Pathology Seminars 
Tumor Suppressor Mechanisms in Long-lived Rodents
Vera Gorbunova, PhD
Associate Professor
Department of Biology
University of Rochester
Tuesday, May 22, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Vera Gorbunova, PhD
Associate Professor
Department of Biology
University of Rochester
Tuesday, May 22, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Nucleic Acid Detection in Host Defense and Autoimmunity
Dan Stetson, Ph.D.
Assistant Professor
UW Medicine Immunology
University of Washington
Wednesday, May 23, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All of our cells have nucleic acid sensors that are essential for activating antiviral immunity. These sensors must be able to distinguish foreign nucleic acids from the abundance of self RNA and self DNA that is present in every cell. In particular, we discovered an innate immune response to intracellular DNA called the Interferon Stimulatory DNA (ISD) pathway, and we have been working to understand the sensors, signaling mechanisms, and relevance of this pathway for antiviral immunity. We found that aberrant activation of the ISD pathway by reverse transcribed DNA of endogenous retroelements causes a number of human autoimmune diseases, including Aicardi-Goutieres Syndrome. Dr. Stetson's presentation will describe recent efforts to characterize the sensors of the ISD pathway, its negative regulators, and its DNA virus-encoded antagonists.
Dan Stetson, Ph.D.
Assistant Professor
UW Medicine Immunology
University of Washington
Wednesday, May 23, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All of our cells have nucleic acid sensors that are essential for activating antiviral immunity. These sensors must be able to distinguish foreign nucleic acids from the abundance of self RNA and self DNA that is present in every cell. In particular, we discovered an innate immune response to intracellular DNA called the Interferon Stimulatory DNA (ISD) pathway, and we have been working to understand the sensors, signaling mechanisms, and relevance of this pathway for antiviral immunity. We found that aberrant activation of the ISD pathway by reverse transcribed DNA of endogenous retroelements causes a number of human autoimmune diseases, including Aicardi-Goutieres Syndrome. Dr. Stetson's presentation will describe recent efforts to characterize the sensors of the ISD pathway, its negative regulators, and its DNA virus-encoded antagonists.
Mutation Rate as a Therapeutic Target in Cancer
Eddie Fox, Ph.D.
Post-Doc, Loeb Lab
UW Medicine Pathology
University of Washington
Wednesday, May 30, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Mutations are a hallmark of cancer, with tens to hundreds of thousands of mutations present in every tumor genome. It has been proposed that these mutations arise from an increased rate of mutagenesis during tumor progression and provide a source of phenotypic variation, including resistance to chemotherapy. Dr. Fox has demonstrated that sequential selection of cancer cells for novel phenotypes, not related to mutagenesis, results in enhanced mutation rates. Thus, the evolution of cancer-related phenotypes itself favors the emergence of mutator lineages. To our knowledge, this this the first real-time demonstration of spontaneous acquisition of a mutator phenotype in a human tumor model. High levels of mutations in tumors, however, could be the Achilles’ heel for killing tumor cells based on targeting enhanced mutagenesis.
Eddie Fox, Ph.D.
Post-Doc, Loeb Lab
UW Medicine Pathology
University of Washington
Wednesday, May 30, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Mutations are a hallmark of cancer, with tens to hundreds of thousands of mutations present in every tumor genome. It has been proposed that these mutations arise from an increased rate of mutagenesis during tumor progression and provide a source of phenotypic variation, including resistance to chemotherapy. Dr. Fox has demonstrated that sequential selection of cancer cells for novel phenotypes, not related to mutagenesis, results in enhanced mutation rates. Thus, the evolution of cancer-related phenotypes itself favors the emergence of mutator lineages. To our knowledge, this this the first real-time demonstration of spontaneous acquisition of a mutator phenotype in a human tumor model. High levels of mutations in tumors, however, could be the Achilles’ heel for killing tumor cells based on targeting enhanced mutagenesis.
Xenobiotic Surveillance and Response in the Regulation of C. Elegans Longevity and Satiety
Gary Ruvkun, PhD
Professor
Department of Genetics
Havard University
Tuesday, June 5, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Gary Ruvkun, PhD
Professor
Department of Genetics
Havard University
Tuesday, June 5, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
10th Annual Alvord Lecture: The Neuropathology of SIDS: Reflections in Honor of Dr. Alvord
Hannah Kinney, MD
Professor
Pathology, Division of Neuropathology
Children's Hospital Boston, Harvard Medical School
Wednesday, June 6, 2012 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Robert Hevner, MD, PhD
A special lecture in memory of the life and scientific legacy of Ellsworth C. Buster Alvord, Jr., M.D. (1923-2010) Professor and Chief, UWMC Neuropathology, 1960-2002
Hannah Kinney, MD
Professor
Pathology, Division of Neuropathology
Children's Hospital Boston, Harvard Medical School
Wednesday, June 6, 2012 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Robert Hevner, MD, PhD
A special lecture in memory of the life and scientific legacy of Ellsworth C. Buster Alvord, Jr., M.D. (1923-2010) Professor and Chief, UWMC Neuropathology, 1960-2002
Bioengineering for Cardiac Repair
Nenad Bursac, PhD
Associate Professor
Biomedical Engineering
Duke University
Wednesday, June 13, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Nenad Bursac's research is aimed at use of cell, tissue, and genetic engineering methodologies and electrophysiological and biomechanical studies to advance fields of somatic and stem cell based therapies for cardiac and skeletal muscle disease. This work has involved: 1) combining DT-MRI and cell micropatternining techniques to create novel 2- and 3-dimensional cardiac cell cultures that replicate micro- and macrostructure of native myocardium, 2) development of specialized co-culture assays to study structural and functional interactions between cardiomyocytes and nonmyocytes, 3) a novel mesoscopic hydrogel molding technique for fabrication of large, aligned, and highly functional skeletal and cardiac muscle tissues derived from stem cells, and 4) generation of novel biosynthetic excitable cells and tissues for basic studies of ion channel function and use in somatic cell therapies for excitable tissue disease.
Nenad Bursac, PhD
Associate Professor
Biomedical Engineering
Duke University
Wednesday, June 13, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Nenad Bursac's research is aimed at use of cell, tissue, and genetic engineering methodologies and electrophysiological and biomechanical studies to advance fields of somatic and stem cell based therapies for cardiac and skeletal muscle disease. This work has involved: 1) combining DT-MRI and cell micropatternining techniques to create novel 2- and 3-dimensional cardiac cell cultures that replicate micro- and macrostructure of native myocardium, 2) development of specialized co-culture assays to study structural and functional interactions between cardiomyocytes and nonmyocytes, 3) a novel mesoscopic hydrogel molding technique for fabrication of large, aligned, and highly functional skeletal and cardiac muscle tissues derived from stem cells, and 4) generation of novel biosynthetic excitable cells and tissues for basic studies of ion channel function and use in somatic cell therapies for excitable tissue disease.
Recent Pathology Seminars
Detection of Ultra-rare Mutations by Next Generation Sequencing
Michael Schmitt, MD, PhD
Post-Doc, Loeb Lab
UW Medicine Pathology
University of Washington
Wednesday, May 16, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry Loeb, MD, PhD
Why Attend?
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology can generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when "deep sequencing" genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, we have developed an alternative to standard sequencing approaches that allows for detection of rare mutations with unprecedented sensitivity.
Michael Schmitt, MD, PhD
Post-Doc, Loeb Lab
UW Medicine Pathology
University of Washington
Wednesday, May 16, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry Loeb, MD, PhD
Why Attend?
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology can generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when "deep sequencing" genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, we have developed an alternative to standard sequencing approaches that allows for detection of rare mutations with unprecedented sensitivity.
The Role of Transsulfuration in the Health and Aging of Drosophila Melanogaster
Scott Pletcher, PhD
Assistant Professor
Molecular Integrative Physiology
University of Michigan Medical School
Tuesday, May 15, 2012 - 11:30 AM
Foege Builiding, Bioengineering Conference Room, N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Scott Pletcher, PhD
Assistant Professor
Molecular Integrative Physiology
University of Michigan Medical School
Tuesday, May 15, 2012 - 11:30 AM
Foege Builiding, Bioengineering Conference Room, N-130
Faculty Sponsor: Matt Kaeberlein, PhD
The Molecular Regulation of Stem Cell Quiescence
CANCELLED: Thomas Rando, M.D., Ph.D.
Professor, Department of Neurology and Neurological Sciences
Director, Glenn Laboratories for the Biology of Aging
Stanford University Medical Center
Wednesday, May 9, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Dr. Rando's seminar originally scheduled for Wednesday, May 9 has been cancelled due to clinical service obligations. We will reschedule Dr. Rando's visit in the next few months.
CANCELLED: Thomas Rando, M.D., Ph.D.
Professor, Department of Neurology and Neurological Sciences
Director, Glenn Laboratories for the Biology of Aging
Stanford University Medical Center
Wednesday, May 9, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Dr. Rando's seminar originally scheduled for Wednesday, May 9 has been cancelled due to clinical service obligations. We will reschedule Dr. Rando's visit in the next few months.
Context-dependent Responses to Hypoxia in C. Elegans
Dana Miller, PhD
Assistant
Department of Biochemistry
University of Washington
Wednesday, May 9, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matt Kaeberlein, PhD
Why Attend?
Oxygen is essential for all metazoans, with only one known exception. Inappropriate or inadequate responses to decreased oxygen availability (hypoxia) are hallmark features of traumatic injury and stroke, and contribute to many diseases that lead to significant human morbidity and mortality. Though there is a critical need to understand normal and pathological responses to hypoxia, few genetically tractable models have been developed that allow for unbiased investigation of hypoxia-responsive pathways. We have developed methods to investigate physiological strategies of adaptation to hypoxia in C. elegans, allowing simultaneous control of genotype and cellular environment in a living animal. Our studies reveal that the response to hypoxia depends greatly on the physiological context. We are working to understand the mechanistic basis of the context-dependent effects on hypoxia. This work will provide an important foundation to develop therapeutic strategies to protect cells and organisms from hypoxia.
Dana Miller, PhD
Assistant
Department of Biochemistry
University of Washington
Wednesday, May 9, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matt Kaeberlein, PhD
Why Attend?
Oxygen is essential for all metazoans, with only one known exception. Inappropriate or inadequate responses to decreased oxygen availability (hypoxia) are hallmark features of traumatic injury and stroke, and contribute to many diseases that lead to significant human morbidity and mortality. Though there is a critical need to understand normal and pathological responses to hypoxia, few genetically tractable models have been developed that allow for unbiased investigation of hypoxia-responsive pathways. We have developed methods to investigate physiological strategies of adaptation to hypoxia in C. elegans, allowing simultaneous control of genotype and cellular environment in a living animal. Our studies reveal that the response to hypoxia depends greatly on the physiological context. We are working to understand the mechanistic basis of the context-dependent effects on hypoxia. This work will provide an important foundation to develop therapeutic strategies to protect cells and organisms from hypoxia.
Function of Nod-like Receptors in Intestinal Immunity
Gabriel Nunez, M.D.
Paul de Kruif Endowed Professor
Department of Pathology
University of Michigan Medical School
Wednesday, May 2, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
The Nunez laboratory is interested in mechanisms regulating innate immunity, the pathogenesis of inflammatory disease and the interaction of the microbiota with the host. Specifically, the research focuses on mechanistic studies to understand the role of pattern recognition receptors (PRRs) and in particular Nod-like receptors (NLRs) in the immune response against microbial pathogens and endogenous damage signals. Several NLR proteins including NOD2 and NLRP3 are mutated in patients with inflammatory diseases, Crohn's disease and autoinflammatory syndromes, respectively. However, the function of NLRs in host defense and the mechanisms by which NLR mutant proteins lead to disease remain unclear. Dr. Nuñez's presentation will present and discuss ongoing studies that attempt to understand the role of NLRs in host defense aqainst bacterial pathogens and inflammatory disease in the intestine.
Gabriel Nunez, M.D.
Paul de Kruif Endowed Professor
Department of Pathology
University of Michigan Medical School
Wednesday, May 2, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
The Nunez laboratory is interested in mechanisms regulating innate immunity, the pathogenesis of inflammatory disease and the interaction of the microbiota with the host. Specifically, the research focuses on mechanistic studies to understand the role of pattern recognition receptors (PRRs) and in particular Nod-like receptors (NLRs) in the immune response against microbial pathogens and endogenous damage signals. Several NLR proteins including NOD2 and NLRP3 are mutated in patients with inflammatory diseases, Crohn's disease and autoinflammatory syndromes, respectively. However, the function of NLRs in host defense and the mechanisms by which NLR mutant proteins lead to disease remain unclear. Dr. Nuñez's presentation will present and discuss ongoing studies that attempt to understand the role of NLRs in host defense aqainst bacterial pathogens and inflammatory disease in the intestine.
Homing Endoncleases for Gene Targeting
Stefan Pellanz, PhD
Post-Doctoral Fellow
Monnat Lab
UW Medicine Pathology
Wednesday, April 25, 2012 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, MD
Why Attend?
Homing endonucleases are rare cutting endonucleases typically encoded in introns or inteins. Their ability to maintain high site specificity of cleavage while tolerating limited target site sequence divergence, together with tight coupling of DNA binding and cleavage, have made HEs attractive reagents for genome engineering. Recent development of HEs with altered specificities has demonstrated their value for targeted gene modifications. Our research focusses on the alteration of these enzymes in order to shift their specificity towards novel, therapeutically interesting target sites and the characterization of these engineered HE variants in living cells.
Stefan Pellanz, PhD
Post-Doctoral Fellow
Monnat Lab
UW Medicine Pathology
Wednesday, April 25, 2012 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, MD
Why Attend?
Homing endonucleases are rare cutting endonucleases typically encoded in introns or inteins. Their ability to maintain high site specificity of cleavage while tolerating limited target site sequence divergence, together with tight coupling of DNA binding and cleavage, have made HEs attractive reagents for genome engineering. Recent development of HEs with altered specificities has demonstrated their value for targeted gene modifications. Our research focusses on the alteration of these enzymes in order to shift their specificity towards novel, therapeutically interesting target sites and the characterization of these engineered HE variants in living cells.
RIG-I Like Receptors in Infection, Immunity and Therapy
Michael Gale, Ph.D.
Professor, UW Medicine Immunology
Adjunct Professor, UW Medicine Global Health
University of Washington
Wednesday, April 18, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Michael Gale, Jr., PhD, is the Director of the National Institutes of Health (NIH)-funded Center for the Study of Immune Mechanisms of Virus Control at the University of Washington, School of Medicine where his research program is focused on understanding the virus-host interactions that regulate innate immunity against RNA viruses. Dr. Gale is also the Director of a Center for the Study of Hepatitis C Virus Infection and Immunity, part of a national network of Hepatitis C Cooperative Research Centers funded by the NIH. In addition, his laboratory is also a component of the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases, where he leads a research program to define therapeutic targets to control pathogenic flavivirus infection. Dr. Gale teaches virology, immunology, infectious disease biology, and public health to medical students and graduate students, and is a member of the editorial board of several biomedical research journals. He is currently a member of the Virology-B study section of the NIH.
Michael Gale, Ph.D.
Professor, UW Medicine Immunology
Adjunct Professor, UW Medicine Global Health
University of Washington
Wednesday, April 18, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Michael Gale, Jr., PhD, is the Director of the National Institutes of Health (NIH)-funded Center for the Study of Immune Mechanisms of Virus Control at the University of Washington, School of Medicine where his research program is focused on understanding the virus-host interactions that regulate innate immunity against RNA viruses. Dr. Gale is also the Director of a Center for the Study of Hepatitis C Virus Infection and Immunity, part of a national network of Hepatitis C Cooperative Research Centers funded by the NIH. In addition, his laboratory is also a component of the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases, where he leads a research program to define therapeutic targets to control pathogenic flavivirus infection. Dr. Gale teaches virology, immunology, infectious disease biology, and public health to medical students and graduate students, and is a member of the editorial board of several biomedical research journals. He is currently a member of the Virology-B study section of the NIH.
CANCELLED Molecular Classification of Breast Cancer: Where Are We and Where Are We Going?
CANCELLED: Stuart Schnitt, M.D,
Professor, Department of Pathology
Director, Anatomic Pathology, Beth Israel Deaconess Medical Center
Harvard Medical School
Wednesday, April 11, 2012 - 5:00 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Residents/Mara Rendi, M.D.
This seminar has been cancelled due to a death in the speaker's family. It will be rescheduled in the next few months.
Why Attend?
Stuart Schnitt is the Director of the Division of Anatomic Pathology at Beth Israel Deaconess Medical Center in Boston and a Professor of Pathology at Harvard Medical School. He is also a Past President of the United States and Canadian Academy of Pathology. Dr. Schnitt is an internationally recognized expert in breast pathology, author of a highly acclaimed breast pathology textbook (Biopsy Interpretation of the Breast), and an editor of the 4th Edition of the WHO Classification of Tumours of the Breast. His research interests in the area of breast diseases is broad and in recent years has focused increasingly on the integration of traditional pathology with newer molecular techniques to refine breast tumor classification, assessment of breast cancer risk in women with benign breast disease, and risk of local recurrence in women with invasive breast cancer and DCIS treated with breast conserving therapy.
CANCELLED: Stuart Schnitt, M.D,
Professor, Department of Pathology
Director, Anatomic Pathology, Beth Israel Deaconess Medical Center
Harvard Medical School
Wednesday, April 11, 2012 - 5:00 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Residents/Mara Rendi, M.D.
This seminar has been cancelled due to a death in the speaker's family. It will be rescheduled in the next few months.
Why Attend?
Stuart Schnitt is the Director of the Division of Anatomic Pathology at Beth Israel Deaconess Medical Center in Boston and a Professor of Pathology at Harvard Medical School. He is also a Past President of the United States and Canadian Academy of Pathology. Dr. Schnitt is an internationally recognized expert in breast pathology, author of a highly acclaimed breast pathology textbook (Biopsy Interpretation of the Breast), and an editor of the 4th Edition of the WHO Classification of Tumours of the Breast. His research interests in the area of breast diseases is broad and in recent years has focused increasingly on the integration of traditional pathology with newer molecular techniques to refine breast tumor classification, assessment of breast cancer risk in women with benign breast disease, and risk of local recurrence in women with invasive breast cancer and DCIS treated with breast conserving therapy.
Therapeutic Targets for Cognitive Impairment
Thomas Montine, M.D., Ph.D.
Alvord Professor and Interim Chair
Department of Pathology
University of Washington
Wednesday, April 11, 2012 - 3:30 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
Thomas Montine, M.D., Ph.D.
Alvord Professor and Interim Chair
Department of Pathology
University of Washington
Wednesday, April 11, 2012 - 3:30 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
New Roles for Pathologists in the Era of Personalized Cancer Care
Stan Hamilton, M.D.
Division Head, Pathology/Lab Medicine
MD Anderson Cancer Center
University of Texas
Wednesday, April 4, 2012 - 5:00 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Melissa Upton, M.D.
Stan Hamilton, M.D.
Division Head, Pathology/Lab Medicine
MD Anderson Cancer Center
University of Texas
Wednesday, April 4, 2012 - 5:00 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Melissa Upton, M.D.
Studies of Dynamic Remodeling: Mucosal Barriers and the Practice of Pathology
Jerrold Turner, MD, PhD
Professor and Vice Chair
Department of Pathology
University of Chicago
Wednesday, April 4, 2012 - 3:00 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
Jerrold Turner, MD, PhD
Professor and Vice Chair
Department of Pathology
University of Chicago
Wednesday, April 4, 2012 - 3:00 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
Apoptosis and Autophagy: Key Partners in Neuronal Cell Death Regulation
Kevin A. Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Friday, March 30, 2012 - 1:30 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
Kevin A. Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Friday, March 30, 2012 - 1:30 PM
Health Sciences Center, Room T-733
Speaker is a candidate for the Chair of the Department of Pathology
For more information contact the Dean of Medicine Office at 206 543-7718.
The Influence of Alternative pre-mRNA Processing in Gene Expression and Disease
Klemens Hertel, Ph.D.
Professor
Department of Microbiology and Molecular Genetics
Univeristy of California, Irvine
Wednesday, March 21, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Pathology Graduate Students
Why Attend?
Research in the Hertel laboratory focuses on elucidating the regulation of alternative splicing with the ultimate goal to faithfully predict pre-mRNA processing changes in disease models. With the realization that most diseases are molecularly heterogeneous, novel high throughput technologies have been employed to identify gene expression markers that could be used for early detection and improved prognosis. However, gene expression levels alone cannot fully explain a cellular phenotype or gene functions without considering alternative pre-mRNA processing. Dr. Hertel’s presentation will discuss the prevalence, mechanisms, and potential implications of alternative pre-mRNA processing in maintaining cellular homeostasis.
Klemens Hertel, Ph.D.
Professor
Department of Microbiology and Molecular Genetics
Univeristy of California, Irvine
Wednesday, March 21, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Pathology Graduate Students
Why Attend?
Research in the Hertel laboratory focuses on elucidating the regulation of alternative splicing with the ultimate goal to faithfully predict pre-mRNA processing changes in disease models. With the realization that most diseases are molecularly heterogeneous, novel high throughput technologies have been employed to identify gene expression markers that could be used for early detection and improved prognosis. However, gene expression levels alone cannot fully explain a cellular phenotype or gene functions without considering alternative pre-mRNA processing. Dr. Hertel’s presentation will discuss the prevalence, mechanisms, and potential implications of alternative pre-mRNA processing in maintaining cellular homeostasis.
The Brain and Fat: Dissecting Systemic Control of Metabolism and Aging in the NAD World
Shin-ichiro Imai, MD, PhD
Associate Professor
Department of Developmental Biology & Medicine
Washington University School of Medicine
Tuesday, March 20, 2012 - 3:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, MD, PhD
Why Attend
Sirtuins have become established as important factors modulating aging-related disease in mammals. The Imai laboratory studies the role of SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) for the regulation of metabolism and aging. Dr. Imai has proposed a comprehensive concept of a novel systemic regulatory network, named NAD World, for the intricate connection between metabolism and aging. This new concept of the NAD World may provide important insights into the systemic regulation of mammalian aging and longevity and also convey ideas of functional hierarchy and frailty for the induction of aging. By understanding the system dynamics of the NAD World, Dr. Imai's goal is to develop therapeutic and preventive interventions for age-associated diseases, such as type 2 diabetes and Alzheimer's disease. Here are three burning questions that the Imai lab is trying to answer: 1) Which organs/tissues play a major role in the regulation of aging and longevity in mammals? Is there any control center of aging? 2) What hormones/factors mediate the communication between the control center of aging and other modulatory organs/tissues? 3) What molecules/signaling pathways coordinate the regulation of mammalian aging at a systemic level?
Shin-ichiro Imai, MD, PhD
Associate Professor
Department of Developmental Biology & Medicine
Washington University School of Medicine
Tuesday, March 20, 2012 - 3:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, MD, PhD
Why Attend
Sirtuins have become established as important factors modulating aging-related disease in mammals. The Imai laboratory studies the role of SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) for the regulation of metabolism and aging. Dr. Imai has proposed a comprehensive concept of a novel systemic regulatory network, named NAD World, for the intricate connection between metabolism and aging. This new concept of the NAD World may provide important insights into the systemic regulation of mammalian aging and longevity and also convey ideas of functional hierarchy and frailty for the induction of aging. By understanding the system dynamics of the NAD World, Dr. Imai's goal is to develop therapeutic and preventive interventions for age-associated diseases, such as type 2 diabetes and Alzheimer's disease. Here are three burning questions that the Imai lab is trying to answer: 1) Which organs/tissues play a major role in the regulation of aging and longevity in mammals? Is there any control center of aging? 2) What hormones/factors mediate the communication between the control center of aging and other modulatory organs/tissues? 3) What molecules/signaling pathways coordinate the regulation of mammalian aging at a systemic level?
CAP-Transformation of a Specialty
Paul Valenstein, MD, FCAP
President, Pathology and Laboratory Management Associates, P.C.
Member, CAP Council on Accreditation
Vice Chair, CAP Council on Scientific Affairs
Wednesday, March 14, 2012 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ben Hoch, MD
Why Attend?
Changes in the organization of care, the availability of funding, and technology advancements have the potential to create a "perfect storm" for the pathology specialty. How will individual practitioners and pathology practices adapt? Dr. Valenstein will discuss some of the challenges and opportunities facing the specialty, and provide insights into steps that can be taken to accelerate adaption in a rapidly evolving market.
Paul Valenstein, MD, FCAP
President, Pathology and Laboratory Management Associates, P.C.
Member, CAP Council on Accreditation
Vice Chair, CAP Council on Scientific Affairs
Wednesday, March 14, 2012 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ben Hoch, MD
Why Attend?
Changes in the organization of care, the availability of funding, and technology advancements have the potential to create a "perfect storm" for the pathology specialty. How will individual practitioners and pathology practices adapt? Dr. Valenstein will discuss some of the challenges and opportunities facing the specialty, and provide insights into steps that can be taken to accelerate adaption in a rapidly evolving market.
Evolution of Sex Chromosomes and Dosage Compensation in Mammals
Jennifer A. Marshall Graves, PhD
Distinguished Professor
Institute of Molecular Sciences
La Trobe University, Melbourne, Australia
Wednesday, March 14, 2012 - 3:30 PM
Genome Sciences Builiding, Foege Auditorium
Faculty Sponsor: Christine Disteche, PhD
A special seminar hosted by the Departments of Pathology and Genome Sciences
Jennifer A. Marshall Graves, PhD
Distinguished Professor
Institute of Molecular Sciences
La Trobe University, Melbourne, Australia
Wednesday, March 14, 2012 - 3:30 PM
Genome Sciences Builiding, Foege Auditorium
Faculty Sponsor: Christine Disteche, PhD
A special seminar hosted by the Departments of Pathology and Genome Sciences
Synergistic Regulation of cAMP-mediated Functions by Multiple PDEs
Joe Beavo, Ph.D.
Professor
UW Medicine Pharmacology
University of Washington
Wednesday, March 7, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Many different physiological and pathophysiological processes are controlled by cAMP- and cGMP-dependent regulatory processes. The amplitude and duration of these cyclic nucleotide signals are in turn controlled by both their rates of synthesis by adenylyl and guanylyl cyclases and their rates of degradation by cyclic nucleotide phosphodiesterases (PDEs). Multiple isozymes of both cyclases and phosphodiesterases have been identified and shown to be important for the ability of the cell to adapt to its environment. Moreover, it also has been amply demonstrated that a particularly good way to pharmacologically manipulate these cyclic nucleotide signals is to modulate the activity of the PDEs that control their degradation. This lecture will address current ideas about how pharmacological regulation of these enzymes has been approached in the past with the goal of obtaining efficacy without side effects and will also suggest likely new and better approaches for the future. Experimental examples to illustrate this approach will be largely from regulation of steroidogenesis by cAMP but the lessons learned are likely to be widely applicable.
Joe Beavo, Ph.D.
Professor
UW Medicine Pharmacology
University of Washington
Wednesday, March 7, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Many different physiological and pathophysiological processes are controlled by cAMP- and cGMP-dependent regulatory processes. The amplitude and duration of these cyclic nucleotide signals are in turn controlled by both their rates of synthesis by adenylyl and guanylyl cyclases and their rates of degradation by cyclic nucleotide phosphodiesterases (PDEs). Multiple isozymes of both cyclases and phosphodiesterases have been identified and shown to be important for the ability of the cell to adapt to its environment. Moreover, it also has been amply demonstrated that a particularly good way to pharmacologically manipulate these cyclic nucleotide signals is to modulate the activity of the PDEs that control their degradation. This lecture will address current ideas about how pharmacological regulation of these enzymes has been approached in the past with the goal of obtaining efficacy without side effects and will also suggest likely new and better approaches for the future. Experimental examples to illustrate this approach will be largely from regulation of steroidogenesis by cAMP but the lessons learned are likely to be widely applicable.
A Systems Approach to Dissecting Immunity
Alan Aderem, Ph.D.
President and Director, Seattle BioMed
Affiliate Professor of Immunology and Medicine, University of Washington
Seattle Biomedical Research Institute
Wednesday, February 29, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Alan Aderem, co-founder of the Institute for Systems Biology, is a pioneer in the field of systems biology and is an internationally recognized immunologist and cell biologist. His research focuses on the innate immune system – how it recognizes and formulates responses to infectious agents, and how it instructs the adaptive immune system to provide long-lived immunity to the pathogen. The Aderem laboratory also applies the tools of systems biology to the study of diseases that significantly impact global health with an emphasis on rational vaccine design. He has recently taken over the helm of Seattle BioMed.
Alan Aderem, Ph.D.
President and Director, Seattle BioMed
Affiliate Professor of Immunology and Medicine, University of Washington
Seattle Biomedical Research Institute
Wednesday, February 29, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Alan Aderem, co-founder of the Institute for Systems Biology, is a pioneer in the field of systems biology and is an internationally recognized immunologist and cell biologist. His research focuses on the innate immune system – how it recognizes and formulates responses to infectious agents, and how it instructs the adaptive immune system to provide long-lived immunity to the pathogen. The Aderem laboratory also applies the tools of systems biology to the study of diseases that significantly impact global health with an emphasis on rational vaccine design. He has recently taken over the helm of Seattle BioMed.
Association of Hyaluronan Metabolic Biomarkers and Inflammation with Aggressiveness in Prostate Cancer
Stephen Schmechel, MD, PhD
Assistant Professor and Director of Cytopathology
Department of Laboratory Medicine
University of Minnesota
Wednesday, February 15, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, MD, PhD
Why Attend?
Steve Schmechel is Assistant Professor and Director of Cytopathology in the Department of Laboratory Medicine at the University of Minnesota (UMN), and founding Director of the UMN Academic Health Center's Biological Materials Procurement Network (BioNet), a central biobank, research histopathology, and digital imaging resource. BioNet supports research by 71 UMN principal investigators and additional studies at other universities and companies in the medical device, biotechnology, and pharmaceutical industries. The Schmechel laboratory utilizes BioNet functions to identify and validate gene products and other metabolic biomarkers of aggressive biologic behavior of prostate cancer. Recent results support a model that a mechanism of aggressive prostate cancer biology is the synthesis of hyaluronan (by HAS2), accumulation of hyaluronan, degradation (presumably) of some hyaluronan (by Hyal1) into hyaluronan fragments*, and upregulation of signaling via the Rhamm pathway that promotes a response including CD45-positive) inflammation.
Stephen Schmechel, MD, PhD
Assistant Professor and Director of Cytopathology
Department of Laboratory Medicine
University of Minnesota
Wednesday, February 15, 2012 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, MD, PhD
Why Attend?
Steve Schmechel is Assistant Professor and Director of Cytopathology in the Department of Laboratory Medicine at the University of Minnesota (UMN), and founding Director of the UMN Academic Health Center's Biological Materials Procurement Network (BioNet), a central biobank, research histopathology, and digital imaging resource. BioNet supports research by 71 UMN principal investigators and additional studies at other universities and companies in the medical device, biotechnology, and pharmaceutical industries. The Schmechel laboratory utilizes BioNet functions to identify and validate gene products and other metabolic biomarkers of aggressive biologic behavior of prostate cancer. Recent results support a model that a mechanism of aggressive prostate cancer biology is the synthesis of hyaluronan (by HAS2), accumulation of hyaluronan, degradation (presumably) of some hyaluronan (by Hyal1) into hyaluronan fragments*, and upregulation of signaling via the Rhamm pathway that promotes a response including CD45-positive) inflammation.
PKA Mutations Regulate Energy Homeostasis in Mice
Stan McKnight, Ph.D.
Professor
UW Medicine Pharmacology
University of Washington
Wednesday, February 8, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
We count on neurons in the hypothalamus to integrate signals from the rest of our body and balance energy intake with our energy expenditure. For most of us, this means we are not constantly gaining or losing weight. The system works reasonably well in humans and in mice until faced with highly palatable, calorie dense foods and an environment where exercise is discouraged by elevators, cars, and in the case of mice, small cages. The result in the US population is that ~60% of us are overweight and ~30% are classified as obese with all of the adverse health effects associated with obesity. Our lab is studying mice with genetically engineered defects in the cAMP/PKA system that protect animals from diet-induced obesity and also have stimulatory effects on voluntary exercise. Our hypothesis is that these changes in signal transduction pathways in leptin-responsive neuronal circuits have produced mice that are hyper-sensitive to leptin, suppressing the normal tendency to store more fat in adipose tissue.
Stan McKnight, Ph.D.
Professor
UW Medicine Pharmacology
University of Washington
Wednesday, February 8, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
We count on neurons in the hypothalamus to integrate signals from the rest of our body and balance energy intake with our energy expenditure. For most of us, this means we are not constantly gaining or losing weight. The system works reasonably well in humans and in mice until faced with highly palatable, calorie dense foods and an environment where exercise is discouraged by elevators, cars, and in the case of mice, small cages. The result in the US population is that ~60% of us are overweight and ~30% are classified as obese with all of the adverse health effects associated with obesity. Our lab is studying mice with genetically engineered defects in the cAMP/PKA system that protect animals from diet-induced obesity and also have stimulatory effects on voluntary exercise. Our hypothesis is that these changes in signal transduction pathways in leptin-responsive neuronal circuits have produced mice that are hyper-sensitive to leptin, suppressing the normal tendency to store more fat in adipose tissue.
Head and Neck Tumors - Emerging Diseases
F. Zahra Aly, MD, BDS, PhD
Cytopathology Fellow
George Washington University Hospital
Thursday, February 2, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Dolphine Oda, BDS, MSc
Speaker is a faculty candidate in Oral Pathology
F. Zahra Aly, MD, BDS, PhD
Cytopathology Fellow
George Washington University Hospital
Thursday, February 2, 2012 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Dolphine Oda, BDS, MSc
Speaker is a faculty candidate in Oral Pathology
Electrophysiology and Calcium Handling of Human Embryonic Stem Cell-Derived Cardiomyocytes
Wei-Zhong Zhu
Post-Doc, Laflamme Lab
UW Medicine Pathology
University of Washington
Wednesday, February 1, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have tremendous promise as a cell source for regenerative medicine. To optimize host-graft electromechanical integration and minimize the risk of arrhythmias following transplantation, however, hESC-CMs must have the appropriate electrophysiological properties and mechanisms of excitation-contraction coupling. Toward that end, I will present our recent work on two topics related to the electrical behavior of hESC-CMs in vitro. First, I will describe advances in the derivation of specialized cardiac subtypes (e.g., pacemaker cells) from hESCs, using genetic selection and pharmacological manipulation of neuregulin-ErbB signaling. Second, I will review our current understanding of the mechanisms of excitation-contraction coupling and calcium handling in hESC-CMs, which seem to be surprisingly adult-like given their relatively immature structure and mechanical properties.
Wei-Zhong Zhu
Post-Doc, Laflamme Lab
UW Medicine Pathology
University of Washington
Wednesday, February 1, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have tremendous promise as a cell source for regenerative medicine. To optimize host-graft electromechanical integration and minimize the risk of arrhythmias following transplantation, however, hESC-CMs must have the appropriate electrophysiological properties and mechanisms of excitation-contraction coupling. Toward that end, I will present our recent work on two topics related to the electrical behavior of hESC-CMs in vitro. First, I will describe advances in the derivation of specialized cardiac subtypes (e.g., pacemaker cells) from hESCs, using genetic selection and pharmacological manipulation of neuregulin-ErbB signaling. Second, I will review our current understanding of the mechanisms of excitation-contraction coupling and calcium handling in hESC-CMs, which seem to be surprisingly adult-like given their relatively immature structure and mechanical properties.
Molecular Diagnostic Cytopathology in an Era of Targeted Therapeutics
Sinchita Roy Chowdhuri, M.D., Ph.D.
Molecular Diagnostic Fellow
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Friday, January 27, 2012 - 12:45 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Rochelle Garcia, M.D.
Speaker is a faculty candidate in pathology.
Sinchita Roy Chowdhuri, M.D., Ph.D.
Molecular Diagnostic Fellow
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Friday, January 27, 2012 - 12:45 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Rochelle Garcia, M.D.
Speaker is a faculty candidate in pathology.
Humoral Control of Proteostasis and its Impact Upon Aging
Andrew Dillin, Ph.D.
Professor
Molecular and Cell Biology
Salk Institute for Biological Studies
Tuesday, January 24, 2012 - 4:30 PM
UW Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Andrew Dillin, Ph.D.
Professor
Molecular and Cell Biology
Salk Institute for Biological Studies
Tuesday, January 24, 2012 - 4:30 PM
UW Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Novel Approaches to GU Cancers: - Is microvessel density significant in prostate cancer biology? - Renal Tumor Subtyping by Multiplex Ligation-Dependent Probe Amplification (MLPA) Assay
Maria Tretiakova, M.D., Ph.D.
Anatomic and Clinical Pathology Resident
Department of Pathology
University of Chicago
Friday, January 13, 2012 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True, M.D.
Speaker is a faculty candidate in Pathology
Maria Tretiakova, M.D., Ph.D.
Anatomic and Clinical Pathology Resident
Department of Pathology
University of Chicago
Friday, January 13, 2012 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True, M.D.
Speaker is a faculty candidate in Pathology
The Challenge of Finding a Clinically Useful Tissue-Based Prostate Cancer Biomarker: A Personal Perspective
Larry True, M.D.
Professor
UW Medicine Pathology
University of Washington
Wednesday, January 11, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Based on my multi-year investigation of tissue-based cancer biomarkers, I will discuss some of the challenges that we all face in identifying prognostic and predictive markers, and proposed solutions. Although I'll focus on markers specific to the prostate, the challenges are common to all cancers. Issues to be discussed include sampling, tumor heterogeneity, observer-variability, prognostic and predictive transcriptomes and proteomes, and quantitative tissue assays.
Larry True, M.D.
Professor
UW Medicine Pathology
University of Washington
Wednesday, January 11, 2012 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Based on my multi-year investigation of tissue-based cancer biomarkers, I will discuss some of the challenges that we all face in identifying prognostic and predictive markers, and proposed solutions. Although I'll focus on markers specific to the prostate, the challenges are common to all cancers. Issues to be discussed include sampling, tumor heterogeneity, observer-variability, prognostic and predictive transcriptomes and proteomes, and quantitative tissue assays.
Deciphering the Mitochondrial Contribution to Intracellular Signaling
Brian Hawkins, Ph.D.
Assistant Professor, UW Medicine Anesthesiology and Pain Medicine
Researcher, Mitochondria and Metabolism Center
University of Washington
Wednesday, December 14, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Bill Mahoney, Ph.D.
Why Attend?
Mitochondria are ubiquitous organelles that are the primary source of energy for most eukaryotic organisms. Aside from ATP generation, mitochondria contribute to intracellular signaling pathways during growth, differentiation, proliferation, and even cell death. Perturbations in mitochondrial function consequently influence a number of conditions including cardiovascular disease, cancer, and neurodegeneration. Due to this almost universal impact on multiple cellular processes and diseases, defining the precise molecular mechanism(s) by which mitochondria decode and transmit cellular metabolic cues into downstream signaling has proven difficult. Our laboratory specializes in delineating how mitochondria direct intracellular signaling by focusing on the delicate relationship between calcium and redox homeostasis. This seminar will highlight our current understanding of mitochondrial-initiated signaling cascades via calcium and reactive oxygen species (ROS) and will introduce a novel means in which mitochondria initiate intracellular signaling through physiologic mitochondrial permeability transition. We anticipate that the identification of unique mitochondrial signaling molecules and pathways will serve as attractive therapeutic targets aimed at combating human disease.
Brian Hawkins, Ph.D.
Assistant Professor, UW Medicine Anesthesiology and Pain Medicine
Researcher, Mitochondria and Metabolism Center
University of Washington
Wednesday, December 14, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Bill Mahoney, Ph.D.
Why Attend?
Mitochondria are ubiquitous organelles that are the primary source of energy for most eukaryotic organisms. Aside from ATP generation, mitochondria contribute to intracellular signaling pathways during growth, differentiation, proliferation, and even cell death. Perturbations in mitochondrial function consequently influence a number of conditions including cardiovascular disease, cancer, and neurodegeneration. Due to this almost universal impact on multiple cellular processes and diseases, defining the precise molecular mechanism(s) by which mitochondria decode and transmit cellular metabolic cues into downstream signaling has proven difficult. Our laboratory specializes in delineating how mitochondria direct intracellular signaling by focusing on the delicate relationship between calcium and redox homeostasis. This seminar will highlight our current understanding of mitochondrial-initiated signaling cascades via calcium and reactive oxygen species (ROS) and will introduce a novel means in which mitochondria initiate intracellular signaling through physiologic mitochondrial permeability transition. We anticipate that the identification of unique mitochondrial signaling molecules and pathways will serve as attractive therapeutic targets aimed at combating human disease.
An Analysis of the Extracellular Matrix in Hutchinson Gilford Progeria Syndrome
Ingrid Harten
Doctoral Dissertation
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, December 8, 2011 - 4:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Thomas Wight, Ph.D.
Ingrid Harten
Doctoral Dissertation
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, December 8, 2011 - 4:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Thomas Wight, Ph.D.
Molecular Logic of Neocortical Projection Neuron Development, Degeneration, and Regeneration
Jeffrey Macklis, M.D.
Professor, Stem Cell and Regenerative Biology
Program Head, Neuroscience / Nervous System Diseases Harvard Stem Cell Institute
Harvard University
Wednesday, December 7, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend?
Jeffrey D. Macklis' laboratory is directed toward both 1) understanding molecular controls over neuron sub-type specification and development in the cerebral cortex, and 2) applying developmental controls toward brain and spinal cord repair - specifically, the cellular repair of complex cerebral cortex and cortical output circuitry (in particular, cortico-spinal motor neuron (CSMN) circuitry that degenerates in ALS and other "upper motor neuron" degenerative diseases, and whose injury is centrally involved in loss of motor function in spinal cord injury). The Macklis lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / "stem cell" biology; induction of adult neurogenesis (the birth of new neurons from within); and directed neuronal differentiation and development of connectivity via molecular manipulation of neural progenitors within murine neocortex. The same biology informs understanding of neuronal subtype specificity of involvement in human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, PLS, HSPs, Huntington's disease, autism spectrum disorders, and Rett Syndrome.
Jeffrey Macklis, M.D.
Professor, Stem Cell and Regenerative Biology
Program Head, Neuroscience / Nervous System Diseases Harvard Stem Cell Institute
Harvard University
Wednesday, December 7, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend?
Jeffrey D. Macklis' laboratory is directed toward both 1) understanding molecular controls over neuron sub-type specification and development in the cerebral cortex, and 2) applying developmental controls toward brain and spinal cord repair - specifically, the cellular repair of complex cerebral cortex and cortical output circuitry (in particular, cortico-spinal motor neuron (CSMN) circuitry that degenerates in ALS and other "upper motor neuron" degenerative diseases, and whose injury is centrally involved in loss of motor function in spinal cord injury). The Macklis lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / "stem cell" biology; induction of adult neurogenesis (the birth of new neurons from within); and directed neuronal differentiation and development of connectivity via molecular manipulation of neural progenitors within murine neocortex. The same biology informs understanding of neuronal subtype specificity of involvement in human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, PLS, HSPs, Huntington's disease, autism spectrum disorders, and Rett Syndrome.
Proteolytic Pathways in Innate Immunity
William Parks, Ph.D.
Professor
Director, Center for Lung Biology
UW Medicine
Wednesday, November 30, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Innate immunity involves the action of resident cells and leukocytes to maintain and restore healthy tissues challenged by injury and infection. As for most biological processes, the extent, pattern, and duration of inflammation are controlled by a balance between positive and negative factors. Matrix metalloproteinases (MMP) have emerged as important effector enzymes that act on diverse proteins to promote or moderate various immune processes. This presentation will highlight two MMPs-MMP7 and MMP10-that control distinct and somewhat opposing immune processes in response to injury and infection. In acute injury, matrilysin (MMP7) controls the transepithelial advancement and activation of neutrophils by shedding the ectodomain of syndecan-1, a transmembrane heparan sulfate proteoglycan. Similar to MMP7, stromelysin-2 (MMP10) is not expressed in resting tissues; however, in response acute or chronic insults, this proteinase is induced by infiltrated macrophages. In models of acute and chronic inflammation, Mmp10–/– mice have an exaggerated inflammatory response, indicating that the enzyme functions normally to repress inflammation. However, whereas Mmp10–/– mice are susceptible to lethality from acute insults, they are protected against tissue damage associated with prolonged inflammation. Data from both models indicate that MMP10 impact macrophage functions by promoting differentiation into immunosuppressive M2 (alternatively activated) cells. Together, these findings demonstrate both pro- and anti-inflammatory functions of distinct MMPs.
William Parks, Ph.D.
Professor
Director, Center for Lung Biology
UW Medicine
Wednesday, November 30, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Mike Laflamme, M.D., Ph.D.
Why Attend?
Innate immunity involves the action of resident cells and leukocytes to maintain and restore healthy tissues challenged by injury and infection. As for most biological processes, the extent, pattern, and duration of inflammation are controlled by a balance between positive and negative factors. Matrix metalloproteinases (MMP) have emerged as important effector enzymes that act on diverse proteins to promote or moderate various immune processes. This presentation will highlight two MMPs-MMP7 and MMP10-that control distinct and somewhat opposing immune processes in response to injury and infection. In acute injury, matrilysin (MMP7) controls the transepithelial advancement and activation of neutrophils by shedding the ectodomain of syndecan-1, a transmembrane heparan sulfate proteoglycan. Similar to MMP7, stromelysin-2 (MMP10) is not expressed in resting tissues; however, in response acute or chronic insults, this proteinase is induced by infiltrated macrophages. In models of acute and chronic inflammation, Mmp10–/– mice have an exaggerated inflammatory response, indicating that the enzyme functions normally to repress inflammation. However, whereas Mmp10–/– mice are susceptible to lethality from acute insults, they are protected against tissue damage associated with prolonged inflammation. Data from both models indicate that MMP10 impact macrophage functions by promoting differentiation into immunosuppressive M2 (alternatively activated) cells. Together, these findings demonstrate both pro- and anti-inflammatory functions of distinct MMPs.
Bone Marrow Derived Cells in Cardiac Repair: From Mouse to Man
April Stempien-Otero, M.D.
Associate Professor, UW Medicine Cardiology
Craig and Julie Tall Endowed Professor in Heart Failure Research
University of Washington
Wednesday, November 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Bill Mahoney, Ph.D.
Why Attend?
Bone marrow-derived cells are critical to myocardial repair contributing directly to cardiac components such as endothelium and fibroblasts and providing paracrine factors that direct neovascularization and collagen production by resident cells. Current data support a model in which bone marrow monocyte-derived macrophages are at the crux of these repair processes in acute injury. Thus, macrophages are an attractive target for cell-based therapies to improve myocardial repair and prevent progression to heart failure. Our interest is in the role of a specific macrophage protease–urokinase plasminogen activator–in directing macrophage phenotype in the heart in mouse models. Moreover, we have initiated human studies of bone marrow cell therapy to the heart to elucidate the role of macrophages and bone marrow derived stem cells in end-stage human heart disease.
April Stempien-Otero, M.D.
Associate Professor, UW Medicine Cardiology
Craig and Julie Tall Endowed Professor in Heart Failure Research
University of Washington
Wednesday, November 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Bill Mahoney, Ph.D.
Why Attend?
Bone marrow-derived cells are critical to myocardial repair contributing directly to cardiac components such as endothelium and fibroblasts and providing paracrine factors that direct neovascularization and collagen production by resident cells. Current data support a model in which bone marrow monocyte-derived macrophages are at the crux of these repair processes in acute injury. Thus, macrophages are an attractive target for cell-based therapies to improve myocardial repair and prevent progression to heart failure. Our interest is in the role of a specific macrophage protease–urokinase plasminogen activator–in directing macrophage phenotype in the heart in mouse models. Moreover, we have initiated human studies of bone marrow cell therapy to the heart to elucidate the role of macrophages and bone marrow derived stem cells in end-stage human heart disease.
Cell Signaling in Space and Time
John D. Scott, Ph.D.
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology
Department of Pharmacology
University of Washington School of Medicine
Wednesday, November 9, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Dr. John Scott is a Howard Hughes Investigator and the Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology with the Department of Pharmacology, University of Washington. Dr. Scott is a fellow of the Royal Society, London, the Royal Society of Edinburgh. He's the author of over 200 scientific articles in peer-reviewed journals and books. He is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates. His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott's lab has identified a family of A-kinase-anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequences of PKA anchoring, and the bigger role of AKAP signaling networks in the coordinate regulation of cellular signaling.
John D. Scott, Ph.D.
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology
Department of Pharmacology
University of Washington School of Medicine
Wednesday, November 9, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Dr. John Scott is a Howard Hughes Investigator and the Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology with the Department of Pharmacology, University of Washington. Dr. Scott is a fellow of the Royal Society, London, the Royal Society of Edinburgh. He's the author of over 200 scientific articles in peer-reviewed journals and books. He is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates. His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott's lab has identified a family of A-kinase-anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequences of PKA anchoring, and the bigger role of AKAP signaling networks in the coordinate regulation of cellular signaling.
Diverse Functions of SKN-1/Nrf Proteins in Stress Defenses and Aging
Keith Blackwell, M.D., Ph.D.
Co-Head, Islet Cell and Regenerative Biology, Joslin Diabetes Center
ofessor of Genetics, Harvard Medical School
Harvard Medical School
Wednesday, November 2, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
Most chronic diseases can be considered to be aging-related, in that they manifest themselves primarily in older individuals. In model organisms both lifespan and healthspan can be increased dramatically by dietary restriction or manipulation of certain metabolic or stress defense pathways, holding promise that an understanding of these mechanisms may ultimately be of great benefit for human health. We study aging in the nematode C. elegans, an advantageous organism for pathway discovery. In the seminar I will describe how a protein that protects against oxidative stress (the SKN-1/Nrf transcription factor) also defends against various other metabolic and proteotoxic stresses. I will also describe how SKN-1/Nrf plays a critical role in an opposing relationship between growth and nutrient signals on one hand, and stress defense mechanisms on the other. This relationship may be of critical importance in dietary restriction, and other growth/nutrient-related mechanisms that influence aging.
Keith Blackwell, M.D., Ph.D.
Co-Head, Islet Cell and Regenerative Biology, Joslin Diabetes Center
ofessor of Genetics, Harvard Medical School
Harvard Medical School
Wednesday, November 2, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
Most chronic diseases can be considered to be aging-related, in that they manifest themselves primarily in older individuals. In model organisms both lifespan and healthspan can be increased dramatically by dietary restriction or manipulation of certain metabolic or stress defense pathways, holding promise that an understanding of these mechanisms may ultimately be of great benefit for human health. We study aging in the nematode C. elegans, an advantageous organism for pathway discovery. In the seminar I will describe how a protein that protects against oxidative stress (the SKN-1/Nrf transcription factor) also defends against various other metabolic and proteotoxic stresses. I will also describe how SKN-1/Nrf plays a critical role in an opposing relationship between growth and nutrient signals on one hand, and stress defense mechanisms on the other. This relationship may be of critical importance in dietary restriction, and other growth/nutrient-related mechanisms that influence aging.
What Leads to Age-Related Changes in the Lenses of Our Eyes? Some Factors Related to Increasing Lens Opacity Leading to Cataract
Norm Wolf, D.V.M., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Wednesday, October 26, 2011 - 4:30 PM
UW Heatlh Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend
My laboratory studies age-related changes in the lens in several species. I will present our studies on changes in mouse, rat, dog, monkey, human and bovine lenses. We also study the long known but, we believe, never satisfactorily explained replication condition of two adjacent regions of the lens surface cells- the non-replicating central zone, and the continuously replicating germinative zone next to it. I also will briefly touch on the role of the Sirt1 gene as it directly or indirectly affects age-related lens opacity.
Norm Wolf, D.V.M., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Wednesday, October 26, 2011 - 4:30 PM
UW Heatlh Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend
My laboratory studies age-related changes in the lens in several species. I will present our studies on changes in mouse, rat, dog, monkey, human and bovine lenses. We also study the long known but, we believe, never satisfactorily explained replication condition of two adjacent regions of the lens surface cells- the non-replicating central zone, and the continuously replicating germinative zone next to it. I also will briefly touch on the role of the Sirt1 gene as it directly or indirectly affects age-related lens opacity.
Fixing the Furnace: A Mitochondrial Targeted Therapy for Energy-deficient Diseases
Hazel Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Wednesday, October 19, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Why Attend?
Dr. Szeto is co-discoverer of a class of mitochondrially targeted peptide drugs that have increasingly wide potential application. Originally thought to behave a simple antioxidant, it is now apparent that the tetrapeptide agent SS-31 directly enhances mitochondrial respiration under diverse conditions of mitochondrial energetic stress. It has been found to have benefits, for example, in attenuating ischemia reperfusion injury to the kidney, heart and brain, and to improve heart and muscle function under oxidative challenge. SS-31 is now in phase II clinical trial for prevention of cardiac injury following acute myocardial infarction.
Hazel Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Wednesday, October 19, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Why Attend?
Dr. Szeto is co-discoverer of a class of mitochondrially targeted peptide drugs that have increasingly wide potential application. Originally thought to behave a simple antioxidant, it is now apparent that the tetrapeptide agent SS-31 directly enhances mitochondrial respiration under diverse conditions of mitochondrial energetic stress. It has been found to have benefits, for example, in attenuating ischemia reperfusion injury to the kidney, heart and brain, and to improve heart and muscle function under oxidative challenge. SS-31 is now in phase II clinical trial for prevention of cardiac injury following acute myocardial infarction.
Distinctive Features of Liver Immunology
Ian N. Crispe, M.D., Ph.D.
Member, Seattle BioMed
Affiliate Professor, UW Medicine Immunology
Seattle BioMed
Wednesday, October 12, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
The liver is the site of common infectious diseases (HAV, HBV, HCV), essential in the development of malaria parasites, and subject to metabolic diseases with an immuno-inflammatory component. There is increasing recognition that immune responses have distinctive local features, and in the liver these are shaped by constitutive exposure to trace levels of bacterial products from the intestinal microbiota. In the presentation, some distinctive features of liver immunology will be discussed. Specifically, we will address: the distinctive lymphocyte populations in the liver; the presentation of hepatocellular antigens to T cells; recruitment of T cells to the liver; and the nature of hepatic immune failure. Experimental models to be discussed include primary human liver leukocytes, AAV gene therapy vectors, and genetically-altered malaria parasites.
Ian N. Crispe, M.D., Ph.D.
Member, Seattle BioMed
Affiliate Professor, UW Medicine Immunology
Seattle BioMed
Wednesday, October 12, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
The liver is the site of common infectious diseases (HAV, HBV, HCV), essential in the development of malaria parasites, and subject to metabolic diseases with an immuno-inflammatory component. There is increasing recognition that immune responses have distinctive local features, and in the liver these are shaped by constitutive exposure to trace levels of bacterial products from the intestinal microbiota. In the presentation, some distinctive features of liver immunology will be discussed. Specifically, we will address: the distinctive lymphocyte populations in the liver; the presentation of hepatocellular antigens to T cells; recruitment of T cells to the liver; and the nature of hepatic immune failure. Experimental models to be discussed include primary human liver leukocytes, AAV gene therapy vectors, and genetically-altered malaria parasites.
Role of Sphingosine 1-Phosphate in Muscle Regeneration: Potential Pharmacotherapy for Muscular Dystrophy
Morayma Reyes, M.D., Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, October 5, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Presently, there is no effective treatment for the lethal muscle wasting disease Duchenne Muscular Dystrophy. In collaboration with Dr. Hannele Ruohola-Baker, through an unbiased suppression screen of the dystrophic phenotype in Drosophila, we found suppressors that upregulate the levels of sphingosine 1 phosphate (S1P) and thereby ameliorate the dystrophic phenotype in the flies. Previously, S1P has been implicated in satellite cell proliferation and myoblast differentiation in vitro. These essential roles for S1P in skeletal muscle enabled us to hypothesize that S1P mechanisms are conserved in mammals. In extending the S1P studies to the mdx mouse, we found that localized elevation of S1P via direct injection into muscle led to an increase in muscle satellite cell proliferation, newly regenerated fibers as well as fiber size. Additionally, we found that the systemic administration of that 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor that strongly suppressed dystrophic muscle wasting in Drosophila, led to a significant amelioration of known hallmarks of DMD pathology, fibrosis and fat deposition and dramatic increase in muscle fiber size in mdx mice. Similar results were also observed in the dysferlinopathy mouse model, AJ/SCID mice with direct administration of S1P. This increase in muscle fiber size can be attributed to anabolic pathways as indicated by increased levels of phosphorylated ribosomal S6. Thus, THI holds promise as a new pharmacotherapy to treat muscular dystrophy. I will present a general discussion of S1P metabolism and its role in cellular processes with emphasis on the skeletal muscle. I will also discuss the pathology of muscular dystrophy and current challenges in finding therapies to treat this lethal, devastating disease.
Morayma Reyes, M.D., Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, October 5, 2011 - 4:30 PM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
Presently, there is no effective treatment for the lethal muscle wasting disease Duchenne Muscular Dystrophy. In collaboration with Dr. Hannele Ruohola-Baker, through an unbiased suppression screen of the dystrophic phenotype in Drosophila, we found suppressors that upregulate the levels of sphingosine 1 phosphate (S1P) and thereby ameliorate the dystrophic phenotype in the flies. Previously, S1P has been implicated in satellite cell proliferation and myoblast differentiation in vitro. These essential roles for S1P in skeletal muscle enabled us to hypothesize that S1P mechanisms are conserved in mammals. In extending the S1P studies to the mdx mouse, we found that localized elevation of S1P via direct injection into muscle led to an increase in muscle satellite cell proliferation, newly regenerated fibers as well as fiber size. Additionally, we found that the systemic administration of that 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor that strongly suppressed dystrophic muscle wasting in Drosophila, led to a significant amelioration of known hallmarks of DMD pathology, fibrosis and fat deposition and dramatic increase in muscle fiber size in mdx mice. Similar results were also observed in the dysferlinopathy mouse model, AJ/SCID mice with direct administration of S1P. This increase in muscle fiber size can be attributed to anabolic pathways as indicated by increased levels of phosphorylated ribosomal S6. Thus, THI holds promise as a new pharmacotherapy to treat muscular dystrophy. I will present a general discussion of S1P metabolism and its role in cellular processes with emphasis on the skeletal muscle. I will also discuss the pathology of muscular dystrophy and current challenges in finding therapies to treat this lethal, devastating disease.
The one-dimensional and three-dimensional architecture of the genome
William Stafford Noble, PhD
Professor
Dept. of Genome Sciences; Dept. of Computer Science and Engineering
UW
Tuesday, October 4, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Zhi-jun Duan (Hematology; ISCRM)
William Stafford Noble, PhD
Professor
Dept. of Genome Sciences; Dept. of Computer Science and Engineering
UW
Tuesday, October 4, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Zhi-jun Duan (Hematology; ISCRM)
Proteolytic Pathways in Immunity, MMPs as Effectors of Inflammation
William C. Parks, PhD
Professor, Division of Pulmonary and Critical Care Medicine, UW
Director, Center for Lung Biology, UW
Affiliate Investigator, Benaroya Research Institute
Tuesday, September 27, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Kelly Smith
William C. Parks, PhD
Professor, Division of Pulmonary and Critical Care Medicine, UW
Director, Center for Lung Biology, UW
Affiliate Investigator, Benaroya Research Institute
Tuesday, September 27, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Kelly Smith
Mechanisms for Cardioprotection and Regeneration
Loren J. Field, PhD
Professor
Medicine & Pediatrics
Indiana University School of Medicine.
Monday, September 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Charles E. Murry
Distingushed Lecture series
Loren J. Field, PhD
Professor
Medicine & Pediatrics
Indiana University School of Medicine.
Monday, September 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Charles E. Murry
Distingushed Lecture series
Platelet Hyperactivity and Inflammation: STAT3 Signaling in Platelets
Jing-Fei Dong, MD, PhD
Full Member, Puget Sound Blood Center Research Institute
Professor of Medicine, Division of Hematology
UW
Tuesday, September 13, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: William C. Parks
Jing-Fei Dong, MD, PhD
Full Member, Puget Sound Blood Center Research Institute
Professor of Medicine, Division of Hematology
UW
Tuesday, September 13, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: William C. Parks
Local Controls of L-type Calcium Channels in Muscle
Luis Fernando Santana, Ph.D.
Professor
Physiology and Biophysics
UW
Tuesday, September 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Luis Fernando Santana, Ph.D.
Professor
Physiology and Biophysics
UW
Tuesday, September 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
DNA Damage and its Repair in Young, Adult and Aging Neurons
Kalluri Subba Rao, Ph.D.
Senior Scientist, Indian National Science Academy
Professor Emeritus, Department of Biochemistry
University of Hyderabad, India
Friday, August 26, 2011 - 10:00 AM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
For many years, Dr. Rao has been one of the few scientists who has addressed important questions about DNA repair in non-dividing eukaryotic cells. His focus has been on the repair of oxygen-mediated DNA damage in neurons by base excision repair and the involvement of DNA polymerase beta in this process. He has considered the importance of deficits in DNA repair in aging and Alzheimer's disease.
Kalluri Subba Rao, Ph.D.
Senior Scientist, Indian National Science Academy
Professor Emeritus, Department of Biochemistry
University of Hyderabad, India
Friday, August 26, 2011 - 10:00 AM
UW Health Sciences Center, Rm. K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
For many years, Dr. Rao has been one of the few scientists who has addressed important questions about DNA repair in non-dividing eukaryotic cells. His focus has been on the repair of oxygen-mediated DNA damage in neurons by base excision repair and the involvement of DNA polymerase beta in this process. He has considered the importance of deficits in DNA repair in aging and Alzheimer's disease.
Mechanisms Underlying Differential Responses to Dietary Restriction
Jennifer Schleit
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, August 23, 2011 - 1:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Jennifer Schleit
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, August 23, 2011 - 1:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
The Role of TNF-alpha Converting Enzyme in Liver Injury and Regeneration
Ryan McMahan
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, August 12, 2011 - 2:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Nelson Fausto, M.D. and Jean Campbell, Ph.D.
Ryan McMahan
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, August 12, 2011 - 2:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Nelson Fausto, M.D. and Jean Campbell, Ph.D.
Electrophysiology of Human Embryonic Stem Cell-Derived Cardiomyocytes
Michael Laflamme, M.D., Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, July 20, 2011 - 4:30 PM
Health Sciences Center, Rm. T-625
Why Attend?
Cardiomyocytes derived from pluripotent human embryonic stem cells (hESCs) have a number of attractive properties for use in cell-based cardiac repair, and their transplantation has been shown to improve mechanical function in rodent models of myocardial infarction. In this presentation, I will address three questions that all relate to the electrophysiological behavior of hESC-derived cardiomyocytes in vivo: 1) Can we derive specialized cardiac subtypes from hESCs, i.e. ventricular versus nodal myocytes? 2) Do hESC-derived cardiac grafts become electromechanically integrated and contract synchronously with host myocardium? 3) Will the transplantation of hESC-derived cardiomyocytes increase or decrease the incidence of arrhythmias?
Michael Laflamme, M.D., Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, July 20, 2011 - 4:30 PM
Health Sciences Center, Rm. T-625
Why Attend?
Cardiomyocytes derived from pluripotent human embryonic stem cells (hESCs) have a number of attractive properties for use in cell-based cardiac repair, and their transplantation has been shown to improve mechanical function in rodent models of myocardial infarction. In this presentation, I will address three questions that all relate to the electrophysiological behavior of hESC-derived cardiomyocytes in vivo: 1) Can we derive specialized cardiac subtypes from hESCs, i.e. ventricular versus nodal myocytes? 2) Do hESC-derived cardiac grafts become electromechanically integrated and contract synchronously with host myocardium? 3) Will the transplantation of hESC-derived cardiomyocytes increase or decrease the incidence of arrhythmias?
Systems Pathology: Moving Omics to Clinics
Michael Roehrl, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
Boston University School of Medicine
Monday, July 11, 2011 - 12:00 PM
UW Health Sciences Center, Room K-069
Faculty Sponsor: Drs. Swanson and True
Why Attend? Pathology will be the key player in personalized health care. We will illustrate recent advances in personalized molecular medicine with a particular emphasis on proteomic and metabolomic characterization of cancers. We show that systems-based and quantitative analyses of disease biomarkers will transform pathology into a key discipline for patient-centered tissue-based diagnostics, molecularly targeted therapy selection, and treatment response monitoring. We have also developed novel ultra-rapid biobanking strategies in pathology as a springboard for patient-focused basic cancer research.
Michael Roehrl, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
Boston University School of Medicine
Monday, July 11, 2011 - 12:00 PM
UW Health Sciences Center, Room K-069
Faculty Sponsor: Drs. Swanson and True
Why Attend? Pathology will be the key player in personalized health care. We will illustrate recent advances in personalized molecular medicine with a particular emphasis on proteomic and metabolomic characterization of cancers. We show that systems-based and quantitative analyses of disease biomarkers will transform pathology into a key discipline for patient-centered tissue-based diagnostics, molecularly targeted therapy selection, and treatment response monitoring. We have also developed novel ultra-rapid biobanking strategies in pathology as a springboard for patient-focused basic cancer research.
Ca2+ Mediated Myocyte Hypertrophy, Death, and Regeneration
Steven R. Houser, Ph.D., FAHA
Laura H. Carnell Professor of Physiology and Medicine; Director, Cardiovascular Research Group
Chair, Department of Physiology
Temple University School of Medicine, Philadelphia
Tuesday, June 21, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
Steven R. Houser, Ph.D., FAHA
Laura H. Carnell Professor of Physiology and Medicine; Director, Cardiovascular Research Group
Chair, Department of Physiology
Temple University School of Medicine, Philadelphia
Tuesday, June 21, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
Mitochondria beyond ATP production
Georgios Karamanlidis, Ph.D.
Postdoctoral Fellow
Mitochondria and Metabolism Center
University of Washington
Tuesday, June 14, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
Georgios Karamanlidis, Ph.D.
Postdoctoral Fellow
Mitochondria and Metabolism Center
University of Washington
Tuesday, June 14, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
Dynamic Recruitment of MicroRNAs to mRNA Targets in the Regenerating Liver
Linda Greenbaum, M.D.
Associate Professor of Cancer Biology
Associate Professor of Medicine, Division of Gastroenterology and Hepatology
Thomas Jefferson Medical College
Wednesday, June 8, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
The regenerative capacity of the liver is essential for recovery in response to hepatocyte loss due to acute or chronic viral, metabolic or toxic liver injury. Although microRNAs have been implicated for regulation of proliferation in a variety of tissues including patients with hepatocellular carcinoma and other liver diseases, the mRNAs targeted by specific microRNAs and their function during hepatocyte proliferation is not well understood. Obstacles that have limited identification of important mRNA:miRNA functional relationships have included the identification of a small number of differentially expressed miRNAs in the regenerating liver and limited prediction power of current miRNA prediction programs. We applied the HITS-CLIP assay (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation; Licatolosi, Nature 2008) to the partial hepatectomy model, an established model of liver regeneration. We have identified a large number of mRNAs that are bound by miRNAs in the regenerating liver, thus expanding the functional importance of microRNAs for regulation of liver regeneration. In addition, this assay has allowed us to identified miRNA binding sites in the coding region, 5'UTR in addition to 3'UTR regions of mRNAs. We are currently validating selected miRNA targets target and will use gain and loss-of-function approaches to elucidate the function of these miRNAs during the regenerative response. We anticipate that these studies will advance the current understanding of how miRNAs regulate hepatocyte proliferation in physiologic and pathophysiological states including cirrhosis and hepatocellular carcinoma.
Linda Greenbaum, M.D.
Associate Professor of Cancer Biology
Associate Professor of Medicine, Division of Gastroenterology and Hepatology
Thomas Jefferson Medical College
Wednesday, June 8, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jean Campbell, Ph.D.
Why Attend?
The regenerative capacity of the liver is essential for recovery in response to hepatocyte loss due to acute or chronic viral, metabolic or toxic liver injury. Although microRNAs have been implicated for regulation of proliferation in a variety of tissues including patients with hepatocellular carcinoma and other liver diseases, the mRNAs targeted by specific microRNAs and their function during hepatocyte proliferation is not well understood. Obstacles that have limited identification of important mRNA:miRNA functional relationships have included the identification of a small number of differentially expressed miRNAs in the regenerating liver and limited prediction power of current miRNA prediction programs. We applied the HITS-CLIP assay (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation; Licatolosi, Nature 2008) to the partial hepatectomy model, an established model of liver regeneration. We have identified a large number of mRNAs that are bound by miRNAs in the regenerating liver, thus expanding the functional importance of microRNAs for regulation of liver regeneration. In addition, this assay has allowed us to identified miRNA binding sites in the coding region, 5'UTR in addition to 3'UTR regions of mRNAs. We are currently validating selected miRNA targets target and will use gain and loss-of-function approaches to elucidate the function of these miRNAs during the regenerative response. We anticipate that these studies will advance the current understanding of how miRNAs regulate hepatocyte proliferation in physiologic and pathophysiological states including cirrhosis and hepatocellular carcinoma.
Supercharging Stem Cell-mediated Regeneration
Mark Sussman, Ph.D.
Professor, SDSU Heart Institute
Department of Biology
California State University, San Diego, California
Tuesday, June 7, 2011 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
Mark Sussman, Ph.D.
Professor, SDSU Heart Institute
Department of Biology
California State University, San Diego, California
Tuesday, June 7, 2011 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
Axon Degeneration: A Neglected Therapeutic Target in Parkinson's Disease
Robert Burke, M.D.
Professor, Neuroology and Pathology
Director, Udall Parkinson's Disease Research Center
Columbia Unversity
Wednesday, June 1, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jing Zhang, MD, PhD
9th Annual Alvord Lecture in Neuropathology
A special lecture in memory of the life and scientific legacy of Ellsworth C. Alvord, Jr., M.D. (1923-2010), Professor and Chief, UWMC Neuropathology, 1960-2002.
Robert Burke, M.D.
Professor, Neuroology and Pathology
Director, Udall Parkinson's Disease Research Center
Columbia Unversity
Wednesday, June 1, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Jing Zhang, MD, PhD
9th Annual Alvord Lecture in Neuropathology
A special lecture in memory of the life and scientific legacy of Ellsworth C. Alvord, Jr., M.D. (1923-2010), Professor and Chief, UWMC Neuropathology, 1960-2002.
Insights into regulation of endothelial and smooth muscle function in vivo
William C. Sessa, Ph.D.
Professor of Pharmacology; Vice Chairman, Pharmacology; Director, Vascular Biology & Therapeutics Program
Yale University
Tuesday, May 31, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
William C. Sessa, Ph.D.
Professor of Pharmacology; Vice Chairman, Pharmacology; Director, Vascular Biology & Therapeutics Program
Yale University
Tuesday, May 31, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
Signaling Pathways and Chromatin Dynamics Regulate Cardiac Differentiation from Human Embryonic Stem Cells
Sharon Paige
Graduate Student
UW Medicine Pathology and MSTP
University of Washington
Thursday, May 26, 2011 - 10:00 AM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Sharon Paige
Graduate Student
UW Medicine Pathology and MSTP
University of Washington
Thursday, May 26, 2011 - 10:00 AM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Calcium Currents, Mitochondrial Stress and Parkinson's Disease
Dalton Surmeier, Ph.D.
Professor and Chair, Ph.D.
Department Physiology
Feinberg School of Medicine, Northwestern University
Wednesday, May 25, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Dr. D. James Surmeier is the Nathan Smith Davis Professor and Chair of the Department of Physiology at the Feinberg School of Medicine at Northwestern University and Director of the Morris K. Udall Research Center of Research Excellence for Parkinson's Disease at Northwestern University. Dr. Surmeier received his Ph.D. in Physiology and Biophysics from the University of Washington in 1983. He trained with leaders in the field of neurophysiology, including Dr. Arnold Towe, Dr. William Willis, and Dr. Stephen Kitai. In 1998, he moved to the Department of Physiology at Northwestern University and assumed his current position in 2001. Dr. Surmeier's research program focuses on the basal ganglia – neural structures controlling movement and intimately involved in the pathophysiology of Parkinson's disease. He has authored over 150 peer-reviewed publications in journals such as Science, Nature, Neuron, Nature Neuroscience and the Journal of Neuroscience. He has served in several advisory capacities to the National Institutes of Health, including chairing study sections for the National Institute of Neurological Disorders and Stroke (NINDS) and acting as a Councilor for NIAAA. He also serves on the scientific advisory boards of several private foundations and serves on a number of editorial boards, including Molecular and Cellular Neuroscience, Neuron and Current Opinion in Neurobiology. He was elected as a Fellow of the American Association for the Advancement of Science and has received many other scientific awards including the NARSAD Established Investigator award, the Riker Award, the Picower Foundation Award, and the Jacob Javits Neuroscience Investigator Award.
Dalton Surmeier, Ph.D.
Professor and Chair, Ph.D.
Department Physiology
Feinberg School of Medicine, Northwestern University
Wednesday, May 25, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Dr. D. James Surmeier is the Nathan Smith Davis Professor and Chair of the Department of Physiology at the Feinberg School of Medicine at Northwestern University and Director of the Morris K. Udall Research Center of Research Excellence for Parkinson's Disease at Northwestern University. Dr. Surmeier received his Ph.D. in Physiology and Biophysics from the University of Washington in 1983. He trained with leaders in the field of neurophysiology, including Dr. Arnold Towe, Dr. William Willis, and Dr. Stephen Kitai. In 1998, he moved to the Department of Physiology at Northwestern University and assumed his current position in 2001. Dr. Surmeier's research program focuses on the basal ganglia – neural structures controlling movement and intimately involved in the pathophysiology of Parkinson's disease. He has authored over 150 peer-reviewed publications in journals such as Science, Nature, Neuron, Nature Neuroscience and the Journal of Neuroscience. He has served in several advisory capacities to the National Institutes of Health, including chairing study sections for the National Institute of Neurological Disorders and Stroke (NINDS) and acting as a Councilor for NIAAA. He also serves on the scientific advisory boards of several private foundations and serves on a number of editorial boards, including Molecular and Cellular Neuroscience, Neuron and Current Opinion in Neurobiology. He was elected as a Fellow of the American Association for the Advancement of Science and has received many other scientific awards including the NARSAD Established Investigator award, the Riker Award, the Picower Foundation Award, and the Jacob Javits Neuroscience Investigator Award.
The Nitric Oxide/cGMP Pathway and Its Effects on Vascular Inflammation and Atherosclerosis
Andrew Cheng, M.D.
Fellow
Medicine/Cardiology
UW
Tuesday, May 24, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Francis Kim
Andrew Cheng, M.D.
Fellow
Medicine/Cardiology
UW
Tuesday, May 24, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Francis Kim
A Genetic Mechanism of the Evolutionary Theory of Aging:
Rong Yuan, Ph.D.
Scientific Manager, Jackson Aging Center
Research Scientist, Jackson Laboratory
Jackson Laboratory, Bar Harbor, Maine
Wednesday, May 18, 2011 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
The objective of my research, guided by the evolutionary theory of aging, is to discover biomarkers of aging and healthspan that can be measured at an early age. Then I use mouse genetics and bioinformatics methods to identify genes that regulate these markers and investigate the effects of these genes on aging and healthspan. My overall goal is to define new ways of delaying aging and extending healthspan.
Rong Yuan, Ph.D.
Scientific Manager, Jackson Aging Center
Research Scientist, Jackson Laboratory
Jackson Laboratory, Bar Harbor, Maine
Wednesday, May 18, 2011 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
The objective of my research, guided by the evolutionary theory of aging, is to discover biomarkers of aging and healthspan that can be measured at an early age. Then I use mouse genetics and bioinformatics methods to identify genes that regulate these markers and investigate the effects of these genes on aging and healthspan. My overall goal is to define new ways of delaying aging and extending healthspan.
Extracellular Matrix and the Control of Inflammation
Thomas N. Wight, Ph.D.
Director, Hope Heart Matrix Program, Benaroya research Institute
Professor of Pathology (Affiliate)
University of Washington
Tuesday, May 17, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
Thomas N. Wight, Ph.D.
Director, Hope Heart Matrix Program, Benaroya research Institute
Professor of Pathology (Affiliate)
University of Washington
Tuesday, May 17, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
Regulation of Cardiac Tissue Structure and Function by Nano-architectured Matrix Control
Deok-Ho Kim, Ph.D.
Assistant Professor
Bioengineering; Center for Cardiovascular Biology; Institute of Stem Cell and Regenerative Medicine
UW
Tuesday, May 10, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry
Deok-Ho Kim, Ph.D.
Assistant Professor
Bioengineering; Center for Cardiovascular Biology; Institute of Stem Cell and Regenerative Medicine
UW
Tuesday, May 10, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry
Vascular Biology and Health Disparities: Defining Molecular Pathways
Gary H. Gibbons, M.D.
Director, Cardiovascular Research Institute
Chairman, Department of Physiology; Professor of Medicine
Morehouse School of Medicine
Friday, May 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
This is a Special Breakfast Club webcast from Atlanta
Gary H. Gibbons, M.D.
Director, Cardiovascular Research Institute
Chairman, Department of Physiology; Professor of Medicine
Morehouse School of Medicine
Friday, May 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz
This is a Special Breakfast Club webcast from Atlanta
The CSF-1 Receptor and its Ligands in Development, Cancer and Inflammatory Disease
E. Richard Stanley, Ph.D.
Renee and Robert A. Belfer Professor of Developmental Biology
Professor, Department of Developmental and Molecular Biology
Albert Einstein College of Medicine
Wednesday, May 4, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Elaine Raines, M.S.
Why Attend
Colony stimulating factor-1 (CSF-1), or M-CSF, controls macrophage and osteoclast production and function. These cells, via trophic and scavenger actions, play critical roles in development. CSF-1, via its receptor (CSF-1R), also regulates development of other cell types, including Langerhans cells and Paneth cells, plays autocrine and paracrine roles in neoplasia and is an important regulatory cytokine in many chronic inflammatory diseases. The identification of a second CSF-1R ligand, IL-34, coupled with studies of CSF-1 receptor signal transduction, offer new approaches to our understanding of the regulation by the CSF-1R and its role in these diseases.
E. Richard Stanley, Ph.D.
Renee and Robert A. Belfer Professor of Developmental Biology
Professor, Department of Developmental and Molecular Biology
Albert Einstein College of Medicine
Wednesday, May 4, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Elaine Raines, M.S.
Why Attend
Colony stimulating factor-1 (CSF-1), or M-CSF, controls macrophage and osteoclast production and function. These cells, via trophic and scavenger actions, play critical roles in development. CSF-1, via its receptor (CSF-1R), also regulates development of other cell types, including Langerhans cells and Paneth cells, plays autocrine and paracrine roles in neoplasia and is an important regulatory cytokine in many chronic inflammatory diseases. The identification of a second CSF-1R ligand, IL-34, coupled with studies of CSF-1 receptor signal transduction, offer new approaches to our understanding of the regulation by the CSF-1R and its role in these diseases.
Regulation of TRPV1 by Phosphoinositides
Sharona E. Gordon, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, May 3, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Eric Senning
Sharona E. Gordon, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, May 3, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Eric Senning
Molecular and Biochemical Mechanisms of Recessive Osteogenesis Imperfecta
Shawna Pyott
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Thursday, April 28, 2011 - 1:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers, M.D.
Shawna Pyott
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Thursday, April 28, 2011 - 1:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers, M.D.
Preventing Vein Graft Stenosis in Peripheral Vascular Surgery
Katie Moreno, M.D.
General Surgery Resident
Surgery, VA Puget Sound health Care System
University of Washington
Tuesday, April 26, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Sobel
Katie Moreno, M.D.
General Surgery Resident
Surgery, VA Puget Sound health Care System
University of Washington
Tuesday, April 26, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Sobel
Breast Cancer Testing: From Arbitrary to Evidence Based
Kim Allison, M.D.
Assistant Professor, UW Medicine Pathology
Director, UW Medicine Pathology Breast Service
University of Washington
Wednesday, April 20, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Tissue-based testing of tumors in pathology has evolved from serving a diagnostic purpose to providing key information about the likelihood a particular neoplasm will respond to a specific therapeutic agent. Because these test results have such a large impact on treatment decisions, there has been a recent focus on standardizing how these tests are performed, interpreted, reported and validated. Dr. Allison will discuss current issues in setting the standards for testing in breast cancer including sentinel lymph node analysis, HER2 testing, hormone receptor testing and RT-PCR based tests, with a focus of where current standards may need to be reevaluated.
Kim Allison, M.D.
Assistant Professor, UW Medicine Pathology
Director, UW Medicine Pathology Breast Service
University of Washington
Wednesday, April 20, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Tissue-based testing of tumors in pathology has evolved from serving a diagnostic purpose to providing key information about the likelihood a particular neoplasm will respond to a specific therapeutic agent. Because these test results have such a large impact on treatment decisions, there has been a recent focus on standardizing how these tests are performed, interpreted, reported and validated. Dr. Allison will discuss current issues in setting the standards for testing in breast cancer including sentinel lymph node analysis, HER2 testing, hormone receptor testing and RT-PCR based tests, with a focus of where current standards may need to be reevaluated.
Multi-Scale Modeling of the Heart: From Crossbridge to Organ
Andrew McCulloch, PhD
Professor
Bioengineering and Medicine
University of California, San Diego
Tuesday, April 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier
Distinguished Lecture Series
Andrew McCulloch, PhD
Professor
Bioengineering and Medicine
University of California, San Diego
Tuesday, April 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier
Distinguished Lecture Series
Doctoral Dissertation: Epigenetic Regulation of X Inactivation and Escape from X Inactivation
Fan Yang
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, April 15, 2011 - 2:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Fan Yang
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, April 15, 2011 - 2:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Using Human Pluripotent Stem Cells to Study Hepatic Disease and Development
Stephen Duncan, Ph.D.
Professor, Human and Molecular Genetics
Director, Regenerative Medicine and Stem Cell Biology
Medical College of Wisconsin
Wednesday, April 13, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Graduate Program Students
Why Attend?
Dr Duncan is the Markus Professor of Human and Molecular Genetics and Director of the Regenerative Medicine Program at the Medical College of Wisconsin. He has authored over 70 articles in scientific journals and books. His research focuses on the use of mice and stem cells to understand the contribution of transcription factors during embryonic development and function of the liver, pancreas, and heart. Traditionally his lab has relied on the use of mouse models including knockout mice and mouse embryonic stem cells. During this time the laboratory has garnered a substantial understanding of the basic molecular pathways controlling hepatic function and development. While the mouse has been a valuable model, the Duncan lab has introduced the use of induced human and mouse pluripotent stem cells as well as human embryonic stem cells because of the belief that they could offer a new and robust experimental model. Members of the Duncan lab have shown that they can control differentiation of human pluripotent stem cells into hepatocytes with high efficiency, to the extent that >95% of cells in the culture dish express characteristic markers of differentiated hepatocytes. In addition they have developed technologies to control differentiation of hepatocytes into both cardiac and pancreatic-like cells. Such approaches have raised the possibility of using stem cell–derived cells for the study of the fundamental molecular mechanisms underlying hepatic, cardiac and pancreatic disease and development.
Stephen Duncan, Ph.D.
Professor, Human and Molecular Genetics
Director, Regenerative Medicine and Stem Cell Biology
Medical College of Wisconsin
Wednesday, April 13, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Graduate Program Students
Why Attend?
Dr Duncan is the Markus Professor of Human and Molecular Genetics and Director of the Regenerative Medicine Program at the Medical College of Wisconsin. He has authored over 70 articles in scientific journals and books. His research focuses on the use of mice and stem cells to understand the contribution of transcription factors during embryonic development and function of the liver, pancreas, and heart. Traditionally his lab has relied on the use of mouse models including knockout mice and mouse embryonic stem cells. During this time the laboratory has garnered a substantial understanding of the basic molecular pathways controlling hepatic function and development. While the mouse has been a valuable model, the Duncan lab has introduced the use of induced human and mouse pluripotent stem cells as well as human embryonic stem cells because of the belief that they could offer a new and robust experimental model. Members of the Duncan lab have shown that they can control differentiation of human pluripotent stem cells into hepatocytes with high efficiency, to the extent that >95% of cells in the culture dish express characteristic markers of differentiated hepatocytes. In addition they have developed technologies to control differentiation of hepatocytes into both cardiac and pancreatic-like cells. Such approaches have raised the possibility of using stem cell–derived cells for the study of the fundamental molecular mechanisms underlying hepatic, cardiac and pancreatic disease and development.
A Journey in Translational Research: From Molecular Mechanisms in Chemical Carcinogenesis to a Phase I Clinical Trial on Adverse Drug Interactions
David Eaton, Ph.D.
Associate Vice Provost, Office of Research
Professor, Env. and Occ. Health Sciences
University of Washington
Wednesday, April 6, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Dr. Eaton received his Ph.D. in pharmacology from the University of Kansas Medical Center (KUMC) in 1978, then joined the UW School of Public Health in 1979, and has been here ever since. He is Professor of Environmental and Occupational Health Sciences, with adjunct appointments in Public Health Genetics and Medicinal Chemistry, and serves as founding Director of the Center for Ecogenetics and Environmental Health. He served as Associate Dean for Research in the School of Public Health from 2000-2005, and as Associate Vice Provost for Research from 2005-2010. He is currently Interim Vice Provost for Research, at the UW. He has published over 150 scientific articles and book chapters in the field of toxicology. Dr. Eaton is an Elected Fellow of the American Association for the Advancement of Science and the Academy of Toxicological Sciences, and a Lifetime National Associate of the National Academies of Sciences. This talk will describe an adventure to discover the molecular basis for a remarkable species difference in susceptibility to the potent liver carcinogen, aflatoxin B1, and how unexpected discoveries along the way led to a phase I clinical trial to prevent adverse drug interactions in HIV/AIDS patients being treated for TB.
David Eaton, Ph.D.
Associate Vice Provost, Office of Research
Professor, Env. and Occ. Health Sciences
University of Washington
Wednesday, April 6, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Dr. Eaton received his Ph.D. in pharmacology from the University of Kansas Medical Center (KUMC) in 1978, then joined the UW School of Public Health in 1979, and has been here ever since. He is Professor of Environmental and Occupational Health Sciences, with adjunct appointments in Public Health Genetics and Medicinal Chemistry, and serves as founding Director of the Center for Ecogenetics and Environmental Health. He served as Associate Dean for Research in the School of Public Health from 2000-2005, and as Associate Vice Provost for Research from 2005-2010. He is currently Interim Vice Provost for Research, at the UW. He has published over 150 scientific articles and book chapters in the field of toxicology. Dr. Eaton is an Elected Fellow of the American Association for the Advancement of Science and the Academy of Toxicological Sciences, and a Lifetime National Associate of the National Academies of Sciences. This talk will describe an adventure to discover the molecular basis for a remarkable species difference in susceptibility to the potent liver carcinogen, aflatoxin B1, and how unexpected discoveries along the way led to a phase I clinical trial to prevent adverse drug interactions in HIV/AIDS patients being treated for TB.
Decoding cell lineage from acquired mutations using deep sequencing
Marshall Horwitz, MD, PhD
Professor
Pathology; Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, April 5, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Mark Majesky
Marshall Horwitz, MD, PhD
Professor
Pathology; Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, April 5, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Mark Majesky
PRDM1 beta in Marginal Zone Lymphoma and Lymphoplasmacytic Lymphoma
Cecilia Yeung, M.D.
Molecular Genetics Pathology Fellow
Washington University
Tuesday, April 5, 2011 - 8:00 AM
FHCRC, Thomas Building, Sze E/W Conference Room
Videoconferencing
SCCA, Rm. 3100/3102
UWMC, Rm. 8121
Seattle Children's Hospital, Rm. T-3246
VAPSHCS, Bldg 24, Room 14
Speaker is a candidate for a faculty position in Pathology
Cecilia Yeung, M.D.
Molecular Genetics Pathology Fellow
Washington University
Tuesday, April 5, 2011 - 8:00 AM
FHCRC, Thomas Building, Sze E/W Conference Room
Videoconferencing
SCCA, Rm. 3100/3102
UWMC, Rm. 8121
Seattle Children's Hospital, Rm. T-3246
VAPSHCS, Bldg 24, Room 14
Speaker is a candidate for a faculty position in Pathology
Innate Immunity Genetics & Susceptibility to Tuberculosis
Thomas Hawn, M.D., Ph.D.
Associate Professor
UW Medicine Allergy and Infectious Diseases
University of Washington
Wednesday, March 30, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Why do humans respond differently to infections? How does genetic variation of human innate immunity genes regulate inflammation? To address these questions, Dr. Hawn studies the role of Toll-like Receptors (TLRs) and other genes in coordinating the innate immune response of macrophages to bacterial infection with an emphasis on tuberculosis. He uses a combination of molecular, cellular, and human genetic techniques to pursue an overall research goal of understanding the genetic basis and molecular mechanisms of human susceptibility to infectious diseases.
Thomas Hawn, M.D., Ph.D.
Associate Professor
UW Medicine Allergy and Infectious Diseases
University of Washington
Wednesday, March 30, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Why do humans respond differently to infections? How does genetic variation of human innate immunity genes regulate inflammation? To address these questions, Dr. Hawn studies the role of Toll-like Receptors (TLRs) and other genes in coordinating the innate immune response of macrophages to bacterial infection with an emphasis on tuberculosis. He uses a combination of molecular, cellular, and human genetic techniques to pursue an overall research goal of understanding the genetic basis and molecular mechanisms of human susceptibility to infectious diseases.
Slicing tissue with photons: non-invasive 3D imaging of microstructure andmicrocirculation in tissue in vivo
Ruikang K. Wang, PhD
Professor
Bioengineering
UW
Tuesday, March 29, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier, Bioengineering
Ruikang K. Wang, PhD
Professor
Bioengineering
UW
Tuesday, March 29, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier, Bioengineering
Charting Human Epigenomes and Regulation of the Non-coding Genome
Bradley Bernstein, M.D., Ph.D.
Associate Professor of Pathology
Senior Associate Member, Broad Institute of Harvard and MIT
Harvard Medical School
Wednesday, March 23, 2011 - 4:30 PM
University of Washington Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz, M.D., Ph.D.
Benditt Lectureship Webcast
Please copy and paste the following website address into your browser to view a live webcast of the Benditt Lectureship: http://mediasite.hs.washington.edu/Mediasite/SilverlightPlayer/Default.aspx?peid=246fd75917c94d1298548bef1149fef81d
This recording uses the Microsoft Silverlight browser plugin. To view the presentation you will need to install the Silverlight plugin which can be downloaded here: http://www.microsoft.com/getsilverlight/Get-Started/Install/Default.aspx Download and run the installer for your platform (Mac or PC) and refresh your web browser.
Bradley Bernstein, M.D., Ph.D.
Associate Professor of Pathology
Senior Associate Member, Broad Institute of Harvard and MIT
Harvard Medical School
Wednesday, March 23, 2011 - 4:30 PM
University of Washington Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz, M.D., Ph.D.
Benditt Lectureship Webcast
Please copy and paste the following website address into your browser to view a live webcast of the Benditt Lectureship: http://mediasite.hs.washington.edu/Mediasite/SilverlightPlayer/Default.aspx?peid=246fd75917c94d1298548bef1149fef81d
This recording uses the Microsoft Silverlight browser plugin. To view the presentation you will need to install the Silverlight plugin which can be downloaded here: http://www.microsoft.com/getsilverlight/Get-Started/Install/Default.aspx Download and run the installer for your platform (Mac or PC) and refresh your web browser.
Thin-Filament Related Cardiomyopathies: An Integrative Approach to a Complex Disorder
Jill Tardiff, MD, PhD
Associate Professor of Physiology and Biophysics
Associate Professor of Internal Medicine (Adult Cardiology)
Albert Einstein College of Medicine, Bronx, New York
Tuesday, March 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier, Bioengineering,
DISTINGUISHED LECTURE Series
Jill Tardiff, MD, PhD
Associate Professor of Physiology and Biophysics
Associate Professor of Internal Medicine (Adult Cardiology)
Albert Einstein College of Medicine, Bronx, New York
Tuesday, March 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Michael Regnier, Bioengineering,
DISTINGUISHED LECTURE Series
Role of PDGF-C in the Genesis of the Hepatic Tumor Microenvironment
Jean Campbell, Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Hepatocellular carcinoma (HCC) most commonly arises in the setting of chronic inflammation and cirrhosis, supporting the hypothesis that an abnormal microenvironment contributes to disease progression. Yet understanding the complex cellular interactions in the liver that contribute to the evolution of the tumor microenvironment, and ultimately to tumorigenesis, has been challenging due to a lack of animal models that recapitulate the disease progression observed in humans. During this presentation I will describe a unique mouse model of hepatocellular carcinogenesis that mimics the step-wise progression from fibrosis to cirrhosis, and finally to HCC. We are exploiting this model to understand the role of non-parenchymal cells in regulating fibrogenesis and neoangiogenesis, and to define the contribution of these cells to the tumor microenvironment. My talk will highlight data demonstrating the merits of using this pre-clinical model to evaluate therapeutic strategies that target the hepatic tumor microenvironment by blocking the processes that contribute to its development, including fibrosis and angiogenesis.
Jean Campbell, Ph.D.
Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Hepatocellular carcinoma (HCC) most commonly arises in the setting of chronic inflammation and cirrhosis, supporting the hypothesis that an abnormal microenvironment contributes to disease progression. Yet understanding the complex cellular interactions in the liver that contribute to the evolution of the tumor microenvironment, and ultimately to tumorigenesis, has been challenging due to a lack of animal models that recapitulate the disease progression observed in humans. During this presentation I will describe a unique mouse model of hepatocellular carcinogenesis that mimics the step-wise progression from fibrosis to cirrhosis, and finally to HCC. We are exploiting this model to understand the role of non-parenchymal cells in regulating fibrogenesis and neoangiogenesis, and to define the contribution of these cells to the tumor microenvironment. My talk will highlight data demonstrating the merits of using this pre-clinical model to evaluate therapeutic strategies that target the hepatic tumor microenvironment by blocking the processes that contribute to its development, including fibrosis and angiogenesis.
The Sequelae of Dysfunctional BMPRII Signaling
Marlene Rabinovitch, MD
Pfizer Visiting Professorship in Pulmonary Vascular Disease
Dwight and Vera Dunlevie Professor of Pediatric Cardiology
Stanford University School of Medicine
Tuesday, March 15, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: William C. Parks
Marlene Rabinovitch, MD
Pfizer Visiting Professorship in Pulmonary Vascular Disease
Dwight and Vera Dunlevie Professor of Pediatric Cardiology
Stanford University School of Medicine
Tuesday, March 15, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: William C. Parks
Sphingosine-1-phosphate Receptor 2 Induces Expression of Smooth Muscle Alpha-actin: A Role for Rho and Calcium
Allison De Wispelaere
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, March 11, 2011 - 3:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Alec Clowes, M.D.
Allison De Wispelaere
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, March 11, 2011 - 3:30 PM
UW Medicine South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Alec Clowes, M.D.
Using Network Modeling to Predict Wnt Pathway Dysregulation
Hamid Bolouri, Ph.D.
Research Member
Division of Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, March 9, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Inter-individual variations, and (nonlinear) gene-gene and gene-environment interactions complicate the analysis of healthy and dysregulated cellular processes. Network models offer integrated views of cellular pathways and can be used to highlight hidden features of large-scale datasets, and to arrive at insights and testable hypotheses. In this talk, I will present a case study in which we used network modeling to re-analyze published data and arrived at new insights and hypotheses. Our methodology is novel in its approach, straight-forward in usage, and general in its applicability to other cellular pathways and processes. For more information please visit Dr. Bolouri's website: http://labs.fhcrc.org/bolouri/
Hamid Bolouri, Ph.D.
Research Member
Division of Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, March 9, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Inter-individual variations, and (nonlinear) gene-gene and gene-environment interactions complicate the analysis of healthy and dysregulated cellular processes. Network models offer integrated views of cellular pathways and can be used to highlight hidden features of large-scale datasets, and to arrive at insights and testable hypotheses. In this talk, I will present a case study in which we used network modeling to re-analyze published data and arrived at new insights and hypotheses. Our methodology is novel in its approach, straight-forward in usage, and general in its applicability to other cellular pathways and processes. For more information please visit Dr. Bolouri's website: http://labs.fhcrc.org/bolouri/
Role of transcription factor CHF1/Hey2 in cardiac differentiation and hypertrophy
Farid Moussavi-Harami, M.D.
Cardiology Fellow
Department of Internal Medicine
UW
Tuesday, March 8, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Chin
Farid Moussavi-Harami, M.D.
Cardiology Fellow
Department of Internal Medicine
UW
Tuesday, March 8, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Michael Chin
The Role of the Hypoxic Stress Pathway in Worm Aging
Scott F. Leiser, Ph.D.
Post-Doctoral Fellow
Kaeberlein Lab
UW Medicine Pathology
Wednesday, March 2, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
The aging process is involved in the development of many of the most common human pathologies. By using model organisms to find conserved aging pathways, we are searching for ways to slow human aging and prevent many diseases. Using the nematode, C. elegans, our lab and others have recently implicated a role for the highly-conserved hypoxia pathway in aging. Initial papers suggest that the hypoxia inducible factor, HIF-1, can act as both a positive and negative regulator of aging in worms. This seminar will discuss how HIF-1 can affect lifespan and healthspan in worms and how this work may translate to future human research.
Scott F. Leiser, Ph.D.
Post-Doctoral Fellow
Kaeberlein Lab
UW Medicine Pathology
Wednesday, March 2, 2011 - 4:30 PM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, Ph.D.
Why Attend?
The aging process is involved in the development of many of the most common human pathologies. By using model organisms to find conserved aging pathways, we are searching for ways to slow human aging and prevent many diseases. Using the nematode, C. elegans, our lab and others have recently implicated a role for the highly-conserved hypoxia pathway in aging. Initial papers suggest that the hypoxia inducible factor, HIF-1, can act as both a positive and negative regulator of aging in worms. This seminar will discuss how HIF-1 can affect lifespan and healthspan in worms and how this work may translate to future human research.
Unraveling Genome Architecture
Zhi-jun Duan, Ph.D.
Research Assistant Professor
Department of Hematology
UW Institute for Stem Cell and Regenerative Medicine
Tuesday, March 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz, Pathology
Zhi-jun Duan, Ph.D.
Research Assistant Professor
Department of Hematology
UW Institute for Stem Cell and Regenerative Medicine
Tuesday, March 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz, Pathology
University of North Carolina at Chapel Hill
James E. Faber, Ph.D
Professor, Department of Cell and Molecular Physiology
McAllister Heart Institute
University of North Carolina at Chapel Hill
Tuesday, February 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz, Pathology
This is a podcast from Chapel Hill. Dr. Faber is not physically present at the UW SLU campus but is webcasting from UNC, Chapel Hill.
James E. Faber, Ph.D
Professor, Department of Cell and Molecular Physiology
McAllister Heart Institute
University of North Carolina at Chapel Hill
Tuesday, February 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz, Pathology
This is a podcast from Chapel Hill. Dr. Faber is not physically present at the UW SLU campus but is webcasting from UNC, Chapel Hill.
The Impact of Dropping the Requirement for Goblet Cells from the Diagnosis of Barrett's Esophagus
Maria Westerhoff, M.D.
GI & Liver Pathology Fellow
Department of Pathology
University of Chicago Medical Center
Thursday, February 17, 2011 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Speaker is a candidate for a faculty position with UWMC AP.
Maria Westerhoff, M.D.
GI & Liver Pathology Fellow
Department of Pathology
University of Chicago Medical Center
Thursday, February 17, 2011 - 12:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Speaker is a candidate for a faculty position with UWMC AP.
Molecular Classification of Breast Cancer: What Have We Learned?
David Dabbs, M.D.
Chief of Pathology
Magee Women's Hospital
University of Pittsburgh Medical Center
Wednesday, February 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Mara Rendi
Why Attend?
The molecular classification of breast cancer has ushered in a new perspective on breast carcinomas. This classification offers a framework that is useful to clinicians and pathologists, and has spawned a host of rival molecular tests that are touted as predictors of patient outcomes to therapy. Select aspects of these molecular tests will be discussed in concert with traditional pathologic analysis of breast carcinomas
David Dabbs, M.D.
Chief of Pathology
Magee Women's Hospital
University of Pittsburgh Medical Center
Wednesday, February 16, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Mara Rendi
Why Attend?
The molecular classification of breast cancer has ushered in a new perspective on breast carcinomas. This classification offers a framework that is useful to clinicians and pathologists, and has spawned a host of rival molecular tests that are touted as predictors of patient outcomes to therapy. Select aspects of these molecular tests will be discussed in concert with traditional pathologic analysis of breast carcinomas
Insulin Resistance and Cardiovascular Dysfunction – Elucidating Novel Mechanisms
E. Dale Abel, M.D., D Phil
Professor of Medicine and Biochemistry
Chief, Division of Endocrinology, Metabolism and Diabetes
University of Utah School of Medicine
Tuesday, February 15, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, UW Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Abel is a world expert in the regulation of myocardial biology and metabolism by insulin signaling. His work in the last decade has significantly advanced our knowledge of disease mechanisms for the cardiomyopathy caused by metabolic disorders. Representative publications: 1. Cardiac remodelingin obesity. Physiol Rev. 2008 Apr;88(2):389-419 2. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306
E. Dale Abel, M.D., D Phil
Professor of Medicine and Biochemistry
Chief, Division of Endocrinology, Metabolism and Diabetes
University of Utah School of Medicine
Tuesday, February 15, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, UW Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Abel is a world expert in the regulation of myocardial biology and metabolism by insulin signaling. His work in the last decade has significantly advanced our knowledge of disease mechanisms for the cardiomyopathy caused by metabolic disorders. Representative publications: 1. Cardiac remodelingin obesity. Physiol Rev. 2008 Apr;88(2):389-419 2. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306
CANCELLED due illness. Rescheduled seminar TBA.
Alan Adereem, Ph.D.
Co-Founder, Institute for Systems Biology
Affiliate Professor, UW Medicine Immunology
Institute for Systems Biology
Wednesday, February 9, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Macrophages and dendritic cells represent one of the cornerstones of the innate immune system. They detect infectious organisms and then orchestrate an appropriate host response to them. In order to precisely define the nature of the threat the immune cell needs to read the molecular bar code that is displayed on the specific pathogen. The molecular bar codes have been referred to as PAMPS and they are recognized by pattern recognition receptors (PRR). The Toll-like receptors (TLRs) and the Nod-like receptors (NLRs) are prototypic PRRs that detect extracellular PAMPS and intracellular PAMPS respectively. Since infectious agents carry many different PAMPS the information must be integrated in order to define the specific pathogen and enable the host to formulate an appropriate response. We use the tools of systems biology to identify the molecular networks that lead to this decision-making. Biological results and technological developments will be discussed.
Alan Adereem, Ph.D.
Co-Founder, Institute for Systems Biology
Affiliate Professor, UW Medicine Immunology
Institute for Systems Biology
Wednesday, February 9, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Macrophages and dendritic cells represent one of the cornerstones of the innate immune system. They detect infectious organisms and then orchestrate an appropriate host response to them. In order to precisely define the nature of the threat the immune cell needs to read the molecular bar code that is displayed on the specific pathogen. The molecular bar codes have been referred to as PAMPS and they are recognized by pattern recognition receptors (PRR). The Toll-like receptors (TLRs) and the Nod-like receptors (NLRs) are prototypic PRRs that detect extracellular PAMPS and intracellular PAMPS respectively. Since infectious agents carry many different PAMPS the information must be integrated in order to define the specific pathogen and enable the host to formulate an appropriate response. We use the tools of systems biology to identify the molecular networks that lead to this decision-making. Biological results and technological developments will be discussed.
Targeting chromatin to accelerate tumor cell senescence
Stephen Kron, MD, PhD
Ludwig Center for Metastasis Research
The University of Chicago
Tuesday, February 8, 2011 - 9:00 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Charles E. Murry, Pathology and Bioengineering
Stephen Kron, MD, PhD
Ludwig Center for Metastasis Research
The University of Chicago
Tuesday, February 8, 2011 - 9:00 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Charles E. Murry, Pathology and Bioengineering
Applying Oligonucleotide Aptamers to Diagnostic Pathology and Laboratory Medicine
Geoffrey Baird, M.D., Ph.D.
Assistant Professor, UW Laboratory Medicine
Adjunct Assistant Professor, UW Medicine Pathology
UW Medicine
Wednesday, February 2, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Oligonucleotide aptamers are short strands of DNA or RNA that specifically bind other chemical species, much in the same way as monoclonal antibodies. Despite being discovered nearly 20 years ago, none of the hundreds of published applications of aptamers have penetrated into current anatomic or clinical pathology practice, and only very few are utilized in the research setting. This seminar will cover the reasons why this has happened and how the trend is now reversing, focusing on the potential benefits of incorporating aptamers into both clinical and research pathology. Specifically, the seminar will cover work in our laboratory and others describing how one may use aptamers for tissue and fluid proteomics, biomarker discovery, and histochemistry.
Geoffrey Baird, M.D., Ph.D.
Assistant Professor, UW Laboratory Medicine
Adjunct Assistant Professor, UW Medicine Pathology
UW Medicine
Wednesday, February 2, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Oligonucleotide aptamers are short strands of DNA or RNA that specifically bind other chemical species, much in the same way as monoclonal antibodies. Despite being discovered nearly 20 years ago, none of the hundreds of published applications of aptamers have penetrated into current anatomic or clinical pathology practice, and only very few are utilized in the research setting. This seminar will cover the reasons why this has happened and how the trend is now reversing, focusing on the potential benefits of incorporating aptamers into both clinical and research pathology. Specifically, the seminar will cover work in our laboratory and others describing how one may use aptamers for tissue and fluid proteomics, biomarker discovery, and histochemistry.
Gene Regulation Beyond Promoters: Direct, Complete, Integrated, Transcriptional Analysis
Daniel Morris, Ph.D.
Research Assistant Professor
Department of Anesthesiology
UW
Tuesday, February 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Debra Schwinn, Anesthesiology and Pain Medicine
Daniel Morris, Ph.D.
Research Assistant Professor
Department of Anesthesiology
UW
Tuesday, February 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Debra Schwinn, Anesthesiology and Pain Medicine
Patient-Specific Mathematical Neuro-Oncology: A Paradigm Shift in Glioma Treatment
Kristin Swanson, Ph.D.
Associate Research Professor
UW Medicine Pathology
University of Washington
Wednesday, January 26, 2011 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Gliomas are complex heterogeneous tumors with a spectrum of behaviors with an overall dismal prognosis. The relative low incidence and the wide variability of this disease across (and within) patients is a challenge to routine clinical studies to determine optimal treatment strategies. This heterogeneity suggests a patient-specific quantification of disease kinetics and treatment response is essential to improving outcomes for these patients. This seminar will discuss the role of the burgeoning field of Mathematical NeuroOncology specifically focusing on the practical application of patient-specific mathematical modeling approaches in providing predictive insight into tumor growth kinetics and response to therapy in individual patients.
Kristin Swanson, Ph.D.
Associate Research Professor
UW Medicine Pathology
University of Washington
Wednesday, January 26, 2011 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Kelly Smith, M.D., Ph.D.
Why Attend?
Gliomas are complex heterogeneous tumors with a spectrum of behaviors with an overall dismal prognosis. The relative low incidence and the wide variability of this disease across (and within) patients is a challenge to routine clinical studies to determine optimal treatment strategies. This heterogeneity suggests a patient-specific quantification of disease kinetics and treatment response is essential to improving outcomes for these patients. This seminar will discuss the role of the burgeoning field of Mathematical NeuroOncology specifically focusing on the practical application of patient-specific mathematical modeling approaches in providing predictive insight into tumor growth kinetics and response to therapy in individual patients.
Novel regulators of ischemic injury and ventricular remodeling
Thomas Force, MD
James C. Wilson Professor of Medicine
Clinical Director, Center for Translational Medicine
Thomas Jefferson University
Tuesday, January 25, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Force is a recognized leader in stress-induced signaling cascades in cardiac growth and survival. His lab has pioneered research on the cardiotoxicity caused by tyrosine kinase inhibitor cancer therapeutics. His recent work has elucidated the isoform-specific role of GSK-3 in cardiac hypertrophy. Representative publications: 1. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 2. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol. 2009 3. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006
Thomas Force, MD
James C. Wilson Professor of Medicine
Clinical Director, Center for Translational Medicine
Thomas Jefferson University
Tuesday, January 25, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Force is a recognized leader in stress-induced signaling cascades in cardiac growth and survival. His lab has pioneered research on the cardiotoxicity caused by tyrosine kinase inhibitor cancer therapeutics. His recent work has elucidated the isoform-specific role of GSK-3 in cardiac hypertrophy. Representative publications: 1. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 2. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol. 2009 3. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006
The Cooperation of Epigenetic and Genetic Alterations in Gastrointestinal Cancer
William Grady, M.D.
Associate Professor
UW Medicine
University of Washington
Wednesday, January 19, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Dr. Grady will discuss the role of genetic alterations and epigenetic alterations that occur in colon cancer on the behavior of the cancer cells. In particular, an understanding of signal network deregulation and gene cooperation will be gained from attending this lecture.
This seminar was originally scheduled for December 15, 2010.
William Grady, M.D.
Associate Professor
UW Medicine
University of Washington
Wednesday, January 19, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Dr. Grady will discuss the role of genetic alterations and epigenetic alterations that occur in colon cancer on the behavior of the cancer cells. In particular, an understanding of signal network deregulation and gene cooperation will be gained from attending this lecture.
This seminar was originally scheduled for December 15, 2010.
The State of Seattle Biotech in 2011
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 18, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: David Dichek
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 18, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: David Dichek
T Cell Therapy of Cancer
Cassian Yee, M.D.
Professor, UW Medicine Oncology
Member, Clinical Research Division, FHCRC
University of Washington
Wednesday, January 12, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
A Renaissance in immunotherapy or another passing fad? My NIH reviewers want to know. Find out what I told them and where the field is headed.
Cassian Yee, M.D.
Professor, UW Medicine Oncology
Member, Clinical Research Division, FHCRC
University of Washington
Wednesday, January 12, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
A Renaissance in immunotherapy or another passing fad? My NIH reviewers want to know. Find out what I told them and where the field is headed.
Enhanced peer review of NIH grant proposals: how the process is supposed to work but often doesn't: A panel discussion with current members of NIH study sections and review groups
Michael E. Rosenfeld, PhD; Karin Bornfeldt, PhD; William Parks, PhD; Jay Heinecke, MD
Members of NIH Study Sections
Scool of Medicine
UW
Tuesday, January 11, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz
Michael E. Rosenfeld, PhD Professor, Environmental & Occupational Health Sciences; Professor, Pathology Karin Bornfeldt, PhD Professor, Pathology, Diabetes and Obesity Center of Excellence William Parks, PhD Professor, Center for Lung Biology Jay Heinecke, MD Professor, Division of Metabolism, Endocrinology and Nutrition
Michael E. Rosenfeld, PhD; Karin Bornfeldt, PhD; William Parks, PhD; Jay Heinecke, MD
Members of NIH Study Sections
Scool of Medicine
UW
Tuesday, January 11, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Steve Schwartz
Michael E. Rosenfeld, PhD Professor, Environmental & Occupational Health Sciences; Professor, Pathology Karin Bornfeldt, PhD Professor, Pathology, Diabetes and Obesity Center of Excellence William Parks, PhD Professor, Center for Lung Biology Jay Heinecke, MD Professor, Division of Metabolism, Endocrinology and Nutrition
Mouse Model of Leigh Syndrome: Identifying Critical Brain Regions Involved
Richard Palmiter, Ph.D.
Professor
UW Medicine Biochemistry
University of Washington
Wednesday, January 5, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Leigh syndrome is a necrotizing encephalopathy caused by mitochondrial dysfunction due to mutations in either mitochondrial or nuclear genes involved in electron transport. We have created a mouse with a mutation in Ndufs4, one of the 45 subunits of complex 1, the recapitulates virtually all of the symptoms of Leigh syndrome. We have shown that the disease is caused by mitochondrial dysfunction in the central nervous system and that it results in progressive gliosis, and eventually neuronal loss, in the olfactory bulb, vestibular nucleus and cerebellum. The knockout mice have breathing defects that may be responsible for their demise by about 50 days after birth. Selective inactivation of Ndufs4 in the vestibular nucleus results in premature death, whereas selective restoration of Ndufs4 in the vestibular nucleus prolongs life.
Richard Palmiter, Ph.D.
Professor
UW Medicine Biochemistry
University of Washington
Wednesday, January 5, 2011 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
Leigh syndrome is a necrotizing encephalopathy caused by mitochondrial dysfunction due to mutations in either mitochondrial or nuclear genes involved in electron transport. We have created a mouse with a mutation in Ndufs4, one of the 45 subunits of complex 1, the recapitulates virtually all of the symptoms of Leigh syndrome. We have shown that the disease is caused by mitochondrial dysfunction in the central nervous system and that it results in progressive gliosis, and eventually neuronal loss, in the olfactory bulb, vestibular nucleus and cerebellum. The knockout mice have breathing defects that may be responsible for their demise by about 50 days after birth. Selective inactivation of Ndufs4 in the vestibular nucleus results in premature death, whereas selective restoration of Ndufs4 in the vestibular nucleus prolongs life.
HDL, inflammation, and atherosclerosis. A paradigm shift?
Tomas Vaisar, PhD
Research Assistant Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, January 4, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Tomas Vaisar, PhD
Research Assistant Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, January 4, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Adult Stem Cells for Cardiac Repair and Regeneration: In it to WNT
Ronglih Liao, PhD
Associate Professor of Medicine
Harvard Medical Schoopl
Tuesday, December 14, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
Ronglih Liao, PhD
Associate Professor of Medicine
Harvard Medical Schoopl
Tuesday, December 14, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian
A Systems-Pathology Approach in Transplantation
Michael Mengel, M.D.
Associate Professor
Laboratory Medicine and Pathology
University of Alberta Hospital
Wednesday, December 8, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
After studying medicine at the Semmelweiss University in Budapest, Hungary, Dr. Mengel did his residency in the Department of Pathology at Hannover Medical School, Germany. While there he became specialized in pathology and subsequently transplantation and nephropathology. He was head of the transplant pathology service with responsibility for diagnostics and research based on transplant biopsies at the transplant centre in Hannover. In collaboration with the Department of Nephrology, one of the largest protocol biopsy programs after renal transplantation was established at the transplant centre in Hannover. In December 2006 he came to the University of Alberta in Edmonton, Canada and joined the Alberta Transplant Applied Genomics Centre (Director Philip F. Halloran) where he had the opportunity to apply modern molecular microarray techniques together with sophisticated bioinformatics tools to well-documented clinical material from large biopsy series. Currently he is a Lead Investigator at the Alberta Transplant Applied Genomics Centre and his major research focus is the molecular based refinement of the histopathological assessment of organ transplant biopsies. In November 2008 he joined the faculty as an Associate Professor in the Division of Anatomical Pathology where he assumed the role of the Section Head of Transplantation Pathology.
Michael Mengel, M.D.
Associate Professor
Laboratory Medicine and Pathology
University of Alberta Hospital
Wednesday, December 8, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
After studying medicine at the Semmelweiss University in Budapest, Hungary, Dr. Mengel did his residency in the Department of Pathology at Hannover Medical School, Germany. While there he became specialized in pathology and subsequently transplantation and nephropathology. He was head of the transplant pathology service with responsibility for diagnostics and research based on transplant biopsies at the transplant centre in Hannover. In collaboration with the Department of Nephrology, one of the largest protocol biopsy programs after renal transplantation was established at the transplant centre in Hannover. In December 2006 he came to the University of Alberta in Edmonton, Canada and joined the Alberta Transplant Applied Genomics Centre (Director Philip F. Halloran) where he had the opportunity to apply modern molecular microarray techniques together with sophisticated bioinformatics tools to well-documented clinical material from large biopsy series. Currently he is a Lead Investigator at the Alberta Transplant Applied Genomics Centre and his major research focus is the molecular based refinement of the histopathological assessment of organ transplant biopsies. In November 2008 he joined the faculty as an Associate Professor in the Division of Anatomical Pathology where he assumed the role of the Section Head of Transplantation Pathology.
Generation of S1P -based therapy for muscular dystrophy
Hannele Ruohola-Baker, PhD
Professor
Biochemistry
UW
Tuesday, December 7, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Hannele Ruohola-Baker, PhD
Professor
Biochemistry
UW
Tuesday, December 7, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Microchimerism and Cancer
V.K. Gadi
Assistant Professor
UW Medicine
University of Washington
Wednesday, December 1, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
A prior history of pregnancy is generally a protective factor against malignancy. How this protection is mediated is presently not completely understood. Dr. Gadi's work involves the study of fetal microchimerism, small numbers of stably persistent cells in a woman originally derived from her fetus. In this seminar, the data supporting a protective role of fetal microchimerism against breast cancer will be discussed.
V.K. Gadi
Assistant Professor
UW Medicine
University of Washington
Wednesday, December 1, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
A prior history of pregnancy is generally a protective factor against malignancy. How this protection is mediated is presently not completely understood. Dr. Gadi's work involves the study of fetal microchimerism, small numbers of stably persistent cells in a woman originally derived from her fetus. In this seminar, the data supporting a protective role of fetal microchimerism against breast cancer will be discussed.
Taming the Beast: Structural biology of alphaB-crystallin, a small heat shock protein implicated in cardiomyopathy
Rachel E, Klevit, D. Phil.
Professor
Biochemistry and Biomolecular Structure Center
UW
Tuesday, November 30, 2010 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium
Rachel E, Klevit, D. Phil.
Professor
Biochemistry and Biomolecular Structure Center
UW
Tuesday, November 30, 2010 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium
Microchimerism: For better or for worse?
J. Lee Nelson, M.D.
Member, Fred Hutchinson Cancer Research Ctr
Professor, Rheumatology, University of Washington
UW
Tuesday, November 23, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
J. Lee Nelson, M.D.
Member, Fred Hutchinson Cancer Research Ctr
Professor, Rheumatology, University of Washington
UW
Tuesday, November 23, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium
Companion Diagnostics; The Pathologist as the Prescribing Physician
David Rimm, M.D., Ph.D.
Professor
Department of Pathology
Yale University School of Medicine
Wednesday, November 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry True, M.D.
Why Attend?
Personalized medicine has put the pathologist in a key position with respect to patient care. Companion diagnostic tests are now required for therapeutic decisions that can save patients lives. So exactly how accurate those tests? This seminar will explore the accuracy of current companion diagnostic tests in breast cancer. You may be surprised to see data that suggests your treatment depends on where you send your tissue. Sources of error, including sampling, pre-analytic variables, and reagents will be shown. Then alternative methods of standardization using quantitative immunofluorescence (AQUA) will be illustrated. Finally some exploratory data for new companion diagnostics will be presented.
David Rimm, M.D., Ph.D.
Professor
Department of Pathology
Yale University School of Medicine
Wednesday, November 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry True, M.D.
Why Attend?
Personalized medicine has put the pathologist in a key position with respect to patient care. Companion diagnostic tests are now required for therapeutic decisions that can save patients lives. So exactly how accurate those tests? This seminar will explore the accuracy of current companion diagnostic tests in breast cancer. You may be surprised to see data that suggests your treatment depends on where you send your tissue. Sources of error, including sampling, pre-analytic variables, and reagents will be shown. Then alternative methods of standardization using quantitative immunofluorescence (AQUA) will be illustrated. Finally some exploratory data for new companion diagnostics will be presented.
The role of phosphodiesterases in inflammation
Angie Hertz
Predoctoral Fellow
Pharmacology
UW
Tuesday, November 16, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Angie Hertz
Predoctoral Fellow
Pharmacology
UW
Tuesday, November 16, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Discovery of 8-Hydroxyguanine (8-oxo-G); Involvement in Mutagenesis and Cancer
Susumu Nishimura
Visiting Scholar
Laboratory Animal Resource Center
University of Tsukuba, Japan
Wednesday, November 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Damage to DNA by oxygen free radicals results from both endogenous metabolic processes and from exposure to environmental agents. In cells, it is estimated that as many as 20,000 nucleotides in DNA are altered per cell per day. Twenty-five years ago, Dr. Susumu Nishimura discovered that 8-hydroxydeoxyguanosine is the principal adduct resulting from oxygen mediated DNA damage. He then established methods to quantify its mutagenic potential and the association of this damage with cancer. He used knockout mice with mutations in DNA repair genes to demonstrate repair of 8- hydroxyguanine lesions in DNA. There is considerable evidence to indicate that 8- hydroxyguanine lesions are involved in human colon and lung cancers. His current studies are directed at reducing the formation of 8- hydroxyguanine lesions in DNA and reducing the frequency by which these lesions mis-code in order to prevent or delay the emergence of human cancers.
Susumu Nishimura
Visiting Scholar
Laboratory Animal Resource Center
University of Tsukuba, Japan
Wednesday, November 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Damage to DNA by oxygen free radicals results from both endogenous metabolic processes and from exposure to environmental agents. In cells, it is estimated that as many as 20,000 nucleotides in DNA are altered per cell per day. Twenty-five years ago, Dr. Susumu Nishimura discovered that 8-hydroxydeoxyguanosine is the principal adduct resulting from oxygen mediated DNA damage. He then established methods to quantify its mutagenic potential and the association of this damage with cancer. He used knockout mice with mutations in DNA repair genes to demonstrate repair of 8- hydroxyguanine lesions in DNA. There is considerable evidence to indicate that 8- hydroxyguanine lesions are involved in human colon and lung cancers. His current studies are directed at reducing the formation of 8- hydroxyguanine lesions in DNA and reducing the frequency by which these lesions mis-code in order to prevent or delay the emergence of human cancers.
Transcriptional regulatory circuits controlling mitochondrial function in the developing and diseased heart
Daniel P. Kelly, MD
Scientific Director
Burnham Institute for Medical Research, Orlando, FL
Tuesday, November 9, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Daniel P. Kelly, MD
Scientific Director
Burnham Institute for Medical Research, Orlando, FL
Tuesday, November 9, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Nephrotic T Cells: From Immunological Synapses to the Genetics of FSGS
Andrey Shaw, M.D.
Professor
Department of Pathology & Immunology
Washington University School of Medicine
Wednesday, November 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jing Zhang, M.D., Ph.D.
Why Attend?
Our work on the immunological synapse led us unexpectedly to become interested in podocytes in the kidney. Our recent work has focused on the genetic causes of FSGS and how the role of NextGen sequencing may transform our understanding of this disease.
Andrey Shaw, M.D.
Professor
Department of Pathology & Immunology
Washington University School of Medicine
Wednesday, November 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jing Zhang, M.D., Ph.D.
Why Attend?
Our work on the immunological synapse led us unexpectedly to become interested in podocytes in the kidney. Our recent work has focused on the genetic causes of FSGS and how the role of NextGen sequencing may transform our understanding of this disease.
The Contribution of Mitochondrial Reactive Oxygen Species to Cellular Signaling
Brian J. Hawkins, PhD
Assistant Professor
Anesthesiology and Pain Medicine; Researcher, Mitochondria and Metabolism Center
UW
Tuesday, November 2, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Brian J. Hawkins, PhD
Assistant Professor
Anesthesiology and Pain Medicine; Researcher, Mitochondria and Metabolism Center
UW
Tuesday, November 2, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Quantifying Proteins by LC-MS/MS
Andy Hoofnagle, M.D., Ph.D.
Assistant Professor
UW Laboratory Medicine
University of Washington
Wednesday, October 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
There have been significant advances in the quantification of proteins by liquid chromatography-tandem mass spectrometry. Targeted proteomics workflows have major advantages over traditional automated immunoassays in the clinical laboratory. In addition, they are more precise than shotgun proteomics approaches. Using standard isotope dilution methods, we have developed several assays that demonstrate the utility of targeted mass spectrometry for the quantification of proteins in human samples. We will discuss the development of these assays and their application to tumor marker detection in serum and to studying the mechanisms of lipoprotein metabolism.
Andy Hoofnagle, M.D., Ph.D.
Assistant Professor
UW Laboratory Medicine
University of Washington
Wednesday, October 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine, M.D., Ph.D.
Why Attend?
There have been significant advances in the quantification of proteins by liquid chromatography-tandem mass spectrometry. Targeted proteomics workflows have major advantages over traditional automated immunoassays in the clinical laboratory. In addition, they are more precise than shotgun proteomics approaches. Using standard isotope dilution methods, we have developed several assays that demonstrate the utility of targeted mass spectrometry for the quantification of proteins in human samples. We will discuss the development of these assays and their application to tumor marker detection in serum and to studying the mechanisms of lipoprotein metabolism.
Mitochondria Production of Reactive Oxygen Species and its Role in Ischemia Reperfusion Injury
Wang Wang, MD, PhD
Assistant Professor
Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center
UW
Tuesday, October 26, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Wang Wang, MD, PhD
Assistant Professor
Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center
UW
Tuesday, October 26, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Immunologic Targeting of Oncogenic Proteins in Breast Cancer
Nora Disis, M.D.
Professor
UW Medicine Oncology/Tumor Vaccine Group
University of Washington
Wednesday, October 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
Human cancers are immunogenic. Immunogenic proteins expressed by tumors have been defined and, in the case of breast cancer, many antigens are proteins that are involved in initiating or maintaining the malignant transformation. The identification of tumor antigens has allowed the development of targeted approaches to immune based breast cancer prevention and treatment strategies. The use of genetically engineered mice provides a model system for investigating the mechanism of action of breast cancer vaccines and clinical trials of vaccines in patients with breast cancer have indicated what type of immune response is needed for tumor eradication.
Nora Disis, M.D.
Professor
UW Medicine Oncology/Tumor Vaccine Group
University of Washington
Wednesday, October 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Kim Allison, M.D.
Why Attend?
Human cancers are immunogenic. Immunogenic proteins expressed by tumors have been defined and, in the case of breast cancer, many antigens are proteins that are involved in initiating or maintaining the malignant transformation. The identification of tumor antigens has allowed the development of targeted approaches to immune based breast cancer prevention and treatment strategies. The use of genetically engineered mice provides a model system for investigating the mechanism of action of breast cancer vaccines and clinical trials of vaccines in patients with breast cancer have indicated what type of immune response is needed for tumor eradication.
Application of Causal Analysis to the Vessel Wall
Stephen M. Schwartz, MD, PhD
Professor
Pathology
UW
Tuesday, October 19, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Stephen M. Schwartz, MD, PhD
Professor
Pathology
UW
Tuesday, October 19, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Monocyte/Macrophage Reprogramming - Novel Mechanisms to Control Outcomes in Inflammatory Diseases
Jeremy Duffield, M.D., Ph.D.
Associate Professor
UW Medicine
University of Washington
Wednesday, October 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
Jeremy Duffield recently joined University of Washington as Associate Professor of Medicine. He graduated from Oxford University in England, UK (MD) and Edinburgh University, Scotland UK (PhD) and moved to the USA in 2003. He was appointed Assistant Prof of Medicine at Harvard Medical School in 2006, after postdoctoral training there. He is a member of the Nephrology division and directs the Laboratory of Inflammation Research at the South Lake Union Campus in the Stem Cell and Regenerative Medicine Institute focused on the role of innate immune response cells, monocytes, in injury and repair and on the role of pericytes in vascular remodeling and fibrosis. Dr. Duffield is a recipient of the Young Investigator Award from the British Renal Association (2001), the Gottschalk Award from the American Society of Nephrology (2006) and an ARRA Challenge Grant from the NIH (2009) and the NIDDK Early Career Investigator/Scholar Award (2010). He serves on a study section at the NIDDK and the Scientific Advisory Board of Promedior Inc. and Regulus Therapeutics. He practices Nephrology part time at the UW Medical Center with special interests in Systemic Lupus Erythematosis, Systemic Vasculitis and Pregnancy related kidney disorders.
In his 'spare' time he races bicycles, climbs mountains, skis, plays tennis, grows organic vegetables, looks after children (his own) and fixes things that are broken.
Jeremy Duffield, M.D., Ph.D.
Associate Professor
UW Medicine
University of Washington
Wednesday, October 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
Jeremy Duffield recently joined University of Washington as Associate Professor of Medicine. He graduated from Oxford University in England, UK (MD) and Edinburgh University, Scotland UK (PhD) and moved to the USA in 2003. He was appointed Assistant Prof of Medicine at Harvard Medical School in 2006, after postdoctoral training there. He is a member of the Nephrology division and directs the Laboratory of Inflammation Research at the South Lake Union Campus in the Stem Cell and Regenerative Medicine Institute focused on the role of innate immune response cells, monocytes, in injury and repair and on the role of pericytes in vascular remodeling and fibrosis. Dr. Duffield is a recipient of the Young Investigator Award from the British Renal Association (2001), the Gottschalk Award from the American Society of Nephrology (2006) and an ARRA Challenge Grant from the NIH (2009) and the NIDDK Early Career Investigator/Scholar Award (2010). He serves on a study section at the NIDDK and the Scientific Advisory Board of Promedior Inc. and Regulus Therapeutics. He practices Nephrology part time at the UW Medical Center with special interests in Systemic Lupus Erythematosis, Systemic Vasculitis and Pregnancy related kidney disorders.
In his 'spare' time he races bicycles, climbs mountains, skis, plays tennis, grows organic vegetables, looks after children (his own) and fixes things that are broken.
Mouse genetics is a powerful approach to understand vascular remodeling
Slava Korshunov, PhD
Assistant Professor of Medicine
Aab Cardiovascular Research Institute
University of Rochester School of Medicine and Dentistry, Rochester, NY
Tuesday, October 12, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Slava Korshunov, PhD
Assistant Professor of Medicine
Aab Cardiovascular Research Institute
University of Rochester School of Medicine and Dentistry, Rochester, NY
Tuesday, October 12, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Saturated Long-chain Acyl-CoA Synthesis: A Novel Link Between TNFα and Saturated Fatty Acid-induced Endothelial Dysfunction
Xin Li
Department of Pathology Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, October 8, 2010 - 1:00 PM
UW Medicine at South Lake Union, Brotman Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Xin Li
Department of Pathology Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Friday, October 8, 2010 - 1:00 PM
UW Medicine at South Lake Union, Brotman Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Renal Mitochondrial Dysfunction in a Mouse Model of Diabetic Nephropathy
Bardia Askari, Ph.D.
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, October 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
Diabetic nephropathy is a major complication of diabetes mellitus, affecting approximately 20-40% of all people diagnosed with diabetes and has become the major cause of end stage renal disease. The risk is even higher in Native-American, African-American and Hispanic populations with type 2 diabetes. Current treatment of diabetic nephropathy includes strict dietary, glycemic and blood pressure control with the use of renin-angiotensin-aldosterone system blockers. However, even in the presence of appropriate pharmacotherapy, diabetes can lead to nephropathy and kidney failure. While progressive diabetic nephropathy is most likely the result of a combination of environmental and genetic influences, the exact mechanisms are not clearly delineated. The mouse strain BTBR with the ob/ob leptin deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resistance. We have demonstrated that these mice rapidly develop renal lesions characteristic of both early and advanced human diabetic nephropathy with corresponding renal dysfunction along with changes in the expression in several regulators of mitochondrial biogenesis. We've also demonstrated an amelioration of the development of type 2 diabetes using a novel peroxisome proliferator activated receptor (PPAR) agonist. These observations can give us a clearer view of the pathophysiologic mechanisms underlying the development of diabetic kidney disease.
Bardia Askari, Ph.D.
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, October 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Charles Alpers, M.D.
Why Attend?
Diabetic nephropathy is a major complication of diabetes mellitus, affecting approximately 20-40% of all people diagnosed with diabetes and has become the major cause of end stage renal disease. The risk is even higher in Native-American, African-American and Hispanic populations with type 2 diabetes. Current treatment of diabetic nephropathy includes strict dietary, glycemic and blood pressure control with the use of renin-angiotensin-aldosterone system blockers. However, even in the presence of appropriate pharmacotherapy, diabetes can lead to nephropathy and kidney failure. While progressive diabetic nephropathy is most likely the result of a combination of environmental and genetic influences, the exact mechanisms are not clearly delineated. The mouse strain BTBR with the ob/ob leptin deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resistance. We have demonstrated that these mice rapidly develop renal lesions characteristic of both early and advanced human diabetic nephropathy with corresponding renal dysfunction along with changes in the expression in several regulators of mitochondrial biogenesis. We've also demonstrated an amelioration of the development of type 2 diabetes using a novel peroxisome proliferator activated receptor (PPAR) agonist. These observations can give us a clearer view of the pathophysiologic mechanisms underlying the development of diabetic kidney disease.
Mitochondrial Dynamics as Studied by Fourier Imaging Correlation Spectroscopy
Eric Senning, PhD
Sr. Fellow
Physiology & Biophysics
UW
Tuesday, October 5, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Eric Senning, PhD
Sr. Fellow
Physiology & Biophysics
UW
Tuesday, October 5, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Coupled gating of L-type calcium channels
Edward P. Cheng
Predoctoral Fellow
Physiology and Biophysics
UW
Tuesday, September 28, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Edward P. Cheng
Predoctoral Fellow
Physiology and Biophysics
UW
Tuesday, September 28, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium
Motors, Movement, and Malignancy
Steven S. Rosenfeld, M.D., Ph.D.
John and Elizabeth Harris Professor
Director, Division of Neuro-Oncology
Department of Neurology, Columbia University
Monday, July 19, 2010 - 4:30 PM
UWMC, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Thomas Montine, M.D., Ph.D.
Steven S. Rosenfeld, M.D., Ph.D.
John and Elizabeth Harris Professor
Director, Division of Neuro-Oncology
Department of Neurology, Columbia University
Monday, July 19, 2010 - 4:30 PM
UWMC, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Thomas Montine, M.D., Ph.D.
Metabolic Remodeling and Dysregulation of Lipid Dynamics in Diseased Hearts
E. Douglas Lewandowski, PhD
Professor, Physiology & Biophysics, and Medicine
Director, Program in Integrative Cardiac Metabolism
University of Illinois at Chicago
Tuesday, July 13, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
.
E. Douglas Lewandowski, PhD
Professor, Physiology & Biophysics, and Medicine
Director, Program in Integrative Cardiac Metabolism
University of Illinois at Chicago
Tuesday, July 13, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
.
Regulation of Neointimal Hyperplasia by Sphingosine-1-phosphate in Mice
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
How to Make a Heart: The Islet Heart Progenitor Story and 'Pregenerative' Medicine
Kenneth R. Chien, M.D., Ph.D.
Director, MGH Cardiovascular Research Center
Department of Cell Biology and Harvard Stem Cell Institute
Harvard University Medical School
Wednesday, June 23, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry
Kenneth R. Chien, M.D., Ph.D.
Director, MGH Cardiovascular Research Center
Department of Cell Biology and Harvard Stem Cell Institute
Harvard University Medical School
Wednesday, June 23, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry
Extending Lifespan by promoting proliferative homeostasis in Drosophila
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Mapping gene expression subsets in systemic sclerosis to molecular pathways and concordant mouse models
Michael L. Whitfield, PhD
Assistant Professor
Genetics
Dartmouth Medical School
Tuesday, June 22, 2010 - 8:30 AM
SLU, 815 Mercer St, Brotman Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
Michael L. Whitfield, PhD
Assistant Professor
Genetics
Dartmouth Medical School
Tuesday, June 22, 2010 - 8:30 AM
SLU, 815 Mercer St, Brotman Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
Mitochondrial signaling in Disease and Aging
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Of Old Mice and Men: Lessons in Comparative Pathology from a Mouse Model of Healthy Aging
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
Adenylyl cyclase type 5 (AC5), cardiac stress and longevity
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
The Adventitia: A Novel Hedgehog Signaling Domain and Progenitor Cell Niche in the Vessel Wall
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Aortic Dissections, Vascular Diseases and ACTA2 Mutations
Dianna M. Milewicz, MD, PhD
Professor and Director
Medical Genetics
University of Texas Medical School at Houston
Tuesday, June 1, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
WEBINAR
Dianna M. Milewicz, MD, PhD
Professor and Director
Medical Genetics
University of Texas Medical School at Houston
Tuesday, June 1, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
WEBINAR
Window of Opportunity: Artificial Cornea Development for Treatable Blindness Worldwide
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Toggling among pluripotent states in embryonic stem cells
Carol Ware, PhD
Professor
Comparative Medicine
Institute for Stem Cell and Regenerative Medicine
Tuesday, May 25, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Carol Ware, PhD
Professor
Comparative Medicine
Institute for Stem Cell and Regenerative Medicine
Tuesday, May 25, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Pyroptosis: Coordinated Inflammatory Response
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Transcriptional Control of Stroma Dependent Apoptosis in MDS
Mario Marcondes
Graduate Student
Department of Pathology
University of Washington School of Medicine
Wednesday, May 19, 2010 - 2:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D.
Mario Marcondes
Graduate Student
Department of Pathology
University of Washington School of Medicine
Wednesday, May 19, 2010 - 2:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D.
Weird Animal Genomes and Sex
Jenny Graves, Ph.D.
Professor, Comparative Genomics
Research School of Biological Sciences
Australian National University, Canberra
Wednesday, May 19, 2010 - 1:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes.
Jenny Graves, Ph.D.
Professor, Comparative Genomics
Research School of Biological Sciences
Australian National University, Canberra
Wednesday, May 19, 2010 - 1:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes.
Quantifying Flow-induced Mechanical Stresses to Understand their Role in Vascular Disease
Alberto Aliseda, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 18, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Alberto Aliseda, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 18, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Cellular and Humoral Immune Responses to the Polyomavirus-linked Merkel Cell Carcinoma: Implications for Pathogenesis, Prognosis and Therapy
Kelly Paulson
Medical Scientist Training Program
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, May 13, 2010 - 1:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Paul Nghiem, M.D., Ph.D.
Kelly Paulson
Medical Scientist Training Program
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, May 13, 2010 - 1:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Paul Nghiem, M.D., Ph.D.
Mechanics and Mechanical Factors in the Structure-Function Relations of Endothelials and Platelets
Nathan J. Sniadecki, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 11, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Nathan J. Sniadecki, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 11, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Long-Chain Acyl-CoA Synthesis at the Crossroads Between Glucose and Fatty Acid-Enhanced Inflammation and Atherosclerosis in Diabetes
Jenny Kanter
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 10, 2010 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Jenny Kanter
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 10, 2010 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Annual Alvord Lecture in Neuropathology
Alexander R.A. Anderson, PhD
H. Lee Moffitt Cancer Center & Research Institute
Co-Director of Integrated Mathematical Oncology
Lee Moffitt Cancer Center & Research Institute
Wednesday, May 5, 2010 - 4:00 PM
University of Washinton, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Drs. T. Montine and K. Swanson
8th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. A special remembrance in honor of Dr. Alvord will precede the lecture. Reception to immediately follow the lecture at the Vista Cafe & Patio
Alexander R.A. Anderson, PhD
H. Lee Moffitt Cancer Center & Research Institute
Co-Director of Integrated Mathematical Oncology
Lee Moffitt Cancer Center & Research Institute
Wednesday, May 5, 2010 - 4:00 PM
University of Washinton, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Drs. T. Montine and K. Swanson
8th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. A special remembrance in honor of Dr. Alvord will precede the lecture. Reception to immediately follow the lecture at the Vista Cafe & Patio
Genetic Variation in Aging and Longevity
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Mechanistic studies of myofilament protein phosphorylation modulating striated muscle contraction
Vijay S. Rao, PhD
Senior Fellow
Heart and Muscle Mechanics Laboratory, Bioengineering
UW
Tuesday, May 4, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Vijay S. Rao, PhD
Senior Fellow
Heart and Muscle Mechanics Laboratory, Bioengineering
UW
Tuesday, May 4, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Molecular Mechanisms of c-Myc-induced Immortalization of Human Fibroblasts
Myra Wang
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 3, 2010 - 3:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Denise Galloway, Ph.D.
Myra Wang
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 3, 2010 - 3:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Denise Galloway, Ph.D.
We Are What We Eat: Food and Water-borne Infectious Diseases of the Gastrointestinal Tract
Laura Lamps, M.D.
Professor
Department of Pathology
University of Arkansas for Medical Sciences
Friday, April 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Melissa Upton, M.D.
Laura Lamps, M.D.
Professor
Department of Pathology
University of Arkansas for Medical Sciences
Friday, April 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Melissa Upton, M.D.
Magnetic resonance imaging - a non-invasive method to study atherosclerosis progression and risk assessment
Chun Yuan, PhD
Professor of Radiology
Vascular Imaging Lab
UW
Tuesday, April 27, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Chun Yuan, PhD
Professor of Radiology
Vascular Imaging Lab
UW
Tuesday, April 27, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Apoptosis and Autophagy: Neuropathology in the Balance
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Chemical Modifications of Proteins during Aging
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Vascular gene therapy: a vector and a transgene that work!
David A. Dichek, MD
Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research
Medicine/Cardiology
UW
Tuesday, April 20, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David A. Dichek, MD
Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research
Medicine/Cardiology
UW
Tuesday, April 20, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Microbe Hunting in the 21st Century
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
S100A9 Has Disparate Affects in Neutrophils and Dendritic Cells, but Myeloid S100A9-Deficiency Does Not Affect Atherosclerosis and Insulin Resistance
Michelle Averill, PhD
Senior Fellow, Karin Bornfeldt Lab
Pathology
UW
Tuesday, April 13, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Michelle Averill, PhD
Senior Fellow, Karin Bornfeldt Lab
Pathology
UW
Tuesday, April 13, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Severe Gastrointestinal Motility Disorders: Understanding the Underlying Pathology of the Neuromuscular Apparatus of the Gut
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Engineering Vascularized Human Cardiac Tissue for Heart Repair
Kareen L. Kreutziger, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, April 6, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Kareen L. Kreutziger, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, April 6, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Diagnosis and Management of Barrett's Esophagus and its Neoplastic Complications
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Using simulation methods to address biomedical problems
Valerie Daggett, PhD
Professor
Bioengineering
UW
Tuesday, March 30, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Valerie Daggett, PhD
Professor
Bioengineering
UW
Tuesday, March 30, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Non-Cell Autonomous Neurodegeneration: A Tale of Two Glia
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Natural and Artificial Extra-visual Ocular Photoreception
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Machine learning approaches for understanding the genetic basis of complex traits
Su-In Lee, PhD
Assistant Professor
Computer Science & Engineering; and Genome Sciences
UW
Tuesday, March 9, 2010 - 8:30 AM
Health Sciences Building, K-069
Su-In Lee, PhD
Assistant Professor
Computer Science & Engineering; and Genome Sciences
UW
Tuesday, March 9, 2010 - 8:30 AM
Health Sciences Building, K-069
Microfluidics-assisted Display of Genomic DNA for Analysis of DNA Replication and Repair in Vivo
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Neuregulin Signaling and Subtype Specialization in Stem Cell Derived Cardiomyocytes
Michael Laflamme, MD, PhD
Assistant Professor
Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, March 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Michael Laflamme, MD, PhD
Assistant Professor
Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, March 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Similarities and Differences of Diabetic Nephropathy in Type 1 vs. Type 2 Diabetic Patients
Behzad Najafian, M.D.
Assistant Professor
Laboratory Medicine and Pathology
University of Minnesota
Thursday, February 25, 2010 - 3:30 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Charles Alpers, M.D.
Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served
Behzad Najafian, M.D.
Assistant Professor
Laboratory Medicine and Pathology
University of Minnesota
Thursday, February 25, 2010 - 3:30 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Charles Alpers, M.D.
Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served
Mapping Gene Expression in the CNS: Tools and Data from the Allen Institute for Brain Science
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Use of the Mouse Conditional and Null Alleles of the Type III Sodium-Dependent Phosphate Cotransporter PiT-1
Maria Festing, PhD
Senior Fellow, Ceci Giachelli Lab
Bioengineering
UW
Tuesday, February 23, 2010 - 8:30 AM
Health Sciences Building , K-069
Maria Festing, PhD
Senior Fellow, Ceci Giachelli Lab
Bioengineering
UW
Tuesday, February 23, 2010 - 8:30 AM
Health Sciences Building , K-069
Regulation of Neointimal Hyperplasia by Sphingosine-1-Phosphate in Mice
Guenter Daum, PhD
Research Associate Professor
Surgery
UW
Tuesday, February 16, 2010 - 8:30 AM
Health Sciences Building , K-069
Guenter Daum, PhD
Research Associate Professor
Surgery
UW
Tuesday, February 16, 2010 - 8:30 AM
Health Sciences Building , K-069
Common Disease - Multiple Rare Alleles: Understanding the Genetic Basis of Complex Human Traits
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
Biomechanics in carotid atherosclerosis and abdominal aortic aneurysms
Gador Canton, PhD
Senior Fellow
Radiology, Vascular Imaging Laboratory
UW
Tuesday, February 9, 2010 - 8:30 AM
Health Sciences Building , K-069
Gador Canton, PhD
Senior Fellow
Radiology, Vascular Imaging Laboratory
UW
Tuesday, February 9, 2010 - 8:30 AM
Health Sciences Building , K-069
RNA-based Molecular Circuitry for Conditional Gene Regulation
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Using BAC Recombineering for the Analysis of Cardiac Progenitors
John L. Mignone, MD, PhD
Cardiology Fellow, Murry Lab
Pathology
UW
Tuesday, February 2, 2010 - 8:30 AM
Health Sciences Building , K-069
John L. Mignone, MD, PhD
Cardiology Fellow, Murry Lab
Pathology
UW
Tuesday, February 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Imaging Circuit Assembly in the Developing Retina
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
When Muscle Runs Out of Gas: nNOS Function in Skeletal and Cardiac Muscle
Justin Percival, PhD
Research Assistant Professor
Physiology and Biophysics
UW
Tuesday, January 26, 2010 - 8:30 AM
Health Sciences Building , K-069
Justin Percival, PhD
Research Assistant Professor
Physiology and Biophysics
UW
Tuesday, January 26, 2010 - 8:30 AM
Health Sciences Building , K-069
High Throughput Screening at the UW: RNA Interference and Small Molecule Screens
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Role of microRNA-155 in inflammatory/immune responses
John M. Harlan, MD
Professor of Medicine
Division of Hematology
UW
Tuesday, January 19, 2010 - 8:30 AM
Health Sciences Building , K-069
John M. Harlan, MD
Professor of Medicine
Division of Hematology
UW
Tuesday, January 19, 2010 - 8:30 AM
Health Sciences Building , K-069
Functional Genetic Approaches in In Vitro Stem Cell Systems Using RNAi
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
Proteolytic Pathways in Immunity
William C. Parks, Ph.D.
Professor of Medicine
Center for Lung Biology
UW
Tuesday, January 12, 2010 - 8:30 AM
Health Sciences Building , K-069
William C. Parks, Ph.D.
Professor of Medicine
Center for Lung Biology
UW
Tuesday, January 12, 2010 - 8:30 AM
Health Sciences Building , K-069
PET Imaging Tumor Phenotype in Sarcomas
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
The State of Seattle’s Biotech Industry
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 5, 2010 - 8:30 AM
Health Sciences Building, K-069
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 5, 2010 - 8:30 AM
Health Sciences Building, K-069
Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Exome Sequencing & Human Disease
Jay Shendure, MD, PhD
Assistant Professor
Dept. of Genome Sciences
UW
Tuesday, December 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jay Shendure, MD, PhD
Assistant Professor
Dept. of Genome Sciences
UW
Tuesday, December 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Fibrillar Collagens and Their Chaperones in Disease: A Tale of Kinky Tails and Brittle Bones
Helena Christiansen
Graduate Student
Molecular and Cellular Biology
University of Washington School of Medicine
Thursday, December 10, 2009 - 12:00 PM
Health Sciences Center, T-739
Faculty Sponsor: Peter Byers, M.D.
Helena Christiansen
Graduate Student
Molecular and Cellular Biology
University of Washington School of Medicine
Thursday, December 10, 2009 - 12:00 PM
Health Sciences Center, T-739
Faculty Sponsor: Peter Byers, M.D.
Nuclear Architecture and Aging
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
The what, why, and where of perivascular cells
Morayma Reyes, MD, PhD
Assistant Professor
Pathology and Lab Medicine
UW
Tuesday, December 1, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Morayma Reyes, MD, PhD
Assistant Professor
Pathology and Lab Medicine
UW
Tuesday, December 1, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease
David Marcinek, PhD
Research Assistant Professor
Dept. of Radiology
UW
Tuesday, November 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging.
David Marcinek, PhD
Research Assistant Professor
Dept. of Radiology
UW
Tuesday, November 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging.
Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Muscle Gene Regulation & Regulatory Cassettes for Gene Therapy
Stephen D. Hauschka, PhD
Professor
Dept. of Biochemistry
UIW
Tuesday, November 17, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles.
Stephen D. Hauschka, PhD
Professor
Dept. of Biochemistry
UIW
Tuesday, November 17, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles.
Exploring the extraordinary regenerative potential of the mammalian fetal heart
Timothy Cox, PhD
Research Associate Professor
Pediatrics, Division of Craniofacial Medicine
UW
Tuesday, November 10, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Timothy Cox, PhD
Research Associate Professor
Pediatrics, Division of Craniofacial Medicine
UW
Tuesday, November 10, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Diet, Death and Demography
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
Skeletal muscle stem cells: from classic to eclectic
Zipora Yablonka-Reuveni, PhD
Professor
Dept. of Biological Structure
UW
Tuesday, October 27, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908).
Zipora Yablonka-Reuveni, PhD
Professor
Dept. of Biological Structure
UW
Tuesday, October 27, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908).
The Amazing Liver: New Perspectives on Regeneration and Cancer
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma
Jean Campbell, PhD
Research Assistant Professor
Dept. of Pathology
UW
Tuesday, October 20, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jean Campbell, PhD
Research Assistant Professor
Dept. of Pathology
UW
Tuesday, October 20, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Mechanisms of enhanced lung injury in febrile hyperthermia
Anne Lipke, MD
Senior Fellow
Division of Pulmonary and Critical Care Medicine
UW
Tuesday, October 13, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Lynn Schnapp, MD
Anne Lipke, MD
Senior Fellow
Division of Pulmonary and Critical Care Medicine
UW
Tuesday, October 13, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Lynn Schnapp, MD
Transcriptional Regulation of Vascular Development
Elisabetta Dejana
Italian Foundation for Cancer Research
Institute of Molecular Oncology
Milan, Italy
Tuesday, October 6, 2009 - 4:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Elaine Raines
Elisabetta Dejana
Italian Foundation for Cancer Research
Institute of Molecular Oncology
Milan, Italy
Tuesday, October 6, 2009 - 4:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Elaine Raines
CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis
Jeffrey A. Ledbetter, PhD
Research Professor
Division of Rheumatology
UW
Tuesday, October 6, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab).
Jeffrey A. Ledbetter, PhD
Research Professor
Division of Rheumatology
UW
Tuesday, October 6, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab).
The role of cardiac metabolism in heart diseases
Rong Tian, MD, PhD
Professor and Director
Mitochondria and Metabolism Center
UW
Tuesday, September 29, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Rong Tian, MD, PhD
Professor and Director
Mitochondria and Metabolism Center
UW
Tuesday, September 29, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury
Tiffany Nguyen
Graduate Student
Pharmacology and Toxicology Department
Medical College of Georgia, Augusta, GA
Tuesday, September 22, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, MD, PhD
Tiffany Nguyen
Graduate Student
Pharmacology and Toxicology Department
Medical College of Georgia, Augusta, GA
Tuesday, September 22, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, MD, PhD
Cell Signaling in Space and Time
John D. Scott, PhD
Edwin G. Krebs-Hilma Speights Professor
Dept. of Pharmacology
UW
Tuesday, September 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
John D. Scott, PhD
Edwin G. Krebs-Hilma Speights Professor
Dept. of Pharmacology
UW
Tuesday, September 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Can We Image a Plaque at Risk?
Mat J.A.P. Daemen, MD, PhD
Scientific Director of the Cardiovascular Research Institute Maastricht
Professor and Head of Pathology
University of Maastricht, The Netherlands
Tuesday, September 8, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chun Yuan
Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses.
Mat J.A.P. Daemen, MD, PhD
Scientific Director of the Cardiovascular Research Institute Maastricht
Professor and Head of Pathology
University of Maastricht, The Netherlands
Tuesday, September 8, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chun Yuan
Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses.
The Neurosecretory Vesicle Protein Phogrin Has Phosphatidylinositol Phosphatase Activity That Regulates Insulin Secretion
Leslie Ann Caromile
Graduate Student
Department of Pathology
University of Washington School of Medicine
Friday, August 14, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Dan Bown-Pope, Ph.D.
Leslie Ann Caromile
Graduate Student
Department of Pathology
University of Washington School of Medicine
Friday, August 14, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Dan Bown-Pope, Ph.D.
Long-chain acyl-CoA Synthetase Isoforms 1 and 4 Exhibit Differences in Fatty Acid Preference and Functions in Human Arterial Smooth Muscle Cells
Deidre Golej
MCB Graduate Student
University of Washington School of Medicine
Wednesday, August 12, 2009 - 2:00 PM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Deidre Golej
MCB Graduate Student
University of Washington School of Medicine
Wednesday, August 12, 2009 - 2:00 PM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Mitochondria, Age and the Heart
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D
Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry
Daniel Martin, M.D.
Institute for Systems Biology
Tuesday, June 16, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Daniel Martin, M.D.
Institute for Systems Biology
Tuesday, June 16, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Loss of DNA Polymerase Proofreading Leads to Cancer and Tumor Acceleration in MIce
Tina M. Albertson
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, June 9, 2009 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Brad Preston, Ph.D.
Tina M. Albertson
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, June 9, 2009 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Brad Preston, Ph.D.
.
talk cancelled
UW School of Medicine
Tuesday, June 9, 2009 - 8:30 AM
HSC, NE110
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
talk cancelled
UW School of Medicine
Tuesday, June 9, 2009 - 8:30 AM
HSC, NE110
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Nitric Oxide and the Development of Insulin Resistance
Francis Kim, MD
Associate Professor of Medicine
Division of Cardiology
Harborview Medical Center
Tuesday, June 9, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Francis Kim, MD
Associate Professor of Medicine
Division of Cardiology
Harborview Medical Center
Tuesday, June 9, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
MicroRNAs as Blood-based Cancer Biomarkers
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Genes and Vascular Disease
Gail P. Jarvik, MD, PhD
Professor of Medicine and Head
Division of Medical Genetics
UW
Tuesday, June 2, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gail P. Jarvik, MD, PhD
Professor of Medicine and Head
Division of Medical Genetics
UW
Tuesday, June 2, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Pancreatic Cancer: Genes to Patients
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?)
Ian R. Sweet, PhD
Research Assitant Professor
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 26, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Ian R. Sweet, PhD
Research Assitant Professor
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 26, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Sterol regulation of the macrophage immune response
Jay W. Heinecke, MD
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 19, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld
Jay W. Heinecke, MD
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 19, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld
Signaling Networks in Vascular Morphogenesis and Homeostasis
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Anti-Aging Genes, DNA Damage and Cancer
Valter Longo, Ph.D.
Assistant Professor
Department of Gerontology/Alzheimer's Research
University of Southern California
Tuesday, May 12, 2009 - 12:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence
Valter Longo, Ph.D.
Assistant Professor
Department of Gerontology/Alzheimer's Research
University of Southern California
Tuesday, May 12, 2009 - 12:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence
Cell Cycle Regulation in Hematopoietic Disorders
Keith Loeb, M.D., Ph.D.
Assistant Professor
Pathology
UW School of Medicine
Tuesday, May 12, 2009 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Thomas Montine, MD, PhD
Keith Loeb, M.D., Ph.D.
Assistant Professor
Pathology
UW School of Medicine
Tuesday, May 12, 2009 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Thomas Montine, MD, PhD
Versican: A Matrix Molecule With Some Clout!
Thomas N. Wight, Ph.D.
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Affiliate Professor, Pathology, UW
Tuesday, May 12, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Thomas N. Wight, Ph.D.
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Affiliate Professor, Pathology, UW
Tuesday, May 12, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Mitochondrial Signaling and Dynamics in Health and Disease
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Tumor Cell Metabolism: How is it different?
David M. Hockenbery, MD
Professor of Medicine, UWMC
Member, FHCRC
Tuesday, May 5, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David M. Hockenbery, MD
Professor of Medicine, UWMC
Member, FHCRC
Tuesday, May 5, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Mechanisms of Cell Fate Acquisition in the Differentiation of Pluripotent Stem Cells
Jonathan Golob
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, April 29, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Jonathan Golob
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, April 29, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Mapping Cell Fate through Somatic Mutations
Marshall Horwitz, MD, PhD
Professor of Pathology
Institute for Stem Cell and Regenerative Medicine
UW
Tuesday, April 28, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Marshall Horwitz, MD, PhD
Professor of Pathology
Institute for Stem Cell and Regenerative Medicine
UW
Tuesday, April 28, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Deciphering the Hereditary Prion Protein Amyloidoses
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Shaping the vertebrate body: cell migration in development and disease
Douglas C. Weiser, PhD
Postdoctoral fellow
Department of Biochemistry
UW
Tuesday, April 21, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Douglas C. Weiser, PhD
Postdoctoral fellow
Department of Biochemistry
UW
Tuesday, April 21, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Mitochondrial Oxidative Stress in Cardiac Aging, Pressure-Overload Induced Cardiac Hypertrophy and Failure
Dao-Fu Dai
Graduate Student
UW Medicine Department of Pathology
University of Washington
Tuesday, April 14, 2009 - 1:00 PM
UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Doctoral Dissertation
Dao-Fu Dai
Graduate Student
UW Medicine Department of Pathology
University of Washington
Tuesday, April 14, 2009 - 1:00 PM
UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Doctoral Dissertation
Chordoma
Benjamin Hoch, MD
Associate Professor, Pathology
UW School of Medicine
Tuesday, April 14, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Benjamin Hoch, MD
Associate Professor, Pathology
UW School of Medicine
Tuesday, April 14, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Matrix remodeling during lung injury and repair
Lynn M. Schnapp, MD
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, April 14, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Lynn M. Schnapp, MD
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, April 14, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Genomic Dosage Disorders: Diagnostic Insights and Challenges
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Translational control during monocyte/macrophage adherence
David Pritchard, PhD
Acting Instructor
Department of Pathology
UW
Tuesday, April 7, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Pritchard, PhD
Acting Instructor
Department of Pathology
UW
Tuesday, April 7, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gene Networks as Sensors and Drivers of Disease
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Water, Energy and Life: Fresh Views from the Water’s Edge
Gerald H. Pollack, PhD
Professor
Department of Bioengineering
UW
Tuesday, March 31, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gerald H. Pollack, PhD
Professor
Department of Bioengineering
UW
Tuesday, March 31, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?
David Wu, MD, PhD
Assistant Professor
Laboratory medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Wu, MD, PhD
Assistant Professor
Laboratory medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?
David Wu, MD, PhD
Assistant Professor
Dept. of Laboratory Medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Wu, MD, PhD
Assistant Professor
Dept. of Laboratory Medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Metabolic Stability and the Evolution of Life Span
Lloyd Demetrius, PhD
Department of Evolutionary & Organismic Biology
Harvard University
Tuesday, March 10, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant
Lloyd Demetrius, PhD
Department of Evolutionary & Organismic Biology
Harvard University
Tuesday, March 10, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant
Human Pluripotent Stem Cells for Myocardial Repair
Michael LaFlamme, MD, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, March 10, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Michael LaFlamme, MD, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, March 10, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Local Control of Excitation-Transcription Coupling in Smooth Muscle
Luis Fernando Santana, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, March 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Luis Fernando Santana, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, March 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Chromatin and G-quadruplex Functions at Telomeres and Beyond
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms
Jie Hong Hu, Ph.D.
Senior Fellow
Division of Cardiology
UW
Tuesday, March 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Jie Hong Hu, Ph.D.
Senior Fellow
Division of Cardiology
UW
Tuesday, March 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Lost in Translation: Ribosomes in Hematopoiesis
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury
John C. Keech, M.D.
Postdoctoral Fellow
Surgery
UW
Tuesday, February 24, 2009 - 8:30 AM
Health Sciences Building, K-069
John C. Keech, M.D.
Postdoctoral Fellow
Surgery
UW
Tuesday, February 24, 2009 - 8:30 AM
Health Sciences Building, K-069
Translating Pathways to Pancreatic Cancer
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Mitochondrial-targeted Peptides: Novel Cardio-, Neuro- and Renal-protective Agents
Hazel H. Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Tuesday, February 17, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant
Hazel H. Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Tuesday, February 17, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant
Myofilament Regulation of the Frank-Starling Law of the Heart
F. Steven Korte, Ph.D.
Senior Fellow
Bioengineering
UW
Tuesday, February 17, 2009 - 8:30 AM
Health Sciences Building, K-069
F. Steven Korte, Ph.D.
Senior Fellow
Bioengineering
UW
Tuesday, February 17, 2009 - 8:30 AM
Health Sciences Building, K-069
Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
The FGF Axis: New Therapeutic Opportunities
Norman M. Greenberg, Ph.D.
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington
FHCRC and UW
Tuesday, February 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Norman M. Greenberg, Ph.D.
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington
FHCRC and UW
Tuesday, February 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Water
Gerald Pollack, PhD
Professor, Bioengineering
Department of Engineering, Bioengineering Division
UW School of Medicine
Monday, February 9, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php
Gerald Pollack, PhD
Professor, Bioengineering
Department of Engineering, Bioengineering Division
UW School of Medicine
Monday, February 9, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php
Archaeoctyes: Monocytes as Universal Probes for Disease
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays
Steven Pelech, Ph.D.
President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia
Kinexus Bioinformatics Corp. and Univ. of British Columbia
Tuesday, February 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Steven Pelech, Ph.D.
President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia
Kinexus Bioinformatics Corp. and Univ. of British Columbia
Tuesday, February 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Roles of Transcription in Genomic Stability or Instability
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
SMC plasticity and reprogramming in calcifying vasculature
Yanfeng (Mei) Speer, Ph.D.
Research Assistant Professor
Bioengineering
UW
Tuesday, January 27, 2009 - 8:30 AM
Health Sciences Building, K-069
Yanfeng (Mei) Speer, Ph.D.
Research Assistant Professor
Bioengineering
UW
Tuesday, January 27, 2009 - 8:30 AM
Health Sciences Building, K-069
Studying Hematopoietic Disease with Genetics & Genomics
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
Genetic & epigenetic control of aging
George Martin, MD
Emeritus Professor (active), Pathology
UW School of Medicine
Tuesday, January 13, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/
George Martin, MD
Emeritus Professor (active), Pathology
UW School of Medicine
Tuesday, January 13, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/
Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells
Jonathan Golob
Graduate Student
Pathology
UW
Tuesday, January 13, 2009 - 8:30 AM
Health Sciences Building, K-069
Jonathan Golob
Graduate Student
Pathology
UW
Tuesday, January 13, 2009 - 8:30 AM
Health Sciences Building, K-069
Inights Into Vascular Diseases and Their Treatments from Human Genetics
Richard Lifton, M.D., Ph.D.
Professor and Chair
Department of Genetics
Yale University
Wednesday, January 7, 2009 - 5:00 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz
Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222
Richard Lifton, M.D., Ph.D.
Professor and Chair
Department of Genetics
Yale University
Wednesday, January 7, 2009 - 5:00 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz
Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222
AAV vectors: biology and utility for gene addition and gene correction
David Russell, MD, PhD
Professor of Medicine
Div. of Hematology
UW
Tuesday, January 6, 2009 - 8:30 AM
Health Sciences Building, K-069
David Russell, MD, PhD
Professor of Medicine
Div. of Hematology
UW
Tuesday, January 6, 2009 - 8:30 AM
Health Sciences Building, K-069
Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you
Alan Weiner, PhD
Professor and ZymoGenetics Chair
Biochemistry
UW
Tuesday, December 16, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Alan Weiner, PhD
Professor and ZymoGenetics Chair
Biochemistry
UW
Tuesday, December 16, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
"Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes"
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Climb High, Sleep Low
Lawrence True, MD
Professor, Pathology
UW School of Medicine
Tuesday, December 9, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Lawrence True, MD
Professor, Pathology
UW School of Medicine
Tuesday, December 9, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
A-type nuclear lamins in aging and disease
Brian Kennedy, PhD
Associate Professor
Biochemistry
UW
Tuesday, December 9, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Brian Kennedy, PhD
Associate Professor
Biochemistry
UW
Tuesday, December 9, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
Delta 1: A Notch up on cord blood stem cell transplantation
Irwin Bernstein, MD
Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society
UW and FHCRC
Tuesday, November 25, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Irwin Bernstein, MD
Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society
UW and FHCRC
Tuesday, November 25, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
“Quantum Dots for Cancer Imaging and Therapeutics”
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Dissection, disruption, and death--aortic dissection and its causes
Peter Byers, MD
Professor, Pathology and Medicine
UW School of Medicine
Tuesday, November 18, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Peter Byers, MD
Professor, Pathology and Medicine
UW School of Medicine
Tuesday, November 18, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer
Jay Rothstein, PhD
Director
Inflammation Research
Amgen, Inc., Seattle, WA
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Jay Rothstein, PhD
Director
Inflammation Research
Amgen, Inc., Seattle, WA
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs
Wei-Zhong Zhu, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Michael Laflamme
Wei-Zhong Zhu, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Michael Laflamme
Neuroregeneration in the Cerebral Cortex: Impossible and Crazy?
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
"Structural and Functional Characterizations of Alternative Gene Products of an Adaptor Protein (FE65) and an Orphan G-Protein Coupled Receptor (Gprc5b) in Learning- and Memory-Impaired Mice with a Selective Knockout of p97FE65"
Bethany Cool
Graduate Student
Pathology
University of Washington
Monday, November 10, 2008 - 2:30 PM
Health Science Center, K-0690
Faculty Sponsor: Dr. Martin
Bethany Cool
Graduate Student
Pathology
University of Washington
Monday, November 10, 2008 - 2:30 PM
Health Science Center, K-0690
Faculty Sponsor: Dr. Martin
"Pathogenesis of NASH: new insights from mice with metabolic syndrome"
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
"The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast"
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
"Control of Cardiovascular Signaling by RGS Proteins"
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
Epigenetic programming of mesenchymal stem cells
Philippe Collas, PhD
Professor
Institute of Basic Medical Sciences, Dept. of Biochemistry
University of Oslo, Norway
Tuesday, October 21, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Karol Bomsztyk
Philippe Collas, PhD
Professor
Institute of Basic Medical Sciences, Dept. of Biochemistry
University of Oslo, Norway
Tuesday, October 21, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Karol Bomsztyk
Exploring the Interface Between Glial Progenitors and Gliomas
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Regulation of Nodal Signaling by microRNAs
Wen-Yee Choi
Graduate Researcher
Molecular and Cellular Biology
Harvard University
Tuesday, October 14, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Charles Murry
Wen-Yee Choi
Graduate Researcher
Molecular and Cellular Biology
Harvard University
Tuesday, October 14, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Charles Murry
Contribution of interstitial valve cells to valve calcification
Marcello Rattazzi, MD
Clinical and Experimental Medicine
University of Padua, Italy
Wednesday, October 8, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Marcello Rattazzi, MD
Clinical and Experimental Medicine
University of Padua, Italy
Wednesday, October 8, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Molecular mechanisms of aging: What can we learn from yeast and worms?
Matt Kaeberlein, PhD
Assistant Professor
Pathology
UW
Tuesday, October 7, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Matt Kaeberlein, PhD
Assistant Professor
Pathology
UW
Tuesday, October 7, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Pancreatic Cancer: Emerging Ideas About How the Cancer Forms
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
PSGL-1 Mediated Signal Transduction and Translational Control Mechanisms During Adherence of Macrophages
Richard Fox
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, August 14, 2008 - 1:00 PM
South Lake Union Auditorium, K-111
Faculty Sponsor: Dr. Schwartz
Richard Fox
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, August 14, 2008 - 1:00 PM
South Lake Union Auditorium, K-111
Faculty Sponsor: Dr. Schwartz
“Magnetic Resonance Imaging of Gene Expression"
Anna Naumova, Ph.D.
Senior Fellow
Radiology
UW
Tuesday, June 24, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Anna Naumova, Ph.D.
Senior Fellow
Radiology
UW
Tuesday, June 24, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Directly targeting myofibrillar proteins to improve cardiomyocyte contraction"
F. Steven Korte, PhD
Senior fellow
Bioengineering
UW
Tuesday, June 17, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
F. Steven Korte, PhD
Senior fellow
Bioengineering
UW
Tuesday, June 17, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus”
Bardia Askari, Ph.D.
Acting Instructor
Pathology
UW
Tuesday, June 10, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Bardia Askari, Ph.D.
Acting Instructor
Pathology
UW
Tuesday, June 10, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Understanding aging through conserved longevity pathways
Matt Kaeberlein, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, June 10, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Matt Kaeberlein, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, June 10, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
“Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model”
Karin E. Bornfeldt, Ph.D.
Professor
Pathology
Medicine
Tuesday, June 3, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer
Karin E. Bornfeldt, Ph.D.
Professor
Pathology
Medicine
Tuesday, June 3, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer
“Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes”
Charis L. Himeda, Ph.D.
Senior fellow
Biochemistry
UW
Tuesday, May 20, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Charis L. Himeda, Ph.D.
Senior fellow
Biochemistry
UW
Tuesday, May 20, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment”
Dalin Tang, Ph.D.
Professor
Mathematics and Biomedical Engineering
Worcester Polytechnic Institute
Tuesday, May 13, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chun Yuan, Ph.D.
815 Mercer Street
Dalin Tang, Ph.D.
Professor
Mathematics and Biomedical Engineering
Worcester Polytechnic Institute
Tuesday, May 13, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chun Yuan, Ph.D.
815 Mercer Street
“Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?”
Deidre Golej
Graduate Student, Molecular and Cellular Biology
Pathology
UW
Tuesday, May 6, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Deidre Golej
Graduate Student, Molecular and Cellular Biology
Pathology
UW
Tuesday, May 6, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Why Do Biopsies of Ulcerative Colitis Seem to Look More and More Like Crohn’s Disease? And Whatever Happened to the Old Ulcerative Colitis That We Knew and Loved
Henry Appelman, M.D.
Professor
Department of Pathology
University of Michigan Health System
Thursday, May 1, 2008 - 4:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Dr. Melissa Upton
A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000.
Henry Appelman, M.D.
Professor
Department of Pathology
University of Michigan Health System
Thursday, May 1, 2008 - 4:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Dr. Melissa Upton
A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000.
“Diabetic vascular disease: Hitting below the belt”
Kanchan Chitaley, Ph.D.
Research Assistant Professor
Urology
UW
Tuesday, April 29, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Kanchan Chitaley, Ph.D.
Research Assistant Professor
Urology
UW
Tuesday, April 29, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
6th Annual Alvord Lecture in Neuropathology
Arie Perry, MD
Associate Professor
Pathology, Division of Neuropathology
Washington University, St. Louis
Wednesday, April 23, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Montine
Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed.
Arie Perry, MD
Associate Professor
Pathology, Division of Neuropathology
Washington University, St. Louis
Wednesday, April 23, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Montine
Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed.
“FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero”
Atis Muehlenbachs
MSTP and Incoming Resident
Pathology
UW
Tuesday, April 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Atis Muehlenbachs
MSTP and Incoming Resident
Pathology
UW
Tuesday, April 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Transcriptional regulation of thrombin receptors by vasodilator prostaglandins"
Karsten Schror, M.D.
Professor and Chair
Pharmacology and Clinical Pharmacology
Heinrich-Heine-Universitat Dusseldorf
Tuesday, April 15, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Alexander W. Clowes, MD
815 Mercer Street
Karsten Schror, M.D.
Professor and Chair
Pharmacology and Clinical Pharmacology
Heinrich-Heine-Universitat Dusseldorf
Tuesday, April 15, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Alexander W. Clowes, MD
815 Mercer Street
A Recurrent Mutation, p.R961W, in the MED12/TRAP/HOPA Gene Causes Opitz-Kaveggia (FG) Syndrome
Hiba Risheg, Ph.D.
Director
Clinical Ctyogenetics Laboratory
Genecare Medical Genetics Center
Monday, April 14, 2008 - 3:00 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Christine Disteche
Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology
Hiba Risheg, Ph.D.
Director
Clinical Ctyogenetics Laboratory
Genecare Medical Genetics Center
Monday, April 14, 2008 - 3:00 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Christine Disteche
Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology
Untangling Mitochondrial Mutagenesis and Aging in Mice
Marc Vermulst
Graduate Student
UW Medicine Pathology
University of Washington
Friday, April 11, 2008 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Larry Loeb
Marc Vermulst
Graduate Student
UW Medicine Pathology
University of Washington
Friday, April 11, 2008 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Larry Loeb
“A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice”
Richard Frock
PhD Candidate
Biochemistry
UW
Tuesday, April 8, 2008 - 8:30 AM
Health Sciences Building, K-069
Richard Frock
PhD Candidate
Biochemistry
UW
Tuesday, April 8, 2008 - 8:30 AM
Health Sciences Building, K-069
"I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure"
Chris Hague, Ph.D.
Assistant Professor
Pharmacology
UW
Tuesday, April 1, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chris Hague, Ph.D.
Assistant Professor
Pharmacology
UW
Tuesday, April 1, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Glioma Invasion: Interactions with the Microenvironment
Joanna Phillips, MD, PhD
UW Medicine, Neuropathology Faculty Candidate
Department of Pathology, Division of Neuropathology, Research Fellow
University of California, San Francisco
Wednesday, March 26, 2008 - 9:30 AM
R&T Building, 300 Ninth Ave, auditorium
Faculty Sponsor: Montine
Joanna Phillips, MD, PhD
UW Medicine, Neuropathology Faculty Candidate
Department of Pathology, Division of Neuropathology, Research Fellow
University of California, San Francisco
Wednesday, March 26, 2008 - 9:30 AM
R&T Building, 300 Ninth Ave, auditorium
Faculty Sponsor: Montine
"Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation"
Prabha Sampath, Ph.D.
Postdoctoral Fellow
Pathology
UW
Tuesday, March 25, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Prabha Sampath, Ph.D.
Postdoctoral Fellow
Pathology
UW
Tuesday, March 25, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer”
Jeffrey S. Chamberlain, Ph.D.
Professor
Depts. of Neurology, Medicine and Biochemistry
UW
Tuesday, March 18, 2008 - 8:30 AM
HSB, T-635
Jeffrey S. Chamberlain, Ph.D.
Professor
Depts. of Neurology, Medicine and Biochemistry
UW
Tuesday, March 18, 2008 - 8:30 AM
HSB, T-635
“Human RecQ helicases: new roles in biology and disease”
Raymond Monnat, MD
Professor of Pathology
Pathology
UW School of Medicine
Tuesday, March 11, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level.
Raymond Monnat, MD
Professor of Pathology
Pathology
UW School of Medicine
Tuesday, March 11, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level.
"The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair"
Lynn M. Schnapp, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, March 4, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Lynn M. Schnapp, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, March 4, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
"Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites"
Elaine W. Raines
Research Professor
Pathology
UW
Tuesday, February 12, 2008 - 8:30 AM
HSB, K-069
Elaine W. Raines
Research Professor
Pathology
UW
Tuesday, February 12, 2008 - 8:30 AM
HSB, K-069
The Genetic Basis of Fanconi Anemia and Other Heritable Chromosome Instability Syndromes
Dr. Holger Hoehn
Professor
Humangenetik Institute
University of Wurzburg
Thursday, February 7, 2008 - 3:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Peter Rabinovitch
Dr. Holger Hoehn
Professor
Humangenetik Institute
University of Wurzburg
Thursday, February 7, 2008 - 3:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Peter Rabinovitch
“The Role of Filamin in Transcriptional Control of Laminin Expression”
Christine K. Abrass, MD, FACP
Professor of Medicine
Division of Gerontology and Geriatric Medicine
UW
Tuesday, February 5, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Christine K. Abrass, MD, FACP
Professor of Medicine
Division of Gerontology and Geriatric Medicine
UW
Tuesday, February 5, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Encapsulated vascular smooth muscle cells to treat rat models of diabetes"
William Osborne, PhD
Research Professor
Pediatrics
UW
Tuesday, January 29, 2008 - 8:30 AM
HSB, K-069
William Osborne, PhD
Research Professor
Pediatrics
UW
Tuesday, January 29, 2008 - 8:30 AM
HSB, K-069
“Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system”
Esther Lutgens, MD, PhD
Associate Professor
Pathology
CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands
Tuesday, January 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Michael Rosenfeld, PhD
815 Mercer Street
Esther Lutgens, MD, PhD
Associate Professor
Pathology
CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands
Tuesday, January 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Michael Rosenfeld, PhD
815 Mercer Street
"Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature"
Yanfeng (Mei) Speer, PhD
Research Assistant Professor
Bioengineering
UW
Tuesday, January 15, 2008 - 8:30 AM
HSB, K-069
Yanfeng (Mei) Speer, PhD
Research Assistant Professor
Bioengineering
UW
Tuesday, January 15, 2008 - 8:30 AM
HSB, K-069
TBA
Roger E. Bumgarner, PhD
Associate Professor
Microbiology
UW
Tuesday, December 18, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Roger E. Bumgarner, PhD
Associate Professor
Microbiology
UW
Tuesday, December 18, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Secondary Mutations as a Mechanism of Cisplatin Resistance in BRCA1/2-Mutated Cancers: Lessons Learned from Studies on a Rare Genetic Disease, Fanconi Anemia
Toshiyasu Taniguchi, M.D., Ph.D.
Assistant Member
Divisions of Human Biology and Public Health Sciences
Fred Hutchinson Cancer Research Center
Monday, December 17, 2007 - 3:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology
Toshiyasu Taniguchi, M.D., Ph.D.
Assistant Member
Divisions of Human Biology and Public Health Sciences
Fred Hutchinson Cancer Research Center
Monday, December 17, 2007 - 3:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology
Physiological Functions of Activated Caspases in Macrophages
Thomas Nhan
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, December 13, 2007 - 10:00 AM
South Lake Union, Brotman Building Auditorium
Faculty Sponsor: Stephen Schwartz
Thomas Nhan
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, December 13, 2007 - 10:00 AM
South Lake Union, Brotman Building Auditorium
Faculty Sponsor: Stephen Schwartz
"Innate immune recognition and response to microbial pathogens"
Kelly Smith, MD, PhD
Assistant Professor
Pathology
UW
Tuesday, December 11, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Kelly Smith, MD, PhD
Assistant Professor
Pathology
UW
Tuesday, December 11, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Studying Connections between Cancer and Aging
Peter Rabinovitch, M.D., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Tuesday, December 11, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Peter Rabinovitch, M.D., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Tuesday, December 11, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Macrophage Mediators of Cardiac Fibrosis
April S. Stempien-Otero, MD
Assistant Professor of Medicine
Cardiology
UW
Tuesday, December 4, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
April S. Stempien-Otero, MD
Assistant Professor of Medicine
Cardiology
UW
Tuesday, December 4, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Where Do the Cells of the Atherosclerotic Plaque Come from and Where Do They Go?
Gwen Randolph, Ph.D.
Associate Professor
Department of Gene and Cell Medicine
Mount Sinai School of Medicine
Friday, November 30, 2007 - 4:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Stephen Schwartz
Gwen Randolph, Ph.D.
Associate Professor
Department of Gene and Cell Medicine
Mount Sinai School of Medicine
Friday, November 30, 2007 - 4:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Stephen Schwartz
"Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system"
Gustavo Matute-Bello, MD
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, November 27, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Gustavo Matute-Bello, MD
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, November 27, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Mitochondria, lifespan and the aging heart"
Peter S. Rabinovitch, M.D., Ph.D.
Professor
Pathology
UW
Tuesday, November 20, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Peter S. Rabinovitch, M.D., Ph.D.
Professor
Pathology
UW
Tuesday, November 20, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Loss of the Endocytic Protein Sorting Nexin 1 Promotes Colon Cancer Development
Matthew S. Holdren
University of Washington School of Medicine
Department of Pathology Graduate Student
UW Medicine Pathology
Monday, November 19, 2007 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Dan Bowen-Pope
Matthew S. Holdren
University of Washington School of Medicine
Department of Pathology Graduate Student
UW Medicine Pathology
Monday, November 19, 2007 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Dan Bowen-Pope
---
Christine Disteche, PhD
Professor of Pathology
UW School of Medicine
Tuesday, November 13, 2007 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Christine Disteche, PhD
Professor of Pathology
UW School of Medicine
Tuesday, November 13, 2007 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
"Human Embryonic Stem Cell Niches?"
C. Anthony Blau, MD
Professor of Medicine
Hematology
UW
Tuesday, November 13, 2007 - 8:30 AM
Brotman Building, 815 Mercer Street, SLU Auditorium
C. Anthony Blau, MD
Professor of Medicine
Hematology
UW
Tuesday, November 13, 2007 - 8:30 AM
Brotman Building, 815 Mercer Street, SLU Auditorium
"Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system"
Howard M. Shulman, M.D.
Professor
Pathology/Oncology
FHCRC
Tuesday, November 6, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Howard M. Shulman, M.D.
Professor
Pathology/Oncology
FHCRC
Tuesday, November 6, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
The Role of Epilysin (MMP-28) in Lung Inflammation and Epithelial Cell Survival
Anne Manicone, MD
Pulmonary and Critical Care Medicine
UW - Center for Lung Biology
Thursday, November 1, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street - refreshments at 3:45pm
Anne Manicone, MD
Pulmonary and Critical Care Medicine
UW - Center for Lung Biology
Thursday, November 1, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street - refreshments at 3:45pm
"Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine"
Glenn D. Prestwich, Ph.D.
Presidential Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials
The University of Utah
Tuesday, October 30, 2007 - 8:30 AM
SLU - Brotman Bulding, Blue Flame Auditorium
Faculty Sponsor: Thomas N. Wight, Ph.D.
815 Mercer Street
Glenn D. Prestwich, Ph.D.
Presidential Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials
The University of Utah
Tuesday, October 30, 2007 - 8:30 AM
SLU - Brotman Bulding, Blue Flame Auditorium
Faculty Sponsor: Thomas N. Wight, Ph.D.
815 Mercer Street
Ribosomes and Spindles in Marrow Failure and Cance Predisposition
Akiko Shimamura, MD
Associate Professor of Pediatrics
Division of Hematology/Oncology
UWSOM
Tuesday, October 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Akiko Shimamura, MD
Associate Professor of Pediatrics
Division of Hematology/Oncology
UWSOM
Tuesday, October 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
When Opportunities Arise, Be Ready
Raj Kapur, M.D., Ph.D.
Associate Professor
UW Medicine Pathology
University of Washington
Tuesday, October 9, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Raj Kapur, M.D., Ph.D.
Associate Professor
UW Medicine Pathology
University of Washington
Tuesday, October 9, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Leptin in Cardiovascular Disease
Daniel Eitzman
Assistant Professor
Internal Medicine/Cardiovascular Disease
University of Michigan
Wednesday, September 26, 2007 - 8:30 AM
Brotman Building, SLU, Blue Flame
Faculty Sponsor: Steve Schwartz
815 Mercer Street Reschedule - date tentative
Daniel Eitzman
Assistant Professor
Internal Medicine/Cardiovascular Disease
University of Michigan
Wednesday, September 26, 2007 - 8:30 AM
Brotman Building, SLU, Blue Flame
Faculty Sponsor: Steve Schwartz
815 Mercer Street Reschedule - date tentative
Clinical Experience of High Resolution Oligonucleotide Array:
Ji Yun Lee, Ph.D.
ABMG Training Program Trainee
Department of Human Genetics
Emory University
Monday, September 17, 2007 - 3:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided
Ji Yun Lee, Ph.D.
ABMG Training Program Trainee
Department of Human Genetics
Emory University
Monday, September 17, 2007 - 3:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided
Epithelial Differentiation in the Prostate: Insights from a Primary Cell Culture System
Beatrice Knudsen, M.D., Ph.D.
Affiliate Professor
UW Medicine Pathology
Member, FHCRC Division of Public Health Sciences
Tuesday, September 11, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Beatrice Knudsen, M.D., Ph.D.
Affiliate Professor
UW Medicine Pathology
Member, FHCRC Division of Public Health Sciences
Tuesday, September 11, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Base of Skull Chordoma: The Conundrum of Morphology and Biology
Benjamin Hoch, M.D.
Assistant Professor
Department of Pathology
Mount Sinai School of Medicine
Monday, August 20, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology
Benjamin Hoch, M.D.
Assistant Professor
Department of Pathology
Mount Sinai School of Medicine
Monday, August 20, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology
Multicolor Karyotyping & Banding in Non-Hodgkin Lymphoma and Bac Array CGH in Chronic Lymphocytic Leukemia
Valia S. Lestou, Ph.D.
Researcher
University of British Columbia Center for Disease Control
Tuesday, July 17, 2007 - 2:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Christine Disteche
Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology
Refreshments provided
Valia S. Lestou, Ph.D.
Researcher
University of British Columbia Center for Disease Control
Tuesday, July 17, 2007 - 2:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Christine Disteche
Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology
Refreshments provided
Insulin Modulation of Plasma beta-Amyloid levels
Pattie S. Green, PhD
Research Assistant Professor
Medicine
UWSOM
Tuesday, June 26, 2007 - 8:30 AM
TBA, TBA
Faculty Sponsor: Renee LeBoeuf
Pattie S. Green, PhD
Research Assistant Professor
Medicine
UWSOM
Tuesday, June 26, 2007 - 8:30 AM
TBA, TBA
Faculty Sponsor: Renee LeBoeuf
It's a Small World After All: The MicroRNA Gene Expression Profile of HCV-Associated Hepatocellular Carcinoma
Heike Varnholt, M.D.
Staff Pathologist
Division of Gastrointestinal and Hepatobiliary Pathology
University Hospital of Cologne, Germany
Friday, June 22, 2007 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Melissa Upton
Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided.
Heike Varnholt, M.D.
Staff Pathologist
Division of Gastrointestinal and Hepatobiliary Pathology
University Hospital of Cologne, Germany
Friday, June 22, 2007 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Melissa Upton
Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided.
TBA
Larry Adams
Senior Research Scientist
Pathology
UWSOM
Tuesday, June 19, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Larry Adams
Senior Research Scientist
Pathology
UWSOM
Tuesday, June 19, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Finding Genes for Uterine Fibroids
Jennelle Hodge, Ph.D.
Senior Research Fellow
Department of OB-GYN and Reproductive Biology
Brigham and Women's Hospital, Harvard Medical School
Monday, June 11, 2007 - 3:30 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche
Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology
Jennelle Hodge, Ph.D.
Senior Research Fellow
Department of OB-GYN and Reproductive Biology
Brigham and Women's Hospital, Harvard Medical School
Monday, June 11, 2007 - 3:30 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche
Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology
Roles of cytokines in regulation of bone mass
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
RGS5: Regulating the Regulator
William M. Mahoney Jr.
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, June 5, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
William M. Mahoney Jr.
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, June 5, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Erythropoietin and Cancer – A Window of Opportunity for Pharmacologically Regulated Cell Therapy?
C Anthony (Tony) Blau, MD
Professor
Medicine, Hematology
UWSOM
Thursday, May 31, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
C Anthony (Tony) Blau, MD
Professor
Medicine, Hematology
UWSOM
Thursday, May 31, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease?
Wendy Thomas
Assistant Professor
Bioengineering
UWSOM
Tuesday, May 29, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Wendy Thomas
Assistant Professor
Bioengineering
UWSOM
Tuesday, May 29, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chorea vs Parkinsonism: The Search for Primary Centers for Degeneration
Jean Paul Vonsattel, M.D.
Professor
Department of Pathology
Columbia University Medical Center
Wednesday, May 23, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002.
Jean Paul Vonsattel, M.D.
Professor
Department of Pathology
Columbia University Medical Center
Wednesday, May 23, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002.
Molecular Mechanisms of Regulation of L-type Calcium Channels
Michelle Emrick
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 22, 2007 - 8:30 AM
Health Sciences, K-069
Michelle Emrick
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 22, 2007 - 8:30 AM
Health Sciences, K-069
TGF-beta signaling in kidney cells
Anne-Christine Poncelet
Acting Instructor
Medicine-Gerontology
UW School of Medicine
Tuesday, May 15, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Anne-Christine Poncelet
Acting Instructor
Medicine-Gerontology
UW School of Medicine
Tuesday, May 15, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chromatin Profiling of the Human Genome: Genomic Distribution and Characterization of Insulator Elements
Anton Krumm PhD
Research Assistant Professor
Radiation Oncology
UW School of Medicine
Thursday, May 10, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Anton Krumm PhD
Research Assistant Professor
Radiation Oncology
UW School of Medicine
Thursday, May 10, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Mortar and Bricks
Melissa Upton, M.D.
Associate Professor, Assistant Chief of Anatomic Pathology
Department of Pathology
University of Washington
Tuesday, May 8, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Melissa Upton, M.D.
Associate Professor, Assistant Chief of Anatomic Pathology
Department of Pathology
University of Washington
Tuesday, May 8, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice
Guy Odom
Senior Fellow
Neurology
UWSOM
Tuesday, May 8, 2007 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Guy Odom
Senior Fellow
Neurology
UWSOM
Tuesday, May 8, 2007 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
To Call or Not to Call: The Challenge of Intraoperative Frozen Section
Gang He, M.D., Ph.D.
Bone and Soft Tissue Fellow
Department of Pathology
University of Chicago
Monday, May 7, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. He is a clinical faculty candidate for bone and soft tissue pathology.
Gang He, M.D., Ph.D.
Bone and Soft Tissue Fellow
Department of Pathology
University of Chicago
Monday, May 7, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. He is a clinical faculty candidate for bone and soft tissue pathology.
Diabetes, obesity and the brain
Michael Schwartz
Professor
Metabolism, Endocrinology and Nutrition
UWSOM, Clincal Nutrition, Harborview
Thursday, May 3, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Michael Schwartz
Professor
Metabolism, Endocrinology and Nutrition
UWSOM, Clincal Nutrition, Harborview
Thursday, May 3, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
The role of P2X7 and activated caspases in the regulation of macrophage fusion
Thomas Nhan
PhD Candidate
Pathology
UW School of Medicine
Tuesday, May 1, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Thomas Nhan
PhD Candidate
Pathology
UW School of Medicine
Tuesday, May 1, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Matrilysin (MMP-7) function in acute and chronic lung injury
John K. McGuire, MD
Pediatric Critical Care Medicine
Children's Hospital & Regional Medical Center
UW School of Medicine
Thursday, April 26, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
John K. McGuire, MD
Pediatric Critical Care Medicine
Children's Hospital & Regional Medical Center
UW School of Medicine
Thursday, April 26, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Mechanisms Underlying the Influence of Androgens on Prostate Carcinogenesis
Peter S. Nelson
Associate Professor
Medicine, Oncology
Fred Hutchinson Cancer Research Center
Thursday, April 19, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments 3:45 p.m.
Peter S. Nelson
Associate Professor
Medicine, Oncology
Fred Hutchinson Cancer Research Center
Thursday, April 19, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments 3:45 p.m.
Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction
Daniel J. Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 17, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Steve Schwartz
Daniel J. Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 17, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Steve Schwartz
TBA
Ray Monnat, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, April 10, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Ray Monnat, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, April 10, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad
Joseph McGonigle
Research Assistant
Bioengineering
UWSOM
Tuesday, April 10, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Cecilia Giachelli
815 Mercer Street
Joseph McGonigle
Research Assistant
Bioengineering
UWSOM
Tuesday, April 10, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Cecilia Giachelli
815 Mercer Street
Saving the World from the Next Pandemic: Can Functional Genomics and Computational Biology Save Us?
Michael G. Katze, PhD
Professor of Microbiology
Core Staff Scientist and Associate Director
Washington NPRC
Thursday, April 5, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments 4:45 p.m.
Michael G. Katze, PhD
Professor of Microbiology
Core Staff Scientist and Associate Director
Washington NPRC
Thursday, April 5, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments 4:45 p.m.
Understanding macrophage foam cell formation using a proteomics-based approach
Lev Becker
Senior Fellow
Medicine, Division of Metabolism, Endocrinology and Nutrition
UWSOM
Tuesday, April 3, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Jay Heinecke
815 Mercer Street
Lev Becker
Senior Fellow
Medicine, Division of Metabolism, Endocrinology and Nutrition
UWSOM
Tuesday, April 3, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Jay Heinecke
815 Mercer Street
DNA Processing in Autoimmune Disease
Fred Perrino, Ph.D.
Professor
Department of Biochemistry
Wake Forest University Health Sciences
Monday, April 2, 2007 - 11:30 AM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb and Brad Preston
Fred Perrino, Ph.D.
Professor
Department of Biochemistry
Wake Forest University Health Sciences
Monday, April 2, 2007 - 11:30 AM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb and Brad Preston
Immunomodulation of breast cancer?
Nora Disis, MD
Professor
Medicine
UWSOM, Member Fred Hutchinson Cancer Research Center
Thursday, March 29, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Nora Disis, MD
Professor
Medicine
UWSOM, Member Fred Hutchinson Cancer Research Center
Thursday, March 29, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Probing chromatin dynamics
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, March 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, March 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Repair of oxidative DNA damage and human disease
Dr. Will Bohr
NIA
Wednesday, March 21, 2007 - 4:30 PM
Health Sciences Building, K-069
Faculty Sponsor: Dr. Monnat
This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP).
Dr. Will Bohr
NIA
Wednesday, March 21, 2007 - 4:30 PM
Health Sciences Building, K-069
Faculty Sponsor: Dr. Monnat
This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP).
Angiotensin II-induced vascular pathologies - a multitude of mechanisms
Alan Daugherty
Professor
Cardiovascular Medicine
University of Kentucky
Tuesday, March 20, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Mike Rosenfeld
815 Mercer Street
Alan Daugherty
Professor
Cardiovascular Medicine
University of Kentucky
Tuesday, March 20, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Mike Rosenfeld
815 Mercer Street
Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: Systemic Sclerosis
Richard A Nash, MD
Associate Professor
Medicine, Division of Oncology
Fred Hutchinson Cancer Research Center
Thursday, March 15, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Richard A Nash, MD
Associate Professor
Medicine, Division of Oncology
Fred Hutchinson Cancer Research Center
Thursday, March 15, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
My Adventures in Biomed Research: How You Can Help Us Move Beyond Gleason Grade
Larry True, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, March 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Larry True, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, March 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
A ROCK and Role for Syndecans in Cytoskeletal Regulation
John R. Couchman
Professor
National Heart & Lung Institute
Imperial College, London
Tuesday, March 13, 2007 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Bill Parks
815 Mercer Street
John R. Couchman
Professor
National Heart & Lung Institute
Imperial College, London
Tuesday, March 13, 2007 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Bill Parks
815 Mercer Street
Chemical Genetics and Translational Research in Skin Cancer
Paul Nghiem, MD PhD
Asst. Professor, UW Dermatology/Medicine
Affiliate Investigator
Fred Hutchinson Cancer Research Center
Thursday, March 8, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
* Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer.
Paul Nghiem, MD PhD
Asst. Professor, UW Dermatology/Medicine
Affiliate Investigator
Fred Hutchinson Cancer Research Center
Thursday, March 8, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
* Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer.
Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries?
Jo Fleming
Scleroderma Research Fellow
Pathology
UWSOM
Tuesday, March 6, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street RESCHEDULED!
Jo Fleming
Scleroderma Research Fellow
Pathology
UWSOM
Tuesday, March 6, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street RESCHEDULED!
Understanding HSV-2 Reactivations: New Observations, New Surprises
Lawrence Corey, MD
Professor, Laboratory Medicine
Adjunct Professor, Pediatrics
Fred Hutchinson Cancer Research Center
Thursday, March 1, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Lawrence Corey, MD
Professor, Laboratory Medicine
Adjunct Professor, Pediatrics
Fred Hutchinson Cancer Research Center
Thursday, March 1, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation
Jonathan Golob
Graduate Student
Pathology
UWSOM
Tuesday, February 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Jonathan Golob
Graduate Student
Pathology
UWSOM
Tuesday, February 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
The Regulation of Long-term Repopulating Hematopoietic Stem Cells (LTR-HSC) by Endogenous Transforming Growth Factor Beta (TGF-beta)
Stephen Bartelmez PhD
BetaStem Therapeutics Inc, San Francisco
Thursday, February 22, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Stephen Bartelmez PhD
BetaStem Therapeutics Inc, San Francisco
Thursday, February 22, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Pathological Protein in Neurodegenerative Diseases
Tom Montine, M.D., Ph.D.
Professor, Director of Neuropathology
Department of Pathology
University of Washington
Tuesday, February 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Tom Montine, M.D., Ph.D.
Professor, Director of Neuropathology
Department of Pathology
University of Washington
Tuesday, February 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Adult Stem Cells: Epigenetics, pluripotency and plasticity
Morayma Reyes
Assistant Professor
Pathology and Laboratory Medicine
UWSOM
Tuesday, February 13, 2007 - 8:30 AM
SLU, Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Morayma Reyes
Assistant Professor
Pathology and Laboratory Medicine
UWSOM
Tuesday, February 13, 2007 - 8:30 AM
SLU, Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Immunoexpression of Hypoxia-related Genes in Retroperitoneal Sarcomas
Paul Zhang, M.D.
Associate Professor
Pathology and Lab Medicine
University of Pennsylvania School of Medicine
Monday, February 12, 2007 - 1:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Larry True
Speaker is a candidate for a clinical faculty position with the Department of Pathology
Paul Zhang, M.D.
Associate Professor
Pathology and Lab Medicine
University of Pennsylvania School of Medicine
Monday, February 12, 2007 - 1:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Larry True
Speaker is a candidate for a clinical faculty position with the Department of Pathology
A Trojan Horse Nips at an Achilles Heel: Gallium as an Anti-infective Therapy
Pradeep Singh MD
Associate Professor
Medicine and Microbiology, Pulmonary and Critical Care Medicine
UW School of Medicine
Thursday, February 8, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments: 3:45 p.m.
Pradeep Singh MD
Associate Professor
Medicine and Microbiology, Pulmonary and Critical Care Medicine
UW School of Medicine
Thursday, February 8, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments: 3:45 p.m.
Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies.
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis
Ranjini M. Krishnan
Fellow
Cardiology
UWSOM
Tuesday, February 6, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: David Dichek
Ranjini M. Krishnan
Fellow
Cardiology
UWSOM
Tuesday, February 6, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: David Dichek
Subtelomere Dynamics: Why So Many Breaks?
Katie Rudd, Ph.D.
Postdoctoral Fellow
Fred Hutchinson Cancer Research Center
Wednesday, January 31, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche
Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology
Katie Rudd, Ph.D.
Postdoctoral Fellow
Fred Hutchinson Cancer Research Center
Wednesday, January 31, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche
Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology
Monocytes, Dendritic Cells, and Atherosclerosis
Gwen Randollph
Associate Professor
Gene & Cell Medicine
Mt. Sinai School of Medicine
Tuesday, January 30, 2007 - 10:00 AM
Health Sciences, K-069
Faculty Sponsor: Elaine Raines/Stephen Schwartz
Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project
Gwen Randollph
Associate Professor
Gene & Cell Medicine
Mt. Sinai School of Medicine
Tuesday, January 30, 2007 - 10:00 AM
Health Sciences, K-069
Faculty Sponsor: Elaine Raines/Stephen Schwartz
Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project
Genome of Weird Australian Mammals
Jenny Graves, Ph.D.
Professor
Comparative Genomics
Australian National University
Monday, January 29, 2007 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche
Jenny Graves, Ph.D.
Professor
Comparative Genomics
Australian National University
Monday, January 29, 2007 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche
Gene Action in the Pathobiology of Aging
George M. Martin
Director Emeritus, Alzheimer’s Disease Research Center (ADRC)
Professor Emeritus (Active), Department of Pathology
UW School of Medicine
Thursday, January 25, 2007 - 4:00 PM
Brotman Building (SLU), Blue Flame Auditorium
815 Mercer Street
George M. Martin
Director Emeritus, Alzheimer’s Disease Research Center (ADRC)
Professor Emeritus (Active), Department of Pathology
UW School of Medicine
Thursday, January 25, 2007 - 4:00 PM
Brotman Building (SLU), Blue Flame Auditorium
815 Mercer Street
Magnetic Resonance Imaging of Atherosclerosis
Hunter R. Underhill
Fellow
Vascular Imaging Lab
UWSOM
Tuesday, January 23, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Hunter R. Underhill
Fellow
Vascular Imaging Lab
UWSOM
Tuesday, January 23, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Caspase regulation of macrophage functions
Thomas Q. Nhan
PhD Candidate
Pathology
UWSOM
Tuesday, January 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Thomas Q. Nhan
PhD Candidate
Pathology
UWSOM
Tuesday, January 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
How Autopsies Have Expedited Research on Human Progeroid Syndromes, With Comments on the Viability and Cryopreservation of Postmortem Tissues
George Martin, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, January 9, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
George Martin, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, January 9, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Tissue voxelation with a high-speed transverse microtome
John Welsh, PhD
Associate Professor
Molecular and Cancer Biology Program
Sidney Kimmel Cancer Center, San Diego, California
Tuesday, January 9, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Marshall Horwitz
815 Mercer Street
John Welsh, PhD
Associate Professor
Molecular and Cancer Biology Program
Sidney Kimmel Cancer Center, San Diego, California
Tuesday, January 9, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Marshall Horwitz
815 Mercer Street
Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease
Hangjun Duan
Senior Fellow
Pathology
UWSOM
Tuesday, December 19, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Hangjun Duan
Senior Fellow
Pathology
UWSOM
Tuesday, December 19, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Neurogenesis and Malformations of Cortical Development
Robert Hevner, M.D., Ph.D.
Associate Professor
Department of Pathology
University of Washington
Tuesday, December 12, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Robert Hevner, M.D., Ph.D.
Associate Professor
Department of Pathology
University of Washington
Tuesday, December 12, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
BTNL2, a novel B7 family member and regulator of T cell activation
Heather Arnett
Scientist
Amgen, Inc.
Tuesday, December 5, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Heather Arnett
Scientist
Amgen, Inc.
Tuesday, December 5, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
The Ins and Outs of Bcl-2 in Cell Death
John M. Harlan, MD
Chief
Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology
University of Washington
Tuesday, November 21, 2006 - 8:30 AM
Health Sciences Building, K-069
John M. Harlan, MD
Chief
Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology
University of Washington
Tuesday, November 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Update of Cervical Cancer Control
Nancy Kiviat MD
Professor, Chief of HMC Pathology
Pathology
UWSOM, Harborview
Thursday, November 16, 2006 - 4:00 PM
Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Nancy Kiviat MD
Professor, Chief of HMC Pathology
Pathology
UWSOM, Harborview
Thursday, November 16, 2006 - 4:00 PM
Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Updates on Cervical Cytology
Nancy Kiviat, M.D.
Professor, Chief of HMC Pathology
Department of Pathology
University of Washington
Tuesday, November 14, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Nancy Kiviat, M.D.
Professor, Chief of HMC Pathology
Department of Pathology
University of Washington
Tuesday, November 14, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
TSLP and Th2-mediated inflammation
Steven F. Ziegler, PhD
Director
Immunology Program
Benaroya Research Institute
Tuesday, November 14, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Steven F. Ziegler, PhD
Director
Immunology Program
Benaroya Research Institute
Tuesday, November 14, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Towards Targeted Therapy in Sarcoma: Somatostatin Type-2 Receptor Expression in Bone and Soft Tissue Tumors
William Ahrens
Senior Fellow
Surgical Pathology - Bone and Soft Tissue
Mayo Clinic
Tuesday, November 7, 2006 - 11:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology
William Ahrens
Senior Fellow
Surgical Pathology - Bone and Soft Tissue
Mayo Clinic
Tuesday, November 7, 2006 - 11:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology
Differentiation of Endothelium from Human Embryonic Stem Cells
Marilyn Nourse
PhD Candidate
Pathology
UWSOM
Tuesday, November 7, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Marilyn Nourse
PhD Candidate
Pathology
UWSOM
Tuesday, November 7, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
Fredrik Johansson
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, October 31, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Karin Bornfeldt
Fredrik Johansson
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, October 31, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Karin Bornfeldt
Calcium Sparklets in Vascular Smooth Muscle
Manuel F. Navedo
Senior Fellow
Physiology and Biophysics
UWSOM
Tuesday, October 24, 2006 - 8:30 AM
Health Sciences Building, K-069
Manuel F. Navedo
Senior Fellow
Physiology and Biophysics
UWSOM
Tuesday, October 24, 2006 - 8:30 AM
Health Sciences Building, K-069
Mutation avoidance, disease, and error catastrophy: The great escape
Bradley D. Preston
Professor
Pathology
UWSOM
Thursday, October 19, 2006 - 3:45 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Bradley D. Preston
Professor
Pathology
UWSOM
Thursday, October 19, 2006 - 3:45 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Cancelled will reschedule for spring
David Lovett - postponed
Professor in Residence
Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital
University of California, San Francisco
Tuesday, October 17, 2006 - 8:30 AM
TBA, TBA
David Lovett - postponed
Professor in Residence
Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital
University of California, San Francisco
Tuesday, October 17, 2006 - 8:30 AM
TBA, TBA
Hepatitis C Associated Cryoglobulinemia and Glomerulonephritis: A Tale of Mice and Men
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, October 10, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, October 10, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
PSGL-1 Adherence and mTOR Modulate Translation in Macrophages
Richard Fox
PhD Candidate
Pathology
UW School of Medicine
Tuesday, October 10, 2006 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street
Richard Fox
PhD Candidate
Pathology
UW School of Medicine
Tuesday, October 10, 2006 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street
cFLIP Regulates Fas-induced Apoptosis and Pro-inflammatory Gene Expression in Human Vascular Smooth Muscle Cells
Monja Dishmon
Pathology
UW School of Medicine
Thursday, October 5, 2006 - 1:00 PM
815 Mercer Bldg, Room 111
Faculty Sponsor: Bowen-Pope
Monja Dishmon
Pathology
UW School of Medicine
Thursday, October 5, 2006 - 1:00 PM
815 Mercer Bldg, Room 111
Faculty Sponsor: Bowen-Pope
An unexpected role for the tissue factor pathway in atherosclerosis
Robert D. Simari
Professor
Cardiovascular Diseases
Mayo Clinic
Tuesday, October 3, 2006 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Robert D. Simari
Professor
Cardiovascular Diseases
Mayo Clinic
Tuesday, October 3, 2006 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Of mice and mice; why some do and some don't develop arterial lesions
Michael A Reidy PhD
Professor
Pathology
UWSOM
Tuesday, September 26, 2006 - 8:30 AM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Michael A Reidy PhD
Professor
Pathology
UWSOM
Tuesday, September 26, 2006 - 8:30 AM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Interventional imaging of vascular gene delivery and expression
Xiaoming Yang, MD, PhD
Professor, Director, Image-Guided Bio-Molecular Interventions Research
Radiology
University of Washington School of Medicine
Thursday, September 21, 2006 - 4:00 PM
Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
Xiaoming Yang, MD, PhD
Professor, Director, Image-Guided Bio-Molecular Interventions Research
Radiology
University of Washington School of Medicine
Thursday, September 21, 2006 - 4:00 PM
Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
Thyroid Dysfunction in Heart Failure
A. Martin Gerdes
Professor, Medicine and Director
South Dakota Cardiovascular Research Institute, Sioux Falls
University of South Dakota
Thursday, September 14, 2006 - 8:30 AM
Brotman Building, 815 Mercer Street, Room 111, Auditorium
Faculty Sponsor: Chuck Murry
Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able.
A. Martin Gerdes
Professor, Medicine and Director
South Dakota Cardiovascular Research Institute, Sioux Falls
University of South Dakota
Thursday, September 14, 2006 - 8:30 AM
Brotman Building, 815 Mercer Street, Room 111, Auditorium
Faculty Sponsor: Chuck Murry
Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able.
Arterial Rupture--Pathology and Genetics
Peter Byers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, September 12, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Peter Byers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, September 12, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Electrophysiological Cortical Imaging of Brain Electrical Activity
Yuan Lai, PhD
Fellow Candidate
Electrical Engineering
University of Illinois, Chicago
Thursday, August 31, 2006 - 1:30 PM
Brotman Building (SLU), 110
Faculty Sponsor: Chun Yuan
815 Mercer Street Vascular Imaging Labororatory Seminar
Yuan Lai, PhD
Fellow Candidate
Electrical Engineering
University of Illinois, Chicago
Thursday, August 31, 2006 - 1:30 PM
Brotman Building (SLU), 110
Faculty Sponsor: Chun Yuan
815 Mercer Street Vascular Imaging Labororatory Seminar
Mechanism of Endocytosis of CD33/Siglec-3:Role of ITIMs, Tyrosine Phosphorylation, and Monoubiquitylation
Roland Walter
Pathology
UWSOM
Wednesday, August 9, 2006 - 4:30 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Dr. Steve Collins
Roland Walter
Pathology
UWSOM
Wednesday, August 9, 2006 - 4:30 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Dr. Steve Collins
Toxicogenomics of Endemic Nephropathy: A Multinational Disease
Arthur Grollman, M.D.
Distinguished Professor of Pharmacological Sciences and Medicine
State University of New York at Stony Brook
Wednesday, August 2, 2006 - 3:30 PM
Health Sciencs Center, K-069
Faculty Sponsor: Dr. Larry Loeb
Arthur Grollman, M.D.
Distinguished Professor of Pharmacological Sciences and Medicine
State University of New York at Stony Brook
Wednesday, August 2, 2006 - 3:30 PM
Health Sciencs Center, K-069
Faculty Sponsor: Dr. Larry Loeb
“Functional genomics and liver regeneration”
Jiangning Li
Doctoral Dissertation
Pathology
Medicine
Tuesday, August 1, 2006 - 8:30 AM
HSB, T-473
Faculty Sponsor: Dr. Bumgarner
Jiangning Li
Doctoral Dissertation
Pathology
Medicine
Tuesday, August 1, 2006 - 8:30 AM
HSB, T-473
Faculty Sponsor: Dr. Bumgarner
Role of CHF1/Hey2 in Cardiovascular Development
Michael T. Chin, MD/Phd
Assistant Professor
Medicine
Harvard Medical School
Thursday, July 27, 2006 - 4:15 AM
SLU 815 Mercer Street, 111, Auditorium
SLUGs Present Tapas
Michael T. Chin, MD/Phd
Assistant Professor
Medicine
Harvard Medical School
Thursday, July 27, 2006 - 4:15 AM
SLU 815 Mercer Street, 111, Auditorium
SLUGs Present Tapas
The rupture-prone human plaque: how to define and detect it
Erling Falk
Professor
Department of Cardiology
Skejby University Hospital, Aarhus, Denmark
Tuesday, June 27, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Steve Schwartz
Erling Falk
Professor
Department of Cardiology
Skejby University Hospital, Aarhus, Denmark
Tuesday, June 27, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Steve Schwartz
Protection of cardiovascular stem cells by cholesterol-lowering therapy
Yong-Jian Geng, MD PhD
Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research
Dept. of Internal Medicine, Cardiology Division
University of Texas School of Medicine, Houston, TX
Tuesday, June 20, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Chuck Murry
Yong-Jian Geng, MD PhD
Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research
Dept. of Internal Medicine, Cardiology Division
University of Texas School of Medicine, Houston, TX
Tuesday, June 20, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Chuck Murry
Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
"X Chromosome Upregulation and its Biological Significance in Mammals"
Di Kim Nguyen
Doctoral Dissertation
Pathology
UWSOM
Wednesday, May 31, 2006 - 10:30 AM
HSB, T-435
Faculty Sponsor: Christine Disteche
Di Kim Nguyen
Doctoral Dissertation
Pathology
UWSOM
Wednesday, May 31, 2006 - 10:30 AM
HSB, T-435
Faculty Sponsor: Christine Disteche
Distinct Wnt signaling pathways play opposing roles during organ regeneration
Cristi Stoick-Cooper
CVP Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, May 30, 2006 - 8:30 AM
HSB, K-069
Cristi Stoick-Cooper
CVP Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, May 30, 2006 - 8:30 AM
HSB, K-069
Therapeutic use of the endogenous metalloprotease inhibitor TIMP-3
Roy A. Black, Ph.D.
Associate Director of Research
Department of Inflammation
Amgen Inc.
Thursday, May 25, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Roy A. Black, Ph.D.
Associate Director of Research
Department of Inflammation
Amgen Inc.
Thursday, May 25, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease
Daniel J Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 23, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Stephen M Schwartz
Daniel J Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 23, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Stephen M Schwartz
Matrix Revisited
Thomas N. Wight, Ph.D.
Benaroya Research Institute
Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology
School of Medicine
Thursday, May 18, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Thomas N. Wight, Ph.D.
Benaroya Research Institute
Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology
School of Medicine
Thursday, May 18, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
“Global analysis of X chromosome dosage compensation"
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
Cardiac applications for human embryonic stem cells
Michael Laflamme
Acting Instructor
Pathology
Center for Cardiovascular Biology & Regenerative Medicine, UWSOM
Tuesday, May 2, 2006 - 8:30 AM
SLU 815 Mercer St, 111
Faculty Sponsor: Chuck Murry
Michael Laflamme
Acting Instructor
Pathology
Center for Cardiovascular Biology & Regenerative Medicine, UWSOM
Tuesday, May 2, 2006 - 8:30 AM
SLU 815 Mercer St, 111
Faculty Sponsor: Chuck Murry
Wnt Signaling in Regeneration and Regenerative Medicine
Randall T. Moon, Ph.D.
Professor and Director, Institute for Stem Cell and Regenerative Medicine
Department of Pharmacology
School of Medicine
Thursday, April 27, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: BIll Parks
Randall T. Moon, Ph.D.
Professor and Director, Institute for Stem Cell and Regenerative Medicine
Department of Pharmacology
School of Medicine
Thursday, April 27, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: BIll Parks
Neurovascular Dementia: How Abnormalities of Cerebral Blood Vessels and Brain Parenchyma Compete
Harry Vinters, M.D.
Professor and Chief, Neuropathology
Departments of Pathology and Laboratory Medicine
University of California, Los Angeles
Wednesday, April 26, 2006 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
Harry Vinters, M.D.
Professor and Chief, Neuropathology
Departments of Pathology and Laboratory Medicine
University of California, Los Angeles
Wednesday, April 26, 2006 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
**NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology"
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Inflammation loci and carotid artery disease
Gail Jarvik MD
Professor
Medicine, Medical Genetics
UWSOM
Tuesday, April 25, 2006 - 8:30 AM
SLU 815 Mercer, 111 Auditorium
Faculty Sponsor: Stephen M Schwartz
Gail Jarvik MD
Professor
Medicine, Medical Genetics
UWSOM
Tuesday, April 25, 2006 - 8:30 AM
SLU 815 Mercer, 111 Auditorium
Faculty Sponsor: Stephen M Schwartz
Proteomic Analysis of the Cardiac Calcium Channel
Michelle Emrick PhD
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 18, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Michelle Emrick PhD
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 18, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
The role of estrogens in maintaining brain function after injury: Views of a basic scientist and provost
Phyllis M. Wise, Ph.D.
Provost and Vice President for Academic Affairs
University of Washington
Friday, April 14, 2006 - 12:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Phyllis M. Wise, Ph.D.
Provost and Vice President for Academic Affairs
University of Washington
Friday, April 14, 2006 - 12:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Diabetic Macrovascular Disease in Mice: What the &#@*'s going on?
Renee C. LeBoeuf, Ph.D.
Research Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
School of Medicine
Thursday, April 13, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Renee C. LeBoeuf, Ph.D.
Research Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
School of Medicine
Thursday, April 13, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
The Role of Pattern Recognition Receptors in Macrophage Death
Ira Tabas, MD/PhD
Professor, Medicine and Anatomy & Cell Biology
Deputy Editor - Journal of Clinical Investigation
Columbia University
Tuesday, April 11, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Michael Rosenfeld
Ira Tabas, MD/PhD
Professor, Medicine and Anatomy & Cell Biology
Deputy Editor - Journal of Clinical Investigation
Columbia University
Tuesday, April 11, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Michael Rosenfeld
Defining a Functional Role for Discoidin Domain Receptors in Vascular Biology
Michelle Bendeck, Ph.D.
Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
Friday, April 7, 2006 - 10:00 AM
815 Mercer, Blue Flame Auditorium
Faculty Sponsor: Michael Reidy
Michelle Bendeck, Ph.D.
Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
Friday, April 7, 2006 - 10:00 AM
815 Mercer, Blue Flame Auditorium
Faculty Sponsor: Michael Reidy
Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology?
Adam S. Wilkins
Editor, BioEssays
Company of Biologists, Ltd.
Cambridge, UK
Tuesday, April 4, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Karol Bomsztyk
Adam S. Wilkins
Editor, BioEssays
Company of Biologists, Ltd.
Cambridge, UK
Tuesday, April 4, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Karol Bomsztyk
A Systems Approach to Dissecting Immunity
Alan Aderem, Ph.D.
Institute for Systems Biology, and Affiliate Professor
UW Department of Immunology
Institute for Systems Biology
Thursday, March 30, 2006 - 4:00 AM
815 Mercer St., SLU, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Alan Aderem, Ph.D.
Institute for Systems Biology, and Affiliate Professor
UW Department of Immunology
Institute for Systems Biology
Thursday, March 30, 2006 - 4:00 AM
815 Mercer St., SLU, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
"Effects of Regulated Expression of Hepatitis C Virus Proteins on HH4 Human Hepatocytes"
Weiliang Tang
Pathology
University of Washington
Tuesday, March 28, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Fausto
Weiliang Tang
Pathology
University of Washington
Tuesday, March 28, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Fausto
Regulatory T cells, TGF-beta and atherosclerosis
Goran K. Hansson
Professor
Cardiovascular Research, Molecular Medicine
Karolinska Institutet, Stockhom, Sweden
Tuesday, March 28, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Goran K. Hansson
Professor
Cardiovascular Research, Molecular Medicine
Karolinska Institutet, Stockhom, Sweden
Tuesday, March 28, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Structure Biology of Ubiquitin Ligase Machinery
Ning Zheng
Assistant Professor
Pharmacology
UWSOM
Tuesday, March 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Ning Zheng
Assistant Professor
Pharmacology
UWSOM
Tuesday, March 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Atheroprotective Effects of Transforming Growth Factor Beta-1
Andrew D. Frutkin, MD
Acting Instructor/Senior Fellow
Cardiology Division
UWSOM
Tuesday, March 14, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: David Dichek
Please note change of venue
Andrew D. Frutkin, MD
Acting Instructor/Senior Fellow
Cardiology Division
UWSOM
Tuesday, March 14, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: David Dichek
Please note change of venue
Mechanism of the Cerebral Cortex Malformation Caused by FGFR3 Mutations
Tomoko Iwata, Ph.D.
Beatson Laboratories for Cancer Research
University of Glasgow
Scotland, UK
Friday, March 10, 2006 - 9:30 AM
Harborview Medical Center, R&T Building, Room 109
Faculty Sponsor: Robert Hevner
Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning.
The lecture is free and open to the public.
Tomoko Iwata, Ph.D.
Beatson Laboratories for Cancer Research
University of Glasgow
Scotland, UK
Friday, March 10, 2006 - 9:30 AM
Harborview Medical Center, R&T Building, Room 109
Faculty Sponsor: Robert Hevner
Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning.
The lecture is free and open to the public.
Cell Therapy for Cardiac Arrhythmias and Myocardial Regeneration
Lior Gepstein, M.D., Ph.D.
Associate Professor, Faculty of Medicine
Department of Physiology and Biophysics
Technion-Israel Institute of Technology
Thursday, March 9, 2006 - 4:00 AM
815 Mercer Street, SLU, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Lior Gepstein, M.D., Ph.D.
Associate Professor, Faculty of Medicine
Department of Physiology and Biophysics
Technion-Israel Institute of Technology
Thursday, March 9, 2006 - 4:00 AM
815 Mercer Street, SLU, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
The CD4+ autoreactive T cell: chance or necessity?
Gerald T. Nepom, MD/PhD
Director
Benaroya Research Institute at Virginia Mason
Tuesday, March 7, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Gerald T. Nepom, MD/PhD
Director
Benaroya Research Institute at Virginia Mason
Tuesday, March 7, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Distinguished Faculty Lecture
"Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice"
Michael Rosenfeld, Ph.D.
Professor
Department of Pathobiology
University of Washington
Thursday, March 2, 2006 - 3:30 PM
Health Sciences Center, Room T-625
Faculty Sponsor: Terrance Kavanagh
For more information, please contact Billie Grace at 206.543.1144
"Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice"
Michael Rosenfeld, Ph.D.
Professor
Department of Pathobiology
University of Washington
Thursday, March 2, 2006 - 3:30 PM
Health Sciences Center, Room T-625
Faculty Sponsor: Terrance Kavanagh
For more information, please contact Billie Grace at 206.543.1144
C-reactive protein and cardiovascular risk: a population genomics approach
Alex Reiner, MD MSc
Research Associate Professor
Epidemioloy & Laboratory Medicine
UWSOM
Tuesday, February 28, 2006 - 8:30 AM
SLU 815 Mercer, 111
Faculty Sponsor: Stephen M. Schwartz
Alex Reiner, MD MSc
Research Associate Professor
Epidemioloy & Laboratory Medicine
UWSOM
Tuesday, February 28, 2006 - 8:30 AM
SLU 815 Mercer, 111
Faculty Sponsor: Stephen M. Schwartz
VEGF: From Bench to Bedside
Napoleone Ferrara
Genentech Fellow
Molecular Oncology
Genentech, Inc
Wednesday, February 22, 2006 - 4:00 PM
Health Sciences Center, Room T-739
Faculty Sponsor: Stephen Schwartz
Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer.
The lecture is free and open to the public.
Napoleone Ferrara
Genentech Fellow
Molecular Oncology
Genentech, Inc
Wednesday, February 22, 2006 - 4:00 PM
Health Sciences Center, Room T-739
Faculty Sponsor: Stephen Schwartz
Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer.
The lecture is free and open to the public.
Clinical Genetics and Genomics of Type I Collagen
Peter Byers, MD
Professor
Pathology & Medicine
UWSOM
Tuesday, February 21, 2006 - 8:30 AM
Health Sciences, K-069
Peter Byers, MD
Professor
Pathology & Medicine
UWSOM
Tuesday, February 21, 2006 - 8:30 AM
Health Sciences, K-069
Wnt pathways can control cardiogenesis in mouse embryonic stem cells
Shuichi Ueno, MD/PhD
Senior Fellow
Pathology
UWSOM
Tuesday, February 14, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Chuck Murry
Shuichi Ueno, MD/PhD
Senior Fellow
Pathology
UWSOM
Tuesday, February 14, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Chuck Murry
ABC cholesterol transporters as rescuers from cardiovascular disease
John F. Oram
Research Professor
Medicine
UWSOM
Thursday, February 9, 2006 - 4:00 PM
SLU 815 Mercer Street, 111
South Lake Union Seminar Series
John F. Oram
Research Professor
Medicine
UWSOM
Thursday, February 9, 2006 - 4:00 PM
SLU 815 Mercer Street, 111
South Lake Union Seminar Series
The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions
Alain Mauviel, PhD
Director
INSERM U697
Hospital Saint-Louis, Paris, France
Tuesday, February 7, 2006 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Bill Parks
Alain Mauviel, PhD
Director
INSERM U697
Hospital Saint-Louis, Paris, France
Tuesday, February 7, 2006 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Bill Parks
HnRNP K: Gene expression, hubs and scale-free networks
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, January 31, 2006 - 8:30 AM
Health Sciences Building, K-069
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, January 31, 2006 - 8:30 AM
Health Sciences Building, K-069
Molecular Basis of Information
Daniel Storm
Professor
Pharmacology
UWSOM
Tuesday, January 24, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Daniel Storm
Professor
Pharmacology
UWSOM
Tuesday, January 24, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Metalloproteinases: Effectors of Repair or Conspirators of Disease?
William Parks
Director
Center for Lung Biology
UWSOM
Thursday, January 19, 2006 - 4:00 AM
SLU South Lake Union, 111 (Auditorium)
Faculty Sponsor: Stephen M. Schwartz
Special Tapas. Refreshments 3:45 p.m.
William Parks
Director
Center for Lung Biology
UWSOM
Thursday, January 19, 2006 - 4:00 AM
SLU South Lake Union, 111 (Auditorium)
Faculty Sponsor: Stephen M. Schwartz
Special Tapas. Refreshments 3:45 p.m.
Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons
Jennifer O'Brien
Senior Fellow
Pharmacology
UWSOM
Tuesday, January 17, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M. Schwartz
Jennifer O'Brien
Senior Fellow
Pharmacology
UWSOM
Tuesday, January 17, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M. Schwartz
Regulation of Nitric Oxide Synthase by Shear Stress
David G. Harrison MD
Professor, Medicine
Director, Division of Cardiology
Emory University School of Medicine
Tuesday, January 10, 2006 - 8:30 AM
South Lake Union (SLU), 111
Faculty Sponsor: Stephen M. Schwartz
David G. Harrison MD
Professor, Medicine
Director, Division of Cardiology
Emory University School of Medicine
Tuesday, January 10, 2006 - 8:30 AM
South Lake Union (SLU), 111
Faculty Sponsor: Stephen M. Schwartz
Current Diagnosis of Ovarian Mucinous Tumors
Hongxiu Ji, M.D., Ph.D.
Assistant Professor
Departments of Pathology and Obstetrics/Gynecology
The Johns Hopkins University School of Medicine
Tuesday, January 10, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
The special seminar will be presented as part of a didactic session with the residents.
Hongxiu Ji, M.D., Ph.D.
Assistant Professor
Departments of Pathology and Obstetrics/Gynecology
The Johns Hopkins University School of Medicine
Tuesday, January 10, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
The special seminar will be presented as part of a didactic session with the residents.
Apoptosis and Macrophage Inflammation
Keith Elkon, MD
Prof. of Medicine & Adjunct Prof. Immunology
Head, Division of Rheumatology
UWSOM
Tuesday, December 20, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Keith Elkon, MD
Prof. of Medicine & Adjunct Prof. Immunology
Head, Division of Rheumatology
UWSOM
Tuesday, December 20, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Vaccines Targeting Breast and Ovarian Cancers
Nora Disis MD
Associate Professor
Department of Medicine, Division of Oncology
UWSOM
Thursday, December 15, 2005 - 4:00 PM
SLU 815 Mercer Street, 111
Special Tapas Seminar
Nora Disis MD
Associate Professor
Department of Medicine, Division of Oncology
UWSOM
Thursday, December 15, 2005 - 4:00 PM
SLU 815 Mercer Street, 111
Special Tapas Seminar
Assaying Methylation Markers using Coded Silica Particles
Simon Corrie
Visiting Fellow
Pathology
University of Queensland, Australia
Thursday, December 15, 2005 - 9:30 AM
SLU, 815 Mercer Street, 111
Faculty Sponsor: Nancy Kiviat
SLUG Seminar: A Progress Report
Simon Corrie
Visiting Fellow
Pathology
University of Queensland, Australia
Thursday, December 15, 2005 - 9:30 AM
SLU, 815 Mercer Street, 111
Faculty Sponsor: Nancy Kiviat
SLUG Seminar: A Progress Report
Mechanisms of Arterial Constriction due to Urokinase Overexpression
Philip Massey, MD
Acting Instructor
Medicine/Cardiology
UWSOM
Tuesday, December 13, 2005 - 8:30 AM
Health Sciences Building, K-069
Philip Massey, MD
Acting Instructor
Medicine/Cardiology
UWSOM
Tuesday, December 13, 2005 - 8:30 AM
Health Sciences Building, K-069
"Keeping the Balence: Dosage Compensation of the Active X Chromosome in Mammals"
Christine Disteche
Professor
Department of Pathology
University of Washington
Friday, December 9, 2005 - 12:30 PM
Health Sciences Center, Room K-069
Division of Medical Genetics presents the Markey Molecular Medicine Seminar
Christine Disteche
Professor
Department of Pathology
University of Washington
Friday, December 9, 2005 - 12:30 PM
Health Sciences Center, Room K-069
Division of Medical Genetics presents the Markey Molecular Medicine Seminar
Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin
Samantha Harris, PhD
Research Assistant Professor
Bioengineering
UWSOM
Tuesday, December 6, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Samantha Harris, PhD
Research Assistant Professor
Bioengineering
UWSOM
Tuesday, December 6, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Epigenetic Change in the Differentiating Embryonic Stem Cell
Jonathan Golob PhD
Fellow
Department of Pathology
UWSOM
Thursday, December 1, 2005 - 4:15 PM
South Lake Union, 111
Tapas Seminar
Jonathan Golob PhD
Fellow
Department of Pathology
UWSOM
Thursday, December 1, 2005 - 4:15 PM
South Lake Union, 111
Tapas Seminar
Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS)
Conrad Liles
Associate Professor
Medicine, Infectious Diseases
UWSOM
Tuesday, November 29, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Conrad Liles
Associate Professor
Medicine, Infectious Diseases
UWSOM
Tuesday, November 29, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice?
Karin Bornfeldt PhD
Associate Professor
Pathology
UWSOM
Tuesday, November 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Karin Bornfeldt PhD
Associate Professor
Pathology
UWSOM
Tuesday, November 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Developmental Genome Anatomy Project (DGAP): Identification of Genes Critical to Human Development
Azra H. Ligon, Ph.D.
Assistant Professor
Department of Pathology
Harvard Medical School
Thursday, November 17, 2005 - 12:00 PM
Health Sciences Center, Room T-639
Faculty Sponsor: Christine Disteche
Azra H. Ligon, Ph.D.
Assistant Professor
Department of Pathology
Harvard Medical School
Thursday, November 17, 2005 - 12:00 PM
Health Sciences Center, Room T-639
Faculty Sponsor: Christine Disteche
Transcription Factor Regulation of Glial Progenitor Development and Gliomas
Keith L. Ligon, M.D., Ph.D.
Staff Pathologist and Associate Neuropathologist
Department of Pathology
Brigham and Women's Hospital
Wednesday, November 16, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Keith L. Ligon, M.D., Ph.D.
Staff Pathologist and Associate Neuropathologist
Department of Pathology
Brigham and Women's Hospital
Wednesday, November 16, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Vascular Calcification: role of smooth muscle cells and phosphate
Cecilia Giachelli PhD
Professor
Bioengineering
UWSOM
Tuesday, November 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Cecilia Giachelli PhD
Professor
Bioengineering
UWSOM
Tuesday, November 15, 2005 - 8:30 AM
Health Sciences Building, K-069
N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems
Yong Tae Kwon
Assistant Professor
Pharmaceutical Sciences
University of Pittsburgh
Thursday, November 10, 2005 - 8:30 AM
Health Sciences Building, T-635
Faculty Sponsor: Stephen M. Schwartz
Special Breakfast Club
Yong Tae Kwon
Assistant Professor
Pharmaceutical Sciences
University of Pittsburgh
Thursday, November 10, 2005 - 8:30 AM
Health Sciences Building, T-635
Faculty Sponsor: Stephen M. Schwartz
Special Breakfast Club
Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control
Richard Fox
PhD Candidate
Pathology, Cardiovascular Biology
UWSOM
Tuesday, November 8, 2005 - 8:30 AM
Health Sciences Bldg., K-069
Faculty Sponsor: Stephen M Schwartz
Richard Fox
PhD Candidate
Pathology, Cardiovascular Biology
UWSOM
Tuesday, November 8, 2005 - 8:30 AM
Health Sciences Bldg., K-069
Faculty Sponsor: Stephen M Schwartz
A Genome-wide Hunt for Public Mechanisms of Aging
Matt Kaeberlein, Ph.D.
Senior Fellow
Department of Genome Sciences
University of Washington
Wednesday, November 2, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology
Matt Kaeberlein, Ph.D.
Senior Fellow
Department of Genome Sciences
University of Washington
Wednesday, November 2, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology
Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs
Charles Frevert, DVM, ScD
Research Associate Professor
Medicine/Pulmonary & Critical Care Medicine
VA Medical Center/UWSOM
Tuesday, November 1, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Bill Parks
Charles Frevert, DVM, ScD
Research Associate Professor
Medicine/Pulmonary & Critical Care Medicine
VA Medical Center/UWSOM
Tuesday, November 1, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Bill Parks
FISHing for Answers in Pediatric Gliomas
Christine Fuller, M.D.
Assistant Member
Department of Pathology
St. Jude Children's Research Hospital
Wednesday, October 26, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Christine Fuller, M.D.
Assistant Member
Department of Pathology
St. Jude Children's Research Hospital
Wednesday, October 26, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Role of PAI-1 in Progressive Renal Disease
Allison Eddy, MD
Professor & Head
Division of Pediatric Nephrology
Children's Hospital & Med Center, UWSOM
Tuesday, October 25, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Allison Eddy, MD
Professor & Head
Division of Pediatric Nephrology
Children's Hospital & Med Center, UWSOM
Tuesday, October 25, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
"Stromal" Tumors of the Prostate
Donna Hansel, M.D., Ph.D.
Resident
Department of Pathology
Johns Hopkins Hospital
Friday, October 21, 2005 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True
Dr. Hansel is being considered for a faculty position in the Department of Pathology
Donna Hansel, M.D., Ph.D.
Resident
Department of Pathology
Johns Hopkins Hospital
Friday, October 21, 2005 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True
Dr. Hansel is being considered for a faculty position in the Department of Pathology
Roundtable Discussion: Pathologic implications of vascular developmental biology
Brant Weinstein
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics
NIH National Institute of Child Health & Human Development (NICHD)
Tuesday, October 18, 2005 - 9:30 AM
Health Sciences Building, E-212
Faculty Sponsor: Elaine Raines/Steve Schwartz
Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments.
Brant Weinstein
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics
NIH National Institute of Child Health & Human Development (NICHD)
Tuesday, October 18, 2005 - 9:30 AM
Health Sciences Building, E-212
Faculty Sponsor: Elaine Raines/Steve Schwartz
Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments.
Assembly of the Developing Vasculature
Brant M. Weinstein, Ph.D.
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development
National Institutes of Health, Bethesda, MD
Monday, October 17, 2005 - 3:00 PM
Health Sciences Center, Room D-209
Faculty Sponsor: Elaine Raines
Brant M. Weinstein, Ph.D.
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development
National Institutes of Health, Bethesda, MD
Monday, October 17, 2005 - 3:00 PM
Health Sciences Center, Room D-209
Faculty Sponsor: Elaine Raines
Regulation of GPCR Function by RGS
Chris Hague
Assistant Professor
Pharmacology
UWSOM
Tuesday, October 11, 2005 - 8:30 AM
SLU 815 Mercer Street, Auditorium, Rm. 111
Faculty Sponsor: Stephen M. Schwartz
Chris Hague
Assistant Professor
Pharmacology
UWSOM
Tuesday, October 11, 2005 - 8:30 AM
SLU 815 Mercer Street, Auditorium, Rm. 111
Faculty Sponsor: Stephen M. Schwartz
Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits
Eric Schadt, PhD
Senior Scientific Director
Research Genetics
Rosetta Inpharmatics, Inc., Seattle, WA
Tuesday, October 4, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Eric Schadt, PhD
Senior Scientific Director
Research Genetics
Rosetta Inpharmatics, Inc., Seattle, WA
Tuesday, October 4, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Lifestyle modifications improve vascular dysfunction in a mouse model of Type II Diabetes
Dr. Ismail "Issy" Laher
Associate Professor
Pharmacology & Therapeutics
University of British Columbia
Friday, September 23, 2005 - 1:00 PM
HSB, T-359
Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information.
Dr. Ismail "Issy" Laher
Associate Professor
Pharmacology & Therapeutics
University of British Columbia
Friday, September 23, 2005 - 1:00 PM
HSB, T-359
Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information.
Translation control in activated endothelial cells
Larry W. Kraiss MD
Assistant Professor & Chief
Division of Vascular Surgery
University of Utah
Tuesday, September 13, 2005 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Richard Kenagy
Larry W. Kraiss MD
Assistant Professor & Chief
Division of Vascular Surgery
University of Utah
Tuesday, September 13, 2005 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Richard Kenagy
"Anchoring Molecular Lifelines: Integrin Mediated Survival Signals"
Julie Rice
Graduate Student
Pathology
University of Washington
Thursday, August 18, 2005 - 11:00 AM
Chem, 102
Faculty Sponsor: Giachelli
Doctoral Dissertation
Julie Rice
Graduate Student
Pathology
University of Washington
Thursday, August 18, 2005 - 11:00 AM
Chem, 102
Faculty Sponsor: Giachelli
Doctoral Dissertation
Oncolytic adenoviruses: Progress and Challenges
Andre Lieber, MD PhD
Research Associate Professor
Medical Genetics
UWSOM
Thursday, August 4, 2005 - 4:00 PM
South Lake Union, 815 Mercer St., 111 Auditorium
Faculty Sponsor: Stephen M. Schwartz
Special Tapas Presentation
Andre Lieber, MD PhD
Research Associate Professor
Medical Genetics
UWSOM
Thursday, August 4, 2005 - 4:00 PM
South Lake Union, 815 Mercer St., 111 Auditorium
Faculty Sponsor: Stephen M. Schwartz
Special Tapas Presentation
Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD)
Xia (Clare) Shen PhD
Postdoc Candidate
Pharmacology & Toxicology
University of Louisville
Tuesday, July 26, 2005 - 8:30 AM
HSB, K-069
Faculty Sponsor: Karin Bornfeldt
Special Breakfast Club
Xia (Clare) Shen PhD
Postdoc Candidate
Pharmacology & Toxicology
University of Louisville
Tuesday, July 26, 2005 - 8:30 AM
HSB, K-069
Faculty Sponsor: Karin Bornfeldt
Special Breakfast Club
Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium?
Chris Sullivan
Postdoctoral Fellow
Urology
UWSOM
Tuesday, July 19, 2005 - 9:00 AM
South Lake Union, 111
Faculty Sponsor: Hunter Wessells
Chris Sullivan
Postdoctoral Fellow
Urology
UWSOM
Tuesday, July 19, 2005 - 9:00 AM
South Lake Union, 111
Faculty Sponsor: Hunter Wessells
Arrhythmogenic Right Ventricular Cardiomyopathy: From Anatomical Theatre to Double Helix
Gaetano Thiene, M.D., FRCP
Professor, Cardiovascular Patholology
Director, Institute of Pathological Anatomy
University of Padua Medical School
Thursday, June 16, 2005 - 3:30 PM
Health Sciences Center, Room T-435
Faculty Sponsor: Chuck Murry
Gaetano Thiene, M.D., FRCP
Professor, Cardiovascular Patholology
Director, Institute of Pathological Anatomy
University of Padua Medical School
Thursday, June 16, 2005 - 3:30 PM
Health Sciences Center, Room T-435
Faculty Sponsor: Chuck Murry
The role of wnt signaling in zebrafish heart development and regeneration
Cristi Stoick
Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, June 14, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Cristi Stoick
Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, June 14, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Potassium Channel Regulation in Cerebral Arterial Smooth Muscle
Gregory Amberg
Senior Fellow
Physiology & Biophysics
UWSOM
Tuesday, June 7, 2005 - 8:30 AM
Health Sciences Building, K-069
Gregory Amberg
Senior Fellow
Physiology & Biophysics
UWSOM
Tuesday, June 7, 2005 - 8:30 AM
Health Sciences Building, K-069
Physiological and Genomic Consequences of Mitochondrial Oxidative Stress
Simon Melov
Buck Institute
Tuesday, May 31, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Simon Melov
Buck Institute
Tuesday, May 31, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Aldosterone and cardiovascular disease: past, present and future
Bardia Askari
Acting Instructor
Pathology
UWSOM
Tuesday, May 31, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Bardia Askari
Acting Instructor
Pathology
UWSOM
Tuesday, May 31, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Searching for Conserved Mechanisms of Eukaryotic Aging
Brian Kennedy
University of Washington
Tuesday, May 24, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Brian Kennedy
University of Washington
Tuesday, May 24, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle
Kenneth Marro
Research Assistant Professor
Radiology
UWSOM
Tuesday, May 24, 2005 - 9:00 AM
South Lake Union, 100
Faculty Sponsor: Chun Yuan
Please note change of venue to 815 Mercer Street.
Kenneth Marro
Research Assistant Professor
Radiology
UWSOM
Tuesday, May 24, 2005 - 9:00 AM
South Lake Union, 100
Faculty Sponsor: Chun Yuan
Please note change of venue to 815 Mercer Street.
Role of Renal Biopsy in Renal Transplantion
Robert Colvin, M.D.
Castleman Professor & Chair
Department of Pathology
Massachusetts General Hospital
Monday, May 23, 2005 - 2:00 PM
UWMC, Anatomic Pathology Conference Room, NE-110K
Faculty Sponsor: Charles Alpers
Robert Colvin, M.D.
Castleman Professor & Chair
Department of Pathology
Massachusetts General Hospital
Monday, May 23, 2005 - 2:00 PM
UWMC, Anatomic Pathology Conference Room, NE-110K
Faculty Sponsor: Charles Alpers
Intraepithelial Neoplasia in the Pancrea
David Klimstra
Director, Oncologic Pathology Fellowship Programs
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Thursday, May 19, 2005 - 4:00 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Brian Rubin
David Klimstra
Director, Oncologic Pathology Fellowship Programs
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Thursday, May 19, 2005 - 4:00 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Brian Rubin
New Insights on Mechanisms of Calorie Restriction
Rafael DeCabo
Laboratory of Experimental Gerontology
NIA
Tuesday, May 10, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Rafael DeCabo
Laboratory of Experimental Gerontology
NIA
Tuesday, May 10, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor
Marilyn Nourse
Graduate Student
Bioengineering
UWSOM
Tuesday, May 10, 2005 - 8:30 AM
Health Sciences Building, K-069
Marilyn Nourse
Graduate Student
Bioengineering
UWSOM
Tuesday, May 10, 2005 - 8:30 AM
Health Sciences Building, K-069
Tough mice and aging: How to survive with a damaged proteome"
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
New Roles for Uncoupling Proteins in Protection Against Mitochondrial Radical Production and Aging
Martin Brand
MRC Dunn Human Nutrition Unit, Cambridge, UK
Tuesday, May 3, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Martin Brand
MRC Dunn Human Nutrition Unit, Cambridge, UK
Tuesday, May 3, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies
Robert Welikson
Senior Research Fellow
Biochemistry
UWSOM
Tuesday, May 3, 2005 - 8:30 AM
SLU 815 Mercer Street, 100
Faculty Sponsor: Stephen Schwartz
Please note change of venue.
Robert Welikson
Senior Research Fellow
Biochemistry
UWSOM
Tuesday, May 3, 2005 - 8:30 AM
SLU 815 Mercer Street, 100
Faculty Sponsor: Stephen Schwartz
Please note change of venue.
"Grial Cell Regulated, Apolipoprotein E Isoform-Specific Mechanism of Neuroprotection and Neurodegeneration"
Izumi Maezawa
Doctoral Dissertation
Medicine
Pathology
Monday, May 2, 2005 - 1:00 PM
Health Sciences Center, T-639
Izumi Maezawa
Doctoral Dissertation
Medicine
Pathology
Monday, May 2, 2005 - 1:00 PM
Health Sciences Center, T-639
Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde?
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Age-Related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age
Ahmad Heydari
Wayne State University
Tuesday, April 26, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Ahmad Heydari
Wayne State University
Tuesday, April 26, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Uncovering the role of receptor trafficking in disease
Matthew Holdren
Graduate Student
Pathology
UWSOM
Tuesday, April 26, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tony Parks
Matthew Holdren
Graduate Student
Pathology
UWSOM
Tuesday, April 26, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tony Parks
The Role of Protein Tyrosine Phosphatase Receptor Q in Development of Disease
Carmen Jane Booth, D.V.M.
Doctoral Dissertation
Pathology
University of Washington
Friday, April 22, 2005 - 10:00 AM
815 Mercer Building, Room 111
Faculty Sponsor: Dan Bowen-Pope
Carmen Jane Booth, D.V.M.
Doctoral Dissertation
Pathology
University of Washington
Friday, April 22, 2005 - 10:00 AM
815 Mercer Building, Room 111
Faculty Sponsor: Dan Bowen-Pope
Does Oxidative Stress Play an Important Role in Determining Lifespan
Holly Van Remmen
University of Texas, San Antonio
Tuesday, April 19, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Holly Van Remmen
University of Texas, San Antonio
Tuesday, April 19, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Can bacteria cause blood vessels to calcify?
Michael Rosenfeld
Professor
Pathobiology and Pathology
UWSOM
Tuesday, April 19, 2005 - 8:30 AM
Health Sciences Building, K-069
Michael Rosenfeld
Professor
Pathobiology and Pathology
UWSOM
Tuesday, April 19, 2005 - 8:30 AM
Health Sciences Building, K-069
The Role of GH and IGF-1 in Extension of Lifespan and Resistance to Toxic Challenges in Mice
Andrzej Bartke
Southern Illinois University
Tuesday, April 12, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Andrzej Bartke
Southern Illinois University
Tuesday, April 12, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Exploring the immunomodulatory action of mechanical ventilation
William A. Altemeier
Assistant Professor
Pulmonary & Critical Care Medicine
UWSOM
Tuesday, April 12, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Conrad Liles
Please note change of venue.
William A. Altemeier
Assistant Professor
Pulmonary & Critical Care Medicine
UWSOM
Tuesday, April 12, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Conrad Liles
Please note change of venue.
Modeling Neurodegeneration in Yeast
Susan Lindquist, Ph.D.
Member, Whtitehead Institute for Biomedical Research
Professor, Department of Biology
Massachusetts Institutute of Technology
Wednesday, April 6, 2005 - 4:00 PM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Nelson Fausto
Susan Lindquist, Ph.D.
Member, Whtitehead Institute for Biomedical Research
Professor, Department of Biology
Massachusetts Institutute of Technology
Wednesday, April 6, 2005 - 4:00 PM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Nelson Fausto
Why do Big Mice Die Young? Size, Stress, and the Cell Biology of Aging
Rich Miller
University of Michigan
Tuesday, April 5, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Rich Miller
University of Michigan
Tuesday, April 5, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
FDR, April 12, 1945
Karol Bomsztyk
Professor
Medicine, Allergy and Infectious Disease
UWSOM, South Lake Union
Tuesday, April 5, 2005 - 8:30 AM
Health Sciences Building, K-069
Karol Bomsztyk
Professor
Medicine, Allergy and Infectious Disease
UWSOM, South Lake Union
Tuesday, April 5, 2005 - 8:30 AM
Health Sciences Building, K-069
PKA Mutations in Mice Affect Metabolism and Adiposity
Stanley McKnight
University of Washington
Tuesday, March 29, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Stanley McKnight
University of Washington
Tuesday, March 29, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Integrin Signaling: Grasping the survival mechanisms
Donald Courter
PhD Candidate
Bioengineering
University of Washington
Tuesday, March 29, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Donald Courter
PhD Candidate
Bioengineering
University of Washington
Tuesday, March 29, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Hedgehog signaling in angiogenesis
Ronald Heimark PhD
Associate Professor
Surgery, Cell Biology & Anatomy, and Pathology
Arizona Health Sciences Center
Tuesday, March 22, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Stephen M. Schwartz
Please note change of venue.
Ronald Heimark PhD
Associate Professor
Surgery, Cell Biology & Anatomy, and Pathology
Arizona Health Sciences Center
Tuesday, March 22, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Stephen M. Schwartz
Please note change of venue.
Vascular malformations and guidance
Dean Li
Faculty Candidate
Medicine, Division of Cardiology
University of Utah
Tuesday, March 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Dean Li
Faculty Candidate
Medicine, Division of Cardiology
University of Utah
Tuesday, March 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Research Training Seminar
Narci Teoh
Department of Pathology
Thursday, March 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Fausto
Pathology 511 Seminar
Narci Teoh
Department of Pathology
Thursday, March 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Fausto
Pathology 511 Seminar
"The liver as a model system for cell growth, proliferation, and carcinogenesis"
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Recombomice" Shed Light on Homologous Recombination in Mammals
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix
Robert Mecham
Alumni Endowed Professor Cell Biology and Physiology
Medicine, Pediatrics and Bioengineering
Washington University, St. Louis MO
Tuesday, March 1, 2005 - 9:00 AM
South Lake Union, 815 Mercer Street, 110
Faculty Sponsor: Bill Parks
Please note change of location.
Robert Mecham
Alumni Endowed Professor Cell Biology and Physiology
Medicine, Pediatrics and Bioengineering
Washington University, St. Louis MO
Tuesday, March 1, 2005 - 9:00 AM
South Lake Union, 815 Mercer Street, 110
Faculty Sponsor: Bill Parks
Please note change of location.
Research Training Seminar
Izumi Maezawa
Department of Pathology
Thursday, February 24, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Montine
Pathology 511 Seminar
Izumi Maezawa
Department of Pathology
Thursday, February 24, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Montine
Pathology 511 Seminar
Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble
Anne M. Stevens
Acting Assistant Professor
Pediatrics, Division of Immunology/Rheumatology
Children's Hospital and Regional Medical Center
Tuesday, February 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Anne M. Stevens
Acting Assistant Professor
Pediatrics, Division of Immunology/Rheumatology
Children's Hospital and Regional Medical Center
Tuesday, February 22, 2005 - 8:30 AM
Health Sciences Building, K-069
"DNA Repair: Winning the Race with Replication"
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage
Richard Fox
Graduate Student
Pathology
University of Washington
Tuesday, February 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Richard Fox
Graduate Student
Pathology
University of Washington
Tuesday, February 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Research Training Seminar
Rich Fox
Department of Pathology
Thursday, February 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Schwartz
Pathology 511 Seminar
Rich Fox
Department of Pathology
Thursday, February 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Schwartz
Pathology 511 Seminar
Hepsins: Lethal giant larvae
Valeri Vasioukhin
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Tuesday, February 8, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Bill Parks
Valeri Vasioukhin
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Tuesday, February 8, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Bill Parks
Placental malaria and maternal blood pressure
Atis Muehlenbachs
Graduate Student, Concurrent Degree
Molecular & Cellular Biology
UWSOM
Tuesday, February 1, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Dan Bowen-Pope
Atis Muehlenbachs
Graduate Student, Concurrent Degree
Molecular & Cellular Biology
UWSOM
Tuesday, February 1, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Dan Bowen-Pope
Research Training Seminar
Galynn Zitnik
Department of Pathology
Thursday, January 27, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Martin
Pathology 511 Seminar
Galynn Zitnik
Department of Pathology
Thursday, January 27, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Martin
Pathology 511 Seminar
The Role of PI-3 Kinase in Cardioprotection
Charles Steenbergen, MD PhD
Faculty Candidate
Pathology
Duke University, Durham, NC
Tuesday, January 25, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Chuck Murry
Charles Steenbergen, MD PhD
Faculty Candidate
Pathology
Duke University, Durham, NC
Tuesday, January 25, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Chuck Murry
"Females Have Reduced Cardiac Ischemia-Reperfusion Injury and Hypertrophy: A Role for Estrogen Receptor Beta and Nitric Oxide"
Elizabeth Murphy, Ph.D.
Faculty Candidate
Cell Biology Group, Lab of Signal Transduction
Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC
Monday, January 24, 2005 - 4:00 PM
HSB Turner Autitorium, Room D-209
Elizabeth Murphy, Ph.D.
Faculty Candidate
Cell Biology Group, Lab of Signal Transduction
Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC
Monday, January 24, 2005 - 4:00 PM
HSB Turner Autitorium, Room D-209
Inhibitors of Adipogenesis, Stress and Lipotoxicity: Enough to Drive Aging Preadipocytes Mad?
James Kirkland, M.D., Ph.D.
Associate Professor
Department of Medicine
Boston University School of Medicine
Tuesday, January 18, 2005 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant
James Kirkland, M.D., Ph.D.
Associate Professor
Department of Medicine
Boston University School of Medicine
Tuesday, January 18, 2005 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant
Metalloproteinases: Effectors of Innate Immunity
William C. Parks
Professor
Pulmonary & Critical Care Medicine
UWSOM, Harborview
Tuesday, January 18, 2005 - 8:30 AM
Health Sciences Building, K-069
William C. Parks
Professor
Pulmonary & Critical Care Medicine
UWSOM, Harborview
Tuesday, January 18, 2005 - 8:30 AM
Health Sciences Building, K-069
Research Training Seminar
Ashwini Kamath-Loeb
Department of Pathology
Thursday, January 13, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Loeb
Pathology 511 Seminar
Ashwini Kamath-Loeb
Department of Pathology
Thursday, January 13, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Loeb
Pathology 511 Seminar
Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy
Tom Doetschman
Professor of Molecular Genetics
Biochemistry & Micorbiology
University of Cincinnati College of Medicine
Tuesday, January 11, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek/Stephen M. Schwartz
Tom Doetschman
Professor of Molecular Genetics
Biochemistry & Micorbiology
University of Cincinnati College of Medicine
Tuesday, January 11, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek/Stephen M. Schwartz
"Genome Maintenance, Telomeres and RecQ Helicases"
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Angiogenesis in Prostate Cancer
Norman M. Greenberg
Professor
Clinical Research
Fred Hutchinson Cancer Research Center
Tuesday, December 14, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Norman M. Greenberg
Professor
Clinical Research
Fred Hutchinson Cancer Research Center
Tuesday, December 14, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Chaos out of Order: Splicing and Mosaicism in Genetic Collagen Disorders
Peter H. Byers, M.D.
Professor, Adjunct Professor of Genome Sciences & Oral Biology
Pathology
University of Washington
Thursday, December 9, 2004 - 12:00 PM
HSB, T-625
http://depts.washington.edu/mednews/sim04_05.html
Peter H. Byers, M.D.
Professor, Adjunct Professor of Genome Sciences & Oral Biology
Pathology
University of Washington
Thursday, December 9, 2004 - 12:00 PM
HSB, T-625
http://depts.washington.edu/mednews/sim04_05.html
Defective DNA Damage Responses and Neurodegeneration and Brain Tumors."
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics
Tomas Vaisar
Research Scientist
Metabolism, Endocrinology & Nutrition
University of Washington School of Medicine
Tuesday, December 7, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Elaine Raines
Tomas Vaisar
Research Scientist
Metabolism, Endocrinology & Nutrition
University of Washington School of Medicine
Tuesday, December 7, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Elaine Raines
Angiogenesis and Lymphangiogenesis in Inflammation and Tumor Progression
Sam Dadras, M.D., Ph.D.
candidate for a Pathology Faculty Position
Pathology
University of Washington
Monday, December 6, 2004 - 1:15 PM
UWMC, NE-110K
Sam Dadras, M.D., Ph.D.
candidate for a Pathology Faculty Position
Pathology
University of Washington
Monday, December 6, 2004 - 1:15 PM
UWMC, NE-110K
Patterning of Cortical Regions and Connections
John Rubenstein
Nina Ireland Distinguished Professor in Child Psychiatry
University of California, San Francisco
Wednesday, December 1, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
John Rubenstein
Nina Ireland Distinguished Professor in Child Psychiatry
University of California, San Francisco
Wednesday, December 1, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Endothelial Cell Activation and Apoptosis
John M. Harlan
Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Tuesday, November 30, 2004 - 8:30 AM
Health Sciences Building, K-069
John M. Harlan
Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Tuesday, November 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Probing the determinants of inter-individual variability in innate immune inflammatory responses
Mark Wurfel
Acting Instructor
Division of Pulmonary and Critical Care Medicine
University of Washington
Tuesday, November 23, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tom Martin
Mark Wurfel
Acting Instructor
Division of Pulmonary and Critical Care Medicine
University of Washington
Tuesday, November 23, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tom Martin
Characterization of Adenovirus Serotype 35 as a Gene Therapy Vector
Anuj Gaggar
Doctoral Dissertation
Pathology
Dept of Pathology
Thursday, November 18, 2004 - 2:45 PM
UWMC, RR-134
Anuj Gaggar
Doctoral Dissertation
Pathology
Dept of Pathology
Thursday, November 18, 2004 - 2:45 PM
UWMC, RR-134
The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
Magnetic Resonance Imaging: The Coronary Frontier
Won Yong Kim, MD PhD
MR-Center & Department of Cardiology
Skejby University Hospital, Aarhus Denmark
Tuesday, November 16, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Won Yong Kim, MD PhD
MR-Center & Department of Cardiology
Skejby University Hospital, Aarhus Denmark
Tuesday, November 16, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Hypoxia and Angiogenesis: Why Do Endothelial Cells Move into Growing Tumors?
Randall Johnson
Professor
Molecular Biology Section, Division of Biological Sciences
University of California, San Diego
Monday, November 15, 2004 - 8:30 AM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Chuck Murry
Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine
Randall Johnson
Professor
Molecular Biology Section, Division of Biological Sciences
University of California, San Diego
Monday, November 15, 2004 - 8:30 AM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Chuck Murry
Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine
Pharmacological modulation of medial elastocalcinosis
Pierre Moreau, PhD
Associate Professor
Pharmacology
Universit de Montral
Tuesday, November 9, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecelia Giachelli
Pierre Moreau, PhD
Associate Professor
Pharmacology
Universit de Montral
Tuesday, November 9, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecelia Giachelli
Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo
Jan E. Schnitzer, MD
Professor Cellular & Molecular Biology
Scientific Director
Sidney Kimmel Cancer Center, San Diego, CA
Tuesday, November 2, 2004 - 8:30 AM
Health Sciences Building, K-069
Jan E. Schnitzer, MD
Professor Cellular & Molecular Biology
Scientific Director
Sidney Kimmel Cancer Center, San Diego, CA
Tuesday, November 2, 2004 - 8:30 AM
Health Sciences Building, K-069
Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages
Andrew Bender
Senior Fellow
Pharmacology
University of Washington School of Medicine
Tuesday, October 26, 2004 - 8:30 AM
Health Sciences Building, K-069
Andrew Bender
Senior Fellow
Pharmacology
University of Washington School of Medicine
Tuesday, October 26, 2004 - 8:30 AM
Health Sciences Building, K-069
The Molecular Architecture of Signal Transduction Complexes
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
LMNA mutations in progeroid syndromes
Junko Oshima
Research Associate Professor
Pathology
University of Washington
Tuesday, October 19, 2004 - 8:30 AM
Health Sciences Building, K-069
Junko Oshima
Research Associate Professor
Pathology
University of Washington
Tuesday, October 19, 2004 - 8:30 AM
Health Sciences Building, K-069
Intersections between apoptosis and inflammation
Gustave Matute-Bello
Assistant Professor
Department of Medicine, Division of Pulmonary & Critical Care
University of Washington
Pulmonary Research Laboratories, VA Puget Sound Health Care System
Tuesday, October 12, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Martin
Gustave Matute-Bello
Assistant Professor
Department of Medicine, Division of Pulmonary & Critical Care
University of Washington
Pulmonary Research Laboratories, VA Puget Sound Health Care System
Tuesday, October 12, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Martin
Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis
Giulio Gabbiani
Professor
Departments of Pathology and Immunology
University of Geneva-CMU
Tuesday, October 5, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Giulio Gabbiani
Professor
Departments of Pathology and Immunology
University of Geneva-CMU
Tuesday, October 5, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Longevity and Stress-resistance: Mapping the Genes Responsible for Natural Variation in C. Elegans
Robert J. Reis
Professor
Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology
University of Arkansas
Friday, October 1, 2004 - 11:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Robert J. Reis
Professor
Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology
University of Arkansas
Friday, October 1, 2004 - 11:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
What Are the Roles of Mammalian DNA Damage Binding Protein (DDB) Heterodimer and Its Two Individual Subunits
Stuart Linn
Professor
Department of Biochemistry and Molecular Biology
University of California, Berkeley
Monday, September 27, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Stuart Linn
Professor
Department of Biochemistry and Molecular Biology
University of California, Berkeley
Monday, September 27, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Genetics of Coronary Heart Disease
Jan L. Breslow, M.D.
Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism
Rockefeller University
Monday, September 27, 2004 - 10:30 AM
Health Sciences Center, T-439
Faculty Sponsor: Elaine Raines
Jan L. Breslow, M.D.
Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism
Rockefeller University
Monday, September 27, 2004 - 10:30 AM
Health Sciences Center, T-439
Faculty Sponsor: Elaine Raines
Evolving Concepts in Soft Tissue Neoplasia
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Seminar Title: TBA
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Hepatocellular Carcinoma: A Translational Research Challenge
Jordi Bruix
Director
Liver Cancer Unit
Hospital Clinic, Barcelona, Spain
Friday, July 2, 2004 - 9:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Division of Gastroenterology and the Department of
Jordi Bruix
Director
Liver Cancer Unit
Hospital Clinic, Barcelona, Spain
Friday, July 2, 2004 - 9:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Division of Gastroenterology and the Department of
Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction
Rick Rossow
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, June 15, 2004 - 8:30 AM
Health Sciences Building, K-069
Rick Rossow
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, June 15, 2004 - 8:30 AM
Health Sciences Building, K-069
Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Embryonic Stem Cells for Myocardial Infarct Repair
Jeannette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, June 8, 2004 - 9:30 AM
Health Sciences Center, Room T-733
Jeannette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, June 8, 2004 - 9:30 AM
Health Sciences Center, Room T-733
The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells
Bardia Askari
Associate
Howard Hughes Medical Institute
University of Washington
Tuesday, June 8, 2004 - 8:30 AM
Health Sciences Building, K-069
Bardia Askari
Associate
Howard Hughes Medical Institute
University of Washington
Tuesday, June 8, 2004 - 8:30 AM
Health Sciences Building, K-069
Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Harnessing Adult Stem Cells for Myocardial Repair
Ronglih Liao
Associate Professor
Department of Medicine
Boston University School of Medicine
Wednesday, May 26, 2004 - 10:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Ronglih Liao
Associate Professor
Department of Medicine
Boston University School of Medicine
Wednesday, May 26, 2004 - 10:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Mislocalization of Neutrophil Elastase is the Major Cause of Inherited Neutropenia
Richard E. Person
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Tuesday, May 25, 2004 - 11:30 AM
Health Sciences Center, K-069
Richard E. Person
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Tuesday, May 25, 2004 - 11:30 AM
Health Sciences Center, K-069
Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury
David Granville
University of British Columbia
Tuesday, May 25, 2004 - 8:30 AM
HSB, K-069
David Granville
University of British Columbia
Tuesday, May 25, 2004 - 8:30 AM
HSB, K-069
Understanding protein tolerance to random amino acid change through directed evolution
Haiwei H. Guo
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Friday, May 21, 2004 - 12:15 PM
University of Washington Medical Center, RR-134
Haiwei H. Guo
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Friday, May 21, 2004 - 12:15 PM
University of Washington Medical Center, RR-134
Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Histone Methyltransferases in Tumor Suppression
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development
Ujwal Pyati
Graduate Student
Biochemistry
University of Washington
Tuesday, May 18, 2004 - 8:30 AM
HSB, K-069
Ujwal Pyati
Graduate Student
Biochemistry
University of Washington
Tuesday, May 18, 2004 - 8:30 AM
HSB, K-069
Pathway Profiling of Glioblastoma
Paul Mischel
Assistant Professor
Department of Pathology and Laboratory Medicine
UCLA School of Medicine
Thursday, May 13, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Tom Montine
Paul Mischel
Assistant Professor
Department of Pathology and Laboratory Medicine
UCLA School of Medicine
Thursday, May 13, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Tom Montine
New Entities in Pediatric Renal Neoplasia
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart
Jeanette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, May 11, 2004 - 8:30 AM
Health Sciences Building, K-069
Jeanette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, May 11, 2004 - 8:30 AM
Health Sciences Building, K-069
Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Greater Potency of Adult Stem Cells: Possible Mechanisms and Uses
Catherine Verfaillie
Director
Stem Cell Institute
University of Minnesota
Tuesday, May 4, 2004 - 10:00 AM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Charles Murry
Catherine Verfaillie
Director
Stem Cell Institute
University of Minnesota
Tuesday, May 4, 2004 - 10:00 AM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Charles Murry
Genetic Basis of Aortic Aneurysms and Dissections
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension
Gregory C. Amber
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, April 27, 2004 - 8:30 AM
HSB, K069
Gregory C. Amber
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, April 27, 2004 - 8:30 AM
HSB, K069
Biological Roles of ADAMTS Metalloproteases
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
The role of endothelial cells in erectile function and dysfunction
Hunter Wessells
Associate Professor
Urology
University of Washington
Tuesday, April 20, 2004 - 8:30 AM
HSB, K-069
Hunter Wessells
Associate Professor
Urology
University of Washington
Tuesday, April 20, 2004 - 8:30 AM
HSB, K-069
Smooth Muscle Cells and Disease - Insights from Microarray Studies
Eileen Mulvihill
Research Assistant Professor
Pathology
University of Washington
Tuesday, April 13, 2004 - 8:30 AM
Health Sciences Building, K-069
Eileen Mulvihill
Research Assistant Professor
Pathology
University of Washington
Tuesday, April 13, 2004 - 8:30 AM
Health Sciences Building, K-069
Studies in the Pathology and Pathogenesis of Multiple Sclerosis
Samuel Ludwin
Professor
Department of Neuropathology
Queens University: Kingston, Ontario, Canada
Wednesday, April 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Thomas Montine
Samuel Ludwin
Professor
Department of Neuropathology
Queens University: Kingston, Ontario, Canada
Wednesday, April 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Thomas Montine
Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis
Marta Scatena
Research Assistant Professor
Department of Bioengineering
University of Washington
Tuesday, April 6, 2004 - 8:30 AM
Health Sciences Building, K-069
Marta Scatena
Research Assistant Professor
Department of Bioengineering
University of Washington
Tuesday, April 6, 2004 - 8:30 AM
Health Sciences Building, K-069
Cytologic Diagnosis of Lymphomas
Xiaohua Qian
Clinical Fellow
Department of Pathology
Brigham and Women's Hospital
Friday, April 2, 2004 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Brian Rubin
Xiaohua Qian
Clinical Fellow
Department of Pathology
Brigham and Women's Hospital
Friday, April 2, 2004 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Brian Rubin
C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis
Joachim Fruebis
Associate Director, ZymoGenetics, Inc.
Tuesday, March 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Joachim Fruebis
Associate Director, ZymoGenetics, Inc.
Tuesday, March 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment
Mei Speer
Senior Fellow
Bioengineering
University of Washington
Tuesday, March 23, 2004 - 8:30 AM
HSB, K069
Mei Speer
Senior Fellow
Bioengineering
University of Washington
Tuesday, March 23, 2004 - 8:30 AM
HSB, K069
The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Pathology Reporting of Colorectal Cancer in the Molecular Era - When does research become best clinical practice?
Kieran Sheahan
Consultant Pathologist
Center for Colorectal Disease
St. Vincent's University Hospital: Dublin, Ireland
Friday, March 12, 2004 - 9:00 AM
Health Sciences Center, K-069
Kieran Sheahan
Consultant Pathologist
Center for Colorectal Disease
St. Vincent's University Hospital: Dublin, Ireland
Friday, March 12, 2004 - 9:00 AM
Health Sciences Center, K-069
Development Gone Awry: Genetics and Pathology of Medulloblastoma
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Inflammation and atherosclerosis: Role of serum amyloid A
Alan Chait
Edwin L. Bierman Professor of Medicine
Head, Division of Metabolism,
University of Washington
Tuesday, March 9, 2004 - 8:30 AM
HSB, K069
Alan Chait
Edwin L. Bierman Professor of Medicine
Head, Division of Metabolism,
University of Washington
Tuesday, March 9, 2004 - 8:30 AM
HSB, K069
Vascular Calcification in Chronic Kidney Disease
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
New Developments in an Integrated Model of Cardiac Function
N.P Smith and P.J. Hunter
Bioengineering Institute
University of Auckland
Tuesday, March 2, 2004 - 8:30 AM
Health Science Building, K069
Faculty Sponsor: James B Bassingthwaighte
N.P Smith and P.J. Hunter
Bioengineering Institute
University of Auckland
Tuesday, March 2, 2004 - 8:30 AM
Health Science Building, K069
Faculty Sponsor: James B Bassingthwaighte
Genes, Lymphocytes and Autoimmunity
Abul K. Abbas, M.D.
Professor & Chair
Department of Pathology
University of California, San Francisco
Friday, February 27, 2004 - 12:00 PM
Health Sciences Center, Room T-733
Abul K. Abbas, M.D.
Professor & Chair
Department of Pathology
University of California, San Francisco
Friday, February 27, 2004 - 12:00 PM
Health Sciences Center, Room T-733
Utilizing Human Genetics to Understand Vascular Development
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models
Andrew Frutkin
Senior Fellow
Cardiology
University of Washington
Tuesday, February 24, 2004 - 8:30 AM
HSB, K069
Andrew Frutkin
Senior Fellow
Cardiology
University of Washington
Tuesday, February 24, 2004 - 8:30 AM
HSB, K069
Characterization of Cancer-Associated Mutants of DNA Polymerase Beta
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Functional analysis of RGS5 in vascular smooth muscle
Xi Wang
Senior Fellow
Pathology
University of Washington
Tuesday, February 3, 2004 - 8:30 AM
HSB, K069
Xi Wang
Senior Fellow
Pathology
University of Washington
Tuesday, February 3, 2004 - 8:30 AM
HSB, K069
Reduced BRCA1 Expression and Ovarian Tumorigenesis
Rachel M. Gonzalez
Graduate Student
Department of Pathology
University of Washington
Friday, January 30, 2004 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Mary Claire King
Rachel M. Gonzalez
Graduate Student
Department of Pathology
University of Washington
Friday, January 30, 2004 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Mary Claire King
Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity
Todd Gillis
Senior Fellow
Bioengineering
University of Washington
Tuesday, January 27, 2004 - 8:30 AM
HSB, K069
Todd Gillis
Senior Fellow
Bioengineering
University of Washington
Tuesday, January 27, 2004 - 8:30 AM
HSB, K069
Gene transfer to striated muscles using AAV
Jeff Chamberlain
Professor
Neurology
University of Washington
Tuesday, January 20, 2004 - 8:30 AM
HSB, K069
Jeff Chamberlain
Professor
Neurology
University of Washington
Tuesday, January 20, 2004 - 8:30 AM
HSB, K069
Fundamental Issues in Engineered Vessel Development
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Linking Mathmatical Modeling with Clinical Research to Better Understand Brain Cancer (Gliomas)
Kristin R. Swanson
Research Assistant Professor
Departments of Pathology and Applied Mathematics
University of Washington
Tuesday, January 13, 2004 - 2:30 PM
Guggenheim Hall, 317
Kristin R. Swanson
Research Assistant Professor
Departments of Pathology and Applied Mathematics
University of Washington
Tuesday, January 13, 2004 - 2:30 PM
Guggenheim Hall, 317
Myocardial Reperfusion Injury
Tim Pohlman
Professor
Surgery
University of Washington
Tuesday, January 13, 2004 - 8:30 AM
HSB, K069
Tim Pohlman
Professor
Surgery
University of Washington
Tuesday, January 13, 2004 - 8:30 AM
HSB, K069
Prelamin A Processing and Progeria
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
The role of Factor XIII in Hemostasis and Wound Healing
Paul Bishop
Distinguished Fellow
ZymoGenetics
Tuesday, December 16, 2003 - 8:30 AM
Health Sciences, K069
Paul Bishop
Distinguished Fellow
ZymoGenetics
Tuesday, December 16, 2003 - 8:30 AM
Health Sciences, K069
The Role of Runt-Related Transcription Factor @ (Runx2) in Arterial Smooth Muscle Cell Mineralization
Gabrielle Mercedes Curinga
Graduate Student
Department of Pathology
University of Washington
Friday, December 12, 2003 - 10:30 AM
Health Sciences Center, Room RR-134
Gabrielle Mercedes Curinga
Graduate Student
Department of Pathology
University of Washington
Friday, December 12, 2003 - 10:30 AM
Health Sciences Center, Room RR-134
Leukocyte Bcl-2 and ischemia-reperfusion injury
Robert K. Winn
Research Professor
Surgery and Physiology-Biophysics
Harborview Medical Center
Tuesday, December 9, 2003 - 8:30 AM
Health Sciences, K069
Robert K. Winn
Research Professor
Surgery and Physiology-Biophysics
Harborview Medical Center
Tuesday, December 9, 2003 - 8:30 AM
Health Sciences, K069
Translational Control in Macrophage Inflammation
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science
David Siscovick
Professor of Medicine & Epidemiology
Cardiovascular Health Research Unit
University of Washington
Tuesday, December 2, 2003 - 8:30 AM
HSB, K069
David Siscovick
Professor of Medicine & Epidemiology
Cardiovascular Health Research Unit
University of Washington
Tuesday, December 2, 2003 - 8:30 AM
HSB, K069
Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector
Shan Wen
Acting Instructor
Medicine/Division of Cardiology
University of Washington
Tuesday, November 25, 2003 - 8:30 AM
HSB, K069
Shan Wen
Acting Instructor
Medicine/Division of Cardiology
University of Washington
Tuesday, November 25, 2003 - 8:30 AM
HSB, K069
Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock
John Hogenesch
Program Manager, Genomics
Genomics Institute
Novartis Research Foundation
Tuesday, November 18, 2003 - 8:30 AM
HSB, K069
John Hogenesch
Program Manager, Genomics
Genomics Institute
Novartis Research Foundation
Tuesday, November 18, 2003 - 8:30 AM
HSB, K069
Parkinson's Disease Caused by Alpha-synuclein Locus Triplication
Lee-Way Jin, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Friday, November 7, 2003 - 9:30 AM
Harboview Medical Center, R & T Building, Room 113
Lee-Way Jin, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Friday, November 7, 2003 - 9:30 AM
Harboview Medical Center, R & T Building, Room 113
A Murine Model of Intestinal Pseudo-Obstruction
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes
Dale Abel
Assistant Professor of Medicine and Biochemistry
Division of Endocrinology Diabetes and Metabolism
Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine
Tuesday, November 4, 2003 - 8:30 AM
HSB, K069
Dale Abel
Assistant Professor of Medicine and Biochemistry
Division of Endocrinology Diabetes and Metabolism
Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine
Tuesday, November 4, 2003 - 8:30 AM
HSB, K069
Mechanisms of transforming growth factor-beta1-induced neointimal formation
Goro Otsuka
Senior Fellow
Medicine/Cardiology
University of Washington
Tuesday, October 28, 2003 - 8:30 AM
HSB, K069
Goro Otsuka
Senior Fellow
Medicine/Cardiology
University of Washington
Tuesday, October 28, 2003 - 8:30 AM
HSB, K069
Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding
Emilie Clemmens
Graduate Student (Defense date Oct. 7th)
Bioengineering
University of Washington
Tuesday, October 21, 2003 - 8:30 AM
HSB, K069
Emilie Clemmens
Graduate Student (Defense date Oct. 7th)
Bioengineering
University of Washington
Tuesday, October 21, 2003 - 8:30 AM
HSB, K069
Natural antibodies protect against atherogenesis
Gregg Silverman
Professor in Medicine
Dept. of Medicine
UCSD
Tuesday, October 14, 2003 - 8:30 AM
HSB, K069
Gregg Silverman
Professor in Medicine
Dept. of Medicine
UCSD
Tuesday, October 14, 2003 - 8:30 AM
HSB, K069
Many Genes and Many Tumors: Genetics of Uterine Leiomyomata
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Thyroid Hormone and Cardiac Metabolism
Michael Portman
Professor of Pediatrics
Children's Hospital and Regional Medical Center
University of Washington, Division of Cardiology
Tuesday, October 7, 2003 - 8:30 AM
Health Science Buidling, K069
Michael Portman
Professor of Pediatrics
Children's Hospital and Regional Medical Center
University of Washington, Division of Cardiology
Tuesday, October 7, 2003 - 8:30 AM
Health Science Buidling, K069
The Cell Cycle Phase Specificity of DNA Damage and Repair Induced by Radiation, Oxidation and Anti-Topoisomerase II Chemotherapy Drugs
Alan Potter
Graduate Student
Department of Pathology
University of Washington
Thursday, October 2, 2003 - 10:30 AM
Health Sciences Center, Room D-310
Alan Potter
Graduate Student
Department of Pathology
University of Washington
Thursday, October 2, 2003 - 10:30 AM
Health Sciences Center, Room D-310
"Pituitary Tumor Pathogeneis
M. Beatriz S. Lopes, M.D.
Associate Professor
Department of Pathology
University of Virginia Health Sciences Center
Wednesday, September 17, 2003 - 8:00 AM
Harborview Medical Center, Research and Training Auditori
M. Beatriz S. Lopes, M.D.
Associate Professor
Department of Pathology
University of Virginia Health Sciences Center
Wednesday, September 17, 2003 - 8:00 AM
Harborview Medical Center, Research and Training Auditori
The Role of Hypoxia and Genetics in the Progression of Glioblastoma
Daniel J. Brat
Associate Professor
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
Thursday, September 11, 2003 - 4:30 PM
Health Sciences Center, Room T-739
Daniel J. Brat
Associate Professor
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
Thursday, September 11, 2003 - 4:30 PM
Health Sciences Center, Room T-739
The Functions of FE65 Proteins and Their Roles in Dementias of Alzheimer's Disease
Baiping Wang
Graduate Student
Department of Pathology
University of Washington
Tuesday, August 19, 2003 - 10:00 AM
Health Sciences Center, Room K-069
Baiping Wang
Graduate Student
Department of Pathology
University of Washington
Tuesday, August 19, 2003 - 10:00 AM
Health Sciences Center, Room K-069
"Neurospheres and Neurosphere Forming Cells: Morphological and Ultrastructural Characterization
Alessandra Bez
National Neurologic Institute "C.Besta"
Milan, Italy
Monday, July 28, 2003 - 1:00 PM
VA Medical Center, Building 1, Room 812
Alessandra Bez
National Neurologic Institute "C.Besta"
Milan, Italy
Monday, July 28, 2003 - 1:00 PM
VA Medical Center, Building 1, Room 812
Telomere Length and Chromosomal Instability in the Neoplastic Progression of Barrett's Esophagus
Jennifer C. Finley
Graduate Student
Department of Pathology
University of Washington
Wednesday, July 23, 2003 - 3:00 PM
Health Sciences Center, Room K-069
Jennifer C. Finley
Graduate Student
Department of Pathology
University of Washington
Wednesday, July 23, 2003 - 3:00 PM
Health Sciences Center, Room K-069
Cardiovascular Genomics: Clinical Implications
Gary H. Gibbons, M.D
Cardiovascular Research Institute
Morehouse School of Medicine
Monday, June 23, 2003 - 8:30 AM
Health Sciences Building, K069
Gary H. Gibbons, M.D
Cardiovascular Research Institute
Morehouse School of Medicine
Monday, June 23, 2003 - 8:30 AM
Health Sciences Building, K069
"Links between contractile and electrical dysfunction in heart"
Jeffrey E. Saffitz, M.D., Ph.D.
Lacy Professor of Pathology
Department of Pathology and Immunology
Washington University School of Medicine
Thursday, June 19, 2003 - 10:00 AM
Health Sciences Building, K069
Jeffrey E. Saffitz, M.D., Ph.D.
Lacy Professor of Pathology
Department of Pathology and Immunology
Washington University School of Medicine
Thursday, June 19, 2003 - 10:00 AM
Health Sciences Building, K069
Microscale Systems and Applications for Life-on-a-Chip
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Sheep Retroviral Envelope Glycoprotiens: Mechanisms of Oncogenesis and Incorporation into HIV-1 Lentiviral Vectors
Shan-Lu Liu
Graduate Student
Department of Patholgy
University of Washington
Tuesday, June 10, 2003 - 2:00 PM
Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud
Shan-Lu Liu
Graduate Student
Department of Patholgy
University of Washington
Tuesday, June 10, 2003 - 2:00 PM
Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud
Integrative signaling in angiogenesis
Michael Simons
A. G. Huber Professor of Medicine & Chief of Cardiology
Medical School
Dartmouth
Tuesday, June 10, 2003 - 8:30 AM
Health Sciences Building, T747
Michael Simons
A. G. Huber Professor of Medicine & Chief of Cardiology
Medical School
Dartmouth
Tuesday, June 10, 2003 - 8:30 AM
Health Sciences Building, T747
Biotechnology Drug Discovery in the Post-Human Genome Era
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
An Informal Career/Research Workshop
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 9:30 AM
South Campus Center, Room 303
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 9:30 AM
South Campus Center, Room 303
Evolutionary Theories of Aging and How We Test Them
Daniel Promislow
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Georgia
Tuesday, June 3, 2003 - 12:30 PM
HSB, T-639
Daniel Promislow
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Georgia
Tuesday, June 3, 2003 - 12:30 PM
HSB, T-639
Population Mortality Analyses: A Tool for the Study of Aging
Scott Pletcher
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
Baylor College of Medicine
Tuesday, May 27, 2003 - 12:30 PM
HSB, T-639
Scott Pletcher
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
Baylor College of Medicine
Tuesday, May 27, 2003 - 12:30 PM
HSB, T-639
Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Design of Human Aging Studies
Norm Wolf
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 20, 2003 - 12:30 PM
HSB, T-639
Norm Wolf
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 20, 2003 - 12:30 PM
HSB, T-639
Regional Cardiac Sympathetic Dysfunction in CHF
James Caldwell, MD
Professor
Medicine
VA Medical Center
Tuesday, May 20, 2003 - 8:30 AM
Health Sciences Building, K069
James Caldwell, MD
Professor
Medicine
VA Medical Center
Tuesday, May 20, 2003 - 8:30 AM
Health Sciences Building, K069
Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Oligodendrogliomas and Mixed Gliomas: An Epidemic
Peter Burger, M.D.
Professor
Department of Pathology
Johns Hopkins University
Wednesday, May 14, 2003 - 8:00 AM
Harborview Medical Center, R&T Building Auditorium
Faculty Sponsor: Dr. Tom Montine
Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors.
Peter Burger, M.D.
Professor
Department of Pathology
Johns Hopkins University
Wednesday, May 14, 2003 - 8:00 AM
Harborview Medical Center, R&T Building Auditorium
Faculty Sponsor: Dr. Tom Montine
Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors.
Design of Human Aging Studies
William Hazzard
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 13, 2003 - 12:30 PM
HSB, T-639
William Hazzard
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 13, 2003 - 12:30 PM
HSB, T-639
Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Use of Nonhuman Primates for Studies of Caloric Restriction and Aging
George Roth
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
National Institute on Aging
Tuesday, May 6, 2003 - 12:30 PM
HSB, T-639
George Roth
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
National Institute on Aging
Tuesday, May 6, 2003 - 12:30 PM
HSB, T-639
Quantitative proteomics: new technology and applications
Reudi Abersold
Professor and Co-founder of the Institutes for Systems Biology
The Institute for Systems Biology
Tuesday, May 6, 2003 - 8:30 AM
HSB, K069
Reudi Abersold
Professor and Co-founder of the Institutes for Systems Biology
The Institute for Systems Biology
Tuesday, May 6, 2003 - 8:30 AM
HSB, K069
Bacteriophages: Natures Self-replicating, Self-limiting Antibiotics
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Gene Expression Profile Assays: Strengths and Pitfalls
Richard Miller
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Michigan
Tuesday, April 29, 2003 - 12:30 PM
HSB, T-639
Richard Miller
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Michigan
Tuesday, April 29, 2003 - 12:30 PM
HSB, T-639
Marrow Derived Stem Cells- What do we really know?
Beverly J Torok-Storb
Member & Associate Program Head Transplantation Biology Program
Fred Hutchinson Cancer Research Center
Tuesday, April 29, 2003 - 8:30 AM
HSB, K069
Beverly J Torok-Storb
Member & Associate Program Head Transplantation Biology Program
Fred Hutchinson Cancer Research Center
Tuesday, April 29, 2003 - 8:30 AM
HSB, K069
Why Is the Gastric Cardia Such a Big Deal When It Is So Small?
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Transgenic Models: Strengths and Pitfalls
Warren Ladiges
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 22, 2003 - 12:30 PM
HSB, T-639
Warren Ladiges
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 22, 2003 - 12:30 PM
HSB, T-639
Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Caloric Restriction: A Tool for the Study of Aging
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Tuesday, April 15, 2003 - 12:30 PM
HSB, T-639
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Tuesday, April 15, 2003 - 12:30 PM
HSB, T-639
Use of Rodent Models in Aging Research
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Monday, April 14, 2003 - 12:30 PM
HSB, T-639
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Monday, April 14, 2003 - 12:30 PM
HSB, T-639
Pros and Cons of Non-Mammalian Models in Aging Research
Steven Austad
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Idaho
Tuesday, April 8, 2003 - 12:30 PM
HSB, T-639
Steven Austad
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Idaho
Tuesday, April 8, 2003 - 12:30 PM
HSB, T-639
Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
Concepts and Theories of Aging
George Martin
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 1, 2003 - 12:30 PM
HSB, T-639
George Martin
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 1, 2003 - 12:30 PM
HSB, T-639
The Genetics and Biology of Tumor Suppression by p27/Kipl
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
X Inactivation: The Role of the XIST RNA in Silencing a Chromosome
Carolyn Brown
Associate Professor
Department of Medical Genetics
University of British Columbia
Friday, March 21, 2003 - 12:30 PM
Health Sciences Center, Room K-069
Carolyn Brown
Associate Professor
Department of Medical Genetics
University of British Columbia
Friday, March 21, 2003 - 12:30 PM
Health Sciences Center, Room K-069
TBA
Marsha Whitney
Graduate Student
Bioengineering
University of Washington
Tuesday, March 18, 2003 - 8:30 AM
HSB, K069
Marsha Whitney
Graduate Student
Bioengineering
University of Washington
Tuesday, March 18, 2003 - 8:30 AM
HSB, K069
TBA
Lisa Tannock
Acting Instructor/Senior Fellow
Division of Metabolism, Endocrinology and Nutrition
University of Washington
Tuesday, March 4, 2003 - 8:30 AM
HSB, K069
Lisa Tannock
Acting Instructor/Senior Fellow
Division of Metabolism, Endocrinology and Nutrition
University of Washington
Tuesday, March 4, 2003 - 8:30 AM
HSB, K069
Biology and Evolution of Cervical Squamous Intraepithelial Lesions: A Hypothesis with Diagnostic/Prognostic Implications
Kumarasen Cooper, MBChB, DPhil, FRC Path
Director of Anatomic Pathology
University of Vermont College of Medicine
Thursday, February 27, 2003 - 4:30 PM
University of Washington Medical Center, BB-204
Kumarasen Cooper, MBChB, DPhil, FRC Path
Director of Anatomic Pathology
University of Vermont College of Medicine
Thursday, February 27, 2003 - 4:30 PM
University of Washington Medical Center, BB-204
Array CGH for High Resolution Analysis of Genomic Aberrations
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Innate Immune Recognition and Response to Microbial Pathogens
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
TBA
Joe Beavo/ Sergei Rybalkin
Professor/ Acting Instructor
Pharmacology
University of Washington
Tuesday, February 18, 2003 - 8:30 AM
HSB, K069
Joe Beavo/ Sergei Rybalkin
Professor/ Acting Instructor
Pharmacology
University of Washington
Tuesday, February 18, 2003 - 8:30 AM
HSB, K069
The Role of Proteolysis in the Pathogenesis of Atherosclerosis
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
TBA
Joanne Hulme
Senior Fellow
Pharmacology
University of Washington
Tuesday, February 11, 2003 - 8:30 AM
HSB, K069
Joanne Hulme
Senior Fellow
Pharmacology
University of Washington
Tuesday, February 11, 2003 - 8:30 AM
HSB, K069
Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Signaling Pathways Regulating Endothelial Cell Survival and Activation
Xianwu (James) Li
Graduate Student
Department of Pathology
University of Washington
Friday, January 31, 2003 - 3:15 PM
Health Sciences Center, Room K-069
Xianwu (James) Li
Graduate Student
Department of Pathology
University of Washington
Friday, January 31, 2003 - 3:15 PM
Health Sciences Center, Room K-069
Protein Interactions
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
TBA
Jin-Yong Hwang, M.D. (Visiting Scientist)
Assitant Professor
Department of Medicine
Gyeongsang National University, Republic of South Korea
Tuesday, January 21, 2003 - 8:30 AM
HSB, K069
Jin-Yong Hwang, M.D. (Visiting Scientist)
Assitant Professor
Department of Medicine
Gyeongsang National University, Republic of South Korea
Tuesday, January 21, 2003 - 8:30 AM
HSB, K069
Molecular Medicine in the Post Genome Era
Dr. Richard Klausner
Executive Director, Global Health Program
Gates Foundation
Wednesday, January 15, 2003 - 12:00 PM
Hogness Auditorium,
Dr. Richard Klausner
Executive Director, Global Health Program
Gates Foundation
Wednesday, January 15, 2003 - 12:00 PM
Hogness Auditorium,
TBA
Themis Kyriakides
Research Assistant Professor
Biochemistry
University of Washington
Tuesday, January 14, 2003 - 8:30 AM
HSB, K069
Themis Kyriakides
Research Assistant Professor
Biochemistry
University of Washington
Tuesday, January 14, 2003 - 8:30 AM
HSB, K069
From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Delta1: A Notch Up on Hematopoietic Stem Cell Expansion
Irwin Bernstein
Professor
FHCRC
Tuesday, December 17, 2002 - 8:30 AM
HSC, K-069
Irwin Bernstein
Professor
FHCRC
Tuesday, December 17, 2002 - 8:30 AM
HSC, K-069
Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
"A Genetic Approach to Understanding Basement Membrane Assembly"
Mats Paulsson
Professor of Biochemistry
School of Medicine
University of Cologne
Tuesday, December 3, 2002 - 8:30 AM
HSC, K-069
Mats Paulsson
Professor of Biochemistry
School of Medicine
University of Cologne
Tuesday, December 3, 2002 - 8:30 AM
HSC, K-069
"Microarray Analysis in Cancer Research: Progress and Promise"
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Single Cell Proteomics
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
DNA Repair Genes Select Stem Cells in Vivo
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Science in Medicine Lecture: Genetic Instability and Human Disease
Raymond J. Monnat, Jr., M.D.
Professor
Department of Pathology
University of Washington
Thursday, October 24, 2002 - 12:00 PM
HSC, Turner Auditorium, D-209
Raymond J. Monnat, Jr., M.D.
Professor
Department of Pathology
University of Washington
Thursday, October 24, 2002 - 12:00 PM
HSC, Turner Auditorium, D-209
Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
Mouse Models Unravel the p53 Pathway
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer
Robert F. Hevner, M.D, Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Thursday, September 26, 2002 - 12:00 PM
Health Sciences Center, D-209
Robert F. Hevner, M.D, Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Thursday, September 26, 2002 - 12:00 PM
Health Sciences Center, D-209
Neurochemical Dynamics of Traumatic Brain Injury
J. Clay Goodman, M.D.
Professor and Neuropathology Program Director
Departments of Pathology, Neurology, and Neurosurgery
Baylor College of Medicine
Thursday, September 19, 2002 - 4:30 PM
HSC, T-747
J. Clay Goodman, M.D.
Professor and Neuropathology Program Director
Departments of Pathology, Neurology, and Neurosurgery
Baylor College of Medicine
Thursday, September 19, 2002 - 4:30 PM
HSC, T-747
Fas/FADD-Mediated Activation of a Specific Program of Inflammatory Gene Expression in Vascular Smooth Muscle Cells
Friedemann J. Schaub
Graduate Student
Department of Pathology
University of Washington
Thursday, September 19, 2002 - 11:00 AM
HSC, K-069
Friedemann J. Schaub
Graduate Student
Department of Pathology
University of Washington
Thursday, September 19, 2002 - 11:00 AM
HSC, K-069
Diagnosis of Minimal Prostate Cancer in Needle Biopsies - When Should You Jump off the Fence?
John Srigley
Professor
Department of Pathology and Molecular Medicine
McMaster University
Monday, August 26, 2002 - 8:00 AM
UWMC, BB-204
John Srigley
Professor
Department of Pathology and Molecular Medicine
McMaster University
Monday, August 26, 2002 - 8:00 AM
UWMC, BB-204
Cohesion proteins SMC1 and SMC3: roles in aneuploidy and in meiotic chromosome dynamics
Rosalina James
Graduate Stdent of Pathology
School of Medicine
University of Washington
Friday, August 23, 2002 - 11:00 AM
HSC, D-209
Rosalina James
Graduate Stdent of Pathology
School of Medicine
University of Washington
Friday, August 23, 2002 - 11:00 AM
HSC, D-209
Characterization of Genomic Instability in Neoplastic Progression of Ulcerative Colitis
Ru Chen
Graduate Student of Pathology
School of Medicine
University of Washington
Tuesday, August 20, 2002 - 1:00 PM
HSC, K-069
Ru Chen
Graduate Student of Pathology
School of Medicine
University of Washington
Tuesday, August 20, 2002 - 1:00 PM
HSC, K-069
Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
In Vitro Modeling of Breast Cancer
Krishna Rao
Graduate Student of Pathology
School of Medicine
University of Washington
Wednesday, July 10, 2002 - 1:00 PM
Doctoral Dissertation, Pelton Auditorium
Day Campu
Krishna Rao
Graduate Student of Pathology
School of Medicine
University of Washington
Wednesday, July 10, 2002 - 1:00 PM
Doctoral Dissertation, Pelton Auditorium
Day Campu
"Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing"
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
"Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex"
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
"Immunohistochemistry in Urologic Tumor Pathology"
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Cell Adhesion in the Vasculature
Richard O. Hynes, Ph.D., F.R.S.
Daniel K. Ludwig Professor for Cancer Research
Department of Biology
Massachusetts Institute of Technology
Friday, May 24, 2002 - 11:00 AM
Health Sciences Center, D-209
Richard O. Hynes, Ph.D., F.R.S.
Daniel K. Ludwig Professor for Cancer Research
Department of Biology
Massachusetts Institute of Technology
Friday, May 24, 2002 - 11:00 AM
Health Sciences Center, D-209
Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,
Genetics in Everyday Life
David R. Cox, M.D., Ph.D.
Professor and Associate Chair
Department of Genetics
Stanford University
Thursday, January 10, 2002 - 4:30 PM
Health Sciences Center, T-739
David R. Cox, M.D., Ph.D.
Professor and Associate Chair
Department of Genetics
Stanford University
Thursday, January 10, 2002 - 4:30 PM
Health Sciences Center, T-739