuesday, March 10, 2009 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant Human Pluripotent Stem Cells for Myocardial Repair Michael LaFlamme, MD, PhD Assistant Professor, Pathology UW School of Medicine Tuesday, March 10, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Local Control of Excitation-Transcription Coupling in Smooth Muscle Luis Fernando Santana, Ph.D. Associate Professor Physiology and Biophysics UW Tuesday, March 10, 2009 - 8:30 AM Health Sciences Building, K-069 Chromatin and G-quadruplex Functions at Telomeres and Beyond Brad Johnson, MD, PhD Assistant Professor Pathology/Lab Medicine University of Pennsylvania Wednesday, March 4, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription. Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania. uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms Jie Hong Hu, Ph.D. Senior Fellow Division of Cardiology UW Tuesday, March 3, 2009 - 8:30 AM Health Sciences Building, K-069 Lost in Translation: Ribosomes in Hematopoiesis Akiko Shimamura, MD, PhD Associate Member Division of Pediatric Hematology/Oncology Fred Hutchinson Cancer Research Center Wednesday, February 25, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction. Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital. TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury John C. Keech, M.D. Postdoctoral Fellow Surgery UW Tuesday, February 24, 2009 - 8:30 AM Health Sciences Building, K-069 Translating Pathways to Pancreatic Cancer Sunil Hingorani, MD, PhD Assistant Member Clinical Research and Public Health Sciences Division Fred Hutchinson Cancer Research Center Wednesday, February 18, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Ray Monnat, M.D. Why Attend? Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results. Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance. Mitochondrial-targeted Peptides: Novel Cardio-, Neuro- and Renal-protective Agents Hazel H. Szeto, M.D., Ph.D. Professor Department of Pharmacology Weill Cornell Medical College Tuesday, February 17, 2009 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D. Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant Myofilament Regulation of the Frank-Starling Law of the Heart F. Steven Korte, Ph.D. Senior Fellow Bioengineering UW Tuesday, February 17, 2009 - 8:30 AM Health Sciences Building, K-069 Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility Kristin Swanson, PhD Research Associate Professor, UW Medicine Pathology Adjunct Associate Research Professor, Applied Mathematics University of Washington Wednesday, February 11, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Monnat The FGF Axis: New Therapeutic Opportunities Norman M. Greenberg, Ph.D. Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington FHCRC and UW Tuesday, February 10, 2009 - 8:30 AM Health Sciences Building, K-069 Water Gerald Pollack, PhD Professor, Bioengineering Department of Engineering, Bioengineering Division UW School of Medicine Monday, February 9, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php Archaeoctyes: Monocytes as Universal Probes for Disease Stephen Schwartz, MD, PhD Professor Pathology University of Washington Wednesday, February 4, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Monnat Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays Steven Pelech, Ph.D. President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia Kinexus Bioinformatics Corp. and Univ. of British Columbia Tuesday, February 3, 2009 - 8:30 AM Health Sciences Building, K-069 Roles of Transcription in Genomic Stability or Instability Philip Hanawalt, PhD Professor Biological Sciences Stanford University Wednesday, January 28, 2009 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Loeb SMC plasticity and reprogramming in calcifying vasculature Yanfeng (Mei) Speer, Ph.D. Research Assistant Professor Bioengineering UW Tuesday, January 27, 2009 - 8:30 AM Health Sciences Building, K-069 Studying Hematopoietic Disease with Genetics & Genomics Yajuan Liu, PhD Senior Fellow Medical Genetics University of Washington Wednesday, January 21, 2009 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Dr. Monnat Genetic & epigenetic control of aging George Martin, MD Emeritus Professor (active), Pathology UW School of Medicine Tuesday, January 13, 2009 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/ Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells Jonathan Golob Graduate Student Pathology UW Tuesday, January 13, 2009 - 8:30 AM Health Sciences Building, K-069 Inights Into Vascular Diseases and Their Treatments from Human Genetics Richard Lifton, M.D., Ph.D. Professor and Chair Department of Genetics Yale University Wednesday, January 7, 2009 - 5:00 PM Health Sciences Center, Turner Auditorium, Rm. D-209 Faculty Sponsor: Stephen Schwartz Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222 AAV vectors: biology and utility for gene addition and gene correction David Russell, MD, PhD Professor of Medicine Div. of Hematology UW Tuesday, January 6, 2009 - 8:30 AM Health Sciences Building, K-069 Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you Alan Weiner, PhD Professor and ZymoGenetics Chair Biochemistry UW Tuesday, December 16, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium "Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes" Markus Grompe, MD Professor Molecular & Medical Genetics and Pediatrics Oregon Health & Science University Wednesday, December 10, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat Climb High, Sleep Low Lawrence True, MD Professor, Pathology UW School of Medicine Tuesday, December 9, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. A-type nuclear lamins in aging and disease Brian Kennedy, PhD Associate Professor Biochemistry UW Tuesday, December 9, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers Binghui Shen, PhD Professor Radiation Biology City of Hope Wednesday, December 3, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Loeb Delta 1: A Notch up on cord blood stem cell transplantation Irwin Bernstein, MD Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society UW and FHCRC Tuesday, November 25, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium “Quantum Dots for Cancer Imaging and Therapeutics” Xiaohu Gao, PhD Assistant Professor Bioengineering University of Washington Wednesday, November 19, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat Dissection, disruption, and death--aortic dissection and its causes Peter Byers, MD Professor, Pathology and Medicine UW School of Medicine Tuesday, November 18, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Thomas Montine, MD, PhD Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer Jay Rothstein, PhD Director Inflammation Research Amgen, Inc., Seattle, WA Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs Wei-Zhong Zhu, PhD Postdoctoral Fellow Pathology UW Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Michael Laflamme Neuroregeneration in the Cerebral Cortex: Impossible and Crazy? Robert Hevner, M.D., Ph.D. Professor Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology University of Washington Wednesday, November 12, 2008 - 4:30 PM Health Science Center, K-069 Faculty Sponsor: Dr. Monnat "Structural and Functional Characterizations of Alternative Gene Products of an Adaptor Protein (FE65) and an Orphan G-Protein Coupled Receptor (Gprc5b) in Learning- and Memory-Impaired Mice with a Selective Knockout of p97FE65" Bethany Cool Graduate Student Pathology University of Washington Monday, November 10, 2008 - 2:30 PM Health Science Center, K-0690 Faculty Sponsor: Dr. Martin "Pathogenesis of NASH: new insights from mice with metabolic syndrome" Geoffrey Farrell, MD Director/Professor Gastroenterology and Hepatology Australian National University Wednesday, November 5, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Matthew Yeh "The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast" Alan Herr, PhD Senior Fellow Pathology University of Washington Wednesday, October 29, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brad Preston "Control of Cardiovascular Signaling by RGS Proteins" William Mahoney, PhD Senior Fellow Pathology University of Washington Wednesday, October 22, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Monnat Epigenetic programming of mesenchymal stem cells Philippe Collas, PhD Professor Institute of Basic Medical Sciences, Dept. of Biochemistry University of Oslo, Norway Tuesday, October 21, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Karol Bomsztyk Exploring the Interface Between Glial Progenitors and Gliomas Peter Canoll, MD, PhD Assistant Professor Department of Clinical Pathology Columbia University Wednesday, October 15, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Tom Montine Regulation of Nodal Signaling by microRNAs Wen-Yee Choi Graduate Researcher Molecular and Cellular Biology Harvard University Tuesday, October 14, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Charles Murry Contribution of interstitial valve cells to valve calcification Marcello Rattazzi, MD Clinical and Experimental Medicine University of Padua, Italy Wednesday, October 8, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Molecular mechanisms of aging: What can we learn from yeast and worms? Matt Kaeberlein, PhD Assistant Professor Pathology UW Tuesday, October 7, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Pancreatic Cancer: Emerging Ideas About How the Cancer Forms Teri Brentnall, MD Professor Departments of Medicine and Pathology University of Washington Wednesday, October 1, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Rabinovitch PSGL-1 Mediated Signal Transduction and Translational Control Mechanisms During Adherence of Macrophages Richard Fox Graduate Student UW Medicine Pathology University of Washington Thursday, August 14, 2008 - 1:00 PM South Lake Union Auditorium, K-111 Faculty Sponsor: Dr. Schwartz “Magnetic Resonance Imaging of Gene Expression" Anna Naumova, Ph.D. Senior Fellow Radiology UW Tuesday, June 24, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Directly targeting myofibrillar proteins to improve cardiomyocyte contraction" F. Steven Korte, PhD Senior fellow Bioengineering UW Tuesday, June 17, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus” Bardia Askari, Ph.D. Acting Instructor Pathology UW Tuesday, June 10, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Understanding aging through conserved longevity pathways Matt Kaeberlein, PhD Assistant Professor, Pathology UW School of Medicine Tuesday, June 10, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine “Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model” Karin E. Bornfeldt, Ph.D. Professor Pathology Medicine Tuesday, June 3, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer “Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes” Charis L. Himeda, Ph.D. Senior fellow Biochemistry UW Tuesday, May 20, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment” Dalin Tang, Ph.D. Professor Mathematics and Biomedical Engineering Worcester Polytechnic Institute Tuesday, May 13, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chun Yuan, Ph.D. 815 Mercer Street “Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?” Deidre Golej Graduate Student, Molecular and Cellular Biology Pathology UW Tuesday, May 6, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Why Do Biopsies of Ulcerative Colitis Seem to Look More and More Like Crohn’s Disease? And Whatever Happened to the Old Ulcerative Colitis That We Knew and Loved Henry Appelman, M.D. Professor Department of Pathology University of Michigan Health System Thursday, May 1, 2008 - 4:30 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Dr. Melissa Upton A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000. “Diabetic vascular disease: Hitting below the belt” Kanchan Chitaley, Ph.D. Research Assistant Professor Urology UW Tuesday, April 29, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street 6th Annual Alvord Lecture in Neuropathology Arie Perry, MD Associate Professor Pathology, Division of Neuropathology Washington University, St. Louis Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Montine Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed. “FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero” Atis Muehlenbachs MSTP and Incoming Resident Pathology UW Tuesday, April 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Transcriptional regulation of thrombin receptors by vasodilator prostaglandins" Karsten Schror, M.D. Professor and Chair Pharmacology and Clinical Pharmacology Heinrich-Heine-Universitat Dusseldorf Tuesday, April 15, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Alexander W. Clowes, MD 815 Mercer Street A Recurrent Mutation, p.R961W, in the MED12/TRAP/HOPA Gene Causes Opitz-Kaveggia (FG) Syndrome Hiba Risheg, Ph.D. Director Clinical Ctyogenetics Laboratory Genecare Medical Genetics Center Monday, April 14, 2008 - 3:00 PM Health Sciences Center, T-747 Faculty Sponsor: Dr. Christine Disteche Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology Untangling Mitochondrial Mutagenesis and Aging in Mice Marc Vermulst Graduate Student UW Medicine Pathology University of Washington Friday, April 11, 2008 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Larry Loeb “A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice” Richard Frock PhD Candidate Biochemistry UW Tuesday, April 8, 2008 - 8:30 AM Health Sciences Building, K-069 "I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure" Chris Hague, Ph.D. Assistant Professor Pharmacology UW Tuesday, April 1, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Glioma Invasion: Interactions with the Microenvironment Joanna Phillips, MD, PhD UW Medicine, Neuropathology Faculty Candidate Department of Pathology, Division of Neuropathology, Research Fellow University of California, San Francisco Wednesday, March 26, 2008 - 9:30 AM R&T Building, 300 Ninth Ave, auditorium Faculty Sponsor: Montine "Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation" Prabha Sampath, Ph.D. Postdoctoral Fellow Pathology UW Tuesday, March 25, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer” Jeffrey S. Chamberlain, Ph.D. Professor Depts. of Neurology, Medicine and Biochemistry UW Tuesday, March 18, 2008 - 8:30 AM HSB, T-635 “Human RecQ helicases: new roles in biology and disease” Raymond Monnat, MD Professor of Pathology Pathology UW School of Medicine Tuesday, March 11, 2008 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level. "The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair" Lynn M. Schnapp, M.D. Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, March 4, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend Dr. Paul Carvey Dean Rush Medical School Wednesday, February 20, 2008 - 4:30 AM Health Sciences Building, T639 Faculty Sponsor: Dr. Zhang "Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites" Elaine W. Raines Research Professor Pathology UW Tuesday, February 12, 2008 - 8:30 AM HSB, K-069 The Genetic Basis of Fanconi Anemia and Other Heritable Chromosome Instability Syndromes Dr. Holger Hoehn Professor Humangenetik Institute University of Wurzburg Thursday, February 7, 2008 - 3:30 PM Health Sciences Center, T-747 Faculty Sponsor: Peter Rabinovitch “The Role of Filamin in Transcriptional Control of Laminin Expression” Christine K. Abrass, MD, FACP Professor of Medicine Division of Gerontology and Geriatric Medicine UW Tuesday, February 5, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Encapsulated vascular smooth muscle cells to treat rat models of diabetes" William Osborne, PhD Research Professor Pediatrics UW Tuesday, January 29, 2008 - 8:30 AM HSB, K-069 “Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system” Esther Lutgens, MD, PhD Associate Professor Pathology CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands Tuesday, January 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Michael Rosenfeld, PhD 815 Mercer Street "Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature" Yanfeng (Mei) Speer, PhD Research Assistant Professor Bioengineering UW Tuesday, January 15, 2008 - 8:30 AM HSB, K-069 TBA Roger E. Bumgarner, PhD Associate Professor Microbiology UW Tuesday, December 18, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Secondary Mutations as a Mechanism of Cisplatin Resistance in BRCA1/2-Mutated Cancers: Lessons Learned from Studies on a Rare Genetic Disease, Fanconi Anemia Toshiyasu Taniguchi, M.D., Ph.D. Assistant Member Divisions of Human Biology and Public Health Sciences Fred Hutchinson Cancer Research Center Monday, December 17, 2007 - 3:00 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology Physiological Functions of Activated Caspases in Macrophages Thomas Nhan Graduate Student UW Medicine Pathology University of Washington Thursday, December 13, 2007 - 10:00 AM South Lake Union, Brotman Building Auditorium Faculty Sponsor: Stephen Schwartz "Innate immune recognition and response to microbial pathogens" Kelly Smith, MD, PhD Assistant Professor Pathology UW Tuesday, December 11, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Studying Connections between Cancer and Aging Peter Rabinovitch, M.D., Ph.D. Professor UW Medicine Pathology University of Washington Tuesday, December 11, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Macrophage Mediators of Cardiac Fibrosis April S. Stempien-Otero, MD Assistant Professor of Medicine Cardiology UW Tuesday, December 4, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Where Do the Cells of the Atherosclerotic Plaque Come from and Where Do They Go? Gwen Randolph, Ph.D. Associate Professor Department of Gene and Cell Medicine Mount Sinai School of Medicine Friday, November 30, 2007 - 4:00 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Stephen Schwartz "Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system" Gustavo Matute-Bello, MD Assistant Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, November 27, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Mitochondria, lifespan and the aging heart" Peter S. Rabinovitch, M.D., Ph.D. Professor Pathology UW Tuesday, November 20, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Loss of the Endocytic Protein Sorting Nexin 1 Promotes Colon Cancer Development Matthew S. Holdren University of Washington School of Medicine Department of Pathology Graduate Student UW Medicine Pathology Monday, November 19, 2007 - 2:00 PM Health Sciences Center, K-069 Faculty Sponsor: Dan Bowen-Pope --- Christine Disteche, PhD Professor of Pathology UW School of Medicine Tuesday, November 13, 2007 - 8:30 AM HSC, NE110 Faculty Sponsor: Dr. Thomas Montine "Human Embryonic Stem Cell Niches?" C. Anthony Blau, MD Professor of Medicine Hematology UW Tuesday, November 13, 2007 - 8:30 AM Brotman Building, 815 Mercer Street, SLU Auditorium "Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system" Howard M. Shulman, M.D. Professor Pathology/Oncology FHCRC Tuesday, November 6, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street The Role of Epilysin (MMP-28) in Lung Inflammation and Epithelial Cell Survival Anne Manicone, MD Pulmonary and Critical Care Medicine UW - Center for Lung Biology Thursday, November 1, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street - refreshments at 3:45pm "Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine" Glenn D. Prestwich, Ph.D. Presidential Professor of Medicinal Chemistry Department of Medicinal Chemistry and Center for Therapeutic Biomaterials The University of Utah Tuesday, October 30, 2007 - 8:30 AM SLU - Brotman Bulding, Blue Flame Auditorium Faculty Sponsor: Thomas N. Wight, Ph.D. 815 Mercer Street Ribosomes and Spindles in Marrow Failure and Cance Predisposition Akiko Shimamura, MD Associate Professor of Pediatrics Division of Hematology/Oncology UWSOM Tuesday, October 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street When Opportunities Arise, Be Ready Raj Kapur, M.D., Ph.D. Associate Professor UW Medicine Pathology University of Washington Tuesday, October 9, 2007 - 8:30 AM UWMC Anatomic Pathology, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Leptin in Cardiovascular Disease Daniel Eitzman Assistant Professor Internal Medicine/Cardiovascular Disease University of Michigan Wednesday, September 26, 2007 - 8:30 AM Brotman Building, SLU, Blue Flame Faculty Sponsor: Steve Schwartz 815 Mercer Street Reschedule - date tentative Clinical Experience of High Resolution Oligonucleotide Array: Ji Yun Lee, Ph.D. ABMG Training Program Trainee Department of Human Genetics Emory University Monday, September 17, 2007 - 3:00 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Christine Disteche, Ph.D. Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided Epithelial Differentiation in the Prostate: Insights from a Primary Cell Culture System Beatrice Knudsen, M.D., Ph.D. Affiliate Professor UW Medicine Pathology Member, FHCRC Division of Public Health Sciences Tuesday, September 11, 2007 - 8:30 AM UWMC Anatomic Pathology, NE-110 Conference Room Faculty Sponsor: Dr. Thomas Montine Base of Skull Chordoma: The Conundrum of Morphology and Biology Benjamin Hoch, M.D. Assistant Professor Department of Pathology Mount Sinai School of Medicine Monday, August 20, 2007 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson, M.D. Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology Multicolor Karyotyping & Banding in Non-Hodgkin Lymphoma and Bac Array CGH in Chronic Lymphocytic Leukemia Valia S. Lestou, Ph.D. Researcher University of British Columbia Center for Disease Control Tuesday, July 17, 2007 - 2:00 PM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Christine Disteche Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided Insulin Modulation of Plasma beta-Amyloid levels Pattie S. Green, PhD Research Assistant Professor Medicine UWSOM Tuesday, June 26, 2007 - 8:30 AM TBA, TBA Faculty Sponsor: Renee LeBoeuf It's a Small World After All: The MicroRNA Gene Expression Profile of HCV-Associated Hepatocellular Carcinoma Heike Varnholt, M.D. Staff Pathologist Division of Gastrointestinal and Hepatobiliary Pathology University Hospital of Cologne, Germany Friday, June 22, 2007 - 12:30 PM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Melissa Upton Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided. TBA Larry Adams Senior Research Scientist Pathology UWSOM Tuesday, June 19, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Finding Genes for Uterine Fibroids Jennelle Hodge, Ph.D. Senior Research Fellow Department of OB-GYN and Reproductive Biology Brigham and Women's Hospital, Harvard Medical School Monday, June 11, 2007 - 3:30 PM Health Sciences Center, Turner Auditorium, D-209 Faculty Sponsor: Christine Disteche Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology Roles of cytokines in regulation of bone mass Brendan Boyce Director of Surgical Pathology Department of Pathology and Laboratory Medicine University of Rochester Medical Center in New York Wednesday, June 6, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Larry True RGS5: Regulating the Regulator William M. Mahoney Jr. Postdoctoral Fellow Pathology UWSOM Tuesday, June 5, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Erythropoietin and Cancer – A Window of Opportunity for Pharmacologically Regulated Cell Therapy? C Anthony (Tony) Blau, MD Professor Medicine, Hematology UWSOM Thursday, May 31, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy Dr. Eberhard Neumann Bielefeld, Germany Department of Chemistry University of Bielefeld Wednesday, May 30, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Lawrence Loeb International speaker from Germany How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease? Wendy Thomas Assistant Professor Bioengineering UWSOM Tuesday, May 29, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Chorea vs Parkinsonism: The Search for Primary Centers for Degeneration Jean Paul Vonsattel, M.D. Professor Department of Pathology Columbia University Medical Center Wednesday, May 23, 2007 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tom Montine 5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002. Molecular Mechanisms of Regulation of L-type Calcium Channels Michelle Emrick Senior Fellow Pharmacology UWSOM Tuesday, May 22, 2007 - 8:30 AM Health Sciences, K-069 TGF-beta signaling in kidney cells Anne-Christine Poncelet Acting Instructor Medicine-Gerontology UW School of Medicine Tuesday, May 15, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Chromatin Profiling of the Human Genome: Genomic Distribution and Characterization of Insulator Elements Anton Krumm PhD Research Assistant Professor Radiation Oncology UW School of Medicine Thursday, May 10, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments 3:45 p.m. Mortar and Bricks Melissa Upton, M.D. Associate Professor, Assistant Chief of Anatomic Pathology Department of Pathology University of Washington Tuesday, May 8, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice Guy Odom Senior Fellow Neurology UWSOM Tuesday, May 8, 2007 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek To Call or Not to Call: The Challenge of Intraoperative Frozen Section Gang He, M.D., Ph.D. Bone and Soft Tissue Fellow Department of Pathology University of Chicago Monday, May 7, 2007 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson Dr. He is a clinical faculty candidate for bone and soft tissue pathology. Diabetes, obesity and the brain Michael Schwartz Professor Metabolism, Endocrinology and Nutrition UWSOM, Clincal Nutrition, Harborview Thursday, May 3, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments 3:45 p.m. The role of P2X7 and activated caspases in the regulation of macrophage fusion Thomas Nhan PhD Candidate Pathology UW School of Medicine Tuesday, May 1, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Matrilysin (MMP-7) function in acute and chronic lung injury John K. McGuire, MD Pediatric Critical Care Medicine Children's Hospital & Regional Medical Center UW School of Medicine Thursday, April 26, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Mechanisms Underlying the Influence of Androgens on Prostate Carcinogenesis Peter S. Nelson Associate Professor Medicine, Oncology Fred Hutchinson Cancer Research Center Thursday, April 19, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments 3:45 p.m. Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction Daniel J. Morgan Senior Fellow Pharmacology UWSOM Tuesday, April 17, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Steve Schwartz TBA Ray Monnat, M.D. Professor Department of Pathology University of Washington Tuesday, April 10, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad Joseph McGonigle Research Assistant Bioengineering UWSOM Tuesday, April 10, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Cecilia Giachelli 815 Mercer Street Saving the World from the Next Pandemic: Can Functional Genomics and Computational Biology Save Us? Michael G. Katze, PhD Professor of Microbiology Core Staff Scientist and Associate Director Washington NPRC Thursday, April 5, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street Refreshments 4:45 p.m. Understanding macrophage foam cell formation using a proteomics-based approach Lev Becker Senior Fellow Medicine, Division of Metabolism, Endocrinology and Nutrition UWSOM Tuesday, April 3, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Jay Heinecke 815 Mercer Street DNA Processing in Autoimmune Disease Fred Perrino, Ph.D. Professor Department of Biochemistry Wake Forest University Health Sciences Monday, April 2, 2007 - 11:30 AM Health Sciences Center, K-069 Faculty Sponsor: Larry Loeb and Brad Preston Immunomodulation of breast cancer? Nora Disis, MD Professor Medicine UWSOM, Member Fred Hutchinson Cancer Research Center Thursday, March 29, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street Refreshments at 3:45 p.m. Probing chromatin dynamics Karol Bomsztyk Professor Medicine UWSOM Tuesday, March 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Repair of oxidative DNA damage and human disease Dr. Will Bohr NIA Wednesday, March 21, 2007 - 4:30 PM Health Sciences Building, K-069 Faculty Sponsor: Dr. Monnat This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP). Angiotensin II-induced vascular pathologies - a multitude of mechanisms Alan Daugherty Professor Cardiovascular Medicine University of Kentucky Tuesday, March 20, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Mike Rosenfeld 815 Mercer Street Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: Systemic Sclerosis Richard A Nash, MD Associate Professor Medicine, Division of Oncology Fred Hutchinson Cancer Research Center Thursday, March 15, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments at 3:45 p.m. PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies Steven A. Moore, M.D., Ph.D. Co-Director Wellstone Muscular Dystrophy Research Center University of Iowa Wednesday, March 14, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Hevner Sponsored by PathPresents. My Adventures in Biomed Research: How You Can Help Us Move Beyond Gleason Grade Larry True, M.D. Professor Department of Pathology University of Washington Tuesday, March 13, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine A ROCK and Role for Syndecans in Cytoskeletal Regulation John R. Couchman Professor National Heart & Lung Institute Imperial College, London Tuesday, March 13, 2007 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Bill Parks 815 Mercer Street Chemical Genetics and Translational Research in Skin Cancer Paul Nghiem, MD PhD Asst. Professor, UW Dermatology/Medicine Affiliate Investigator Fred Hutchinson Cancer Research Center Thursday, March 8, 2007 - 4:00 PM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz * Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer. Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries? Jo Fleming Scleroderma Research Fellow Pathology UWSOM Tuesday, March 6, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street RESCHEDULED! Understanding HSV-2 Reactivations: New Observations, New Surprises Lawrence Corey, MD Professor, Laboratory Medicine Adjunct Professor, Pediatrics Fred Hutchinson Cancer Research Center Thursday, March 1, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation Jonathan Golob Graduate Student Pathology UWSOM Tuesday, February 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street The Regulation of Long-term Repopulating Hematopoietic Stem Cells (LTR-HSC) by Endogenous Transforming Growth Factor Beta (TGF-beta) Stephen Bartelmez PhD BetaStem Therapeutics Inc, San Francisco Thursday, February 22, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Pathological Protein in Neurodegenerative Diseases Tom Montine, M.D., Ph.D. Professor, Director of Neuropathology Department of Pathology University of Washington Tuesday, February 13, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Adult Stem Cells: Epigenetics, pluripotency and plasticity Morayma Reyes Assistant Professor Pathology and Laboratory Medicine UWSOM Tuesday, February 13, 2007 - 8:30 AM SLU, Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Immunoexpression of Hypoxia-related Genes in Retroperitoneal Sarcomas Paul Zhang, M.D. Associate Professor Pathology and Lab Medicine University of Pennsylvania School of Medicine Monday, February 12, 2007 - 1:00 PM University of Washington Medical Center, NE-110 Conference Room Faculty Sponsor: Larry True Speaker is a candidate for a clinical faculty position with the Department of Pathology A Trojan Horse Nips at an Achilles Heel: Gallium as an Anti-infective Therapy Pradeep Singh MD Associate Professor Medicine and Microbiology, Pulmonary and Critical Care Medicine UW School of Medicine Thursday, February 8, 2007 - 4:00 PM Brotman Building, SLU, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Refreshments: 3:45 p.m. Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies. Jason D. Morrow F. Tremaine Billings Professor of Medicine and Pharmacology Chief, Division of Clinical Pharmacology Vanderbilt University School of Medicine Wednesday, February 7, 2007 - 4:30 PM HSC, K-069 Faculty Sponsor: Dr. Thomas Montine Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis Ranjini M. Krishnan Fellow Cardiology UWSOM Tuesday, February 6, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: David Dichek Subtelomere Dynamics: Why So Many Breaks? Katie Rudd, Ph.D. Postdoctoral Fellow Fred Hutchinson Cancer Research Center Wednesday, January 31, 2007 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Christine Disteche Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology Monocytes, Dendritic Cells, and Atherosclerosis Gwen Randollph Associate Professor Gene & Cell Medicine Mt. Sinai School of Medicine Tuesday, January 30, 2007 - 10:00 AM Health Sciences, K-069 Faculty Sponsor: Elaine Raines/Stephen Schwartz Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project Genome of Weird Australian Mammals Jenny Graves, Ph.D. Professor Comparative Genomics Australian National University Monday, January 29, 2007 - 4:30 PM Genome Sciences Building, Foege Auditorium Faculty Sponsor: Christine Disteche Gene Action in the Pathobiology of Aging George M. Martin Director Emeritus, Alzheimer’s Disease Research Center (ADRC) Professor Emeritus (Active), Department of Pathology UW School of Medicine Thursday, January 25, 2007 - 4:00 PM Brotman Building (SLU), Blue Flame Auditorium 815 Mercer Street Magnetic Resonance Imaging of Atherosclerosis Hunter R. Underhill Fellow Vascular Imaging Lab UWSOM Tuesday, January 23, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Caspase regulation of macrophage functions Thomas Q. Nhan PhD Candidate Pathology UWSOM Tuesday, January 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street How Autopsies Have Expedited Research on Human Progeroid Syndromes, With Comments on the Viability and Cryopreservation of Postmortem Tissues George Martin, M.D. Professor Department of Pathology University of Washington Tuesday, January 9, 2007 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Tissue voxelation with a high-speed transverse microtome John Welsh, PhD Associate Professor Molecular and Cancer Biology Program Sidney Kimmel Cancer Center, San Diego, California Tuesday, January 9, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Marshall Horwitz 815 Mercer Street Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease Hangjun Duan Senior Fellow Pathology UWSOM Tuesday, December 19, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Neurogenesis and Malformations of Cortical Development Robert Hevner, M.D., Ph.D. Associate Professor Department of Pathology University of Washington Tuesday, December 12, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine BTNL2, a novel B7 family member and regulator of T cell activation Heather Arnett Scientist Amgen, Inc. Tuesday, December 5, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street The Ins and Outs of Bcl-2 in Cell Death John M. Harlan, MD Chief Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology University of Washington Tuesday, November 21, 2006 - 8:30 AM Health Sciences Building, K-069 Update of Cervical Cancer Control Nancy Kiviat MD Professor, Chief of HMC Pathology Pathology UWSOM, Harborview Thursday, November 16, 2006 - 4:00 PM Brotman Building, Blue Flame Auditorium 815 Mercer Street Refreshments at 3:45 p.m. Updates on Cervical Cytology Nancy Kiviat, M.D. Professor, Chief of HMC Pathology Department of Pathology University of Washington Tuesday, November 14, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine TSLP and Th2-mediated inflammation Steven F. Ziegler, PhD Director Immunology Program Benaroya Research Institute Tuesday, November 14, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Towards Targeted Therapy in Sarcoma: Somatostatin Type-2 Receptor Expression in Bone and Soft Tissue Tumors William Ahrens Senior Fellow Surgical Pathology - Bone and Soft Tissue Mayo Clinic Tuesday, November 7, 2006 - 11:00 AM UWMC, NE-110 Conference Room Faculty Sponsor: Paul Swanson Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology Differentiation of Endothelium from Human Embryonic Stem Cells Marilyn Nourse PhD Candidate Pathology UWSOM Tuesday, November 7, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice Fredrik Johansson Postdoctoral Fellow Pathology UWSOM Tuesday, October 31, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Karin Bornfeldt Calcium Sparklets in Vascular Smooth Muscle Manuel F. Navedo Senior Fellow Physiology and Biophysics UWSOM Tuesday, October 24, 2006 - 8:30 AM Health Sciences Building, K-069 Mutation avoidance, disease, and error catastrophy: The great escape Bradley D. Preston Professor Pathology UWSOM Thursday, October 19, 2006 - 3:45 PM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Cancelled will reschedule for spring David Lovett - postponed Professor in Residence Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital University of California, San Francisco Tuesday, October 17, 2006 - 8:30 AM TBA, TBA Hepatitis C Associated Cryoglobulinemia and Glomerulonephritis: A Tale of Mice and Men Charles Alpers, M.D. Professor Department of Pathology University of Washington Tuesday, October 10, 2006 - 8:30 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine PSGL-1 Adherence and mTOR Modulate Translation in Macrophages Richard Fox PhD Candidate Pathology UW School of Medicine Tuesday, October 10, 2006 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street cFLIP Regulates Fas-induced Apoptosis and Pro-inflammatory Gene Expression in Human Vascular Smooth Muscle Cells Monja Dishmon Pathology UW School of Medicine Thursday, October 5, 2006 - 1:00 PM 815 Mercer Bldg, Room 111 Faculty Sponsor: Bowen-Pope An unexpected role for the tissue factor pathway in atherosclerosis Robert D. Simari Professor Cardiovascular Diseases Mayo Clinic Tuesday, October 3, 2006 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Of mice and mice; why some do and some don't develop arterial lesions Michael A Reidy PhD Professor Pathology UWSOM Tuesday, September 26, 2006 - 8:30 AM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street Interventional imaging of vascular gene delivery and expression Xiaoming Yang, MD, PhD Professor, Director, Image-Guided Bio-Molecular Interventions Research Radiology University of Washington School of Medicine Thursday, September 21, 2006 - 4:00 PM Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz Thyroid Dysfunction in Heart Failure A. Martin Gerdes Professor, Medicine and Director South Dakota Cardiovascular Research Institute, Sioux Falls University of South Dakota Thursday, September 14, 2006 - 8:30 AM Brotman Building, 815 Mercer Street, Room 111, Auditorium Faculty Sponsor: Chuck Murry Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able. Arterial Rupture--Pathology and Genetics Peter Byers, M.D. Professor Department of Pathology University of Washington Tuesday, September 12, 2006 - 8:00 AM UWMC, NE-110 Conference Room Faculty Sponsor: Tom Montine Electrophysiological Cortical Imaging of Brain Electrical Activity Yuan Lai, PhD Fellow Candidate Electrical Engineering University of Illinois, Chicago Thursday, August 31, 2006 - 1:30 PM Brotman Building (SLU), 110 Faculty Sponsor: Chun Yuan 815 Mercer Street Vascular Imaging Labororatory Seminar Mechanism of Endocytosis of CD33/Siglec-3:Role of ITIMs, Tyrosine Phosphorylation, and Monoubiquitylation Roland Walter Pathology UWSOM Wednesday, August 9, 2006 - 4:30 PM Fred Hutchinson Cancer Research Center, Pelton Auditorium Faculty Sponsor: Dr. Steve Collins Toxicogenomics of Endemic Nephropathy: A Multinational Disease Arthur Grollman, M.D. Distinguished Professor of Pharmacological Sciences and Medicine State University of New York at Stony Brook Wednesday, August 2, 2006 - 3:30 PM Health Sciencs Center, K-069 Faculty Sponsor: Dr. Larry Loeb “Functional genomics and liver regeneration” Jiangning Li Doctoral Dissertation Pathology Medicine Tuesday, August 1, 2006 - 8:30 AM HSB, T-473 Faculty Sponsor: Dr. Bumgarner Role of CHF1/Hey2 in Cardiovascular Development Michael T. Chin, MD/Phd Assistant Professor Medicine Harvard Medical School Thursday, July 27, 2006 - 4:15 AM SLU 815 Mercer Street, 111, Auditorium SLUGs Present Tapas The rupture-prone human plaque: how to define and detect it Erling Falk Professor Department of Cardiology Skejby University Hospital, Aarhus, Denmark Tuesday, June 27, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Steve Schwartz Protection of cardiovascular stem cells by cholesterol-lowering therapy Yong-Jian Geng, MD PhD Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research Dept. of Internal Medicine, Cardiology Division University of Texas School of Medicine, Houston, TX Tuesday, June 20, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Chuck Murry Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma Laura Beretta Associate Member, FHCRC, Affiliate Associate Professor, UW Pathology UW - Pathology Wednesday, June 7, 2006 - 4:00 AM HSB, K-069 "X Chromosome Upregulation and its Biological Significance in Mammals" Di Kim Nguyen Doctoral Dissertation Pathology UWSOM Wednesday, May 31, 2006 - 10:30 AM HSB, T-435 Faculty Sponsor: Christine Disteche Distinct Wnt signaling pathways play opposing roles during organ regeneration Cristi Stoick-Cooper CVP Graduate Student Neurobiology & Behavior UWSOM Tuesday, May 30, 2006 - 8:30 AM HSB, K-069 Therapeutic use of the endogenous metalloprotease inhibitor TIMP-3 Roy A. Black, Ph.D. Associate Director of Research Department of Inflammation Amgen Inc. Thursday, May 25, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease Daniel J Morgan Senior Fellow Pharmacology UWSOM Tuesday, May 23, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Stephen M Schwartz Matrix Revisited Thomas N. Wight, Ph.D. Benaroya Research Institute Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology School of Medicine Thursday, May 18, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks “Global analysis of X chromosome dosage compensation" Brian Oliver Section Chief of Developmental Genomics National Institutes of Health, Bethesda, MD Wednesday, May 10, 2006 - 4:30 PM HSB, K-069 Faculty Sponsor: Christine Disteche Cardiac applications for human embryonic stem cells Michael Laflamme Acting Instructor Pathology Center for Cardiovascular Biology & Regenerative Medicine, UWSOM Tuesday, May 2, 2006 - 8:30 AM SLU 815 Mercer St, 111 Faculty Sponsor: Chuck Murry Wnt Signaling in Regeneration and Regenerative Medicine Randall T. Moon, Ph.D. Professor and Director, Institute for Stem Cell and Regenerative Medicine Department of Pharmacology School of Medicine Thursday, April 27, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: BIll Parks Neurovascular Dementia: How Abnormalities of Cerebral Blood Vessels and Brain Parenchyma Compete Harry Vinters, M.D. Professor and Chief, Neuropathology Departments of Pathology and Laboratory Medicine University of California, Los Angeles Wednesday, April 26, 2006 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tom Montine **NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology" Keith Cheng Jake Gittlen Cancer Research Foundation Penn State College of Medicine Wednesday, April 26, 2006 - 1:30 PM HSB, K-069 Faculty Sponsor: Dr. Loeb Inflammation loci and carotid artery disease Gail Jarvik MD Professor Medicine, Medical Genetics UWSOM Tuesday, April 25, 2006 - 8:30 AM SLU 815 Mercer, 111 Auditorium Faculty Sponsor: Stephen M Schwartz Proteomic Analysis of the Cardiac Calcium Channel Michelle Emrick PhD Senior Fellow Pharmacology UWSOM Tuesday, April 18, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz The role of estrogens in maintaining brain function after injury: Views of a basic scientist and provost Phyllis M. Wise, Ph.D. Provost and Vice President for Academic Affairs University of Washington Friday, April 14, 2006 - 12:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Chuck Murry Diabetic Macrovascular Disease in Mice: What the &#@*'s going on? Renee C. LeBoeuf, Ph.D. Research Professor of Medicine Division of Metabolism, Endocrinology and Nutrition School of Medicine Thursday, April 13, 2006 - 4:00 PM 815 Mercer Street, Blue Flame Auditorium Faculty Sponsor: Bill Parks The Role of Pattern Recognition Receptors in Macrophage Death Ira Tabas, MD/PhD Professor, Medicine and Anatomy & Cell Biology Deputy Editor - Journal of Clinical Investigation Columbia University Tuesday, April 11, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Michael Rosenfeld Defining a Functional Role for Discoidin Domain Receptors in Vascular Biology Michelle Bendeck, Ph.D. Associate Professor Department of Laboratory Medicine and Pathobiology University of Toronto Friday, April 7, 2006 - 10:00 AM 815 Mercer, Blue Flame Auditorium Faculty Sponsor: Michael Reidy Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology? Adam S. Wilkins Editor, BioEssays Company of Biologists, Ltd. Cambridge, UK Tuesday, April 4, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Karol Bomsztyk A Systems Approach to Dissecting Immunity Alan Aderem, Ph.D. Institute for Systems Biology, and Affiliate Professor UW Department of Immunology Institute for Systems Biology Thursday, March 30, 2006 - 4:00 AM 815 Mercer St., SLU, Blue Flame Auditorium Faculty Sponsor: Bill Parks "Effects of Regulated Expression of Hepatitis C Virus Proteins on HH4 Human Hepatocytes" Weiliang Tang Pathology University of Washington Tuesday, March 28, 2006 - 1:30 PM HSB, K-069 Faculty Sponsor: Dr. Fausto Regulatory T cells, TGF-beta and atherosclerosis Goran K. Hansson Professor Cardiovascular Research, Molecular Medicine Karolinska Institutet, Stockhom, Sweden Tuesday, March 28, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Structure Biology of Ubiquitin Ligase Machinery Ning Zheng Assistant Professor Pharmacology UWSOM Tuesday, March 21, 2006 - 8:30 AM Health Sciences Building, K-069 Atheroprotective Effects of Transforming Growth Factor Beta-1 Andrew D. Frutkin, MD Acting Instructor/Senior Fellow Cardiology Division UWSOM Tuesday, March 14, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: David Dichek Please note change of venue Mechanism of the Cerebral Cortex Malformation Caused by FGFR3 Mutations Tomoko Iwata, Ph.D. Beatson Laboratories for Cancer Research University of Glasgow Scotland, UK Friday, March 10, 2006 - 9:30 AM Harborview Medical Center, R&T Building, Room 109 Faculty Sponsor: Robert Hevner Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning. The lecture is free and open to the public. Cell Therapy for Cardiac Arrhythmias and Myocardial Regeneration Lior Gepstein, M.D., Ph.D. Associate Professor, Faculty of Medicine Department of Physiology and Biophysics Technion-Israel Institute of Technology Thursday, March 9, 2006 - 4:00 AM 815 Mercer Street, SLU, Blue Flame Auditorium Faculty Sponsor: Chuck Murry The CD4+ autoreactive T cell: chance or necessity? Gerald T. Nepom, MD/PhD Director Benaroya Research Institute at Virginia Mason Tuesday, March 7, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Distinguished Faculty Lecture "Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice" Michael Rosenfeld, Ph.D. Professor Department of Pathobiology University of Washington Thursday, March 2, 2006 - 3:30 PM Health Sciences Center, Room T-625 Faculty Sponsor: Terrance Kavanagh For more information, please contact Billie Grace at 206.543.1144 C-reactive protein and cardiovascular risk: a population genomics approach Alex Reiner, MD MSc Research Associate Professor Epidemioloy & Laboratory Medicine UWSOM Tuesday, February 28, 2006 - 8:30 AM SLU 815 Mercer, 111 Faculty Sponsor: Stephen M. Schwartz VEGF: From Bench to Bedside Napoleone Ferrara Genentech Fellow Molecular Oncology Genentech, Inc Wednesday, February 22, 2006 - 4:00 PM Health Sciences Center, Room T-739 Faculty Sponsor: Stephen Schwartz Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer. The lecture is free and open to the public. Clinical Genetics and Genomics of Type I Collagen Peter Byers, MD Professor Pathology & Medicine UWSOM Tuesday, February 21, 2006 - 8:30 AM Health Sciences, K-069 Wnt pathways can control cardiogenesis in mouse embryonic stem cells Shuichi Ueno, MD/PhD Senior Fellow Pathology UWSOM Tuesday, February 14, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Chuck Murry ABC cholesterol transporters as rescuers from cardiovascular disease John F. Oram Research Professor Medicine UWSOM Thursday, February 9, 2006 - 4:00 PM SLU 815 Mercer Street, 111 South Lake Union Seminar Series The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions Alain Mauviel, PhD Director INSERM U697 Hospital Saint-Louis, Paris, France Tuesday, February 7, 2006 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Bill Parks HnRNP K: Gene expression, hubs and scale-free networks Karol Bomsztyk Professor Medicine UWSOM Tuesday, January 31, 2006 - 8:30 AM Health Sciences Building, K-069 Molecular Basis of Information Daniel Storm Professor Pharmacology UWSOM Tuesday, January 24, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz Metalloproteinases: Effectors of Repair or Conspirators of Disease? William Parks Director Center for Lung Biology UWSOM Thursday, January 19, 2006 - 4:00 AM SLU South Lake Union, 111 (Auditorium) Faculty Sponsor: Stephen M. Schwartz Special Tapas. Refreshments 3:45 p.m. Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons Jennifer O'Brien Senior Fellow Pharmacology UWSOM Tuesday, January 17, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M. Schwartz Regulation of Nitric Oxide Synthase by Shear Stress David G. Harrison MD Professor, Medicine Director, Division of Cardiology Emory University School of Medicine Tuesday, January 10, 2006 - 8:30 AM South Lake Union (SLU), 111 Faculty Sponsor: Stephen M. Schwartz Current Diagnosis of Ovarian Mucinous Tumors Hongxiu Ji, M.D., Ph.D. Assistant Professor Departments of Pathology and Obstetrics/Gynecology The Johns Hopkins University School of Medicine Tuesday, January 10, 2006 - 8:00 AM UWMC, NE-110 Conference Room The special seminar will be presented as part of a didactic session with the residents. Apoptosis and Macrophage Inflammation Keith Elkon, MD Prof. of Medicine & Adjunct Prof. Immunology Head, Division of Rheumatology UWSOM Tuesday, December 20, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Vaccines Targeting Breast and Ovarian Cancers Nora Disis MD Associate Professor Department of Medicine, Division of Oncology UWSOM Thursday, December 15, 2005 - 4:00 PM SLU 815 Mercer Street, 111 Special Tapas Seminar Assaying Methylation Markers using Coded Silica Particles Simon Corrie Visiting Fellow Pathology University of Queensland, Australia Thursday, December 15, 2005 - 9:30 AM SLU, 815 Mercer Street, 111 Faculty Sponsor: Nancy Kiviat SLUG Seminar: A Progress Report Mechanisms of Arterial Constriction due to Urokinase Overexpression Philip Massey, MD Acting Instructor Medicine/Cardiology UWSOM Tuesday, December 13, 2005 - 8:30 AM Health Sciences Building, K-069 "Keeping the Balence: Dosage Compensation of the Active X Chromosome in Mammals" Christine Disteche Professor Department of Pathology University of Washington Friday, December 9, 2005 - 12:30 PM Health Sciences Center, Room K-069 Division of Medical Genetics presents the Markey Molecular Medicine Seminar Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin Samantha Harris, PhD Research Assistant Professor Bioengineering UWSOM Tuesday, December 6, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Epigenetic Change in the Differentiating Embryonic Stem Cell Jonathan Golob PhD Fellow Department of Pathology UWSOM Thursday, December 1, 2005 - 4:15 PM South Lake Union, 111 Tapas Seminar Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS) Conrad Liles Associate Professor Medicine, Infectious Diseases UWSOM Tuesday, November 29, 2005 - 8:30 AM SLU 815 Mercer Street, 111 What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice? Karin Bornfeldt PhD Associate Professor Pathology UWSOM Tuesday, November 22, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Developmental Genome Anatomy Project (DGAP): Identification of Genes Critical to Human Development Azra H. Ligon, Ph.D. Assistant Professor Department of Pathology Harvard Medical School Thursday, November 17, 2005 - 12:00 PM Health Sciences Center, Room T-639 Faculty Sponsor: Christine Disteche Transcription Factor Regulation of Glial Progenitor Development and Gliomas Keith L. Ligon, M.D., Ph.D. Staff Pathologist and Associate Neuropathologist Department of Pathology Brigham and Women's Hospital Wednesday, November 16, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Vascular Calcification: role of smooth muscle cells and phosphate Cecilia Giachelli PhD Professor Bioengineering UWSOM Tuesday, November 15, 2005 - 8:30 AM Health Sciences Building, K-069 N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems Yong Tae Kwon Assistant Professor Pharmaceutical Sciences University of Pittsburgh Thursday, November 10, 2005 - 8:30 AM Health Sciences Building, T-635 Faculty Sponsor: Stephen M. Schwartz Special Breakfast Club Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control Richard Fox PhD Candidate Pathology, Cardiovascular Biology UWSOM Tuesday, November 8, 2005 - 8:30 AM Health Sciences Bldg., K-069 Faculty Sponsor: Stephen M Schwartz A Genome-wide Hunt for Public Mechanisms of Aging Matt Kaeberlein, Ph.D. Senior Fellow Department of Genome Sciences University of Washington Wednesday, November 2, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs Charles Frevert, DVM, ScD Research Associate Professor Medicine/Pulmonary & Critical Care Medicine VA Medical Center/UWSOM Tuesday, November 1, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Bill Parks FISHing for Answers in Pediatric Gliomas Christine Fuller, M.D. Assistant Member Department of Pathology St. Jude Children's Research Hospital Wednesday, October 26, 2005 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Role of PAI-1 in Progressive Renal Disease Allison Eddy, MD Professor & Head Division of Pediatric Nephrology Children's Hospital & Med Center, UWSOM Tuesday, October 25, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz "Stromal" Tumors of the Prostate Donna Hansel, M.D., Ph.D. Resident Department of Pathology Johns Hopkins Hospital Friday, October 21, 2005 - 1:00 PM UWMC, NE-110 Conference Room Faculty Sponsor: Larry True Dr. Hansel is being considered for a faculty position in the Department of Pathology Roundtable Discussion: Pathologic implications of vascular developmental biology Brant Weinstein Senior Investigator and Head of Section of Vertebrate Organogenesis Laboratory of Molecular Genetics NIH National Institute of Child Health & Human Development (NICHD) Tuesday, October 18, 2005 - 9:30 AM Health Sciences Building, E-212 Faculty Sponsor: Elaine Raines/Steve Schwartz Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments. Assembly of the Developing Vasculature Brant M. Weinstein, Ph.D. Senior Investigator and Head of Section of Vertebrate Organogenesis Laboratory of Molecular Genetics, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD Monday, October 17, 2005 - 3:00 PM Health Sciences Center, Room D-209 Faculty Sponsor: Elaine Raines Regulation of GPCR Function by RGS Chris Hague Assistant Professor Pharmacology UWSOM Tuesday, October 11, 2005 - 8:30 AM SLU 815 Mercer Street, Auditorium, Rm. 111 Faculty Sponsor: Stephen M. Schwartz Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits Eric Schadt, PhD Senior Scientific Director Research Genetics Rosetta Inpharmatics, Inc., Seattle, WA Tuesday, October 4, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Lifestyle modifications improve vascular dysfunction in a mouse model of Type II Diabetes Dr. Ismail "Issy" Laher Associate Professor Pharmacology & Therapeutics University of British Columbia Friday, September 23, 2005 - 1:00 PM HSB, T-359 Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information. Translation control in activated endothelial cells Larry W. Kraiss MD Assistant Professor & Chief Division of Vascular Surgery University of Utah Tuesday, September 13, 2005 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Richard Kenagy "Anchoring Molecular Lifelines: Integrin Mediated Survival Signals" Julie Rice Graduate Student Pathology University of Washington Thursday, August 18, 2005 - 11:00 AM Chem, 102 Faculty Sponsor: Giachelli Doctoral Dissertation Oncolytic adenoviruses: Progress and Challenges Andre Lieber, MD PhD Research Associate Professor Medical Genetics UWSOM Thursday, August 4, 2005 - 4:00 PM South Lake Union, 815 Mercer St., 111 Auditorium Faculty Sponsor: Stephen M. Schwartz Special Tapas Presentation Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD) Xia (Clare) Shen PhD Postdoc Candidate Pharmacology & Toxicology University of Louisville Tuesday, July 26, 2005 - 8:30 AM HSB, K-069 Faculty Sponsor: Karin Bornfeldt Special Breakfast Club Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium? Chris Sullivan Postdoctoral Fellow Urology UWSOM Tuesday, July 19, 2005 - 9:00 AM South Lake Union, 111 Faculty Sponsor: Hunter Wessells Arrhythmogenic Right Ventricular Cardiomyopathy: From Anatomical Theatre to Double Helix Gaetano Thiene, M.D., FRCP Professor, Cardiovascular Patholology Director, Institute of Pathological Anatomy University of Padua Medical School Thursday, June 16, 2005 - 3:30 PM Health Sciences Center, Room T-435 Faculty Sponsor: Chuck Murry The role of wnt signaling in zebrafish heart development and regeneration Cristi Stoick Graduate Student Neurobiology & Behavior UWSOM Tuesday, June 14, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Potassium Channel Regulation in Cerebral Arterial Smooth Muscle Gregory Amberg Senior Fellow Physiology & Biophysics UWSOM Tuesday, June 7, 2005 - 8:30 AM Health Sciences Building, K-069 Physiological and Genomic Consequences of Mitochondrial Oxidative Stress Simon Melov Buck Institute Tuesday, May 31, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Aldosterone and cardiovascular disease: past, present and future Bardia Askari Acting Instructor Pathology UWSOM Tuesday, May 31, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Searching for Conserved Mechanisms of Eukaryotic Aging Brian Kennedy University of Washington Tuesday, May 24, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle Kenneth Marro Research Assistant Professor Radiology UWSOM Tuesday, May 24, 2005 - 9:00 AM South Lake Union, 100 Faculty Sponsor: Chun Yuan Please note change of venue to 815 Mercer Street. Role of Renal Biopsy in Renal Transplantion Robert Colvin, M.D. Castleman Professor & Chair Department of Pathology Massachusetts General Hospital Monday, May 23, 2005 - 2:00 PM UWMC, Anatomic Pathology Conference Room, NE-110K Faculty Sponsor: Charles Alpers Intraepithelial Neoplasia in the Pancrea David Klimstra Director, Oncologic Pathology Fellowship Programs Department of Pathology Memorial Sloan-Kettering Cancer Center Thursday, May 19, 2005 - 4:00 PM Health Sciences Center, Room T-747 Faculty Sponsor: Brian Rubin New Insights on Mechanisms of Calorie Restriction Rafael DeCabo Laboratory of Experimental Gerontology NIA Tuesday, May 10, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor Marilyn Nourse Graduate Student Bioengineering UWSOM Tuesday, May 10, 2005 - 8:30 AM Health Sciences Building, K-069 Tough mice and aging: How to survive with a damaged proteome" Steve Clarke Professor Department of Chemistry and Biochemistry UCLA Wednesday, May 4, 2005 - 4:30 PM health science bldg, K-069 Faculty Sponsor: George Martin New Roles for Uncoupling Proteins in Protection Against Mitochondrial Radical Production and Aging Martin Brand MRC Dunn Human Nutrition Unit, Cambridge, UK Tuesday, May 3, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies Robert Welikson Senior Research Fellow Biochemistry UWSOM Tuesday, May 3, 2005 - 8:30 AM SLU 815 Mercer Street, 100 Faculty Sponsor: Stephen Schwartz Please note change of venue. "Grial Cell Regulated, Apolipoprotein E Isoform-Specific Mechanism of Neuroprotection and Neurodegeneration" Izumi Maezawa Doctoral Dissertation Medicine Pathology Monday, May 2, 2005 - 1:00 PM Health Sciences Center, T-639 Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde? Catherine Clarke Professor Dept Chemistry and Biochemistry UCLA Wednesday, April 27, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Tony Parks Age-Related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age Ahmad Heydari Wayne State University Tuesday, April 26, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Uncovering the role of receptor trafficking in disease Matthew Holdren Graduate Student Pathology UWSOM Tuesday, April 26, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tony Parks The Role of Protein Tyrosine Phosphatase Receptor Q in Development of Disease Carmen Jane Booth, D.V.M. Doctoral Dissertation Pathology University of Washington Friday, April 22, 2005 - 10:00 AM 815 Mercer Building, Room 111 Faculty Sponsor: Dan Bowen-Pope Does Oxidative Stress Play an Important Role in Determining Lifespan Holly Van Remmen University of Texas, San Antonio Tuesday, April 19, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Can bacteria cause blood vessels to calcify? Michael Rosenfeld Professor Pathobiology and Pathology UWSOM Tuesday, April 19, 2005 - 8:30 AM Health Sciences Building, K-069 The Role of GH and IGF-1 in Extension of Lifespan and Resistance to Toxic Challenges in Mice Andrzej Bartke Southern Illinois University Tuesday, April 12, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Exploring the immunomodulatory action of mechanical ventilation William A. Altemeier Assistant Professor Pulmonary & Critical Care Medicine UWSOM Tuesday, April 12, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Conrad Liles Please note change of venue. Modeling Neurodegeneration in Yeast Susan Lindquist, Ph.D. Member, Whtitehead Institute for Biomedical Research Professor, Department of Biology Massachusetts Institutute of Technology Wednesday, April 6, 2005 - 4:00 PM Health Sciences Center, Hogness Auditorium Faculty Sponsor: Nelson Fausto Why do Big Mice Die Young? Size, Stress, and the Cell Biology of Aging Rich Miller University of Michigan Tuesday, April 5, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center FDR, April 12, 1945 Karol Bomsztyk Professor Medicine, Allergy and Infectious Disease UWSOM, South Lake Union Tuesday, April 5, 2005 - 8:30 AM Health Sciences Building, K-069 PKA Mutations in Mice Affect Metabolism and Adiposity Stanley McKnight University of Washington Tuesday, March 29, 2005 - 1:30 PM HSB, T-747 Faculty Sponsor: The Nathan Shock Center Integrin Signaling: Grasping the survival mechanisms Donald Courter PhD Candidate Bioengineering University of Washington Tuesday, March 29, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Hedgehog signaling in angiogenesis Ronald Heimark PhD Associate Professor Surgery, Cell Biology & Anatomy, and Pathology Arizona Health Sciences Center Tuesday, March 22, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Stephen M. Schwartz Please note change of venue. Vascular malformations and guidance Dean Li Faculty Candidate Medicine, Division of Cardiology University of Utah Tuesday, March 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Research Training Seminar Narci Teoh Department of Pathology Thursday, March 10, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Fausto Pathology 511 Seminar "The liver as a model system for cell growth, proliferation, and carcinogenesis" Jeffrey Albrecht Associate Professor Medicine University of Minnesota Wednesday, March 9, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Tony Parks Recombomice" Shed Light on Homologous Recombination in Mammals Bevin Engelward, Sc.D. Associate Professor of Molecular Toxicology Biological Engineering Division MIT Wednesday, March 2, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Ray Monnat Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix Robert Mecham Alumni Endowed Professor Cell Biology and Physiology Medicine, Pediatrics and Bioengineering Washington University, St. Louis MO Tuesday, March 1, 2005 - 9:00 AM South Lake Union, 815 Mercer Street, 110 Faculty Sponsor: Bill Parks Please note change of location. Research Training Seminar Izumi Maezawa Department of Pathology Thursday, February 24, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Montine Pathology 511 Seminar Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble Anne M. Stevens Acting Assistant Professor Pediatrics, Division of Immunology/Rheumatology Children's Hospital and Regional Medical Center Tuesday, February 22, 2005 - 8:30 AM Health Sciences Building, K-069 "DNA Repair: Winning the Race with Replication" Dr. John Heddle Professor Emeritus & Senior Scholar Department of Biology York University, Toronto, Canada Wednesday, February 16, 2005 - 4:30 PM Health Science Bldg, K-069 Faculty Sponsor: Dr. Loeb ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage Richard Fox Graduate Student Pathology University of Washington Tuesday, February 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Research Training Seminar Rich Fox Department of Pathology Thursday, February 10, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Schwartz Pathology 511 Seminar Hepsins: Lethal giant larvae Valeri Vasioukhin Assistant Member Human Biology Fred Hutchinson Cancer Research Center Tuesday, February 8, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Bill Parks Placental malaria and maternal blood pressure Atis Muehlenbachs Graduate Student, Concurrent Degree Molecular & Cellular Biology UWSOM Tuesday, February 1, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Dan Bowen-Pope Research Training Seminar Galynn Zitnik Department of Pathology Thursday, January 27, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Martin Pathology 511 Seminar The Role of PI-3 Kinase in Cardioprotection Charles Steenbergen, MD PhD Faculty Candidate Pathology Duke University, Durham, NC Tuesday, January 25, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Chuck Murry "Females Have Reduced Cardiac Ischemia-Reperfusion Injury and Hypertrophy: A Role for Estrogen Receptor Beta and Nitric Oxide" Elizabeth Murphy, Ph.D. Faculty Candidate Cell Biology Group, Lab of Signal Transduction Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC Monday, January 24, 2005 - 4:00 PM HSB Turner Autitorium, Room D-209 Inhibitors of Adipogenesis, Stress and Lipotoxicity: Enough to Drive Aging Preadipocytes Mad? James Kirkland, M.D., Ph.D. Associate Professor Department of Medicine Boston University School of Medicine Tuesday, January 18, 2005 - 9:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant Metalloproteinases: Effectors of Innate Immunity William C. Parks Professor Pulmonary & Critical Care Medicine UWSOM, Harborview Tuesday, January 18, 2005 - 8:30 AM Health Sciences Building, K-069 Research Training Seminar Ashwini Kamath-Loeb Department of Pathology Thursday, January 13, 2005 - 4:00 PM Health Sciences Center, Room T-473 Faculty Sponsor: Loeb Pathology 511 Seminar Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination Dr Yannick Saintigny Wednesday, January 12, 2005 - 4:30 PM Health Sciences Center, T-747 Faculty Sponsor: Dr. Ray Monnat Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy Tom Doetschman Professor of Molecular Genetics Biochemistry & Micorbiology University of Cincinnati College of Medicine Tuesday, January 11, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek/Stephen M. Schwartz "Genome Maintenance, Telomeres and RecQ Helicases" Dr. Judith Campisi Professor Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging University of California, Berkeley Wednesday, January 5, 2005 - 3:00 PM HSB, K-069 Faculty Sponsor: Dr. Rabinovitch Angiogenesis in Prostate Cancer Norman M. Greenberg Professor Clinical Research Fred Hutchinson Cancer Research Center Tuesday, December 14, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Chaos out of Order: Splicing and Mosaicism in Genetic Collagen Disorders Peter H. Byers, M.D. Professor, Adjunct Professor of Genome Sciences & Oral Biology Pathology University of Washington Thursday, December 9, 2004 - 12:00 PM HSB, T-625 http://depts.washington.edu/mednews/sim04_05.html Defective DNA Damage Responses and Neurodegeneration and Brain Tumors." Peter McKinnon, Ph.D. Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN Pathology University of Washington Wednesday, December 8, 2004 - 4:30 PM HSB, K-069 Faculty Sponsor: Ray Monnat Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics Tomas Vaisar Research Scientist Metabolism, Endocrinology & Nutrition University of Washington School of Medicine Tuesday, December 7, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Elaine Raines Angiogenesis and Lymphangiogenesis in Inflammation and Tumor Progression Sam Dadras, M.D., Ph.D. candidate for a Pathology Faculty Position Pathology University of Washington Monday, December 6, 2004 - 1:15 PM UWMC, NE-110K Patterning of Cortical Regions and Connections John Rubenstein Nina Ireland Distinguished Professor in Child Psychiatry University of California, San Francisco Wednesday, December 1, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Montine Endothelial Cell Activation and Apoptosis John M. Harlan Professor of Medicine Division of Hematology University of Washington School of Medicine Tuesday, November 30, 2004 - 8:30 AM Health Sciences Building, K-069 Probing the determinants of inter-individual variability in innate immune inflammatory responses Mark Wurfel Acting Instructor Division of Pulmonary and Critical Care Medicine University of Washington Tuesday, November 23, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tom Martin Characterization of Adenovirus Serotype 35 as a Gene Therapy Vector Anuj Gaggar Doctoral Dissertation Pathology Dept of Pathology Thursday, November 18, 2004 - 2:45 PM UWMC, RR-134 The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis Shireen Lamande Departmenet of Pediatrics University of Melbourne, Australia Wednesday, November 17, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Byers Magnetic Resonance Imaging: The Coronary Frontier Won Yong Kim, MD PhD MR-Center & Department of Cardiology Skejby University Hospital, Aarhus Denmark Tuesday, November 16, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Hypoxia and Angiogenesis: Why Do Endothelial Cells Move into Growing Tumors? Randall Johnson Professor Molecular Biology Section, Division of Biological Sciences University of California, San Diego Monday, November 15, 2004 - 8:30 AM Health Sciences Center, Turner Auditorium, Room D-209 Faculty Sponsor: Chuck Murry Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine Pharmacological modulation of medial elastocalcinosis Pierre Moreau, PhD Associate Professor Pharmacology Universit de Montral Tuesday, November 9, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecelia Giachelli Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo Jan E. Schnitzer, MD Professor Cellular & Molecular Biology Scientific Director Sidney Kimmel Cancer Center, San Diego, CA Tuesday, November 2, 2004 - 8:30 AM Health Sciences Building, K-069 Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages Andrew Bender Senior Fellow Pharmacology University of Washington School of Medicine Tuesday, October 26, 2004 - 8:30 AM Health Sciences Building, K-069 The Molecular Architecture of Signal Transduction Complexes John D. Scott Scientist Oregon Health Sciences University Wednesday, October 20, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz LMNA mutations in progeroid syndromes Junko Oshima Research Associate Professor Pathology University of Washington Tuesday, October 19, 2004 - 8:30 AM Health Sciences Building, K-069 Intersections between apoptosis and inflammation Gustave Matute-Bello Assistant Professor Department of Medicine, Division of Pulmonary & Critical Care University of Washington Pulmonary Research Laboratories, VA Puget Sound Health Care System Tuesday, October 12, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Martin Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease Donald McDonald Professor of Anatomy University of California, San Francisco Wednesday, October 6, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis Giulio Gabbiani Professor Departments of Pathology and Immunology University of Geneva-CMU Tuesday, October 5, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz Longevity and Stress-resistance: Mapping the Genes Responsible for Natural Variation in C. Elegans Robert J. Reis Professor Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology University of Arkansas Friday, October 1, 2004 - 11:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Peter Rabinovitch What Are the Roles of Mammalian DNA Damage Binding Protein (DDB) Heterodimer and Its Two Individual Subunits Stuart Linn Professor Department of Biochemistry and Molecular Biology University of California, Berkeley Monday, September 27, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Ray Monnat Genetics of Coronary Heart Disease Jan L. Breslow, M.D. Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism Rockefeller University Monday, September 27, 2004 - 10:30 AM Health Sciences Center, T-439 Faculty Sponsor: Elaine Raines Evolving Concepts in Soft Tissue Neoplasia Christopher Fletcher Professor and Director of Surgical Pathology Brigham & Women's Hospital Boston, MA Wednesday, September 22, 2004 - 4:30 PM Health Sciences Center, Room T-733 Faculty Sponsor: Dr. Brian Rubin Seminar Title: TBA Paul DiCorleto Director Lerner Institute Cleveland Clinic Wednesday, July 14, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Dan Bowen-Pope Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics Joseph Metzger Professor Departments of Physiology and Internal Medicine University of Michigan Tuesday, July 13, 2004 - 4:30 PM Health Sciences Center, Room K-069 Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway Kun-Liang Guan Professor Department of Biological Chemistry University of Michigan Monday, July 12, 2004 - 4:30 PM Health Sciences Center, K-069 Hepatocellular Carcinoma: A Translational Research Challenge Jordi Bruix Director Liver Cancer Unit Hospital Clinic, Barcelona, Spain Friday, July 2, 2004 - 9:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Division of Gastroenterology and the Department of Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy Agnos Fogo Professor Department of Pathology Vanderbilt University Thursday, June 17, 2004 - 10:30 AM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Charles Alpers NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction Rick Rossow Senior Fellow Physiology and Biophysics University of Washington Tuesday, June 15, 2004 - 8:30 AM Health Sciences Building, K-069 Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease Mary Wiser-Evans Assistant Professor Departments of Pediatrics and Cell and Developmental Biology University of Colorado Tuesday, June 8, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Michael Reidy Embryonic Stem Cells for Myocardial Infarct Repair Jeannette Nussbaum Graduate Student Department of Pathology University of Washington Tuesday, June 8, 2004 - 9:30 AM Health Sciences Center, Room T-733 The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells Bardia Askari Associate Howard Hughes Medical Institute University of Washington Tuesday, June 8, 2004 - 8:30 AM Health Sciences Building, K-069 Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart Bodo Levkau Professor Institute of Pathophysiology University of Essen Monday, June 7, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Elaine Raines Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics Andras Nagy Professor Department of Molecular and Medical Genetics University of Toronto Wednesday, May 26, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Stephen Schwartz Harnessing Adult Stem Cells for Myocardial Repair Ronglih Liao Associate Professor Department of Medicine Boston University School of Medicine Wednesday, May 26, 2004 - 10:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Chuck Murry Mislocalization of Neutrophil Elastase is the Major Cause of Inherited Neutropenia Richard E. Person Doctoral Dissertation Department of Pathology University of Washington School of Medicine Tuesday, May 25, 2004 - 11:30 AM Health Sciences Center, K-069 Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury David Granville University of British Columbia Tuesday, May 25, 2004 - 8:30 AM HSB, K-069 Understanding protein tolerance to random amino acid change through directed evolution Haiwei H. Guo Doctoral Dissertation Department of Pathology University of Washington School of Medicine Friday, May 21, 2004 - 12:15 PM University of Washington Medical Center, RR-134 Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate Timothy Hla Professor of Cell Biology and of Genetics and Developmental Biology Director, Center for Vascular Biology University of Connecticut School of Medicine Thursday, May 20, 2004 - 4:30 PM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Michael Reidy Histone Methyltransferases in Tumor Suppression Shi Huang Associate Professor The Burnham Institute La Jolla, California Wednesday, May 19, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Marshall Horwitz Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development Ujwal Pyati Graduate Student Biochemistry University of Washington Tuesday, May 18, 2004 - 8:30 AM HSB, K-069 Pathway Profiling of Glioblastoma Paul Mischel Assistant Professor Department of Pathology and Laboratory Medicine UCLA School of Medicine Thursday, May 13, 2004 - 4:30 PM Health Sciences Center, Room T-747 Faculty Sponsor: Dr. Tom Montine New Entities in Pediatric Renal Neoplasia Pedram Argani Assistant Professor Department of Pathology Johns Hopkins University School of Medicine Wednesday, May 12, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brian Rubin Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart Jeanette Nussbaum Graduate Student Department of Pathology University of Washington Tuesday, May 11, 2004 - 8:30 AM Health Sciences Building, K-069 Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story Stuart Schnitt Professor Department of Pathology Harvard Medical School Wednesday, May 5, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Brian Rubin Greater Potency of Adult Stem Cells: Possible Mechanisms and Uses Catherine Verfaillie  Director Stem Cell Institute University of Minnesota Tuesday, May 4, 2004 - 10:00 AM Health Sciences Center, Hogness Auditorium Faculty Sponsor: Charles Murry Genetic Basis of Aortic Aneurysms and Dissections Dianna Milewicz Professor Department of Medical Genetics University of Texas Medical School Wednesday, April 28, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Eileen Mulvihill Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension Gregory C. Amber Senior Fellow Physiology and Biophysics University of Washington Tuesday, April 27, 2004 - 8:30 AM HSB, K069 Biological Roles of ADAMTS Metalloproteases Suneel Apte Associate Professor Department of Molecular Medicine CANCELED Wednesday, April 21, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Ulrike Schwarze The role of endothelial cells in erectile function and dysfunction Hunter Wessells Associate Professor Urology University of Washington Tuesday, April 20, 2004 - 8:30 AM HSB, K-069 Smooth Muscle Cells and Disease - Insights from Microarray Studies Eileen Mulvihill Research Assistant Professor Pathology University of Washington Tuesday, April 13, 2004 - 8:30 AM Health Sciences Building, K-069 Studies in the Pathology and Pathogenesis of Multiple Sclerosis Samuel Ludwin Professor Department of Neuropathology Queens University: Kingston, Ontario, Canada Wednesday, April 7, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Thomas Montine Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis Marta Scatena Research Assistant Professor Department of Bioengineering University of Washington Tuesday, April 6, 2004 - 8:30 AM Health Sciences Building, K-069 Cytologic Diagnosis of Lymphomas Xiaohua Qian Clinical Fellow Department of Pathology Brigham and Women's Hospital Friday, April 2, 2004 - 12:30 PM UWMC, NE-110 Conference Room Faculty Sponsor: Dr. Brian Rubin C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis Joachim Fruebis Associate Director, ZymoGenetics, Inc. Tuesday, March 30, 2004 - 8:30 AM Health Sciences Building, K-069 Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment Mei Speer Senior Fellow Bioengineering University of Washington Tuesday, March 23, 2004 - 8:30 AM HSB, K069 The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes Paul Hagerman Professor Department of Biological Chemistry University of California, Davis Monday, March 15, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Brad Preston and Charles Laird Pathology Reporting of Colorectal Cancer in the Molecular Era - When does research become best clinical practice? Kieran Sheahan Consultant Pathologist Center for Colorectal Disease St. Vincent's University Hospital: Dublin, Ireland Friday, March 12, 2004 - 9:00 AM Health Sciences Center, K-069 Development Gone Awry: Genetics and Pathology of Medulloblastoma Charles Eberhart Assistant Professor Department of Pathology Johns Hopkins University School of Medicine Wednesday, March 10, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Tom Montine Inflammation and atherosclerosis: Role of serum amyloid A Alan Chait Edwin L. Bierman Professor of Medicine Head, Division of Metabolism, University of Washington Tuesday, March 9, 2004 - 8:30 AM HSB, K069 Vascular Calcification in Chronic Kidney Disease William G. Goodman Professor Department of Medicine U.C.L.A. School of Medicine Wednesday, March 3, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Cecilia Giachelli New Developments in an Integrated Model of Cardiac Function N.P Smith and P.J. Hunter Bioengineering Institute University of Auckland Tuesday, March 2, 2004 - 8:30 AM Health Science Building, K069 Faculty Sponsor: James B Bassingthwaighte Genes, Lymphocytes and Autoimmunity Abul K. Abbas, M.D. Professor & Chair Department of Pathology University of California, San Francisco Friday, February 27, 2004 - 12:00 PM Health Sciences Center, Room T-733 Utilizing Human Genetics to Understand Vascular Development Dean Li Associate Professor Department of Medicine University of Utah Wednesday, February 25, 2004 - 4:30 PM Health Sciences Center, K-069 Faculty Sponsor: Dr. Stephen Schwartz TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models Andrew Frutkin Senior Fellow Cardiology University of Washington Tuesday, February 24, 2004 - 8:30 AM HSB, K069 Characterization of Cancer-Associated Mutants of DNA Polymerase Beta Joann Sweasy Associate Professor Departments of Therapeutic Radiology and Genetics Yale University School of Medicine Wednesday, February 11, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Larry Loeb Functional analysis of RGS5 in vascular smooth muscle Xi Wang Senior Fellow Pathology University of Washington Tuesday, February 3, 2004 - 8:30 AM HSB, K069 Reduced BRCA1 Expression and Ovarian Tumorigenesis Rachel M. Gonzalez Graduate Student Department of Pathology University of Washington Friday, January 30, 2004 - 11:00 AM Health Sciences Center, Room K-069 Faculty Sponsor: Mary Claire King Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer Dusty Miller Member, FHCRC Affiliate Professor, Department of Pathology University of Washington Wednesday, January 28, 2004 - 4:30 PM Health Sciences Center, Room K-069 Faculty Sponsor: Dr. Tony Parks Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity Todd Gillis Senior Fellow Bioengineering University of Washington Tuesday, January 27, 2004 - 8:30 AM HSB, K069 Gene transfer to striated muscles using AAV Jeff Chamberlain Professor Neurology University of Washington Tuesday, January 20, 2004 - 8:30 AM HSB, K069 Fundamental Issues in Engineered Vessel Development Laura Niklason Assistant Professor Departments of Biomedical Engineering, Anesthesia and Surgery Duke University Friday, January 16, 2004 - 3:30 PM Health Sciences Center, K-069 Faculty Sponsor: Chuck Murry and Thomas Wight Linking Mathmatical Modeling with Clinical Research to Better Understand Brain Cancer (Gliomas) Kristin R. Swanson Research Assistant Professor Departments of Pathology and Applied Mathematics University of Washington Tuesday, January 13, 2004 - 2:30 PM Guggenheim Hall, 317 Myocardial Reperfusion Injury Tim Pohlman Professor Surgery University of Washington Tuesday, January 13, 2004 - 8:30 AM HSB, K069 Prelamin A Processing and Progeria Stephen Young, M.D. Senior Investigator Gladstone Institute of Cardiovascular Disease University of California, San Francisco Wednesday, December 17, 2003 - 4:30 PM Health Sciences Center, K-069 The role of Factor XIII in Hemostasis and Wound Healing Paul Bishop Distinguished Fellow ZymoGenetics Tuesday, December 16, 2003 - 8:30 AM Health Sciences, K069 The Role of Runt-Related Transcription Factor @ (Runx2) in Arterial Smooth Muscle Cell Mineralization Gabrielle Mercedes Curinga Graduate Student Department of Pathology University of Washington Friday, December 12, 2003 - 10:30 AM Health Sciences Center, Room RR-134 Leukocyte Bcl-2 and ischemia-reperfusion injury Robert K. Winn Research Professor Surgery and Physiology-Biophysics Harborview Medical Center Tuesday, December 9, 2003 - 8:30 AM Health Sciences, K069 Translational Control in Macrophage Inflammation Paul L. Fox Professor of Molecular Medicine Department of Cell Biology The Lerner Research Institute, Cleveland Clinic Foundation Wednesday, December 3, 2003 - 4:30 PM Health Sciences Center, K-069 Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science David Siscovick Professor of Medicine & Epidemiology Cardiovascular Health Research Unit University of Washington Tuesday, December 2, 2003 - 8:30 AM HSB, K069 Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector Shan Wen Acting Instructor Medicine/Division of Cardiology University of Washington Tuesday, November 25, 2003 - 8:30 AM HSB, K069 Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis Michelle Chaisson Post-Doctoral Fellow Amgen, Inc. Wednesday, November 19, 2003 - 4:30 PM Health Sciences Center, Room K-069 Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock John Hogenesch Program Manager, Genomics Genomics Institute Novartis Research Foundation Tuesday, November 18, 2003 - 8:30 AM HSB, K069 Parkinson's Disease Caused by Alpha-synuclein Locus Triplication Lee-Way Jin, M.D., Ph.D. Assistant Professor Department of Pathology University of Washington Friday, November 7, 2003 - 9:30 AM Harboview Medical Center, R & T Building, Room 113 A Murine Model of Intestinal Pseudo-Obstruction Raj Kapur, M.D., Ph.D. Associate Professor Department of Pathology and Department of Laboratories University of Washington and Children's Hospital and Regional Medical Center Wednesday, November 5, 2003 - 4:30 PM Health Sciences Center, Room K-069 Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes Dale Abel Assistant Professor of Medicine and Biochemistry Division of Endocrinology Diabetes and Metabolism Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine Tuesday, November 4, 2003 - 8:30 AM HSB, K069 Mechanisms of transforming growth factor-beta1-induced neointimal formation Goro Otsuka Senior Fellow Medicine/Cardiology University of Washington Tuesday, October 28, 2003 - 8:30 AM HSB, K069 Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding Emilie Clemmens Graduate Student (Defense date Oct. 7th) Bioengineering University of Washington Tuesday, October 21, 2003 - 8:30 AM HSB, K069 Natural antibodies protect against atherogenesis Gregg Silverman Professor in Medicine Dept. of Medicine UCSD Tuesday, October 14, 2003 - 8:30 AM HSB, K069 Many Genes and Many Tumors: Genetics of Uterine Leiomyomata Cynthia Morton Professor Department of Pathology Brigham and Women's Hospital, Boston, MA Wednesday, October 8, 2003 - 4:30 PM Health Sciences Center, Room K-069 Thyroid Hormone and Cardiac Metabolism Michael Portman Professor of Pediatrics Children's Hospital and Regional Medical Center University of Washington, Division of Cardiology Tuesday, October 7, 2003 - 8:30 AM Health Science Buidling, K069 The Cell Cycle Phase Specificity of DNA Damage and Repair Induced by Radiation, Oxidation and Anti-Topoisomerase II Chemotherapy Drugs Alan Potter Graduate Student Department of Pathology University of Washington Thursday, October 2, 2003 - 10:30 AM Health Sciences Center, Room D-310 "Pituitary Tumor Pathogeneis M. Beatriz S. Lopes, M.D. Associate Professor Department of Pathology University of Virginia Health Sciences Center Wednesday, September 17, 2003 - 8:00 AM Harborview Medical Center, Research and Training Auditori The Role of Hypoxia and Genetics in the Progression of Glioblastoma Daniel J. Brat Associate Professor Department of Pathology and Laboratory Medicine Emory University School of Medicine Thursday, September 11, 2003 - 4:30 PM Health Sciences Center, Room T-739 The Functions of FE65 Proteins and Their Roles in Dementias of Alzheimer's Disease Baiping Wang Graduate Student Department of Pathology University of Washington Tuesday, August 19, 2003 - 10:00 AM Health Sciences Center, Room K-069 "Neurospheres and Neurosphere Forming Cells: Morphological and Ultrastructural Characterization Alessandra Bez National Neurologic Institute "C.Besta" Milan, Italy Monday, July 28, 2003 - 1:00 PM VA Medical Center, Building 1, Room 812 Telomere Length and Chromosomal Instability in the Neoplastic Progression of Barrett's Esophagus Jennifer C. Finley Graduate Student Department of Pathology University of Washington Wednesday, July 23, 2003 - 3:00 PM Health Sciences Center, Room K-069 Cardiovascular Genomics: Clinical Implications Gary H. Gibbons, M.D Cardiovascular Research Institute Morehouse School of Medicine Monday, June 23, 2003 - 8:30 AM Health Sciences Building, K069 "Links between contractile and electrical dysfunction in heart" Jeffrey E. Saffitz, M.D., Ph.D. Lacy Professor of Pathology Department of Pathology and Immunology Washington University School of Medicine Thursday, June 19, 2003 - 10:00 AM Health Sciences Building, K069 Microscale Systems and Applications for Life-on-a-Chip Deirdre Meldrum Professor Department of Electrical Engineering University of Washington Wednesday, June 11, 2003 - 4:30 PM Health Sciences Center, Room K-069 Sheep Retroviral Envelope Glycoprotiens: Mechanisms of Oncogenesis and Incorporation into HIV-1 Lentiviral Vectors Shan-Lu Liu Graduate Student Department of Patholgy University of Washington Tuesday, June 10, 2003 - 2:00 PM Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud Integrative signaling in angiogenesis Michael Simons A. G. Huber Professor of Medicine & Chief of Cardiology Medical School Dartmouth Tuesday, June 10, 2003 - 8:30 AM Health Sciences Building, T747 Biotechnology Drug Discovery in the Post-Human Genome Era Thomas Bumol, Ph.D. Vice President Biotechnology Discovery Research Lilly Research Laboratories Thursday, June 5, 2003 - 4:30 PM Health Sciences Center, T-747 An Informal Career/Research Workshop Thomas Bumol, Ph.D. Vice President Biotechnology Discovery Research Lilly Research Laboratories Thursday, June 5, 2003 - 9:30 AM South Campus Center, Room 303 Evolutionary Theories of Aging and How We Test Them Daniel Promislow Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Georgia Tuesday, June 3, 2003 - 12:30 PM HSB, T-639 Population Mortality Analyses: A Tool for the Study of Aging Scott Pletcher Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 Baylor College of Medicine Tuesday, May 27, 2003 - 12:30 PM HSB, T-639 Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases Hans-Peter Kiem Associate Member Fred Hutchinson Cancer Research Center Wednesday, May 21, 2003 - 4:30 PM Health Sciences Center, K-069 Design of Human Aging Studies Norm Wolf Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, May 20, 2003 - 12:30 PM HSB, T-639 Regional Cardiac Sympathetic Dysfunction in CHF James Caldwell, MD Professor Medicine VA Medical Center Tuesday, May 20, 2003 - 8:30 AM Health Sciences Building, K069 Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum David Ron, M.D. Professor Departments of Medicine and Cell Biology NYU School of Medicine Wednesday, May 14, 2003 - 4:30 PM Health Sciences Center, Room K-069 Oligodendrogliomas and Mixed Gliomas: An Epidemic Peter Burger, M.D. Professor Department of Pathology Johns Hopkins University Wednesday, May 14, 2003 - 8:00 AM Harborview Medical Center, R&T Building Auditorium Faculty Sponsor: Dr. Tom Montine Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors. Design of Human Aging Studies William Hazzard Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, May 13, 2003 - 12:30 PM HSB, T-639 Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome Brad Johnson, M.D., Ph.D. Assistant Professor Department of Pathology and Laboratory Medicine University of Pennsylvania Wednesday, May 7, 2003 - 4:30 PM Health Sciences Center, Room K-069 Use of Nonhuman Primates for Studies of Caloric Restriction and Aging George Roth Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 National Institute on Aging Tuesday, May 6, 2003 - 12:30 PM HSB, T-639 Quantitative proteomics: new technology and applications Reudi Abersold Professor and Co-founder of the Institutes for Systems Biology The Institute for Systems Biology Tuesday, May 6, 2003 - 8:30 AM HSB, K069 Bacteriophages: Natures Self-replicating, Self-limiting Antibiotics Betty Kutter, Ph.D. Faculty Member Department of Biophysics Evergreen State College Wednesday, April 30, 2003 - 4:30 PM HSC, Room K-069 Gene Expression Profile Assays: Strengths and Pitfalls Richard Miller Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Michigan Tuesday, April 29, 2003 - 12:30 PM HSB, T-639 Marrow Derived Stem Cells- What do we really know? Beverly J Torok-Storb Member & Associate Program Head Transplantation Biology Program Fred Hutchinson Cancer Research Center Tuesday, April 29, 2003 - 8:30 AM HSB, K069 Why Is the Gastric Cardia Such a Big Deal When It Is So Small? Henry Appelman, M.D. Professor Pathology University of Michigan Wednesday, April 23, 2003 - 4:30 PM HSC, Room K-069 Transgenic Models: Strengths and Pitfalls Warren Ladiges Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, April 22, 2003 - 12:30 PM HSB, T-639 Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System Michelle Bendeck, Ph.D. Associate Professor Laboratory Medicine and Pathobiology University of Toronto Wednesday, April 16, 2003 - 4:30 PM HSC, Room K-069 Caloric Restriction: A Tool for the Study of Aging Edward Masoro Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Texas at San Antonio Tuesday, April 15, 2003 - 12:30 PM HSB, T-639 Use of Rodent Models in Aging Research Edward Masoro Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Texas at San Antonio Monday, April 14, 2003 - 12:30 PM HSB, T-639 Pros and Cons of Non-Mammalian Models in Aging Research Steven Austad Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Idaho Tuesday, April 8, 2003 - 12:30 PM HSB, T-639 Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y Jenny Graves Professor Comparative Genomics Australian National University Wednesday, April 2, 2003 - 4:30 PM HSC, Room K-069 Concepts and Theories of Aging George Martin Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511 University of Washington Tuesday, April 1, 2003 - 12:30 PM HSB, T-639 The Genetics and Biology of Tumor Suppression by p27/Kipl Chris Kemp, Ph.D. Affiliate Associate Professor Department of Pathology Fred Hutchinson Cancer Research Center Wednesday, March 26, 2003 - 4:30 PM HSC, K-069 X Inactivation: The Role of the XIST RNA in Silencing a Chromosome Carolyn Brown Associate Professor Department of Medical Genetics University of British Columbia Friday, March 21, 2003 - 12:30 PM Health Sciences Center, Room K-069 TBA Marsha Whitney Graduate Student Bioengineering University of Washington Tuesday, March 18, 2003 - 8:30 AM HSB, K069 TBA Lisa Tannock Acting Instructor/Senior Fellow Division of Metabolism, Endocrinology and Nutrition University of Washington Tuesday, March 4, 2003 - 8:30 AM HSB, K069 Biology and Evolution of Cervical Squamous Intraepithelial Lesions: A Hypothesis with Diagnostic/Prognostic Implications Kumarasen Cooper, MBChB, DPhil, FRC Path Director of Anatomic Pathology University of Vermont College of Medicine Thursday, February 27, 2003 - 4:30 PM University of Washington Medical Center, BB-204 Array CGH for High Resolution Analysis of Genomic Aberrations Dan Pinkel, Ph.D. Professor Department of Laboratory Medicine UCSF Tuesday, February 25, 2003 - 4:30 PM Health Sciences Center, Room K-069 Innate Immune Recognition and Response to Microbial Pathogens Kelly Smith, Ph.D., M.D. Department of Pathology University of Washington Wednesday, February 19, 2003 - 4:30 PM Health Sciences Center, Room K-069 TBA Joe Beavo/ Sergei Rybalkin Professor/ Acting Instructor Pharmacology University of Washington Tuesday, February 18, 2003 - 8:30 AM HSB, K069 The Role of Proteolysis in the Pathogenesis of Atherosclerosis Peter Gough Research Assistant Professor Department of Pathology University of Washington Wednesday, February 12, 2003 - 4:30 PM Health Sciences Center, Room K-069 TBA Joanne Hulme Senior Fellow Pharmacology University of Washington Tuesday, February 11, 2003 - 8:30 AM HSB, K069 Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis Karin Bornfeldt, Ph.D. Associate Professor Department of Pathology University of Washington Wednesday, February 5, 2003 - 4:30 PM Health Sciences Center, Room K-069 Signaling Pathways Regulating Endothelial Cell Survival and Activation Xianwu (James) Li Graduate Student Department of Pathology University of Washington Friday, January 31, 2003 - 3:15 PM Health Sciences Center, Room K-069 Protein Interactions Stan Fields, Ph.D. Professor Departments of Genome Sciences and Medicine University of Washington Tuesday, January 21, 2003 - 4:30 PM Health Sciences Center, T-747 TBA Jin-Yong Hwang, M.D. (Visiting Scientist) Assitant Professor Department of Medicine Gyeongsang National University, Republic of South Korea Tuesday, January 21, 2003 - 8:30 AM HSB, K069 Molecular Medicine in the Post Genome Era Dr. Richard Klausner  Executive Director, Global Health Program Gates Foundation Wednesday, January 15, 2003 - 12:00 PM Hogness Auditorium, TBA Themis Kyriakides Research Assistant Professor Biochemistry University of Washington Tuesday, January 14, 2003 - 8:30 AM HSB, K069 From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment Douglas Ross, M.D., Ph.D. Chief Scientific Officer Applied Genomics Inc. Wednesday, December 18, 2002 - 4:30 PM HSC, K-069 Delta1: A Notch Up on Hematopoietic Stem Cell Expansion Irwin Bernstein Professor FHCRC Tuesday, December 17, 2002 - 8:30 AM HSC, K-069 Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma Daniel E. Sabath Associate Professor Laboratory Medicine University of Washington Wednesday, December 4, 2002 - 4:30 PM HSC, K-069 "A Genetic Approach to Understanding Basement Membrane Assembly" Mats Paulsson Professor of Biochemistry School of Medicine University of Cologne Tuesday, December 3, 2002 - 8:30 AM HSC, K-069 "Microarray Analysis in Cancer Research: Progress and Promise" Paul Meltzer, M.D., Ph.D. Senior Investigator Cancer Genetics Branch NIH, National Human Genome Research Institute Wednesday, November 20, 2002 - 4:30 PM Health Sciences Center, K-069 Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome Ulrike Schwarze, M.D. Assistant Professor Department of Pathology University of Washington Wednesday, November 13, 2002 - 4:30 PM Health Sciences Center, K-069 Single Cell Proteomics Norm Dovichi Professor Department of Chemistry University of Washington Wednesday, November 6, 2002 - 4:30 PM HSC, K-069 DNA Repair Genes Select Stem Cells in Vivo Stan Gerson, M.D. Professor and Chief Hematology/Oncology Case Western Reserve University Wednesday, October 30, 2002 - 4:30 PM HSC, K-069 Science in Medicine Lecture: Genetic Instability and Human Disease Raymond J. Monnat, Jr., M.D. Professor Department of Pathology University of Washington Thursday, October 24, 2002 - 12:00 PM HSC, Turner Auditorium, D-209 Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease James Scott Professor Genetics and Genomics Research Institute Imperial College of Science Wednesday, October 16, 2002 - 4:30 PM Health Sciences Center, K-069 Mouse Models Unravel the p53 Pathway Gigi Lozano, Ph.D. Professor and Geneticist Department of Molecular Genetics MD Anderson Cancer Center University of Texas Wednesday, October 2, 2002 - 4:30 PM Health Sciences Center, K-069 Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer Robert F. Hevner, M.D, Ph.D. Assistant Professor Department of Pathology University of Washington Thursday, September 26, 2002 - 12:00 PM Health Sciences Center, D-209 Neurochemical Dynamics of Traumatic Brain Injury J. Clay Goodman, M.D. Professor and Neuropathology Program Director Departments of Pathology, Neurology, and Neurosurgery Baylor College of Medicine Thursday, September 19, 2002 - 4:30 PM HSC, T-747 Fas/FADD-Mediated Activation of a Specific Program of Inflammatory Gene Expression in Vascular Smooth Muscle Cells Friedemann J. Schaub Graduate Student Department of Pathology University of Washington Thursday, September 19, 2002 - 11:00 AM HSC, K-069 Diagnosis of Minimal Prostate Cancer in Needle Biopsies - When Should You Jump off the Fence? John Srigley Professor Department of Pathology and Molecular Medicine McMaster University Monday, August 26, 2002 - 8:00 AM UWMC, BB-204 Cohesion proteins SMC1 and SMC3: roles in aneuploidy and in meiotic chromosome dynamics Rosalina James Graduate Stdent of Pathology School of Medicine University of Washington Friday, August 23, 2002 - 11:00 AM HSC, D-209 Characterization of Genomic Instability in Neoplastic Progression of Ulcerative Colitis Ru Chen Graduate Student of Pathology School of Medicine University of Washington Tuesday, August 20, 2002 - 1:00 PM HSC, K-069 Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer Santo Nicosia, M.D. Professor Interdisciplinary Oncology Program Moffitt Cancer Center and Research Institute University of South Florida Wednesday, July 31, 2002 - 4:30 PM Health Sciences Center, Room T-747 In Vitro Modeling of Breast Cancer Krishna Rao Graduate Student of Pathology School of Medicine University of Washington Wednesday, July 10, 2002 - 1:00 PM Doctoral Dissertation, Pelton Auditorium Day Campu "Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing" Peter J. Dempsey, Ph.D. Principal Scientist Pacific Northwest Research Institute Seattle, Washington Wednesday, June 26, 2002 - 4:30 PM Health Sciences Center, K-069 "Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex" Robert Hevner, M.D., Ph.D. Assistant Professor Department of Pathology University of Washington Wednesday, June 5, 2002 - 4:30 PM Health Sciences Building, K-069 "Immunohistochemistry in Urologic Tumor Pathology" Mark Wick, M.D. Associate Director Surgical Pathology University of Virgina Health System Wednesday, May 29, 2002 - 4:30 PM Health Sciences Building, K-069 Cell Adhesion in the Vasculature Richard O. Hynes, Ph.D., F.R.S. Daniel K. Ludwig Professor for Cancer Research Department of Biology Massachusetts Institute of Technology Friday, May 24, 2002 - 11:00 AM Health Sciences Center, D-209 Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men Charles Alpers, M.D. Professor Department of Pathology University of Washington Wednesday, May 15, 2002 - 4:30 PM Health Sciences Center, Genetics in Everyday Life
David R. Cox, M.D., Ph.D. Professor and Associate Chair Department of Genetics Stanford University Thursday, January 10, 2002 - 4:30 PM Health Sciences Center, T-739 |
|
Copyright 2004 Department of Pathology |
