Department of Pathology, University of Washington
Peter Rabinovitch
Dr. Rabinovitch's primary interests are in cell cycle, cell proliferation, and the role of genomic instability in the aging process and in early events leading to neoplasia.
Dr. Rabinovitch studies alterations in cell proliferation and genetic instability in aging and in neoplastic progression. He is examining the connection between free-radical theories of aging, altered redox status and the basis of the decreased proliferative potential of aged somatic cells. In particular, the progeroid disease Werner Syndrome is being studied as a potential model of the connection between altered DNA repair, genetic instability, and aging.
Dr. Rabinovitch is also the PI for the renewal of the long-standing program project in aging begun by Dr. George Martin. This renewal focuses on mouse models with augmented antioxidant and antimutator capacity. Overexpression of catalase targeted to the mitochondria is the most promising model to date, with extension of both mean and maximal lifespan. Dr. Rabinovitch is also using the premalignant gastrointestinal diseases ulcerative colitis and Barrett's esophagus as models of the relationship between immortalization, genetic instability, and the clinical risk of progression to cancer. He has a special interest in using cytometric technologies to study the cell cycle and genetic instability.
Dr. Rabinovitch is Professor of Pathology, Joint Full Member of the Fred Hutchinson Cancer Research Center, and Director of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington.
2. Poot M, Gollahon KA, Rabinovitch PS. Werner Syndrome lymphoblastoid cells are sensitive to camptothecin induced apoptosis in S phase. Hum. Genet. 104:10-14, 1999.
3. Barrett MT, Sanchez CA, Prevo LJ, Wong DJ, Galipeau PC, Paulson TG, Rabinovitch PS, Reid BJ. Evolution of Neoplastic Cell Lineages in Barrett's Esophagus. Nature Genetics, 22:106–109, 1999.
4. Rabinovitch PS, Dziadon S, Bronner MP, Emond MJ, Crispin DA, Haggitt RC, Brentnall TA. Pancolonic Chromosomal Instability Precedes Dysplasia and Cancer in Ulcerative Colitis. Cancer Research, 59:5148-53,1999.
5. Reid, B.J., Levine, D.S., Longton, G., Blount, P.L., Rabinovitch, P.S. Predictors of Progression to Cancer in Barrett's Esophagus: Baseline Histology and Flow Cytometry Identify Low and High Risk Patient Subsets. American Journal of Gastroenterology, 95: 1669-1676, 2000.
6. Poot, M., Yom JS., Whang, SH., Kato JT, Gollahon KA, Rabinovitch, PS. Werner Syndrome Cells are Sensitive to DNA Cross-linking Drugs. The FASEB Journal 15:1224-6, 2001.
7. Reid, BJ, Prevo, LJ, Galipeau PC, Sanchez CA, Longton G, Levine DS, Blount PL, Rabinovitch PS. Predictors of Progression in Barrett's Esophagus II: Baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression. The American Journal of Gasteroenterology 96:2839-48, 2001.
8. Rabinovitch PS, Longton G, Blount PL, Levine DS, Reid, BJ. Predictors of Progression in Barrett's Esophagus III: Baseline Flow Cytometric Variables. The American Journal of Gasteroenterology 96:3071-3083, 2001.
9. Treuting P, Hopkins H, Ware C, Rabinovitch P, Ladiges W. Generation of genetically altered mouse models for aging studies. Experimental Mol Path, 72:49-55, 2002.
10. Poot M, Silber JR and. Rabinovitch PS. A novel flow cytometric technique for drug cytotoxicity gives results comparable to colony-forming assays. Cytometry 48:1-5, 2002.
11. Potter AJ, Gollahon KA, Palanca BJ, Harbert MJ, Choi YM, Moskovitz AH, Potter JD, Rabinovitch PS. Flow cytometric analysis of the cell cycle phase specificity of DNA damage induced by radiation, hydrogen peroxide and doxorubicin. Carcinogenesis 23:389-401, 2002
12. Barrett MT, Jeri Glogovac, Prevo LJ, Reid BJ, Porter P, Rabinovitch PS. High quality RNA and DNA from flow cytometrically sorted human epithelial cells and tissues. Biotechniques 32:888-896 2002
13. Barrett MT, Yeung KY, Ruzzo WL, Hsu L, Blount PL, Sullivan R, Zarbl H, Delrow J, Rabinovitch PS, Reid BJ. Transcriptional Analyses of Barrett's Metaplasia and Normal Upper GI Mucosae. Neoplasia 4:121-8, 2002.
14. Poot M, Gollahon KA, Emond MJ, Silber JR, Rabinovitch PS. Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. FASEB J. 16:757-8, 2002.
15. O'Sullivan JN, Bronner MP, Brentnall TA, Finley JC, Shen W-T, Emerson S, Emond MJ, Gollahon KA, Moskovitz AH, Crispin DA, Potter JD, and Rabinovitch PS. Chromosomal Instability is Related to Telomere Shortening in a Human Preneoplastic Disease (Ulcerative Colitis). Nature Genetics, Oct;32(2):280-4, 2002
16. Chen R, Rabinovitch PS, Crispin DA, Emond MJ, Koprowicz KM, Bronner MP, Brentnall TA. DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free. Am J Pathol. Feb;162(2):665-72, 2003
17. Palanca-Wessels MCA, Klingelhutz A, Reid BJ, Norwood TH, Opheim KE, Paulson TG, Feng Z, Rabinovitch PS. Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model. Carcinogenesis. Jul;24(7):1183-90, 2003.