Basic Biology of Aging Lecture Series 
The Nathan Shock Center of Excellence in the Basic Biology of Aging, and the Genetic Approaches to Aging Training Grant present the Basic Biology of Aging Seminar Lecture Series.
No upcoming seminars are currently posted.
Past Basic Biology of Aging Lecture Series
Aging, Adipose Tissue Inflammation, and Cellular Senescence
James Kirkland, MD, PhD
Robert and Arlene Kogod Center on Aging
Mayo Clinic
Friday, April 5, 2013 - 1:30 PM
Bioengineering Building, Foege N-130
Faculty Sponsor: Peter Rabinovitch and Matt Kaeberlein
Why Attend?
This seminar will show how these three topics are closely intertwined. Adipose tissue is often the largest organ in humans and is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat cell progenitors, preadipocytes, dysdifferentiate in old age, switching into a pro-inflammatory, tissue-remodeling, senescent-like state. Pro-inflammatory processes may amplify each other and have systemic consequences. Senescent, pro-inflammatory cells in fat could have profound clinical consequences because of the large size of the fat organ and its central metabolic role. Consistent with this, clearance of p16INK4a-positive senescent cells delays ageing-associated disorders.
For further information contact Rachel Wilsey: wilseyr@uw.edu, 206-897-1759 or Peter Rabinovitch: PeterR@medicine.washington.edu, 206-685-3761.
James Kirkland, MD, PhD
Robert and Arlene Kogod Center on Aging
Mayo Clinic
Friday, April 5, 2013 - 1:30 PM
Bioengineering Building, Foege N-130
Faculty Sponsor: Peter Rabinovitch and Matt Kaeberlein
Why Attend?
This seminar will show how these three topics are closely intertwined. Adipose tissue is often the largest organ in humans and is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat cell progenitors, preadipocytes, dysdifferentiate in old age, switching into a pro-inflammatory, tissue-remodeling, senescent-like state. Pro-inflammatory processes may amplify each other and have systemic consequences. Senescent, pro-inflammatory cells in fat could have profound clinical consequences because of the large size of the fat organ and its central metabolic role. Consistent with this, clearance of p16INK4a-positive senescent cells delays ageing-associated disorders.
For further information contact Rachel Wilsey: wilseyr@uw.edu, 206-897-1759 or Peter Rabinovitch: PeterR@medicine.washington.edu, 206-685-3761.
Is the Life-extending Action of Cu/ZnSOD Overexpression in Mammals Obesity Dependent?
Yuji Ikeno, MD, PhD
Assistant Professor
Pathology Department & the Barshop Institute
University of Texas Health Science Center at San Antonio, Texas
Tuesday, October 2, 2012 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Matt Kaeberlein and Peter Rabinovitch
Why Attend?
Dr. Ikeno’s lab has recently found that Sprague-Dawley rats overexpressing Cu/ZnSOD (SOD1) in (SD) have a significant increase in lifespan and a reduction in age-related pathologies. In contrast, F344 rats that overexpress SOD1 have little increase in lifespan compared to wild-type rats. Interestingly, Sprague-Dawley, but not F344 rats have an age-related increase in body fat and insulin sensitivity. Dr. Ikeno will discuss the hypothesis that overexpression of Cu/ZnSOD is most protective against oxidative stress and attenuates aging and age-related diseases mainly under obese conditions in mammals.
For more information contact Matt Kaeberlein at 543-4849 or Peter Rabinovitch at 685-3761
Yuji Ikeno, MD, PhD
Assistant Professor
Pathology Department & the Barshop Institute
University of Texas Health Science Center at San Antonio, Texas
Tuesday, October 2, 2012 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Matt Kaeberlein and Peter Rabinovitch
Why Attend?
Dr. Ikeno’s lab has recently found that Sprague-Dawley rats overexpressing Cu/ZnSOD (SOD1) in (SD) have a significant increase in lifespan and a reduction in age-related pathologies. In contrast, F344 rats that overexpress SOD1 have little increase in lifespan compared to wild-type rats. Interestingly, Sprague-Dawley, but not F344 rats have an age-related increase in body fat and insulin sensitivity. Dr. Ikeno will discuss the hypothesis that overexpression of Cu/ZnSOD is most protective against oxidative stress and attenuates aging and age-related diseases mainly under obese conditions in mammals.
For more information contact Matt Kaeberlein at 543-4849 or Peter Rabinovitch at 685-3761
A Network Perspective on the Biology of Aging
Daniel Promislow, Ph.D.
Professor
Department of Genetics
University of Georgia
Wednesday, July 11, 2012 - 10:30 AM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, PhD
Why Attend?
Knocking out a single gene can more than double the life expectancy of a small worm. Over the past two decades, scientists have uncovered scores of single mutants that increase lifespan in laboratory organisms. But in the case of aging, the links between genotype and phenotype are extremely complex. On closer inspection, the molecular basis of aging involves a large and complex network of genes, proteins and metabolites. In fact, a comprehensive understanding of the genetics of aging calls for an integrated approach, linking not just genes or proteins in molecular networks, but a suite of molecular, behavioral, physiological and demographic traits, from single cells to large populations. Recognizing this complexity, Dr. Promislow's work on the evolution of aging attempts to answer two key questions. First, why is there variation in rates of aging among individuals, and second, why do different processes fail at different rates within individuals? This seminar will describe how a network approach, applied to inbred, laboratory models as well as to genetically heterogeneous populations, can shed new light on these important questions.
For more information contact Matt Kaeberlein at 543-4849 or George Martin at 543-5088
Daniel Promislow, Ph.D.
Professor
Department of Genetics
University of Georgia
Wednesday, July 11, 2012 - 10:30 AM
Health Sciences Center, Rm. K-069
Faculty Sponsor: Matt Kaeberlein, PhD
Why Attend?
Knocking out a single gene can more than double the life expectancy of a small worm. Over the past two decades, scientists have uncovered scores of single mutants that increase lifespan in laboratory organisms. But in the case of aging, the links between genotype and phenotype are extremely complex. On closer inspection, the molecular basis of aging involves a large and complex network of genes, proteins and metabolites. In fact, a comprehensive understanding of the genetics of aging calls for an integrated approach, linking not just genes or proteins in molecular networks, but a suite of molecular, behavioral, physiological and demographic traits, from single cells to large populations. Recognizing this complexity, Dr. Promislow's work on the evolution of aging attempts to answer two key questions. First, why is there variation in rates of aging among individuals, and second, why do different processes fail at different rates within individuals? This seminar will describe how a network approach, applied to inbred, laboratory models as well as to genetically heterogeneous populations, can shed new light on these important questions.
For more information contact Matt Kaeberlein at 543-4849 or George Martin at 543-5088
Xenobiotic Surveillance and Response in the Regulation of C. Elegans Longevity and Satiety
Gary Ruvkun, PhD
Professor
Department of Genetics
Havard University
Tuesday, June 5, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Gary Ruvkun, PhD
Professor
Department of Genetics
Havard University
Tuesday, June 5, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Tumor Suppressor Mechanisms in Long-lived Rodents
Vera Gorbunova, PhD
Associate Professor
Department of Biology
University of Rochester
Tuesday, May 22, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Vera Gorbunova, PhD
Associate Professor
Department of Biology
University of Rochester
Tuesday, May 22, 2012 - 11:30 AM
Bioengineering Building, Foege N-130
Faculty Sponsor: Matt Kaeberlein, PhD
The Role of Transsulfuration in the Health and Aging of Drosophila Melanogaster
Scott Pletcher, PhD
Assistant Professor
Molecular Integrative Physiology
University of Michigan Medical School
Tuesday, May 15, 2012 - 11:30 AM
Foege Builiding, Bioengineering Conference Room, N-130
Faculty Sponsor: Matt Kaeberlein, PhD
Scott Pletcher, PhD
Assistant Professor
Molecular Integrative Physiology
University of Michigan Medical School
Tuesday, May 15, 2012 - 11:30 AM
Foege Builiding, Bioengineering Conference Room, N-130
Faculty Sponsor: Matt Kaeberlein, PhD
The Brain and Fat: Dissecting Systemic Control of Metabolism and Aging in the NAD World
Shin-ichiro Imai, MD, PhD
Associate Professor
Department of Developmental Biology & Medicine
Washington University School of Medicine
Tuesday, March 20, 2012 - 3:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, MD, PhD
Why Attend
Sirtuins have become established as important factors modulating aging-related disease in mammals. The Imai laboratory studies the role of SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) for the regulation of metabolism and aging. Dr. Imai has proposed a comprehensive concept of a novel systemic regulatory network, named NAD World, for the intricate connection between metabolism and aging. This new concept of the NAD World may provide important insights into the systemic regulation of mammalian aging and longevity and also convey ideas of functional hierarchy and frailty for the induction of aging. By understanding the system dynamics of the NAD World, Dr. Imai's goal is to develop therapeutic and preventive interventions for age-associated diseases, such as type 2 diabetes and Alzheimer's disease. Here are three burning questions that the Imai lab is trying to answer: 1) Which organs/tissues play a major role in the regulation of aging and longevity in mammals? Is there any control center of aging? 2) What hormones/factors mediate the communication between the control center of aging and other modulatory organs/tissues? 3) What molecules/signaling pathways coordinate the regulation of mammalian aging at a systemic level?
Shin-ichiro Imai, MD, PhD
Associate Professor
Department of Developmental Biology & Medicine
Washington University School of Medicine
Tuesday, March 20, 2012 - 3:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch, MD, PhD
Why Attend
Sirtuins have become established as important factors modulating aging-related disease in mammals. The Imai laboratory studies the role of SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) for the regulation of metabolism and aging. Dr. Imai has proposed a comprehensive concept of a novel systemic regulatory network, named NAD World, for the intricate connection between metabolism and aging. This new concept of the NAD World may provide important insights into the systemic regulation of mammalian aging and longevity and also convey ideas of functional hierarchy and frailty for the induction of aging. By understanding the system dynamics of the NAD World, Dr. Imai's goal is to develop therapeutic and preventive interventions for age-associated diseases, such as type 2 diabetes and Alzheimer's disease. Here are three burning questions that the Imai lab is trying to answer: 1) Which organs/tissues play a major role in the regulation of aging and longevity in mammals? Is there any control center of aging? 2) What hormones/factors mediate the communication between the control center of aging and other modulatory organs/tissues? 3) What molecules/signaling pathways coordinate the regulation of mammalian aging at a systemic level?
Extending Lifespan by promoting proliferative homeostasis in Drosophila
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Mitochondrial signaling in Disease and Aging
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Adenylyl cyclase type 5 (AC5), cardiac stress and longevity
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Genetic Variation in Aging and Longevity
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Chemical Modifications of Proteins during Aging
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Diet, Death and Demography
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Mitochondria, Age and the Heart
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D