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Cardiovascular Research Center Breakfast ClubThe Cardiovascular Research Center Breakfast Club meets on Tuesday mornings under the sponsorship of the Reaction to Injury Program Project Grant
and training grants in Cardiovascular Pathology and Cardiology. Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease David Marcinek, PhD Research Assistant Professor Dept. of Radiology UW Tuesday, November 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging. TBA Morayma Reyes, MD, PhD Assistant Professor Pathology and Lab Medicine UW Tuesday, December 1, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium TBA Mark Majesky, PhD Professor Dept. of Pathology University of North Carolina at Chapel Hill Tuesday, December 8, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Exome Sequencing & Human Disease Jay Shendure, MD, PhD Assistant Professor Dept. of Genome Sciences UW Tuesday, December 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Recent Breakfast Club LecturesMuscle Gene Regulation & Regulatory Cassettes for Gene Therapy Stephen D. Hauschka, PhD Professor Dept. of Biochemistry UIW Tuesday, November 17, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles. Exploring the extraordinary regenerative potential of the mammalian fetal heart Timothy Cox, PhD Research Associate Professor Pediatrics, Division of Craniofacial Medicine UW Tuesday, November 10, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Skeletal muscle stem cells: from classic to eclectic Zipora Yablonka-Reuveni, PhD Professor Dept. of Biological Structure UW Tuesday, October 27, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908). Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma Jean Campbell, PhD Research Assistant Professor Dept. of Pathology UW Tuesday, October 20, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mechanisms of enhanced lung injury in febrile hyperthermia Anne Lipke, MD Senior Fellow Division of Pulmonary and Critical Care Medicine UW Tuesday, October 13, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Lynn Schnapp, MD CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis Jeffrey A. Ledbetter, PhD Research Professor Division of Rheumatology UW Tuesday, October 6, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab). The role of cardiac metabolism in heart diseases Rong Tian, MD, PhD Professor and Director Mitochondria and Metabolism Center UW Tuesday, September 29, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury Tiffany Nguyen Graduate Student Pharmacology and Toxicology Department Medical College of Georgia, Augusta, GA Tuesday, September 22, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Rong Tian, MD, PhD Cell Signaling in Space and Time John D. Scott, PhD Edwin G. Krebs-Hilma Speights Professor Dept. of Pharmacology UW Tuesday, September 15, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Can We Image a Plaque at Risk? Mat J.A.P. Daemen, MD, PhD Scientific Director of the Cardiovascular Research Institute Maastricht Professor and Head of Pathology University of Maastricht, The Netherlands Tuesday, September 8, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Faculty Sponsor: Chun Yuan Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses. Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry Daniel Martin, M.D. Institute for Systems Biology Tuesday, June 16, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Nitric Oxide and the Development of Insulin Resistance Francis Kim, MD Associate Professor of Medicine Division of Cardiology Harborview Medical Center Tuesday, June 9, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Genes and Vascular Disease Gail P. Jarvik, MD, PhD Professor of Medicine and Head Division of Medical Genetics UW Tuesday, June 2, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?) Ian R. Sweet, PhD Research Assitant Professor Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 26, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Sterol regulation of the macrophage immune response Jay W. Heinecke, MD Professor of Medicine Division of Metabolism, Endocrinology and Nutrition UW Tuesday, May 19, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld Versican: A Matrix Molecule With Some Clout! Thomas N. Wight, Ph.D. Member and Director, Hope Heart Program Benaroya Research Institute at Virginia Mason Affiliate Professor, Pathology, UW Tuesday, May 12, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Tumor Cell Metabolism: How is it different? David M. Hockenbery, MD Professor of Medicine, UWMC Member, FHCRC Tuesday, May 5, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Mapping Cell Fate through Somatic Mutations Marshall Horwitz, MD, PhD Professor of Pathology Institute for Stem Cell and Regenerative Medicine UW Tuesday, April 28, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Shaping the vertebrate body: cell migration in development and disease Douglas C. Weiser, PhD Postdoctoral fellow Department of Biochemistry UW Tuesday, April 21, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Matrix remodeling during lung injury and repair Lynn M. Schnapp, MD Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, April 14, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Translational control during monocyte/macrophage adherence David Pritchard, PhD Acting Instructor Department of Pathology UW Tuesday, April 7, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Water, Energy and Life: Fresh Views from the Water’s Edge Gerald H. Pollack, PhD Professor Department of Bioengineering UW Tuesday, March 31, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Laboratory medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios? David Wu, MD, PhD Assistant Professor Dept. of Laboratory Medicine UW Tuesday, March 24, 2009 - 8:30 AM SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium Local Control of Excitation-Transcription Coupling in Smooth Muscle Luis Fernando Santana, Ph.D. Associate Professor Physiology and Biophysics UW Tuesday, March 10, 2009 - 8:30 AM Health Sciences Building, K-069 uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms Jie Hong Hu, Ph.D. Senior Fellow Division of Cardiology UW Tuesday, March 3, 2009 - 8:30 AM Health Sciences Building, K-069 TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury John C. Keech, M.D. Postdoctoral Fellow Surgery UW Tuesday, February 24, 2009 - 8:30 AM Health Sciences Building, K-069 Myofilament Regulation of the Frank-Starling Law of the Heart F. Steven Korte, Ph.D. Senior Fellow Bioengineering UW Tuesday, February 17, 2009 - 8:30 AM Health Sciences Building, K-069 The FGF Axis: New Therapeutic Opportunities Norman M. Greenberg, Ph.D. Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington FHCRC and UW Tuesday, February 10, 2009 - 8:30 AM Health Sciences Building, K-069 Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays Steven Pelech, Ph.D. President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia Kinexus Bioinformatics Corp. and Univ. of British Columbia Tuesday, February 3, 2009 - 8:30 AM Health Sciences Building, K-069 SMC plasticity and reprogramming in calcifying vasculature Yanfeng (Mei) Speer, Ph.D. Research Assistant Professor Bioengineering UW Tuesday, January 27, 2009 - 8:30 AM Health Sciences Building, K-069 Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells Jonathan Golob Graduate Student Pathology UW Tuesday, January 13, 2009 - 8:30 AM Health Sciences Building, K-069 AAV vectors: biology and utility for gene addition and gene correction David Russell, MD, PhD Professor of Medicine Div. of Hematology UW Tuesday, January 6, 2009 - 8:30 AM Health Sciences Building, K-069 Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you Alan Weiner, PhD Professor and ZymoGenetics Chair Biochemistry UW Tuesday, December 16, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium A-type nuclear lamins in aging and disease Brian Kennedy, PhD Associate Professor Biochemistry UW Tuesday, December 9, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Delta 1: A Notch up on cord blood stem cell transplantation Irwin Bernstein, MD Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society UW and FHCRC Tuesday, November 25, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer Jay Rothstein, PhD Director Inflammation Research Amgen, Inc., Seattle, WA Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs Wei-Zhong Zhu, PhD Postdoctoral Fellow Pathology UW Tuesday, November 18, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Michael Laflamme Epigenetic programming of mesenchymal stem cells Philippe Collas, PhD Professor Institute of Basic Medical Sciences, Dept. of Biochemistry University of Oslo, Norway Tuesday, October 21, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Karol Bomsztyk Regulation of Nodal Signaling by microRNAs Wen-Yee Choi Graduate Researcher Molecular and Cellular Biology Harvard University Tuesday, October 14, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Faculty Sponsor: Charles Murry Contribution of interstitial valve cells to valve calcification Marcello Rattazzi, MD Clinical and Experimental Medicine University of Padua, Italy Wednesday, October 8, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium Molecular mechanisms of aging: What can we learn from yeast and worms? Matt Kaeberlein, PhD Assistant Professor Pathology UW Tuesday, October 7, 2008 - 8:30 AM South Lake Union, 815 Mercer Street, Orin Smith Auditorium “Magnetic Resonance Imaging of Gene Expression" Anna Naumova, Ph.D. Senior Fellow Radiology UW Tuesday, June 24, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Directly targeting myofibrillar proteins to improve cardiomyocyte contraction" F. Steven Korte, PhD Senior fellow Bioengineering UW Tuesday, June 17, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus” Bardia Askari, Ph.D. Acting Instructor Pathology UW Tuesday, June 10, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model” Karin E. Bornfeldt, Ph.D. Professor Pathology Medicine Tuesday, June 3, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer “Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes” Charis L. Himeda, Ph.D. Senior fellow Biochemistry UW Tuesday, May 20, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment” Dalin Tang, Ph.D. Professor Mathematics and Biomedical Engineering Worcester Polytechnic Institute Tuesday, May 13, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chun Yuan, Ph.D. 815 Mercer Street “Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?” Deidre Golej Graduate Student, Molecular and Cellular Biology Pathology UW Tuesday, May 6, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Diabetic vascular disease: Hitting below the belt” Kanchan Chitaley, Ph.D. Research Assistant Professor Urology UW Tuesday, April 29, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero” Atis Muehlenbachs MSTP and Incoming Resident Pathology UW Tuesday, April 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Transcriptional regulation of thrombin receptors by vasodilator prostaglandins" Karsten Schror, M.D. Professor and Chair Pharmacology and Clinical Pharmacology Heinrich-Heine-Universitat Dusseldorf Tuesday, April 15, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Alexander W. Clowes, MD 815 Mercer Street “A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice” Richard Frock PhD Candidate Biochemistry UW Tuesday, April 8, 2008 - 8:30 AM Health Sciences Building, K-069 "I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure" Chris Hague, Ph.D. Assistant Professor Pharmacology UW Tuesday, April 1, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation" Prabha Sampath, Ph.D. Postdoctoral Fellow Pathology UW Tuesday, March 25, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street “Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer” Jeffrey S. Chamberlain, Ph.D. Professor Depts. of Neurology, Medicine and Biochemistry UW Tuesday, March 18, 2008 - 8:30 AM HSB, T-635 "The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair" Lynn M. Schnapp, M.D. Associate Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, March 4, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites" Elaine W. Raines Research Professor Pathology UW Tuesday, February 12, 2008 - 8:30 AM HSB, K-069 “The Role of Filamin in Transcriptional Control of Laminin Expression” Christine K. Abrass, MD, FACP Professor of Medicine Division of Gerontology and Geriatric Medicine UW Tuesday, February 5, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Encapsulated vascular smooth muscle cells to treat rat models of diabetes" William Osborne, PhD Research Professor Pediatrics UW Tuesday, January 29, 2008 - 8:30 AM HSB, K-069 “Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system” Esther Lutgens, MD, PhD Associate Professor Pathology CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands Tuesday, January 22, 2008 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Michael Rosenfeld, PhD 815 Mercer Street "Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature" Yanfeng (Mei) Speer, PhD Research Assistant Professor Bioengineering UW Tuesday, January 15, 2008 - 8:30 AM HSB, K-069 TBA Roger E. Bumgarner, PhD Associate Professor Microbiology UW Tuesday, December 18, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Innate immune recognition and response to microbial pathogens" Kelly Smith, MD, PhD Assistant Professor Pathology UW Tuesday, December 11, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Macrophage Mediators of Cardiac Fibrosis April S. Stempien-Otero, MD Assistant Professor of Medicine Cardiology UW Tuesday, December 4, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system" Gustavo Matute-Bello, MD Assistant Professor of Medicine Pulmonary and Critical Care Medicine UW Tuesday, November 27, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Mitochondria, lifespan and the aging heart" Peter S. Rabinovitch, M.D., Ph.D. Professor Pathology UW Tuesday, November 20, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Human Embryonic Stem Cell Niches?" C. Anthony Blau, MD Professor of Medicine Hematology UW Tuesday, November 13, 2007 - 8:30 AM Brotman Building, 815 Mercer Street, SLU Auditorium "Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system" Howard M. Shulman, M.D. Professor Pathology/Oncology FHCRC Tuesday, November 6, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street "Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine" Glenn D. Prestwich, Ph.D. Presidential Professor of Medicinal Chemistry Department of Medicinal Chemistry and Center for Therapeutic Biomaterials The University of Utah Tuesday, October 30, 2007 - 8:30 AM SLU - Brotman Bulding, Blue Flame Auditorium Faculty Sponsor: Thomas N. Wight, Ph.D. 815 Mercer Street Ribosomes and Spindles in Marrow Failure and Cance Predisposition Akiko Shimamura, MD Associate Professor of Pediatrics Division of Hematology/Oncology UWSOM Tuesday, October 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Leptin in Cardiovascular Disease Daniel Eitzman Assistant Professor Internal Medicine/Cardiovascular Disease University of Michigan Wednesday, September 26, 2007 - 8:30 AM Brotman Building, SLU, Blue Flame Faculty Sponsor: Steve Schwartz 815 Mercer Street Reschedule - date tentative Insulin Modulation of Plasma beta-Amyloid levels Pattie S. Green, PhD Research Assistant Professor Medicine UWSOM Tuesday, June 26, 2007 - 8:30 AM TBA, TBA Faculty Sponsor: Renee LeBoeuf TBA Larry Adams Senior Research Scientist Pathology UWSOM Tuesday, June 19, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street RGS5: Regulating the Regulator William M. Mahoney Jr. Postdoctoral Fellow Pathology UWSOM Tuesday, June 5, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease? Wendy Thomas Assistant Professor Bioengineering UWSOM Tuesday, May 29, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street Molecular Mechanisms of Regulation of L-type Calcium Channels Michelle Emrick Senior Fellow Pharmacology UWSOM Tuesday, May 22, 2007 - 8:30 AM Health Sciences, K-069 TGF-beta signaling in kidney cells Anne-Christine Poncelet Acting Instructor Medicine-Gerontology UW School of Medicine Tuesday, May 15, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium 815 Mercer Street AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice Guy Odom Senior Fellow Neurology UWSOM Tuesday, May 8, 2007 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek The role of P2X7 and activated caspases in the regulation of macrophage fusion Thomas Nhan PhD Candidate Pathology UW School of Medicine Tuesday, May 1, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction Daniel J. Morgan Senior Fellow Pharmacology UWSOM Tuesday, April 17, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Steve Schwartz Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad Joseph McGonigle Research Assistant Bioengineering UWSOM Tuesday, April 10, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Cecilia Giachelli 815 Mercer Street Understanding macrophage foam cell formation using a proteomics-based approach Lev Becker Senior Fellow Medicine, Division of Metabolism, Endocrinology and Nutrition UWSOM Tuesday, April 3, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Jay Heinecke 815 Mercer Street Probing chromatin dynamics Karol Bomsztyk Professor Medicine UWSOM Tuesday, March 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Angiotensin II-induced vascular pathologies - a multitude of mechanisms Alan Daugherty Professor Cardiovascular Medicine University of Kentucky Tuesday, March 20, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Mike Rosenfeld 815 Mercer Street A ROCK and Role for Syndecans in Cytoskeletal Regulation John R. Couchman Professor National Heart & Lung Institute Imperial College, London Tuesday, March 13, 2007 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Bill Parks 815 Mercer Street Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries? Jo Fleming Scleroderma Research Fellow Pathology UWSOM Tuesday, March 6, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street RESCHEDULED! Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation Jonathan Golob Graduate Student Pathology UWSOM Tuesday, February 27, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street Adult Stem Cells: Epigenetics, pluripotency and plasticity Morayma Reyes Assistant Professor Pathology and Laboratory Medicine UWSOM Tuesday, February 13, 2007 - 8:30 AM SLU, Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis Ranjini M. Krishnan Fellow Cardiology UWSOM Tuesday, February 6, 2007 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: David Dichek Monocytes, Dendritic Cells, and Atherosclerosis Gwen Randollph Associate Professor Gene & Cell Medicine Mt. Sinai School of Medicine Tuesday, January 30, 2007 - 10:00 AM Health Sciences, K-069 Faculty Sponsor: Elaine Raines/Stephen Schwartz Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project Magnetic Resonance Imaging of Atherosclerosis Hunter R. Underhill Fellow Vascular Imaging Lab UWSOM Tuesday, January 23, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium 815 Mercer Street Caspase regulation of macrophage functions Thomas Q. Nhan PhD Candidate Pathology UWSOM Tuesday, January 16, 2007 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Tissue voxelation with a high-speed transverse microtome John Welsh, PhD Associate Professor Molecular and Cancer Biology Program Sidney Kimmel Cancer Center, San Diego, California Tuesday, January 9, 2007 - 8:30 AM SLU Brotman Building, Blue Flame Auditorium Faculty Sponsor: Marshall Horwitz 815 Mercer Street Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease Hangjun Duan Senior Fellow Pathology UWSOM Tuesday, December 19, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street BTNL2, a novel B7 family member and regulator of T cell activation Heather Arnett Scientist Amgen, Inc. Tuesday, December 5, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street The Ins and Outs of Bcl-2 in Cell Death John M. Harlan, MD Chief Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology University of Washington Tuesday, November 21, 2006 - 8:30 AM Health Sciences Building, K-069 TSLP and Th2-mediated inflammation Steven F. Ziegler, PhD Director Immunology Program Benaroya Research Institute Tuesday, November 14, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Steve Schwartz 815 Mercer Street Differentiation of Endothelium from Human Embryonic Stem Cells Marilyn Nourse PhD Candidate Pathology UWSOM Tuesday, November 7, 2006 - 8:30 AM SLU - Brotman Building, Blue Flame Auditorium Faculty Sponsor: Chuck Murry 815 Mercer Street Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice Fredrik Johansson Postdoctoral Fellow Pathology UWSOM Tuesday, October 31, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Karin Bornfeldt Calcium Sparklets in Vascular Smooth Muscle Manuel F. Navedo Senior Fellow Physiology and Biophysics UWSOM Tuesday, October 24, 2006 - 8:30 AM Health Sciences Building, K-069 Cancelled will reschedule for spring David Lovett - postponed Professor in Residence Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital University of California, San Francisco Tuesday, October 17, 2006 - 8:30 AM TBA, TBA PSGL-1 Adherence and mTOR Modulate Translation in Macrophages Richard Fox PhD Candidate Pathology UW School of Medicine Tuesday, October 10, 2006 - 8:30 AM Brotman Building (SLU), Blue Flame Auditorium Faculty Sponsor: Stephen M. Schwartz 815 Mercer Street An unexpected role for the tissue factor pathway in atherosclerosis Robert D. Simari Professor Cardiovascular Diseases Mayo Clinic Tuesday, October 3, 2006 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Of mice and mice; why some do and some don't develop arterial lesions Michael A Reidy PhD Professor Pathology UWSOM Tuesday, September 26, 2006 - 8:30 AM Brotman Building, SLU, Blue Flame Auditorium 815 Mercer Street The rupture-prone human plaque: how to define and detect it Erling Falk Professor Department of Cardiology Skejby University Hospital, Aarhus, Denmark Tuesday, June 27, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Steve Schwartz Protection of cardiovascular stem cells by cholesterol-lowering therapy Yong-Jian Geng, MD PhD Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research Dept. of Internal Medicine, Cardiology Division University of Texas School of Medicine, Houston, TX Tuesday, June 20, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Chuck Murry Distinct Wnt signaling pathways play opposing roles during organ regeneration Cristi Stoick-Cooper CVP Graduate Student Neurobiology & Behavior UWSOM Tuesday, May 30, 2006 - 8:30 AM HSB, K-069 Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease Daniel J Morgan Senior Fellow Pharmacology UWSOM Tuesday, May 23, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Stephen M Schwartz Cardiac applications for human embryonic stem cells Michael Laflamme Acting Instructor Pathology Center for Cardiovascular Biology & Regenerative Medicine, UWSOM Tuesday, May 2, 2006 - 8:30 AM SLU 815 Mercer St, 111 Faculty Sponsor: Chuck Murry Inflammation loci and carotid artery disease Gail Jarvik MD Professor Medicine, Medical Genetics UWSOM Tuesday, April 25, 2006 - 8:30 AM SLU 815 Mercer, 111 Auditorium Faculty Sponsor: Stephen M Schwartz Proteomic Analysis of the Cardiac Calcium Channel Michelle Emrick PhD Senior Fellow Pharmacology UWSOM Tuesday, April 18, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz The Role of Pattern Recognition Receptors in Macrophage Death Ira Tabas, MD/PhD Professor, Medicine and Anatomy & Cell Biology Deputy Editor - Journal of Clinical Investigation Columbia University Tuesday, April 11, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Michael Rosenfeld Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology? Adam S. Wilkins Editor, BioEssays Company of Biologists, Ltd. Cambridge, UK Tuesday, April 4, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Karol Bomsztyk Regulatory T cells, TGF-beta and atherosclerosis Goran K. Hansson Professor Cardiovascular Research, Molecular Medicine Karolinska Institutet, Stockhom, Sweden Tuesday, March 28, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Structure Biology of Ubiquitin Ligase Machinery Ning Zheng Assistant Professor Pharmacology UWSOM Tuesday, March 21, 2006 - 8:30 AM Health Sciences Building, K-069 Atheroprotective Effects of Transforming Growth Factor Beta-1 Andrew D. Frutkin, MD Acting Instructor/Senior Fellow Cardiology Division UWSOM Tuesday, March 14, 2006 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: David Dichek Please note change of venue The CD4+ autoreactive T cell: chance or necessity? Gerald T. Nepom, MD/PhD Director Benaroya Research Institute at Virginia Mason Tuesday, March 7, 2006 - 8:30 AM SLU 815 Mercer Street, 111 C-reactive protein and cardiovascular risk: a population genomics approach Alex Reiner, MD MSc Research Associate Professor Epidemioloy & Laboratory Medicine UWSOM Tuesday, February 28, 2006 - 8:30 AM SLU 815 Mercer, 111 Faculty Sponsor: Stephen M. Schwartz Clinical Genetics and Genomics of Type I Collagen Peter Byers, MD Professor Pathology & Medicine UWSOM Tuesday, February 21, 2006 - 8:30 AM Health Sciences, K-069 Wnt pathways can control cardiogenesis in mouse embryonic stem cells Shuichi Ueno, MD/PhD Senior Fellow Pathology UWSOM Tuesday, February 14, 2006 - 8:30 AM Health Sciences, K-069 Faculty Sponsor: Chuck Murry The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions Alain Mauviel, PhD Director INSERM U697 Hospital Saint-Louis, Paris, France Tuesday, February 7, 2006 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Bill Parks HnRNP K: Gene expression, hubs and scale-free networks Karol Bomsztyk Professor Medicine UWSOM Tuesday, January 31, 2006 - 8:30 AM Health Sciences Building, K-069 Molecular Basis of Information Daniel Storm Professor Pharmacology UWSOM Tuesday, January 24, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M Schwartz Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons Jennifer O'Brien Senior Fellow Pharmacology UWSOM Tuesday, January 17, 2006 - 8:30 AM HSB, K-069 Faculty Sponsor: Stephen M. Schwartz Regulation of Nitric Oxide Synthase by Shear Stress David G. Harrison MD Professor, Medicine Director, Division of Cardiology Emory University School of Medicine Tuesday, January 10, 2006 - 8:30 AM South Lake Union (SLU), 111 Faculty Sponsor: Stephen M. Schwartz Apoptosis and Macrophage Inflammation Keith Elkon, MD Prof. of Medicine & Adjunct Prof. Immunology Head, Division of Rheumatology UWSOM Tuesday, December 20, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Mechanisms of Arterial Constriction due to Urokinase Overexpression Philip Massey, MD Acting Instructor Medicine/Cardiology UWSOM Tuesday, December 13, 2005 - 8:30 AM Health Sciences Building, K-069 Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin Samantha Harris, PhD Research Assistant Professor Bioengineering UWSOM Tuesday, December 6, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS) Conrad Liles Associate Professor Medicine, Infectious Diseases UWSOM Tuesday, November 29, 2005 - 8:30 AM SLU 815 Mercer Street, 111 What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice? Karin Bornfeldt PhD Associate Professor Pathology UWSOM Tuesday, November 22, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Vascular Calcification: role of smooth muscle cells and phosphate Cecilia Giachelli PhD Professor Bioengineering UWSOM Tuesday, November 15, 2005 - 8:30 AM Health Sciences Building, K-069 N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems Yong Tae Kwon Assistant Professor Pharmaceutical Sciences University of Pittsburgh Thursday, November 10, 2005 - 8:30 AM Health Sciences Building, T-635 Faculty Sponsor: Stephen M. Schwartz Special Breakfast Club Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control Richard Fox PhD Candidate Pathology, Cardiovascular Biology UWSOM Tuesday, November 8, 2005 - 8:30 AM Health Sciences Bldg., K-069 Faculty Sponsor: Stephen M Schwartz Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs Charles Frevert, DVM, ScD Research Associate Professor Medicine/Pulmonary & Critical Care Medicine VA Medical Center/UWSOM Tuesday, November 1, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Bill Parks Role of PAI-1 in Progressive Renal Disease Allison Eddy, MD Professor & Head Division of Pediatric Nephrology Children's Hospital & Med Center, UWSOM Tuesday, October 25, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Roundtable Discussion: Pathologic implications of vascular developmental biology Brant Weinstein Senior Investigator and Head of Section of Vertebrate Organogenesis Laboratory of Molecular Genetics NIH National Institute of Child Health & Human Development (NICHD) Tuesday, October 18, 2005 - 9:30 AM Health Sciences Building, E-212 Faculty Sponsor: Elaine Raines/Steve Schwartz Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments. Regulation of GPCR Function by RGS Chris Hague Assistant Professor Pharmacology UWSOM Tuesday, October 11, 2005 - 8:30 AM SLU 815 Mercer Street, Auditorium, Rm. 111 Faculty Sponsor: Stephen M. Schwartz Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits Eric Schadt, PhD Senior Scientific Director Research Genetics Rosetta Inpharmatics, Inc., Seattle, WA Tuesday, October 4, 2005 - 8:30 AM SLU 815 Mercer Street, 111 Faculty Sponsor: Stephen M. Schwartz Translation control in activated endothelial cells Larry W. Kraiss MD Assistant Professor & Chief Division of Vascular Surgery University of Utah Tuesday, September 13, 2005 - 8:30 AM South Lake Union, 111 Faculty Sponsor: Richard Kenagy Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD) Xia (Clare) Shen PhD Postdoc Candidate Pharmacology & Toxicology University of Louisville Tuesday, July 26, 2005 - 8:30 AM HSB, K-069 Faculty Sponsor: Karin Bornfeldt Special Breakfast Club Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium? Chris Sullivan Postdoctoral Fellow Urology UWSOM Tuesday, July 19, 2005 - 9:00 AM South Lake Union, 111 Faculty Sponsor: Hunter Wessells The role of wnt signaling in zebrafish heart development and regeneration Cristi Stoick Graduate Student Neurobiology & Behavior UWSOM Tuesday, June 14, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Potassium Channel Regulation in Cerebral Arterial Smooth Muscle Gregory Amberg Senior Fellow Physiology & Biophysics UWSOM Tuesday, June 7, 2005 - 8:30 AM Health Sciences Building, K-069 Aldosterone and cardiovascular disease: past, present and future Bardia Askari Acting Instructor Pathology UWSOM Tuesday, May 31, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Steve Schwartz Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle Kenneth Marro Research Assistant Professor Radiology UWSOM Tuesday, May 24, 2005 - 9:00 AM South Lake Union, 100 Faculty Sponsor: Chun Yuan Please note change of venue to 815 Mercer Street. Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor Marilyn Nourse Graduate Student Bioengineering UWSOM Tuesday, May 10, 2005 - 8:30 AM Health Sciences Building, K-069 Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies Robert Welikson Senior Research Fellow Biochemistry UWSOM Tuesday, May 3, 2005 - 8:30 AM SLU 815 Mercer Street, 100 Faculty Sponsor: Stephen Schwartz Please note change of venue. Uncovering the role of receptor trafficking in disease Matthew Holdren Graduate Student Pathology UWSOM Tuesday, April 26, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tony Parks Can bacteria cause blood vessels to calcify? Michael Rosenfeld Professor Pathobiology and Pathology UWSOM Tuesday, April 19, 2005 - 8:30 AM Health Sciences Building, K-069 Exploring the immunomodulatory action of mechanical ventilation William A. Altemeier Assistant Professor Pulmonary & Critical Care Medicine UWSOM Tuesday, April 12, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Conrad Liles Please note change of venue. FDR, April 12, 1945 Karol Bomsztyk Professor Medicine, Allergy and Infectious Disease UWSOM, South Lake Union Tuesday, April 5, 2005 - 8:30 AM Health Sciences Building, K-069 Integrin Signaling: Grasping the survival mechanisms Donald Courter PhD Candidate Bioengineering University of Washington Tuesday, March 29, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecilia Giachelli Hedgehog signaling in angiogenesis Ronald Heimark PhD Associate Professor Surgery, Cell Biology & Anatomy, and Pathology Arizona Health Sciences Center Tuesday, March 22, 2005 - 9:00 AM SLU 815 Mercer Street (Blue Flame), 100 Faculty Sponsor: Stephen M. Schwartz Please note change of venue. Vascular malformations and guidance Dean Li Faculty Candidate Medicine, Division of Cardiology University of Utah Tuesday, March 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix Robert Mecham Alumni Endowed Professor Cell Biology and Physiology Medicine, Pediatrics and Bioengineering Washington University, St. Louis MO Tuesday, March 1, 2005 - 9:00 AM South Lake Union, 815 Mercer Street, 110 Faculty Sponsor: Bill Parks Please note change of location. Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble Anne M. Stevens Acting Assistant Professor Pediatrics, Division of Immunology/Rheumatology Children's Hospital and Regional Medical Center Tuesday, February 22, 2005 - 8:30 AM Health Sciences Building, K-069 ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage Richard Fox Graduate Student Pathology University of Washington Tuesday, February 15, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Hepsins: Lethal giant larvae Valeri Vasioukhin Assistant Member Human Biology Fred Hutchinson Cancer Research Center Tuesday, February 8, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Bill Parks Placental malaria and maternal blood pressure Atis Muehlenbachs Graduate Student, Concurrent Degree Molecular & Cellular Biology UWSOM Tuesday, February 1, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Dan Bowen-Pope The Role of PI-3 Kinase in Cardioprotection Charles Steenbergen, MD PhD Faculty Candidate Pathology Duke University, Durham, NC Tuesday, January 25, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Chuck Murry Metalloproteinases: Effectors of Innate Immunity William C. Parks Professor Pulmonary & Critical Care Medicine UWSOM, Harborview Tuesday, January 18, 2005 - 8:30 AM Health Sciences Building, K-069 Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy Tom Doetschman Professor of Molecular Genetics Biochemistry & Micorbiology University of Cincinnati College of Medicine Tuesday, January 11, 2005 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: David Dichek/Stephen M. Schwartz Angiogenesis in Prostate Cancer Norman M. Greenberg Professor Clinical Research Fred Hutchinson Cancer Research Center Tuesday, December 14, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics Tomas Vaisar Research Scientist Metabolism, Endocrinology & Nutrition University of Washington School of Medicine Tuesday, December 7, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Elaine Raines Endothelial Cell Activation and Apoptosis John M. Harlan Professor of Medicine Division of Hematology University of Washington School of Medicine Tuesday, November 30, 2004 - 8:30 AM Health Sciences Building, K-069 Probing the determinants of inter-individual variability in innate immune inflammatory responses Mark Wurfel Acting Instructor Division of Pulmonary and Critical Care Medicine University of Washington Tuesday, November 23, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Tom Martin Magnetic Resonance Imaging: The Coronary Frontier Won Yong Kim, MD PhD MR-Center & Department of Cardiology Skejby University Hospital, Aarhus Denmark Tuesday, November 16, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Stephen M. Schwartz Pharmacological modulation of medial elastocalcinosis Pierre Moreau, PhD Associate Professor Pharmacology Universit de Montral Tuesday, November 9, 2004 - 8:30 AM Health Sciences Building, K-069 Faculty Sponsor: Cecelia Giachelli Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo Jan E. Schnitzer, MD Professor Cellular & Molecular Biology Scientific Director Sidney Kimmel Cancer Center, San Diego, CA Tuesday, November 2, 2004 - 8:30 AM Health Sciences Building, K-069 Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages Andrew Bender Senior Fellow Pharmacology University of Washington School of Medicine Tuesday, October 26, 2004 - 8:30 AM Health Sciences Building, K-069 LMNA mutations in progeroid syndromes Junko Oshima Research Associate Professor Pathology University of Washington Tuesday, October 19, 2004 - 8:30 AM Health Sciences Building, K-069 Intersections between apoptosis and inflammation Gustave Matute-Bello Assistant Professor Department of Medicine, Division of Pulmonary & Critical Care University of Washington Pulmonary Research Laboratories, VA Puget Sound Health Care System Tuesday, October 12, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Tom Martin Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis Giulio Gabbiani Professor Departments of Pathology and Immunology University of Geneva-CMU Tuesday, October 5, 2004 - 8:30 AM Health Sciences Center, Room K-069 Faculty Sponsor: Stephen Schwartz NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction Rick Rossow Senior Fellow Physiology and Biophysics University of Washington Tuesday, June 15, 2004 - 8:30 AM Health Sciences Building, K-069 The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells Bardia Askari Associate Howard Hughes Medical Institute University of Washington Tuesday, June 8, 2004 - 8:30 AM Health Sciences Building, K-069 Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury David Granville University of British Columbia Tuesday, May 25, 2004 - 8:30 AM HSB, K-069 Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development Ujwal Pyati Graduate Student Biochemistry University of Washington Tuesday, May 18, 2004 - 8:30 AM HSB, K-069 Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart Jeanette Nussbaum Graduate Student Department of Pathology University of Washington Tuesday, May 11, 2004 - 8:30 AM Health Sciences Building, K-069 Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension Gregory C. Amber Senior Fellow Physiology and Biophysics University of Washington Tuesday, April 27, 2004 - 8:30 AM HSB, K069 The role of endothelial cells in erectile function and dysfunction Hunter Wessells Associate Professor Urology University of Washington Tuesday, April 20, 2004 - 8:30 AM HSB, K-069 Smooth Muscle Cells and Disease - Insights from Microarray Studies Eileen Mulvihill Research Assistant Professor Pathology University of Washington Tuesday, April 13, 2004 - 8:30 AM Health Sciences Building, K-069 Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis Marta Scatena Research Assistant Professor Department of Bioengineering University of Washington Tuesday, April 6, 2004 - 8:30 AM Health Sciences Building, K-069 C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis Joachim Fruebis Associate Director, ZymoGenetics, Inc. Tuesday, March 30, 2004 - 8:30 AM Health Sciences Building, K-069 Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment Mei Speer Senior Fellow Bioengineering University of Washington Tuesday, March 23, 2004 - 8:30 AM HSB, K069 Inflammation and atherosclerosis: Role of serum amyloid A Alan Chait Edwin L. Bierman Professor of Medicine Head, Division of Metabolism, University of Washington Tuesday, March 9, 2004 - 8:30 AM HSB, K069 New Developments in an Integrated Model of Cardiac Function N.P Smith and P.J. Hunter Bioengineering Institute University of Auckland Tuesday, March 2, 2004 - 8:30 AM Health Science Building, K069 Faculty Sponsor: James B Bassingthwaighte TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models Andrew Frutkin Senior Fellow Cardiology University of Washington Tuesday, February 24, 2004 - 8:30 AM HSB, K069 Functional analysis of RGS5 in vascular smooth muscle Xi Wang Senior Fellow Pathology University of Washington Tuesday, February 3, 2004 - 8:30 AM HSB, K069 Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity Todd Gillis Senior Fellow Bioengineering University of Washington Tuesday, January 27, 2004 - 8:30 AM HSB, K069 Gene transfer to striated muscles using AAV Jeff Chamberlain Professor Neurology University of Washington Tuesday, January 20, 2004 - 8:30 AM HSB, K069 Myocardial Reperfusion Injury Tim Pohlman Professor Surgery University of Washington Tuesday, January 13, 2004 - 8:30 AM HSB, K069 The role of Factor XIII in Hemostasis and Wound Healing Paul Bishop Distinguished Fellow ZymoGenetics Tuesday, December 16, 2003 - 8:30 AM Health Sciences, K069 Leukocyte Bcl-2 and ischemia-reperfusion injury Robert K. Winn Research Professor Surgery and Physiology-Biophysics Harborview Medical Center Tuesday, December 9, 2003 - 8:30 AM Health Sciences, K069 Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science David Siscovick Professor of Medicine & Epidemiology Cardiovascular Health Research Unit University of Washington Tuesday, December 2, 2003 - 8:30 AM HSB, K069 Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector Shan Wen Acting Instructor Medicine/Division of Cardiology University of Washington Tuesday, November 25, 2003 - 8:30 AM HSB, K069 Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock John Hogenesch Program Manager, Genomics Genomics Institute Novartis Research Foundation Tuesday, November 18, 2003 - 8:30 AM HSB, K069 Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes Dale Abel Assistant Professor of Medicine and Biochemistry Division of Endocrinology Diabetes and Metabolism Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine Tuesday, November 4, 2003 - 8:30 AM HSB, K069 Mechanisms of transforming growth factor-beta1-induced neointimal formation Goro Otsuka Senior Fellow Medicine/Cardiology University of Washington Tuesday, October 28, 2003 - 8:30 AM HSB, K069 Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding Emilie Clemmens Graduate Student (Defense date Oct. 7th) Bioengineering University of Washington Tuesday, October 21, 2003 - 8:30 AM HSB, K069 Natural antibodies protect against atherogenesis Gregg Silverman Professor in Medicine Dept. of Medicine UCSD Tuesday, October 14, 2003 - 8:30 AM HSB, K069 Thyroid Hormone and Cardiac Metabolism Michael Portman Professor of Pediatrics Children's Hospital and Regional Medical Center University of Washington, Division of Cardiology Tuesday, October 7, 2003 - 8:30 AM Health Science Buidling, K069 Cardiovascular Genomics: Clinical Implications Gary H. Gibbons, M.D Cardiovascular Research Institute Morehouse School of Medicine Monday, June 23, 2003 - 8:30 AM Health Sciences Building, K069 "Links between contractile and electrical dysfunction in heart" Jeffrey E. Saffitz, M.D., Ph.D. Lacy Professor of Pathology Department of Pathology and Immunology Washington University School of Medicine Thursday, June 19, 2003 - 10:00 AM Health Sciences Building, K069 Integrative signaling in angiogenesis Michael Simons A. G. Huber Professor of Medicine & Chief of Cardiology Medical School Dartmouth Tuesday, June 10, 2003 - 8:30 AM Health Sciences Building, T747 Regional Cardiac Sympathetic Dysfunction in CHF James Caldwell, MD Professor Medicine VA Medical Center Tuesday, May 20, 2003 - 8:30 AM Health Sciences Building, K069 Quantitative proteomics: new technology and applications Reudi Abersold Professor and Co-founder of the Institutes for Systems Biology The Institute for Systems Biology Tuesday, May 6, 2003 - 8:30 AM HSB, K069 Marrow Derived Stem Cells- What do we really know? Beverly J Torok-Storb Member & Associate Program Head Transplantation Biology Program Fred Hutchinson Cancer Research Center Tuesday, April 29, 2003 - 8:30 AM HSB, K069 TBA Marsha Whitney Graduate Student Bioengineering University of Washington Tuesday, March 18, 2003 - 8:30 AM HSB, K069 TBA Lisa Tannock Acting Instructor/Senior Fellow Division of Metabolism, Endocrinology and Nutrition University of Washington Tuesday, March 4, 2003 - 8:30 AM HSB, K069 TBA Joe Beavo/ Sergei Rybalkin Professor/ Acting Instructor Pharmacology University of Washington Tuesday, February 18, 2003 - 8:30 AM HSB, K069 TBA Joanne Hulme Senior Fellow Pharmacology University of Washington Tuesday, February 11, 2003 - 8:30 AM HSB, K069 TBA Jin-Yong Hwang, M.D. (Visiting Scientist) Assitant Professor Department of Medicine Gyeongsang National University, Republic of South Korea Tuesday, January 21, 2003 - 8:30 AM HSB, K069 TBA Themis Kyriakides Research Assistant Professor Biochemistry University of Washington Tuesday, January 14, 2003 - 8:30 AM HSB, K069 Delta1: A Notch Up on Hematopoietic Stem Cell Expansion Irwin Bernstein Professor FHCRC Tuesday, December 17, 2002 - 8:30 AM HSC, K-069 "A Genetic Approach to Understanding Basement Membrane Assembly"
Mats Paulsson Professor of Biochemistry School of Medicine University of Cologne Tuesday, December 3, 2002 - 8:30 AM HSC, K-069 |
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Copyright 2004 Department of Pathology |
